Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8U8_LEIIN

TriTrypDb:

LINF_330015800

Length:

916

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8U8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	394	398	PF00656	0.718
CLV_C14_Caspase3-7	405	409	PF00656	0.781
CLV_C14_Caspase3-7	574	578	PF00656	0.762
CLV_C14_Caspase3-7	584	588	PF00656	0.603
CLV_NRD_NRD_1	11	13	PF00675	0.635
CLV_NRD_NRD_1	160	162	PF00675	0.752
CLV_NRD_NRD_1	171	173	PF00675	0.645
CLV_NRD_NRD_1	322	324	PF00675	0.517
CLV_NRD_NRD_1	4	6	PF00675	0.676
CLV_NRD_NRD_1	412	414	PF00675	0.673
CLV_NRD_NRD_1	442	444	PF00675	0.726
CLV_NRD_NRD_1	466	468	PF00675	0.592
CLV_NRD_NRD_1	47	49	PF00675	0.587
CLV_NRD_NRD_1	774	776	PF00675	0.734
CLV_NRD_NRD_1	783	785	PF00675	0.664
CLV_PCSK_FUR_1	45	49	PF00082	0.588
CLV_PCSK_KEX2_1	11	13	PF00082	0.635
CLV_PCSK_KEX2_1	160	162	PF00082	0.702
CLV_PCSK_KEX2_1	171	173	PF00082	0.597
CLV_PCSK_KEX2_1	322	324	PF00082	0.514
CLV_PCSK_KEX2_1	4	6	PF00082	0.676
CLV_PCSK_KEX2_1	441	443	PF00082	0.724
CLV_PCSK_KEX2_1	47	49	PF00082	0.587
CLV_PCSK_KEX2_1	783	785	PF00082	0.705
CLV_PCSK_SKI1_1	445	449	PF00082	0.706
CLV_PCSK_SKI1_1	809	813	PF00082	0.676
CLV_PCSK_SKI1_1	820	824	PF00082	0.674
CLV_PCSK_SKI1_1	836	840	PF00082	0.503
CLV_PCSK_SKI1_1	875	879	PF00082	0.552
DEG_APCC_DBOX_1	808	816	PF00400	0.679
DEG_Nend_Nbox_1	1	3	PF02207	0.691
DEG_SCF_FBW7_1	482	489	PF00400	0.733
DEG_SCF_FBW7_1	897	903	PF00400	0.736
DEG_SPOP_SBC_1	547	551	PF00917	0.711
DEG_SPOP_SBC_1	581	585	PF00917	0.674
DOC_CDC14_PxL_1	153	161	PF14671	0.727
DOC_CKS1_1	824	829	PF01111	0.734
DOC_CKS1_1	897	902	PF01111	0.635
DOC_CYCLIN_yCln2_LP_2	695	701	PF00134	0.647
DOC_MAPK_DCC_7	322	331	PF00069	0.374
DOC_MAPK_DCC_7	689	697	PF00069	0.595
DOC_MAPK_gen_1	11	18	PF00069	0.585
DOC_MAPK_gen_1	319	329	PF00069	0.503
DOC_MAPK_gen_1	423	432	PF00069	0.771
DOC_MAPK_HePTP_8	215	227	PF00069	0.488
DOC_MAPK_MEF2A_6	146	153	PF00069	0.518
DOC_MAPK_MEF2A_6	218	227	PF00069	0.492
DOC_MAPK_MEF2A_6	322	331	PF00069	0.374
DOC_MAPK_MEF2A_6	689	697	PF00069	0.595
DOC_PP1_RVXF_1	251	258	PF00149	0.471
DOC_PP2B_LxvP_1	227	230	PF13499	0.443
DOC_PP2B_LxvP_1	500	503	PF13499	0.745
DOC_PP2B_LxvP_1	695	698	PF13499	0.639
DOC_PP2B_LxvP_1	895	898	PF13499	0.605
DOC_PP4_FxxP_1	177	180	PF00568	0.664
DOC_PP4_FxxP_1	257	260	PF00568	0.459
DOC_PP4_FxxP_1	721	724	PF00568	0.635
DOC_USP7_MATH_1	109	113	PF00917	0.614
DOC_USP7_MATH_1	173	177	PF00917	0.702
DOC_USP7_MATH_1	270	274	PF00917	0.673
DOC_USP7_MATH_1	3	7	PF00917	0.669
DOC_USP7_MATH_1	392	396	PF00917	0.692
DOC_USP7_MATH_1	398	402	PF00917	0.762
DOC_USP7_MATH_1	449	453	PF00917	0.672
DOC_USP7_MATH_1	486	490	PF00917	0.692
DOC_USP7_MATH_1	548	552	PF00917	0.659
DOC_USP7_MATH_1	702	706	PF00917	0.706
DOC_USP7_MATH_1	796	800	PF00917	0.648
DOC_WW_Pin1_4	130	135	PF00397	0.713
DOC_WW_Pin1_4	382	387	PF00397	0.776
DOC_WW_Pin1_4	445	450	PF00397	0.706
DOC_WW_Pin1_4	470	475	PF00397	0.715
DOC_WW_Pin1_4	482	487	PF00397	0.762
DOC_WW_Pin1_4	543	548	PF00397	0.765
DOC_WW_Pin1_4	603	608	PF00397	0.706
DOC_WW_Pin1_4	688	693	PF00397	0.528
DOC_WW_Pin1_4	823	828	PF00397	0.740
DOC_WW_Pin1_4	896	901	PF00397	0.564
LIG_14-3-3_CanoR_1	160	170	PF00244	0.676
LIG_14-3-3_CanoR_1	171	180	PF00244	0.479
LIG_14-3-3_CanoR_1	232	240	PF00244	0.447
LIG_14-3-3_CanoR_1	253	258	PF00244	0.465
LIG_14-3-3_CanoR_1	399	403	PF00244	0.815
LIG_14-3-3_CanoR_1	523	533	PF00244	0.780
LIG_14-3-3_CanoR_1	57	65	PF00244	0.646
LIG_14-3-3_CterR_2	912	916	PF00244	0.567
LIG_Actin_WH2_2	700	718	PF00022	0.710
LIG_APCC_ABBA_1	145	150	PF00400	0.494
LIG_APCC_ABBA_1	813	818	PF00400	0.663
LIG_BIR_III_2	501	505	PF00653	0.697
LIG_BIR_III_4	577	581	PF00653	0.573
LIG_BRCT_BRCA1_1	235	239	PF00533	0.441
LIG_BRCT_BRCA1_1	253	257	PF00533	0.466
LIG_BRCT_BRCA1_1	834	838	PF00533	0.733
LIG_CSL_BTD_1	738	741	PF09270	0.613
LIG_deltaCOP1_diTrp_1	250	257	PF00928	0.572
LIG_FHA_1	229	235	PF00498	0.451
LIG_FHA_1	260	266	PF00498	0.598
LIG_FHA_1	897	903	PF00498	0.634
LIG_FHA_2	131	137	PF00498	0.599
LIG_FHA_2	22	28	PF00498	0.670
LIG_FHA_2	403	409	PF00498	0.832
LIG_FHA_2	446	452	PF00498	0.707
LIG_FHA_2	530	536	PF00498	0.696
LIG_FHA_2	584	590	PF00498	0.642
LIG_FHA_2	845	851	PF00498	0.608
LIG_LIR_Apic_2	175	180	PF02991	0.682
LIG_LIR_Apic_2	254	260	PF02991	0.454
LIG_LIR_Apic_2	651	657	PF02991	0.478
LIG_LIR_Gen_1	100	110	PF02991	0.575
LIG_LIR_Gen_1	292	301	PF02991	0.517
LIG_LIR_Nem_3	100	106	PF02991	0.669
LIG_LIR_Nem_3	250	255	PF02991	0.479
LIG_LIR_Nem_3	27	32	PF02991	0.572
LIG_LIR_Nem_3	292	298	PF02991	0.527
LIG_LIR_Nem_3	908	914	PF02991	0.600
LIG_NRBOX	242	248	PF00104	0.460
LIG_NRBOX	567	573	PF00104	0.636
LIG_Pex14_1	667	671	PF04695	0.519
LIG_SH2_CRK	700	704	PF00017	0.687
LIG_SH2_SRC	103	106	PF00017	0.593
LIG_SH2_SRC	816	819	PF00017	0.538
LIG_SH2_STAP1	103	107	PF00017	0.557
LIG_SH2_STAP1	266	270	PF00017	0.707
LIG_SH2_STAP1	333	337	PF00017	0.551
LIG_SH2_STAT3	113	116	PF00017	0.589
LIG_SH2_STAT5	113	116	PF00017	0.565
LIG_SH2_STAT5	367	370	PF00017	0.719
LIG_SH2_STAT5	517	520	PF00017	0.551
LIG_SH2_STAT5	598	601	PF00017	0.685
LIG_SH3_1	383	389	PF00018	0.739
LIG_SH3_2	684	689	PF14604	0.580
LIG_SH3_3	103	109	PF00018	0.695
LIG_SH3_3	131	137	PF00018	0.696
LIG_SH3_3	274	280	PF00018	0.690
LIG_SH3_3	383	389	PF00018	0.761
LIG_SH3_3	681	687	PF00018	0.665
LIG_SH3_3	78	84	PF00018	0.624
LIG_SH3_3	894	900	PF00018	0.615
LIG_SUMO_SIM_anti_2	347	355	PF11976	0.600
LIG_SUMO_SIM_par_1	643	648	PF11976	0.387
LIG_TRAF2_1	359	362	PF00917	0.737
LIG_TRAF2_1	377	380	PF00917	0.508
LIG_TRAF2_1	532	535	PF00917	0.774
LIG_TRAF2_1	729	732	PF00917	0.653
LIG_TRAF2_1	847	850	PF00917	0.551
LIG_TRAF2_1	869	872	PF00917	0.743
LIG_TRAF2_1	903	906	PF00917	0.642
LIG_TRAF2_2	389	394	PF00917	0.776
LIG_TRFH_1	823	827	PF08558	0.644
LIG_WRC_WIRS_1	29	34	PF05994	0.571
LIG_WRC_WIRS_1	343	348	PF05994	0.512
MOD_CDK_SPxxK_3	603	610	PF00069	0.707
MOD_CK1_1	118	124	PF00069	0.697
MOD_CK1_1	130	136	PF00069	0.618
MOD_CK1_1	251	257	PF00069	0.497
MOD_CK1_1	281	287	PF00069	0.761
MOD_CK1_1	489	495	PF00069	0.693
MOD_CK1_1	541	547	PF00069	0.839
MOD_CK1_1	603	609	PF00069	0.754
MOD_CK1_1	624	630	PF00069	0.592
MOD_CK1_1	97	103	PF00069	0.578
MOD_CK2_1	109	115	PF00069	0.426
MOD_CK2_1	130	136	PF00069	0.618
MOD_CK2_1	21	27	PF00069	0.670
MOD_CK2_1	374	380	PF00069	0.791
MOD_CK2_1	445	451	PF00069	0.744
MOD_CK2_1	529	535	PF00069	0.699
MOD_CK2_1	548	554	PF00069	0.725
MOD_CK2_1	583	589	PF00069	0.637
MOD_CK2_1	726	732	PF00069	0.727
MOD_CK2_1	784	790	PF00069	0.812
MOD_CK2_1	844	850	PF00069	0.578
MOD_CK2_1	900	906	PF00069	0.658
MOD_CK2_1	98	104	PF00069	0.561
MOD_DYRK1A_RPxSP_1	445	449	PF00069	0.704
MOD_GlcNHglycan	117	120	PF01048	0.703
MOD_GlcNHglycan	129	132	PF01048	0.629
MOD_GlcNHglycan	268	271	PF01048	0.672
MOD_GlcNHglycan	280	283	PF01048	0.792
MOD_GlcNHglycan	376	379	PF01048	0.777
MOD_GlcNHglycan	40	43	PF01048	0.682
MOD_GlcNHglycan	444	448	PF01048	0.712
MOD_GlcNHglycan	475	478	PF01048	0.767
MOD_GlcNHglycan	489	492	PF01048	0.614
MOD_GlcNHglycan	5	8	PF01048	0.689
MOD_GlcNHglycan	540	543	PF01048	0.841
MOD_GlcNHglycan	577	581	PF01048	0.634
MOD_GlcNHglycan	59	62	PF01048	0.644
MOD_GlcNHglycan	623	626	PF01048	0.667
MOD_GlcNHglycan	631	634	PF01048	0.558
MOD_GlcNHglycan	704	707	PF01048	0.707
MOD_GlcNHglycan	74	77	PF01048	0.483
MOD_GlcNHglycan	809	812	PF01048	0.559
MOD_GlcNHglycan	96	99	PF01048	0.696
MOD_GSK3_1	160	167	PF00069	0.713
MOD_GSK3_1	266	273	PF00069	0.739
MOD_GSK3_1	28	35	PF00069	0.660
MOD_GSK3_1	342	349	PF00069	0.544
MOD_GSK3_1	370	377	PF00069	0.750
MOD_GSK3_1	398	405	PF00069	0.811
MOD_GSK3_1	445	452	PF00069	0.639
MOD_GSK3_1	473	480	PF00069	0.700
MOD_GSK3_1	482	489	PF00069	0.649
MOD_GSK3_1	534	541	PF00069	0.762
MOD_GSK3_1	543	550	PF00069	0.717
MOD_GSK3_1	576	583	PF00069	0.711
MOD_GSK3_1	596	603	PF00069	0.508
MOD_GSK3_1	648	655	PF00069	0.427
MOD_GSK3_1	68	75	PF00069	0.745
MOD_GSK3_1	731	738	PF00069	0.662
MOD_GSK3_1	896	903	PF00069	0.661
MOD_GSK3_1	94	101	PF00069	0.617
MOD_N-GLC_1	470	475	PF02516	0.733
MOD_N-GLC_1	557	562	PF02516	0.629
MOD_N-GLC_1	862	867	PF02516	0.631
MOD_NEK2_1	233	238	PF00069	0.447
MOD_NEK2_1	314	319	PF00069	0.581
MOD_NEK2_1	32	37	PF00069	0.575
MOD_NEK2_1	346	351	PF00069	0.477
MOD_NEK2_1	487	492	PF00069	0.722
MOD_NEK2_1	59	64	PF00069	0.724
MOD_NEK2_1	652	657	PF00069	0.509
MOD_NEK2_1	748	753	PF00069	0.618
MOD_NEK2_1	79	84	PF00069	0.522
MOD_NEK2_1	855	860	PF00069	0.755
MOD_NEK2_1	907	912	PF00069	0.599
MOD_PIKK_1	21	27	PF00454	0.670
MOD_PIKK_1	233	239	PF00454	0.445
MOD_PIKK_1	524	530	PF00454	0.790
MOD_PIKK_1	59	65	PF00454	0.721
MOD_PIKK_1	671	677	PF00454	0.681
MOD_PK_1	48	54	PF00069	0.561
MOD_PK_1	784	790	PF00069	0.812
MOD_PKA_1	160	166	PF00069	0.760
MOD_PKA_1	467	473	PF00069	0.588
MOD_PKA_2	160	166	PF00069	0.713
MOD_PKA_2	173	179	PF00069	0.688
MOD_PKA_2	3	9	PF00069	0.668
MOD_PKA_2	392	398	PF00069	0.806
MOD_PKA_2	422	428	PF00069	0.669
MOD_PKA_2	524	530	PF00069	0.713
MOD_PKA_2	596	602	PF00069	0.716
MOD_PKB_1	441	449	PF00069	0.818
MOD_PKB_1	465	473	PF00069	0.644
MOD_Plk_1	149	155	PF00069	0.554
MOD_Plk_1	291	297	PF00069	0.425
MOD_Plk_1	346	352	PF00069	0.479
MOD_Plk_1	494	500	PF00069	0.803
MOD_Plk_1	511	517	PF00069	0.540
MOD_Plk_1	557	563	PF00069	0.623
MOD_Plk_1	762	768	PF00069	0.635
MOD_Plk_1	855	861	PF00069	0.680
MOD_Plk_1	862	868	PF00069	0.551
MOD_Plk_1	907	913	PF00069	0.627
MOD_Plk_4	109	115	PF00069	0.591
MOD_Plk_4	173	179	PF00069	0.727
MOD_Plk_4	28	34	PF00069	0.669
MOD_Plk_4	346	352	PF00069	0.479
MOD_Plk_4	511	517	PF00069	0.731
MOD_Plk_4	648	654	PF00069	0.471
MOD_Plk_4	68	74	PF00069	0.537
MOD_Plk_4	735	741	PF00069	0.617
MOD_ProDKin_1	130	136	PF00069	0.704
MOD_ProDKin_1	382	388	PF00069	0.780
MOD_ProDKin_1	445	451	PF00069	0.709
MOD_ProDKin_1	470	476	PF00069	0.718
MOD_ProDKin_1	482	488	PF00069	0.760
MOD_ProDKin_1	543	549	PF00069	0.765
MOD_ProDKin_1	603	609	PF00069	0.705
MOD_ProDKin_1	688	694	PF00069	0.512
MOD_ProDKin_1	823	829	PF00069	0.736
MOD_ProDKin_1	896	902	PF00069	0.559
MOD_SUMO_for_1	561	564	PF00179	0.744
MOD_SUMO_rev_2	831	838	PF00179	0.618
TRG_DiLeu_BaEn_1	567	572	PF01217	0.600
TRG_DiLeu_BaEn_1	710	715	PF01217	0.601
TRG_DiLeu_BaEn_1	763	768	PF01217	0.706
TRG_DiLeu_BaEn_4	722	728	PF01217	0.699
TRG_DiLeu_BaEn_4	731	737	PF01217	0.649
TRG_DiLeu_BaEn_4	850	856	PF01217	0.545
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.480
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.453
TRG_DiLeu_BaLyEn_6	890	895	PF01217	0.625
TRG_DiLeu_LyEn_5	567	572	PF01217	0.698
TRG_DiLeu_LyEn_5	710	715	PF01217	0.601
TRG_DiLeu_LyEn_5	722	727	PF01217	0.654
TRG_DiLeu_LyEn_5	763	768	PF01217	0.706
TRG_ENDOCYTIC_2	103	106	PF00928	0.650
TRG_ENDOCYTIC_2	29	32	PF00928	0.573
TRG_ENDOCYTIC_2	700	703	PF00928	0.640
TRG_ER_diArg_1	10	12	PF00400	0.684
TRG_ER_diArg_1	159	161	PF00400	0.704
TRG_ER_diArg_1	170	172	PF00400	0.664
TRG_ER_diArg_1	321	323	PF00400	0.523
TRG_ER_diArg_1	44	47	PF00400	0.672
TRG_ER_diArg_1	440	443	PF00400	0.750
TRG_ER_diArg_1	464	467	PF00400	0.567
TRG_ER_diArg_1	523	526	PF00400	0.760
TRG_ER_diArg_1	764	767	PF00400	0.613
TRG_NES_CRM1_1	238	250	PF08389	0.561
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	508	512	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.739
TRG_Pf-PMV_PEXEL_1	713	717	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	766	770	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH80	Leptomonas seymouri	39%	92%
A0A3S7X6H4	Leishmania donovani	99%	100%
A4HLD9	Leishmania braziliensis	64%	100%
E9B3R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q4A7	Leishmania major	87%	100%