Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8U7_LEIIN

TriTrypDb:

LINF_330015700

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I8U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8U7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.604
CLV_NRD_NRD_1	112	114	PF00675	0.686
CLV_NRD_NRD_1	23	25	PF00675	0.688
CLV_NRD_NRD_1	281	283	PF00675	0.638
CLV_NRD_NRD_1	314	316	PF00675	0.528
CLV_NRD_NRD_1	599	601	PF00675	0.638
CLV_NRD_NRD_1	664	666	PF00675	0.560
CLV_NRD_NRD_1	704	706	PF00675	0.683
CLV_NRD_NRD_1	73	75	PF00675	0.744
CLV_PCSK_FUR_1	110	114	PF00082	0.714
CLV_PCSK_FUR_1	278	282	PF00082	0.644
CLV_PCSK_FUR_1	702	706	PF00082	0.767
CLV_PCSK_KEX2_1	112	114	PF00082	0.686
CLV_PCSK_KEX2_1	23	25	PF00082	0.688
CLV_PCSK_KEX2_1	278	280	PF00082	0.625
CLV_PCSK_KEX2_1	281	283	PF00082	0.666
CLV_PCSK_KEX2_1	599	601	PF00082	0.638
CLV_PCSK_KEX2_1	664	666	PF00082	0.567
CLV_PCSK_KEX2_1	704	706	PF00082	0.729
CLV_PCSK_KEX2_1	73	75	PF00082	0.744
CLV_PCSK_SKI1_1	315	319	PF00082	0.490
CLV_PCSK_SKI1_1	392	396	PF00082	0.525
CLV_PCSK_SKI1_1	460	464	PF00082	0.428
CLV_PCSK_SKI1_1	534	538	PF00082	0.621
CLV_PCSK_SKI1_1	600	604	PF00082	0.645
CLV_PCSK_SKI1_1	78	82	PF00082	0.718
CLV_PCSK_SKI1_1	8	12	PF00082	0.704
DEG_Nend_Nbox_1	1	3	PF02207	0.683
DEG_SCF_FBW7_1	552	557	PF00400	0.712
DEG_SPOP_SBC_1	46	50	PF00917	0.797
DOC_AGCK_PIF_2	484	489	PF00069	0.531
DOC_CKS1_1	132	137	PF01111	0.683
DOC_CKS1_1	27	32	PF01111	0.706
DOC_CKS1_1	51	56	PF01111	0.699
DOC_CYCLIN_RxL_1	309	320	PF00134	0.652
DOC_CYCLIN_RxL_1	454	467	PF00134	0.518
DOC_CYCLIN_RxL_1	596	605	PF00134	0.672
DOC_CYCLIN_yCln2_LP_2	76	82	PF00134	0.580
DOC_MAPK_gen_1	236	246	PF00069	0.677
DOC_MAPK_gen_1	492	501	PF00069	0.460
DOC_MAPK_gen_1	680	688	PF00069	0.623
DOC_MAPK_MEF2A_6	495	503	PF00069	0.425
DOC_PP1_RVXF_1	6	12	PF00149	0.662
DOC_PP2B_LxvP_1	297	300	PF13499	0.714
DOC_PP2B_LxvP_1	368	371	PF13499	0.493
DOC_PP2B_LxvP_1	86	89	PF13499	0.722
DOC_PP4_FxxP_1	11	14	PF00568	0.706
DOC_USP7_MATH_1	154	158	PF00917	0.635
DOC_USP7_MATH_1	207	211	PF00917	0.537
DOC_USP7_MATH_1	254	258	PF00917	0.744
DOC_USP7_MATH_1	335	339	PF00917	0.563
DOC_USP7_MATH_1	379	383	PF00917	0.513
DOC_USP7_MATH_1	554	558	PF00917	0.712
DOC_USP7_MATH_1	89	93	PF00917	0.723
DOC_WW_Pin1_4	115	120	PF00397	0.691
DOC_WW_Pin1_4	12	17	PF00397	0.664
DOC_WW_Pin1_4	131	136	PF00397	0.546
DOC_WW_Pin1_4	26	31	PF00397	0.717
DOC_WW_Pin1_4	455	460	PF00397	0.419
DOC_WW_Pin1_4	47	52	PF00397	0.754
DOC_WW_Pin1_4	550	555	PF00397	0.717
DOC_WW_Pin1_4	649	654	PF00397	0.728
LIG_14-3-3_CanoR_1	227	232	PF00244	0.595
LIG_14-3-3_CanoR_1	309	313	PF00244	0.530
LIG_14-3-3_CanoR_1	4	11	PF00244	0.654
LIG_14-3-3_CanoR_1	512	520	PF00244	0.541
LIG_14-3-3_CanoR_1	547	553	PF00244	0.808
LIG_BIR_III_2	650	654	PF00653	0.591
LIG_BRCT_BRCA1_1	138	142	PF00533	0.686
LIG_eIF4E_1	312	318	PF01652	0.599
LIG_eIF4E_1	497	503	PF01652	0.474
LIG_FHA_1	27	33	PF00498	0.590
LIG_FHA_1	437	443	PF00498	0.520
LIG_FHA_1	509	515	PF00498	0.537
LIG_FHA_1	51	57	PF00498	0.701
LIG_FHA_1	553	559	PF00498	0.776
LIG_FHA_2	261	267	PF00498	0.794
LIG_FHA_2	268	274	PF00498	0.577
LIG_FHA_2	289	295	PF00498	0.708
LIG_FHA_2	328	334	PF00498	0.477
LIG_FHA_2	511	517	PF00498	0.612
LIG_FHA_2	551	557	PF00498	0.699
LIG_LIR_Gen_1	201	211	PF02991	0.570
LIG_LIR_Gen_1	500	509	PF02991	0.451
LIG_LIR_Nem_3	131	136	PF02991	0.729
LIG_LIR_Nem_3	139	143	PF02991	0.722
LIG_LIR_Nem_3	201	206	PF02991	0.583
LIG_LIR_Nem_3	210	216	PF02991	0.508
LIG_LIR_Nem_3	414	418	PF02991	0.602
LIG_LIR_Nem_3	500	506	PF02991	0.417
LIG_LYPXL_yS_3	452	455	PF13949	0.545
LIG_NRBOX	340	346	PF00104	0.440
LIG_PCNA_PIPBox_1	387	396	PF02747	0.401
LIG_PTB_Apo_2	211	218	PF02174	0.676
LIG_PTB_Phospho_1	211	217	PF10480	0.675
LIG_REV1ctd_RIR_1	8	13	PF16727	0.521
LIG_RPA_C_Fungi	660	672	PF08784	0.700
LIG_SH2_CRK	213	217	PF00017	0.491
LIG_SH2_CRK	325	329	PF00017	0.517
LIG_SH2_STAP1	364	368	PF00017	0.446
LIG_SH2_STAP1	489	493	PF00017	0.560
LIG_SH2_STAT3	102	105	PF00017	0.742
LIG_SH2_STAT5	102	105	PF00017	0.758
LIG_SH2_STAT5	352	355	PF00017	0.486
LIG_SH2_STAT5	359	362	PF00017	0.399
LIG_SH2_STAT5	430	433	PF00017	0.371
LIG_SH3_1	24	30	PF00018	0.707
LIG_SH3_1	447	453	PF00018	0.581
LIG_SH3_2	18	23	PF14604	0.692
LIG_SH3_3	15	21	PF00018	0.646
LIG_SH3_3	24	30	PF00018	0.549
LIG_SH3_3	302	308	PF00018	0.650
LIG_SH3_3	397	403	PF00018	0.404
LIG_SH3_3	447	453	PF00018	0.472
LIG_SH3_3	462	468	PF00018	0.406
LIG_SH3_3	48	54	PF00018	0.769
LIG_SH3_3	76	82	PF00018	0.651
LIG_TRAF2_1	263	266	PF00917	0.793
LIG_TRAF2_1	270	273	PF00917	0.711
LIG_TRAF2_1	300	303	PF00917	0.694
LIG_TRAF2_1	580	583	PF00917	0.696
LIG_TYR_ITIM	323	328	PF00017	0.587
LIG_WRC_WIRS_1	412	417	PF05994	0.615
MOD_CDK_SPK_2	26	31	PF00069	0.627
MOD_CDK_SPK_2	455	460	PF00069	0.409
MOD_CDK_SPK_2	47	52	PF00069	0.608
MOD_CDK_SPxxK_3	131	138	PF00069	0.657
MOD_CDK_SPxxK_3	649	656	PF00069	0.704
MOD_CK1_1	131	137	PF00069	0.670
MOD_CK1_1	426	432	PF00069	0.516
MOD_CK1_1	50	56	PF00069	0.703
MOD_CK2_1	172	178	PF00069	0.560
MOD_CK2_1	260	266	PF00069	0.724
MOD_CK2_1	267	273	PF00069	0.738
MOD_CK2_1	288	294	PF00069	0.713
MOD_CK2_1	327	333	PF00069	0.485
MOD_CK2_1	510	516	PF00069	0.617
MOD_CK2_1	550	556	PF00069	0.664
MOD_CK2_1	89	95	PF00069	0.711
MOD_GlcNHglycan	174	177	PF01048	0.708
MOD_GlcNHglycan	209	212	PF01048	0.557
MOD_GlcNHglycan	252	255	PF01048	0.738
MOD_GlcNHglycan	256	259	PF01048	0.742
MOD_GlcNHglycan	415	418	PF01048	0.444
MOD_GlcNHglycan	624	627	PF01048	0.698
MOD_GlcNHglycan	659	662	PF01048	0.692
MOD_GSK3_1	115	122	PF00069	0.688
MOD_GSK3_1	124	131	PF00069	0.686
MOD_GSK3_1	250	257	PF00069	0.711
MOD_GSK3_1	422	429	PF00069	0.553
MOD_GSK3_1	46	53	PF00069	0.737
MOD_GSK3_1	508	515	PF00069	0.589
MOD_GSK3_1	548	555	PF00069	0.755
MOD_GSK3_1	613	620	PF00069	0.656
MOD_GSK3_1	96	103	PF00069	0.705
MOD_N-GLC_2	404	406	PF02516	0.386
MOD_NEK2_1	212	217	PF00069	0.635
MOD_NEK2_1	250	255	PF00069	0.684
MOD_NEK2_1	288	293	PF00069	0.718
MOD_NEK2_1	3	8	PF00069	0.627
MOD_NEK2_1	301	306	PF00069	0.704
MOD_NEK2_1	378	383	PF00069	0.512
MOD_NEK2_1	411	416	PF00069	0.608
MOD_NEK2_1	436	441	PF00069	0.408
MOD_NEK2_1	536	541	PF00069	0.658
MOD_NEK2_1	56	61	PF00069	0.766
MOD_NEK2_1	679	684	PF00069	0.617
MOD_PIKK_1	101	107	PF00454	0.605
MOD_PIKK_1	33	39	PF00454	0.689
MOD_PKA_2	154	160	PF00069	0.608
MOD_PKA_2	165	171	PF00069	0.709
MOD_PKA_2	3	9	PF00069	0.610
MOD_PKA_2	308	314	PF00069	0.523
MOD_PKA_2	491	497	PF00069	0.508
MOD_PKB_1	225	233	PF00069	0.592
MOD_PKB_1	611	619	PF00069	0.766
MOD_Plk_1	333	339	PF00069	0.538
MOD_Plk_2-3	267	273	PF00069	0.626
MOD_Plk_2-3	333	339	PF00069	0.543
MOD_Plk_4	128	134	PF00069	0.742
MOD_Plk_4	212	218	PF00069	0.614
MOD_Plk_4	426	432	PF00069	0.453
MOD_Plk_4	437	443	PF00069	0.350
MOD_ProDKin_1	115	121	PF00069	0.698
MOD_ProDKin_1	12	18	PF00069	0.668
MOD_ProDKin_1	131	137	PF00069	0.542
MOD_ProDKin_1	26	32	PF00069	0.718
MOD_ProDKin_1	455	461	PF00069	0.414
MOD_ProDKin_1	47	53	PF00069	0.754
MOD_ProDKin_1	550	556	PF00069	0.716
MOD_ProDKin_1	649	655	PF00069	0.726
MOD_SUMO_rev_2	525	533	PF00179	0.517
TRG_DiLeu_BaEn_1	340	345	PF01217	0.441
TRG_DiLeu_BaLyEn_6	691	696	PF01217	0.740
TRG_ENDOCYTIC_2	143	146	PF00928	0.677
TRG_ENDOCYTIC_2	213	216	PF00928	0.558
TRG_ENDOCYTIC_2	325	328	PF00928	0.453
TRG_ENDOCYTIC_2	391	394	PF00928	0.508
TRG_ENDOCYTIC_2	430	433	PF00928	0.371
TRG_ENDOCYTIC_2	452	455	PF00928	0.524
TRG_ER_diArg_1	109	112	PF00400	0.691
TRG_ER_diArg_1	23	25	PF00400	0.689
TRG_ER_diArg_1	278	281	PF00400	0.626
TRG_ER_diArg_1	563	566	PF00400	0.631
TRG_ER_diArg_1	598	600	PF00400	0.634
TRG_ER_diArg_1	611	614	PF00400	0.762
TRG_ER_diArg_1	664	666	PF00400	0.567
TRG_ER_diArg_1	683	686	PF00400	0.643
TRG_ER_diArg_1	704	706	PF00400	0.746
TRG_ER_diArg_1	73	75	PF00400	0.744
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	512	516	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	541	545	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	600	605	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3E3	Leptomonas seymouri	60%	99%
A0A1X0P130	Trypanosomatidae	50%	100%
A0A3Q8IK12	Leishmania donovani	100%	100%
A0A422P2K6	Trypanosoma rangeli	50%	100%
A4HLD8	Leishmania braziliensis	81%	100%
D0A4U5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B3R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4A8	Leishmania major	93%	100%
V5AZV9	Trypanosoma cruzi	49%	100%