LeishMANIAdb
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Dnaj chaperone-like protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Dnaj chaperone-like protein
Gene product:
dnaj chaperone-like protein
Species:
Leishmania infantum
UniProt:
A4I8V3_LEIIN
TriTrypDb:
LINF_330016300
Length:
581

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, Dnaj chaperone-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Phosphorylation

Promastigote/Amastigote: 510, 578

Expansion

Sequence features

A4I8V3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8V3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 114 118 PF00656 0.374
CLV_C14_Caspase3-7 383 387 PF00656 0.530
CLV_NRD_NRD_1 191 193 PF00675 0.354
CLV_NRD_NRD_1 225 227 PF00675 0.549
CLV_NRD_NRD_1 24 26 PF00675 0.480
CLV_NRD_NRD_1 345 347 PF00675 0.674
CLV_NRD_NRD_1 360 362 PF00675 0.683
CLV_NRD_NRD_1 542 544 PF00675 0.516
CLV_NRD_NRD_1 563 565 PF00675 0.483
CLV_PCSK_FUR_1 189 193 PF00082 0.348
CLV_PCSK_KEX2_1 12 14 PF00082 0.516
CLV_PCSK_KEX2_1 191 193 PF00082 0.354
CLV_PCSK_KEX2_1 20 22 PF00082 0.478
CLV_PCSK_KEX2_1 225 227 PF00082 0.549
CLV_PCSK_KEX2_1 24 26 PF00082 0.474
CLV_PCSK_KEX2_1 345 347 PF00082 0.674
CLV_PCSK_KEX2_1 359 361 PF00082 0.687
CLV_PCSK_KEX2_1 541 543 PF00082 0.519
CLV_PCSK_PC1ET2_1 12 14 PF00082 0.516
CLV_PCSK_PC1ET2_1 20 22 PF00082 0.478
CLV_PCSK_SKI1_1 12 16 PF00082 0.558
CLV_PCSK_SKI1_1 225 229 PF00082 0.566
CLV_PCSK_SKI1_1 25 29 PF00082 0.447
CLV_PCSK_SKI1_1 294 298 PF00082 0.548
DEG_APCC_DBOX_1 293 301 PF00400 0.350
DOC_ANK_TNKS_1 540 547 PF00023 0.715
DOC_CDC14_PxL_1 138 146 PF14671 0.329
DOC_MAPK_gen_1 20 28 PF00069 0.294
DOC_MAPK_MEF2A_6 459 468 PF00069 0.350
DOC_MAPK_NFAT4_5 459 467 PF00069 0.350
DOC_PP1_RVXF_1 241 247 PF00149 0.333
DOC_USP7_MATH_1 340 344 PF00917 0.568
DOC_USP7_MATH_1 396 400 PF00917 0.536
DOC_WW_Pin1_4 12 17 PF00397 0.309
DOC_WW_Pin1_4 127 132 PF00397 0.523
DOC_WW_Pin1_4 151 156 PF00397 0.531
DOC_WW_Pin1_4 344 349 PF00397 0.473
DOC_WW_Pin1_4 563 568 PF00397 0.714
LIG_14-3-3_CanoR_1 121 126 PF00244 0.567
LIG_14-3-3_CanoR_1 189 198 PF00244 0.580
LIG_14-3-3_CanoR_1 294 300 PF00244 0.322
LIG_14-3-3_CanoR_1 359 366 PF00244 0.485
LIG_14-3-3_CanoR_1 395 401 PF00244 0.486
LIG_BRCT_BRCA1_1 129 133 PF00533 0.494
LIG_Clathr_ClatBox_1 132 136 PF01394 0.372
LIG_FHA_1 172 178 PF00498 0.329
LIG_FHA_1 191 197 PF00498 0.569
LIG_FHA_1 286 292 PF00498 0.329
LIG_FHA_1 423 429 PF00498 0.366
LIG_FHA_1 433 439 PF00498 0.389
LIG_FHA_1 472 478 PF00498 0.295
LIG_FHA_1 86 92 PF00498 0.382
LIG_FHA_1 98 104 PF00498 0.329
LIG_FHA_2 46 52 PF00498 0.294
LIG_FHA_2 564 570 PF00498 0.727
LIG_GBD_Chelix_1 422 430 PF00786 0.361
LIG_IBAR_NPY_1 405 407 PF08397 0.474
LIG_LIR_Gen_1 122 133 PF02991 0.536
LIG_LIR_Gen_1 209 218 PF02991 0.329
LIG_LIR_Gen_1 3 10 PF02991 0.294
LIG_LIR_Nem_3 122 128 PF02991 0.543
LIG_LIR_Nem_3 209 214 PF02991 0.329
LIG_LIR_Nem_3 272 278 PF02991 0.333
LIG_LIR_Nem_3 3 8 PF02991 0.294
LIG_LIR_Nem_3 450 454 PF02991 0.494
LIG_LIR_Nem_3 48 53 PF02991 0.294
LIG_LIR_Nem_3 60 65 PF02991 0.293
LIG_NRBOX 163 169 PF00104 0.390
LIG_NRBOX 426 432 PF00104 0.350
LIG_Pex14_2 111 115 PF04695 0.502
LIG_Pex14_2 129 133 PF04695 0.420
LIG_SH2_CRK 23 27 PF00017 0.294
LIG_SH2_CRK 241 245 PF00017 0.341
LIG_SH2_CRK 451 455 PF00017 0.494
LIG_SH2_GRB2like 445 448 PF00017 0.590
LIG_SH2_NCK_1 241 245 PF00017 0.341
LIG_SH2_PTP2 125 128 PF00017 0.517
LIG_SH2_STAT3 407 410 PF00017 0.468
LIG_SH2_STAT5 125 128 PF00017 0.573
LIG_SH2_STAT5 195 198 PF00017 0.595
LIG_SH2_STAT5 206 209 PF00017 0.290
LIG_SH2_STAT5 241 244 PF00017 0.329
LIG_SH2_STAT5 275 278 PF00017 0.329
LIG_SH2_STAT5 303 306 PF00017 0.396
LIG_SH3_1 519 525 PF00018 0.676
LIG_SH3_3 125 131 PF00018 0.527
LIG_SH3_3 136 142 PF00018 0.329
LIG_SH3_3 519 525 PF00018 0.732
LIG_SUMO_SIM_anti_2 163 169 PF11976 0.350
LIG_SUMO_SIM_par_1 226 232 PF11976 0.342
LIG_SUMO_SIM_par_1 295 302 PF11976 0.346
LIG_SUMO_SIM_par_1 452 458 PF11976 0.333
LIG_SUMO_SIM_par_1 6 11 PF11976 0.276
LIG_TYR_ITIM 273 278 PF00017 0.350
LIG_UBA3_1 227 231 PF00899 0.419
LIG_WRC_WIRS_1 112 117 PF05994 0.350
LIG_WRC_WIRS_1 82 87 PF05994 0.557
MOD_CDK_SPK_2 563 568 PF00069 0.672
MOD_CDK_SPxxK_3 563 570 PF00069 0.653
MOD_CK1_1 154 160 PF00069 0.500
MOD_CK1_1 220 226 PF00069 0.475
MOD_CK1_1 302 308 PF00069 0.483
MOD_CK2_1 45 51 PF00069 0.329
MOD_CK2_1 507 513 PF00069 0.639
MOD_CK2_1 556 562 PF00069 0.650
MOD_CK2_1 563 569 PF00069 0.603
MOD_CMANNOS 198 201 PF00535 0.404
MOD_Cter_Amidation 357 360 PF01082 0.592
MOD_GlcNHglycan 548 551 PF01048 0.683
MOD_GlcNHglycan 558 561 PF01048 0.606
MOD_GSK3_1 216 223 PF00069 0.380
MOD_GSK3_1 295 302 PF00069 0.418
MOD_GSK3_1 340 347 PF00069 0.615
MOD_GSK3_1 396 403 PF00069 0.590
MOD_GSK3_1 443 450 PF00069 0.451
MOD_GSK3_1 552 559 PF00069 0.646
MOD_GSK3_1 571 578 PF00069 0.615
MOD_GSK3_1 81 88 PF00069 0.509
MOD_N-GLC_1 239 244 PF02516 0.420
MOD_NEK2_1 111 116 PF00069 0.309
MOD_NEK2_1 285 290 PF00069 0.394
MOD_NEK2_1 295 300 PF00069 0.376
MOD_NEK2_1 431 436 PF00069 0.364
MOD_NEK2_1 455 460 PF00069 0.462
MOD_NEK2_1 85 90 PF00069 0.508
MOD_NEK2_2 206 211 PF00069 0.350
MOD_PIKK_1 471 477 PF00454 0.273
MOD_PKA_1 359 365 PF00069 0.598
MOD_PKA_2 190 196 PF00069 0.397
MOD_PKA_2 359 365 PF00069 0.598
MOD_PKA_2 575 581 PF00069 0.710
MOD_Plk_1 239 245 PF00069 0.449
MOD_Plk_1 572 578 PF00069 0.712
MOD_Plk_4 111 117 PF00069 0.312
MOD_Plk_4 160 166 PF00069 0.394
MOD_Plk_4 171 177 PF00069 0.279
MOD_Plk_4 285 291 PF00069 0.329
MOD_Plk_4 295 301 PF00069 0.411
MOD_Plk_4 422 428 PF00069 0.435
MOD_ProDKin_1 12 18 PF00069 0.350
MOD_ProDKin_1 127 133 PF00069 0.371
MOD_ProDKin_1 151 157 PF00069 0.527
MOD_ProDKin_1 344 350 PF00069 0.577
MOD_ProDKin_1 563 569 PF00069 0.637
MOD_SUMO_rev_2 224 233 PF00179 0.450
MOD_SUMO_rev_2 499 508 PF00179 0.613
TRG_ENDOCYTIC_2 125 128 PF00928 0.380
TRG_ENDOCYTIC_2 23 26 PF00928 0.329
TRG_ENDOCYTIC_2 241 244 PF00928 0.398
TRG_ENDOCYTIC_2 275 278 PF00928 0.329
TRG_ENDOCYTIC_2 451 454 PF00928 0.329
TRG_ENDOCYTIC_2 5 8 PF00928 0.329
TRG_ENDOCYTIC_2 50 53 PF00928 0.329
TRG_ER_diArg_1 189 192 PF00400 0.401
TRG_ER_diArg_1 225 227 PF00400 0.410
TRG_ER_diArg_1 23 25 PF00400 0.309
TRG_ER_diArg_1 344 346 PF00400 0.584
TRG_ER_diArg_1 359 361 PF00400 0.598
TRG_ER_diArg_1 540 543 PF00400 0.636
TRG_Pf-PMV_PEXEL_1 225 229 PF00026 0.451
TRG_Pf-PMV_PEXEL_1 318 322 PF00026 0.572

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0P4 Leptomonas seymouri 51% 100%
A0A3S7X6M9 Leishmania donovani 100% 100%
A4HLE4 Leishmania braziliensis 67% 100%
E9B3S2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q4A2 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS