Zf-Tim10_DDP domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8V2_LEIIN

TriTrypDb:

LINF_330016200

Length:

114

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I8V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8V2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_3	1	3	PF02207	0.582
DEG_SCF_FBW7_2	6	13	PF00400	0.546
DOC_CKS1_1	7	12	PF01111	0.552
DOC_PP4_MxPP_1	1	4	PF00568	0.573
DOC_WW_Pin1_4	6	11	PF00397	0.591
LIG_14-3-3_CanoR_1	26	33	PF00244	0.509
LIG_APCC_ABBA_1	8	13	PF00400	0.530
LIG_BRCT_BRCA1_1	34	38	PF00533	0.417
LIG_FHA_1	35	41	PF00498	0.502
LIG_FHA_1	44	50	PF00498	0.469
LIG_FHA_2	7	13	PF00498	0.477
LIG_FHA_2	86	92	PF00498	0.550
LIG_LIR_Gen_1	16	27	PF02991	0.412
LIG_LIR_Gen_1	48	58	PF02991	0.454
LIG_LIR_Gen_1	78	89	PF02991	0.529
LIG_LIR_Nem_3	16	22	PF02991	0.460
LIG_LIR_Nem_3	78	84	PF02991	0.524
LIG_Pex14_1	81	85	PF04695	0.393
LIG_SH2_CRK	19	23	PF00017	0.494
LIG_SH2_GRB2like	21	24	PF00017	0.558
LIG_SH2_SRC	21	24	PF00017	0.484
LIG_SH2_STAP1	11	15	PF00017	0.565
LIG_SH2_STAT3	62	65	PF00017	0.552
LIG_SH2_STAT5	21	24	PF00017	0.558
LIG_SH2_STAT5	50	53	PF00017	0.477
LIG_SH3_3	1	7	PF00018	0.551
LIG_TRAF2_1	10	13	PF00917	0.577
MOD_CK2_1	6	12	PF00069	0.490
MOD_CK2_1	85	91	PF00069	0.536
MOD_GlcNHglycan	28	31	PF01048	0.423
MOD_GlcNHglycan	77	80	PF01048	0.514
MOD_GSK3_1	48	55	PF00069	0.456
MOD_GSK3_1	85	92	PF00069	0.529
MOD_N-GLC_1	13	18	PF02516	0.552
MOD_N-GLC_1	33	38	PF02516	0.409
MOD_N-GLC_1	75	80	PF02516	0.512
MOD_N-GLC_1	85	90	PF02516	0.539
MOD_NEK2_1	32	37	PF00069	0.428
MOD_NEK2_1	52	57	PF00069	0.458
MOD_NEK2_1	85	90	PF00069	0.539
MOD_PIKK_1	43	49	PF00454	0.462
MOD_PKA_2	53	59	PF00069	0.461
MOD_Plk_1	33	39	PF00069	0.507
MOD_Plk_1	85	91	PF00069	0.542
MOD_Plk_4	48	54	PF00069	0.455
MOD_ProDKin_1	6	12	PF00069	0.585
MOD_SUMO_rev_2	67	74	PF00179	0.413
TRG_DiLeu_BaEn_1	48	53	PF01217	0.491
TRG_ENDOCYTIC_2	19	22	PF00928	0.501
TRG_ENDOCYTIC_2	50	53	PF00928	0.477
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I217	Leptomonas seymouri	68%	100%
A0A0S4JGU8	Bodo saltans	58%	98%
A0A1X0P0S4	Trypanosomatidae	60%	100%
A0A3Q8IDN3	Leishmania donovani	100%	100%
A0A422P2N7	Trypanosoma rangeli	59%	100%
A4HLE3	Leishmania braziliensis	91%	100%
D0A4U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	97%
E9B3S1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q4A3	Leishmania major	96%	100%