LeishMANIAdb
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Putative CYC2-like cyclin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative CYC2-like cyclin
Gene product:
G1 cyclin CycE4 - putative
Species:
Leishmania infantum
UniProt:
A4I8U4_LEIIN
TriTrypDb:
LINF_330014700
Length:
881

Annotations

Annotations by Jardim et al.

Cell Cycle, CYC2-like cyclin CYC5

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I8U4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8U4

Function

Biological processes
Term Name Level Count
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 6 6
GO:0001932 regulation of protein phosphorylation 7 6
GO:0019220 regulation of phosphate metabolic process 6 6
GO:0019222 regulation of metabolic process 3 6
GO:0031323 regulation of cellular metabolic process 4 6
GO:0031399 regulation of protein modification process 6 6
GO:0042325 regulation of phosphorylation 7 6
GO:0043549 regulation of kinase activity 5 6
GO:0045859 regulation of protein kinase activity 6 6
GO:0050789 regulation of biological process 2 6
GO:0050790 regulation of catalytic activity 3 6
GO:0050794 regulation of cellular process 3 6
GO:0051171 regulation of nitrogen compound metabolic process 4 6
GO:0051174 regulation of phosphorus metabolic process 5 6
GO:0051246 regulation of protein metabolic process 5 6
GO:0051338 regulation of transferase activity 4 6
GO:0051726 regulation of cell cycle 4 6
GO:0060255 regulation of macromolecule metabolic process 4 6
GO:0065007 biological regulation 1 6
GO:0065009 regulation of molecular function 2 6
GO:0071900 regulation of protein serine/threonine kinase activity 7 6
GO:0080090 regulation of primary metabolic process 4 6
GO:1904029 regulation of cyclin-dependent protein kinase activity 5 6
Molecular functions
Term Name Level Count
GO:0005488 binding 1 6
GO:0005515 protein binding 2 6
GO:0019899 enzyme binding 3 6
GO:0019900 kinase binding 4 6
GO:0019901 protein kinase binding 5 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 449 453 PF00656 0.689
CLV_NRD_NRD_1 304 306 PF00675 0.567
CLV_NRD_NRD_1 474 476 PF00675 0.714
CLV_NRD_NRD_1 496 498 PF00675 0.632
CLV_NRD_NRD_1 579 581 PF00675 0.680
CLV_NRD_NRD_1 60 62 PF00675 0.439
CLV_NRD_NRD_1 610 612 PF00675 0.649
CLV_NRD_NRD_1 692 694 PF00675 0.667
CLV_NRD_NRD_1 710 712 PF00675 0.569
CLV_NRD_NRD_1 727 729 PF00675 0.561
CLV_NRD_NRD_1 756 758 PF00675 0.763
CLV_PCSK_KEX2_1 304 306 PF00082 0.567
CLV_PCSK_KEX2_1 474 476 PF00082 0.714
CLV_PCSK_KEX2_1 495 497 PF00082 0.637
CLV_PCSK_KEX2_1 579 581 PF00082 0.685
CLV_PCSK_KEX2_1 60 62 PF00082 0.439
CLV_PCSK_KEX2_1 609 611 PF00082 0.722
CLV_PCSK_KEX2_1 692 694 PF00082 0.737
CLV_PCSK_KEX2_1 727 729 PF00082 0.644
CLV_PCSK_KEX2_1 756 758 PF00082 0.763
CLV_PCSK_PC1ET2_1 495 497 PF00082 0.637
CLV_PCSK_PC1ET2_1 609 611 PF00082 0.722
CLV_PCSK_SKI1_1 496 500 PF00082 0.628
CLV_PCSK_SKI1_1 540 544 PF00082 0.734
CLV_PCSK_SKI1_1 622 626 PF00082 0.643
CLV_PCSK_SKI1_1 727 731 PF00082 0.644
DEG_APCC_DBOX_1 270 278 PF00400 0.439
DEG_APCC_DBOX_1 632 640 PF00400 0.706
DEG_SCF_FBW7_1 307 313 PF00400 0.596
DEG_SCF_FBW7_1 327 334 PF00400 0.469
DEG_SPOP_SBC_1 403 407 PF00917 0.574
DEG_SPOP_SBC_1 778 782 PF00917 0.660
DOC_CDC14_PxL_1 429 437 PF14671 0.590
DOC_CKS1_1 307 312 PF01111 0.588
DOC_CKS1_1 748 753 PF01111 0.682
DOC_CYCLIN_RxL_1 490 500 PF00134 0.632
DOC_MAPK_DCC_7 474 483 PF00069 0.645
DOC_MAPK_HePTP_8 471 483 PF00069 0.666
DOC_MAPK_MEF2A_6 199 206 PF00069 0.490
DOC_MAPK_MEF2A_6 474 483 PF00069 0.645
DOC_PP2B_LxvP_1 153 156 PF13499 0.384
DOC_PP2B_LxvP_1 18 21 PF13499 0.668
DOC_PP2B_LxvP_1 425 428 PF13499 0.680
DOC_PP2B_LxvP_1 489 492 PF13499 0.774
DOC_PP2B_LxvP_1 528 531 PF13499 0.765
DOC_PP2B_LxvP_1 651 654 PF13499 0.764
DOC_PP4_FxxP_1 123 126 PF00568 0.512
DOC_PP4_FxxP_1 477 480 PF00568 0.642
DOC_PP4_FxxP_1 92 95 PF00568 0.439
DOC_USP7_MATH_1 126 130 PF00917 0.347
DOC_USP7_MATH_1 259 263 PF00917 0.439
DOC_USP7_MATH_1 28 32 PF00917 0.726
DOC_USP7_MATH_1 331 335 PF00917 0.751
DOC_USP7_MATH_1 403 407 PF00917 0.671
DOC_USP7_MATH_1 437 441 PF00917 0.711
DOC_USP7_MATH_1 602 606 PF00917 0.714
DOC_USP7_MATH_1 684 688 PF00917 0.713
DOC_USP7_MATH_1 723 727 PF00917 0.695
DOC_USP7_MATH_1 770 774 PF00917 0.693
DOC_USP7_MATH_1 778 782 PF00917 0.634
DOC_USP7_MATH_1 95 99 PF00917 0.439
DOC_WW_Pin1_4 113 118 PF00397 0.287
DOC_WW_Pin1_4 148 153 PF00397 0.444
DOC_WW_Pin1_4 306 311 PF00397 0.586
DOC_WW_Pin1_4 319 324 PF00397 0.548
DOC_WW_Pin1_4 327 332 PF00397 0.611
DOC_WW_Pin1_4 356 361 PF00397 0.762
DOC_WW_Pin1_4 507 512 PF00397 0.700
DOC_WW_Pin1_4 521 526 PF00397 0.583
DOC_WW_Pin1_4 747 752 PF00397 0.659
DOC_WW_Pin1_4 755 760 PF00397 0.682
DOC_WW_Pin1_4 761 766 PF00397 0.614
DOC_WW_Pin1_4 874 879 PF00397 0.694
DOC_WW_Pin1_4 91 96 PF00397 0.439
DOC_WW_Pin1_4 98 103 PF00397 0.355
LIG_14-3-3_CanoR_1 122 126 PF00244 0.318
LIG_14-3-3_CanoR_1 13 19 PF00244 0.619
LIG_14-3-3_CanoR_1 148 152 PF00244 0.384
LIG_14-3-3_CanoR_1 233 241 PF00244 0.439
LIG_14-3-3_CanoR_1 4 10 PF00244 0.659
LIG_14-3-3_CanoR_1 438 448 PF00244 0.711
LIG_14-3-3_CanoR_1 474 478 PF00244 0.590
LIG_14-3-3_CanoR_1 496 502 PF00244 0.689
LIG_14-3-3_CanoR_1 579 586 PF00244 0.647
LIG_14-3-3_CanoR_1 676 684 PF00244 0.688
LIG_14-3-3_CanoR_1 711 720 PF00244 0.640
LIG_14-3-3_CanoR_1 727 736 PF00244 0.616
LIG_14-3-3_CanoR_1 871 881 PF00244 0.706
LIG_14-3-3_CanoR_1 96 103 PF00244 0.439
LIG_Actin_WH2_2 272 289 PF00022 0.439
LIG_Actin_WH2_2 371 387 PF00022 0.575
LIG_BRCT_BRCA1_1 119 123 PF00533 0.384
LIG_BRCT_BRCA1_1 537 541 PF00533 0.692
LIG_BRCT_BRCA1_1 725 729 PF00533 0.633
LIG_BRCT_BRCA1_2 537 543 PF00533 0.687
LIG_Clathr_ClatBox_1 279 283 PF01394 0.439
LIG_Clathr_ClatBox_1 295 299 PF01394 0.313
LIG_CtBP_PxDLS_1 645 649 PF00389 0.638
LIG_deltaCOP1_diTrp_1 292 297 PF00928 0.508
LIG_EVH1_1 700 704 PF00568 0.768
LIG_FHA_1 122 128 PF00498 0.476
LIG_FHA_1 234 240 PF00498 0.505
LIG_FHA_1 298 304 PF00498 0.498
LIG_FHA_1 311 317 PF00498 0.486
LIG_FHA_1 320 326 PF00498 0.568
LIG_FHA_1 357 363 PF00498 0.672
LIG_FHA_1 424 430 PF00498 0.716
LIG_FHA_1 626 632 PF00498 0.644
LIG_FHA_1 668 674 PF00498 0.695
LIG_FHA_1 778 784 PF00498 0.680
LIG_FHA_2 268 274 PF00498 0.439
LIG_FHA_2 338 344 PF00498 0.676
LIG_FXI_DFP_1 279 283 PF00024 0.439
LIG_LIR_Apic_2 120 126 PF02991 0.384
LIG_LIR_Apic_2 476 480 PF02991 0.525
LIG_LIR_Apic_2 89 95 PF02991 0.439
LIG_LIR_Gen_1 221 229 PF02991 0.439
LIG_LIR_Gen_1 273 284 PF02991 0.439
LIG_LIR_Gen_1 41 51 PF02991 0.531
LIG_LIR_Gen_1 452 463 PF02991 0.749
LIG_LIR_Nem_3 221 226 PF02991 0.439
LIG_LIR_Nem_3 273 279 PF02991 0.439
LIG_LIR_Nem_3 281 285 PF02991 0.259
LIG_LIR_Nem_3 41 46 PF02991 0.553
LIG_LIR_Nem_3 452 458 PF02991 0.779
LIG_LIR_Nem_3 699 703 PF02991 0.768
LIG_LIR_Nem_3 817 823 PF02991 0.650
LIG_LIR_Nem_3 825 831 PF02991 0.539
LIG_LIR_Nem_3 839 845 PF02991 0.568
LIG_MYND_1 433 437 PF01753 0.586
LIG_REV1ctd_RIR_1 539 547 PF16727 0.728
LIG_SH2_CRK 7 11 PF00017 0.632
LIG_SH2_NCK_1 7 11 PF00017 0.632
LIG_SH2_SRC 246 249 PF00017 0.439
LIG_SH2_SRC 801 804 PF00017 0.753
LIG_SH2_STAP1 47 51 PF00017 0.505
LIG_SH2_STAP1 779 783 PF00017 0.740
LIG_SH2_STAP1 842 846 PF00017 0.685
LIG_SH2_STAT5 211 214 PF00017 0.439
LIG_SH2_STAT5 278 281 PF00017 0.439
LIG_SH2_STAT5 314 317 PF00017 0.630
LIG_SH2_STAT5 779 782 PF00017 0.681
LIG_SH2_STAT5 828 831 PF00017 0.600
LIG_SH2_STAT5 866 869 PF00017 0.683
LIG_SH3_1 745 751 PF00018 0.615
LIG_SH3_2 433 438 PF14604 0.698
LIG_SH3_3 115 121 PF00018 0.404
LIG_SH3_3 149 155 PF00018 0.433
LIG_SH3_3 427 433 PF00018 0.675
LIG_SH3_3 441 447 PF00018 0.608
LIG_SH3_3 476 482 PF00018 0.631
LIG_SH3_3 485 491 PF00018 0.597
LIG_SH3_3 505 511 PF00018 0.467
LIG_SH3_3 524 530 PF00018 0.639
LIG_SH3_3 635 641 PF00018 0.796
LIG_SH3_3 698 704 PF00018 0.764
LIG_SH3_3 735 741 PF00018 0.728
LIG_SH3_3 745 751 PF00018 0.610
LIG_SUMO_SIM_anti_2 379 386 PF11976 0.572
LIG_SUMO_SIM_par_1 379 386 PF11976 0.572
LIG_SUMO_SIM_par_1 428 434 PF11976 0.590
LIG_SUMO_SIM_par_1 446 452 PF11976 0.471
LIG_TRAF2_1 174 177 PF00917 0.419
LIG_TRAF2_1 50 53 PF00917 0.546
LIG_WW_2 479 482 PF00397 0.596
LIG_WW_3 435 439 PF00397 0.717
LIG_WW_3 689 693 PF00397 0.752
MOD_CDC14_SPxK_1 526 529 PF00782 0.769
MOD_CDK_SPK_2 117 122 PF00069 0.384
MOD_CDK_SPK_2 327 332 PF00069 0.618
MOD_CDK_SPK_2 91 96 PF00069 0.439
MOD_CDK_SPxK_1 523 529 PF00069 0.757
MOD_CDK_SPxxK_3 755 762 PF00069 0.705
MOD_CK1_1 113 119 PF00069 0.287
MOD_CK1_1 157 163 PF00069 0.420
MOD_CK1_1 267 273 PF00069 0.450
MOD_CK1_1 319 325 PF00069 0.648
MOD_CK1_1 334 340 PF00069 0.571
MOD_CK1_1 377 383 PF00069 0.682
MOD_CK1_1 439 445 PF00069 0.727
MOD_CK1_1 456 462 PF00069 0.714
MOD_CK1_1 510 516 PF00069 0.716
MOD_CK1_1 523 529 PF00069 0.664
MOD_CK1_1 544 550 PF00069 0.721
MOD_CK1_1 578 584 PF00069 0.682
MOD_CK1_1 669 675 PF00069 0.750
MOD_CK1_1 773 779 PF00069 0.731
MOD_CK1_1 88 94 PF00069 0.439
MOD_CK1_1 98 104 PF00069 0.319
MOD_CK2_1 267 273 PF00069 0.439
MOD_CK2_1 286 292 PF00069 0.512
MOD_CK2_1 337 343 PF00069 0.700
MOD_CK2_1 804 810 PF00069 0.748
MOD_CMANNOS 294 297 PF00535 0.495
MOD_GlcNHglycan 165 168 PF01048 0.428
MOD_GlcNHglycan 261 264 PF01048 0.439
MOD_GlcNHglycan 31 34 PF01048 0.747
MOD_GlcNHglycan 317 321 PF01048 0.680
MOD_GlcNHglycan 439 442 PF01048 0.779
MOD_GlcNHglycan 455 458 PF01048 0.677
MOD_GlcNHglycan 556 559 PF01048 0.726
MOD_GlcNHglycan 590 593 PF01048 0.706
MOD_GlcNHglycan 598 601 PF01048 0.699
MOD_GlcNHglycan 641 644 PF01048 0.764
MOD_GlcNHglycan 673 676 PF01048 0.716
MOD_GlcNHglycan 686 689 PF01048 0.591
MOD_GlcNHglycan 772 775 PF01048 0.664
MOD_GlcNHglycan 97 100 PF01048 0.402
MOD_GSK3_1 106 113 PF00069 0.317
MOD_GSK3_1 117 124 PF00069 0.282
MOD_GSK3_1 218 225 PF00069 0.439
MOD_GSK3_1 306 313 PF00069 0.596
MOD_GSK3_1 315 322 PF00069 0.597
MOD_GSK3_1 327 334 PF00069 0.652
MOD_GSK3_1 335 342 PF00069 0.567
MOD_GSK3_1 356 363 PF00069 0.680
MOD_GSK3_1 373 380 PF00069 0.475
MOD_GSK3_1 392 399 PF00069 0.682
MOD_GSK3_1 403 410 PF00069 0.661
MOD_GSK3_1 417 424 PF00069 0.580
MOD_GSK3_1 436 443 PF00069 0.572
MOD_GSK3_1 5 12 PF00069 0.698
MOD_GSK3_1 584 591 PF00069 0.709
MOD_GSK3_1 667 674 PF00069 0.741
MOD_GSK3_1 723 730 PF00069 0.747
MOD_GSK3_1 769 776 PF00069 0.693
MOD_GSK3_1 84 91 PF00069 0.439
MOD_GSK3_1 94 101 PF00069 0.319
MOD_LATS_1 134 140 PF00433 0.439
MOD_N-GLC_1 146 151 PF02516 0.347
MOD_N-GLC_2 255 257 PF02516 0.439
MOD_NEK2_1 127 132 PF00069 0.446
MOD_NEK2_1 224 229 PF00069 0.439
MOD_NEK2_1 234 239 PF00069 0.319
MOD_NEK2_1 258 263 PF00069 0.439
MOD_NEK2_1 316 321 PF00069 0.659
MOD_NEK2_1 335 340 PF00069 0.510
MOD_NEK2_1 451 456 PF00069 0.700
MOD_NEK2_1 520 525 PF00069 0.624
MOD_NEK2_1 541 546 PF00069 0.722
MOD_NEK2_1 625 630 PF00069 0.640
MOD_NEK2_1 729 734 PF00069 0.635
MOD_NEK2_1 85 90 PF00069 0.439
MOD_PIKK_1 21 27 PF00454 0.640
MOD_PIKK_1 541 547 PF00454 0.686
MOD_PIKK_1 660 666 PF00454 0.760
MOD_PIKK_1 69 75 PF00454 0.439
MOD_PIKK_1 773 779 PF00454 0.735
MOD_PK_1 497 503 PF00069 0.691
MOD_PK_1 529 535 PF00069 0.754
MOD_PKA_1 727 733 PF00069 0.640
MOD_PKA_2 121 127 PF00069 0.347
MOD_PKA_2 147 153 PF00069 0.384
MOD_PKA_2 213 219 PF00069 0.442
MOD_PKA_2 232 238 PF00069 0.490
MOD_PKA_2 259 265 PF00069 0.365
MOD_PKA_2 437 443 PF00069 0.657
MOD_PKA_2 473 479 PF00069 0.578
MOD_PKA_2 578 584 PF00069 0.676
MOD_PKA_2 666 672 PF00069 0.713
MOD_PKA_2 69 75 PF00069 0.414
MOD_PKA_2 691 697 PF00069 0.667
MOD_PKA_2 727 733 PF00069 0.710
MOD_PKA_2 95 101 PF00069 0.439
MOD_Plk_1 176 182 PF00069 0.402
MOD_Plk_1 267 273 PF00069 0.494
MOD_Plk_1 646 652 PF00069 0.769
MOD_Plk_1 850 856 PF00069 0.625
MOD_Plk_2-3 36 42 PF00069 0.617
MOD_Plk_4 310 316 PF00069 0.608
MOD_Plk_4 377 383 PF00069 0.608
MOD_Plk_4 440 446 PF00069 0.711
MOD_Plk_4 627 633 PF00069 0.652
MOD_ProDKin_1 113 119 PF00069 0.287
MOD_ProDKin_1 148 154 PF00069 0.444
MOD_ProDKin_1 306 312 PF00069 0.589
MOD_ProDKin_1 319 325 PF00069 0.547
MOD_ProDKin_1 327 333 PF00069 0.611
MOD_ProDKin_1 356 362 PF00069 0.766
MOD_ProDKin_1 507 513 PF00069 0.698
MOD_ProDKin_1 521 527 PF00069 0.586
MOD_ProDKin_1 747 753 PF00069 0.660
MOD_ProDKin_1 755 761 PF00069 0.678
MOD_ProDKin_1 874 880 PF00069 0.700
MOD_ProDKin_1 91 97 PF00069 0.439
MOD_ProDKin_1 98 104 PF00069 0.355
MOD_SUMO_rev_2 705 713 PF00179 0.667
TRG_DiLeu_BaEn_4 646 652 PF01217 0.769
TRG_ENDOCYTIC_2 700 703 PF00928 0.771
TRG_ER_diArg_1 303 305 PF00400 0.558
TRG_ER_diArg_1 496 498 PF00400 0.684
TRG_ER_diArg_1 60 62 PF00400 0.437
TRG_ER_diArg_1 610 612 PF00400 0.649
TRG_ER_diArg_1 691 693 PF00400 0.660
TRG_ER_diArg_1 727 729 PF00400 0.644
TRG_ER_diArg_1 869 872 PF00400 0.694
TRG_NES_CRM1_1 275 290 PF08389 0.439
TRG_NES_CRM1_1 293 306 PF08389 0.523
TRG_NLS_MonoExtN_4 492 499 PF00514 0.631
TRG_Pf-PMV_PEXEL_1 136 141 PF00026 0.439

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IDM6 Leishmania donovani 100% 100%
A4HLB8 Leishmania braziliensis 71% 100%
E9B3R0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q4C8 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS