LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I8U9_LEIIN
TriTrypDb:
LINF_310010200
Length:
434

Annotations

LeishMANIAdb annotations

A small folded protein with a long C-terminal TM segment. Very unclear topology.. Expanded on multiple lineages, especially Strigomonas.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 5, no: 12
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4I8U9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8U9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016491 oxidoreductase activity 2 1
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 1
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 218 220 PF00675 0.300
CLV_NRD_NRD_1 26 28 PF00675 0.403
CLV_NRD_NRD_1 3 5 PF00675 0.412
CLV_NRD_NRD_1 73 75 PF00675 0.347
CLV_PCSK_KEX2_1 218 220 PF00082 0.300
CLV_PCSK_KEX2_1 3 5 PF00082 0.412
CLV_PCSK_KEX2_1 407 409 PF00082 0.627
CLV_PCSK_PC1ET2_1 407 409 PF00082 0.656
CLV_PCSK_SKI1_1 168 172 PF00082 0.271
CLV_PCSK_SKI1_1 218 222 PF00082 0.289
CLV_PCSK_SKI1_1 396 400 PF00082 0.534
CLV_PCSK_SKI1_1 77 81 PF00082 0.328
DEG_SPOP_SBC_1 112 116 PF00917 0.423
DOC_CYCLIN_RxL_1 39 47 PF00134 0.476
DOC_CYCLIN_yCln2_LP_2 294 300 PF00134 0.528
DOC_CYCLIN_yCln2_LP_2 5 11 PF00134 0.194
DOC_MAPK_FxFP_2 13 16 PF00069 0.194
DOC_MAPK_gen_1 3 9 PF00069 0.209
DOC_MAPK_gen_1 333 341 PF00069 0.513
DOC_MAPK_MEF2A_6 206 214 PF00069 0.528
DOC_MAPK_MEF2A_6 334 343 PF00069 0.446
DOC_PP1_RVXF_1 175 181 PF00149 0.528
DOC_PP2B_LxvP_1 100 103 PF13499 0.528
DOC_PP2B_LxvP_1 294 297 PF13499 0.486
DOC_PP2B_LxvP_1 36 39 PF13499 0.548
DOC_PP2B_LxvP_1 5 8 PF13499 0.242
DOC_PP4_FxxP_1 13 16 PF00568 0.194
DOC_USP7_MATH_1 111 115 PF00917 0.520
DOC_USP7_MATH_1 119 123 PF00917 0.593
DOC_USP7_MATH_1 128 132 PF00917 0.574
DOC_USP7_MATH_1 155 159 PF00917 0.528
DOC_USP7_MATH_1 234 238 PF00917 0.519
DOC_USP7_MATH_1 316 320 PF00917 0.457
DOC_USP7_MATH_1 402 406 PF00917 0.381
DOC_USP7_MATH_1 419 423 PF00917 0.445
DOC_USP7_UBL2_3 403 407 PF12436 0.318
DOC_WW_Pin1_4 121 126 PF00397 0.477
DOC_WW_Pin1_4 134 139 PF00397 0.406
DOC_WW_Pin1_4 220 225 PF00397 0.489
DOC_WW_Pin1_4 30 35 PF00397 0.600
DOC_WW_Pin1_4 53 58 PF00397 0.490
LIG_14-3-3_CanoR_1 27 37 PF00244 0.611
LIG_14-3-3_CanoR_1 77 82 PF00244 0.492
LIG_Actin_WH2_2 203 220 PF00022 0.528
LIG_APCC_ABBA_1 376 381 PF00400 0.428
LIG_APCC_ABBAyCdc20_2 139 145 PF00400 0.423
LIG_APCC_ABBAyCdc20_2 369 375 PF00400 0.287
LIG_BRCT_BRCA1_1 405 409 PF00533 0.311
LIG_deltaCOP1_diTrp_1 285 293 PF00928 0.480
LIG_EVH1_1 36 40 PF00568 0.520
LIG_EVH1_2 10 14 PF00568 0.194
LIG_FHA_1 107 113 PF00498 0.594
LIG_FHA_1 165 171 PF00498 0.476
LIG_FHA_1 253 259 PF00498 0.528
LIG_FHA_1 31 37 PF00498 0.613
LIG_FHA_1 334 340 PF00498 0.416
LIG_FHA_2 318 324 PF00498 0.528
LIG_FHA_2 66 72 PF00498 0.500
LIG_GBD_Chelix_1 345 353 PF00786 0.258
LIG_LIR_Apic_2 185 190 PF02991 0.528
LIG_LIR_Gen_1 153 164 PF02991 0.482
LIG_LIR_Gen_1 237 247 PF02991 0.423
LIG_LIR_Gen_1 292 301 PF02991 0.542
LIG_LIR_Gen_1 358 368 PF02991 0.334
LIG_LIR_Gen_1 84 89 PF02991 0.461
LIG_LIR_Gen_1 96 103 PF02991 0.461
LIG_LIR_Nem_3 153 159 PF02991 0.482
LIG_LIR_Nem_3 285 290 PF02991 0.483
LIG_LIR_Nem_3 292 296 PF02991 0.489
LIG_LIR_Nem_3 358 364 PF02991 0.321
LIG_LIR_Nem_3 367 371 PF02991 0.331
LIG_LIR_Nem_3 84 88 PF02991 0.461
LIG_LIR_Nem_3 96 100 PF02991 0.461
LIG_MAD2 42 50 PF02301 0.446
LIG_MYND_1 34 38 PF01753 0.531
LIG_NRBOX 348 354 PF00104 0.394
LIG_Pex14_2 13 17 PF04695 0.194
LIG_SH2_STAP1 361 365 PF00017 0.273
LIG_SH2_STAT5 361 364 PF00017 0.372
LIG_SH2_STAT5 371 374 PF00017 0.383
LIG_SH2_STAT5 67 70 PF00017 0.468
LIG_SH3_2 37 42 PF14604 0.582
LIG_SH3_3 135 141 PF00018 0.498
LIG_SH3_3 145 151 PF00018 0.453
LIG_SH3_3 169 175 PF00018 0.486
LIG_SH3_3 293 299 PF00018 0.524
LIG_SH3_3 306 312 PF00018 0.542
LIG_SH3_3 31 37 PF00018 0.693
LIG_SH3_3 5 11 PF00018 0.213
LIG_SH3_CIN85_PxpxPR_1 134 139 PF14604 0.423
LIG_SH3_CIN85_PxpxPR_1 37 42 PF14604 0.498
LIG_SUMO_SIM_anti_2 166 174 PF11976 0.468
LIG_SUMO_SIM_par_1 166 174 PF11976 0.468
LIG_SUMO_SIM_par_1 350 356 PF11976 0.447
LIG_SUMO_SIM_par_1 42 47 PF11976 0.486
LIG_SxIP_EBH_1 42 55 PF03271 0.445
LIG_UBA3_1 426 434 PF00899 0.356
LIG_WRC_WIRS_1 354 359 PF05994 0.461
LIG_WW_2 34 37 PF00397 0.537
LIG_WW_3 39 43 PF00397 0.596
MOD_CDK_SPK_2 134 139 PF00069 0.433
MOD_CDK_SPxxK_3 53 60 PF00069 0.554
MOD_CK1_1 319 325 PF00069 0.504
MOD_CK1_1 355 361 PF00069 0.380
MOD_CK1_1 391 397 PF00069 0.448
MOD_CK2_1 353 359 PF00069 0.497
MOD_GlcNHglycan 115 118 PF01048 0.342
MOD_GlcNHglycan 134 137 PF01048 0.261
MOD_GlcNHglycan 197 200 PF01048 0.223
MOD_GlcNHglycan 258 261 PF01048 0.281
MOD_GlcNHglycan 30 33 PF01048 0.440
MOD_GlcNHglycan 389 393 PF01048 0.666
MOD_GlcNHglycan 423 426 PF01048 0.598
MOD_GSK3_1 128 135 PF00069 0.453
MOD_GSK3_1 247 254 PF00069 0.591
MOD_GSK3_1 355 362 PF00069 0.437
MOD_GSK3_1 65 72 PF00069 0.485
MOD_N-GLC_1 202 207 PF02516 0.244
MOD_N-GLC_1 317 322 PF02516 0.334
MOD_NEK2_1 143 148 PF00069 0.566
MOD_NEK2_1 256 261 PF00069 0.416
MOD_NEK2_1 332 337 PF00069 0.505
MOD_NEK2_1 352 357 PF00069 0.334
MOD_NEK2_1 44 49 PF00069 0.487
MOD_NEK2_1 69 74 PF00069 0.472
MOD_PIKK_1 359 365 PF00454 0.319
MOD_PKA_1 333 339 PF00069 0.396
MOD_PKA_1 403 409 PF00069 0.403
MOD_PKA_2 164 170 PF00069 0.544
MOD_PKA_2 256 262 PF00069 0.485
MOD_Plk_1 359 365 PF00069 0.283
MOD_Plk_1 388 394 PF00069 0.394
MOD_Plk_1 69 75 PF00069 0.508
MOD_Plk_4 143 149 PF00069 0.475
MOD_Plk_4 155 161 PF00069 0.439
MOD_Plk_4 44 50 PF00069 0.480
MOD_ProDKin_1 121 127 PF00069 0.477
MOD_ProDKin_1 134 140 PF00069 0.406
MOD_ProDKin_1 220 226 PF00069 0.489
MOD_ProDKin_1 30 36 PF00069 0.596
MOD_ProDKin_1 53 59 PF00069 0.490
TRG_DiLeu_BaEn_4 173 179 PF01217 0.528
TRG_DiLeu_BaLyEn_6 274 279 PF01217 0.433
TRG_DiLeu_BaLyEn_6 74 79 PF01217 0.453
TRG_ENDOCYTIC_2 361 364 PF00928 0.377
TRG_ER_diArg_1 2 4 PF00400 0.360
TRG_ER_diArg_1 217 219 PF00400 0.530
TRG_ER_diArg_1 231 234 PF00400 0.590
TRG_ER_diArg_1 281 284 PF00400 0.423

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P304 Leptomonas seymouri 56% 100%
A0A0N0P958 Leptomonas seymouri 26% 100%
A0A0S4JG88 Bodo saltans 31% 100%
A0A1X0P126 Trypanosomatidae 34% 100%
A0A3Q8IGS5 Leishmania donovani 100% 100%
A0A3S7X466 Leishmania donovani 26% 100%
A4HJ26 Leishmania braziliensis 28% 100%
A4HLE0 Leishmania braziliensis 82% 100%
A4I6E8 Leishmania infantum 28% 100%
D0A4U6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E8NHM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B1J8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B3R8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q4A6 Leishmania major 93% 100%
Q4Q6L5 Leishmania major 25% 92%
V5BPD5 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS