LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I8U9_LEIIN
TriTrypDb:
LINF_310010200
Length:
434

Annotations

LeishMANIAdb annotations

A small folded protein with a long C-terminal TM segment. Very unclear topology.. Expanded on multiple lineages, especially Strigomonas.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 5, no: 12
NetGPI no yes: 0, no: 17
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
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Expansion

Sequence features

A4I8U9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8U9

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 1
GO:0016491 oxidoreductase activity 2 1
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 1
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 218 220 PF00675 0.300
CLV_NRD_NRD_1 26 28 PF00675 0.403
CLV_NRD_NRD_1 3 5 PF00675 0.412
CLV_NRD_NRD_1 73 75 PF00675 0.347
CLV_PCSK_KEX2_1 218 220 PF00082 0.300
CLV_PCSK_KEX2_1 3 5 PF00082 0.412
CLV_PCSK_KEX2_1 407 409 PF00082 0.627
CLV_PCSK_PC1ET2_1 407 409 PF00082 0.656
CLV_PCSK_SKI1_1 168 172 PF00082 0.271
CLV_PCSK_SKI1_1 218 222 PF00082 0.289
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P304 Leptomonas seymouri 56% 100%
A0A0N0P958 Leptomonas seymouri 26% 100%
A0A0S4JG88 Bodo saltans 31% 100%
A0A1X0P126 Trypanosomatidae 34% 100%
A0A3Q8IGS5 Leishmania donovani 100% 100%
A0A3S7X466 Leishmania donovani 26% 100%
A4HJ26 Leishmania braziliensis 28% 100%
A4HLE0 Leishmania braziliensis 82% 100%
A4I6E8 Leishmania infantum 28% 100%
D0A4U6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS