Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8U1_LEIIN

TriTrypDb:

LINF_330014400

Length:

771

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I8U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8U1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.457
CLV_NRD_NRD_1	19	21	PF00675	0.358
CLV_NRD_NRD_1	197	199	PF00675	0.540
CLV_NRD_NRD_1	238	240	PF00675	0.671
CLV_NRD_NRD_1	679	681	PF00675	0.617
CLV_NRD_NRD_1	683	685	PF00675	0.626
CLV_NRD_NRD_1	705	707	PF00675	0.461
CLV_PCSK_FUR_1	234	238	PF00082	0.696
CLV_PCSK_FUR_1	680	684	PF00082	0.512
CLV_PCSK_KEX2_1	118	120	PF00082	0.457
CLV_PCSK_KEX2_1	19	21	PF00082	0.358
CLV_PCSK_KEX2_1	197	199	PF00082	0.620
CLV_PCSK_KEX2_1	234	236	PF00082	0.659
CLV_PCSK_KEX2_1	237	239	PF00082	0.664
CLV_PCSK_KEX2_1	675	677	PF00082	0.570
CLV_PCSK_KEX2_1	679	681	PF00082	0.620
CLV_PCSK_KEX2_1	682	684	PF00082	0.628
CLV_PCSK_KEX2_1	705	707	PF00082	0.461
CLV_PCSK_KEX2_1	757	759	PF00082	0.615
CLV_PCSK_PC1ET2_1	675	677	PF00082	0.550
CLV_PCSK_PC1ET2_1	757	759	PF00082	0.405
CLV_PCSK_PC7_1	193	199	PF00082	0.559
CLV_PCSK_PC7_1	234	240	PF00082	0.687
CLV_PCSK_PC7_1	679	685	PF00082	0.554
CLV_PCSK_SKI1_1	201	205	PF00082	0.573
CLV_PCSK_SKI1_1	376	380	PF00082	0.359
CLV_PCSK_SKI1_1	411	415	PF00082	0.434
CLV_PCSK_SKI1_1	457	461	PF00082	0.524
CLV_PCSK_SKI1_1	604	608	PF00082	0.494
CLV_PCSK_SKI1_1	758	762	PF00082	0.448
DEG_APCC_DBOX_1	375	383	PF00400	0.487
DEG_APCC_DBOX_1	410	418	PF00400	0.430
DEG_APCC_DBOX_1	603	611	PF00400	0.402
DEG_Nend_Nbox_1	1	3	PF02207	0.451
DEG_SCF_FBW7_1	64	71	PF00400	0.387
DEG_SPOP_SBC_1	562	566	PF00917	0.487
DOC_CKS1_1	713	718	PF01111	0.548
DOC_CYCLIN_RxL_1	373	381	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	416	419	PF00134	0.432
DOC_MAPK_DCC_7	308	316	PF00069	0.420
DOC_MAPK_gen_1	457	465	PF00069	0.369
DOC_MAPK_gen_1	705	713	PF00069	0.608
DOC_MAPK_gen_1	757	765	PF00069	0.404
DOC_MAPK_MEF2A_6	274	281	PF00069	0.752
DOC_MAPK_MEF2A_6	477	486	PF00069	0.404
DOC_MAPK_MEF2A_6	757	765	PF00069	0.447
DOC_MAPK_NFAT4_5	758	766	PF00069	0.393
DOC_PP1_RVXF_1	358	365	PF00149	0.395
DOC_PP1_RVXF_1	475	482	PF00149	0.434
DOC_PP1_RVXF_1	61	67	PF00149	0.551
DOC_PP2B_LxvP_1	416	419	PF13499	0.432
DOC_USP7_MATH_1	167	171	PF00917	0.606
DOC_USP7_MATH_1	196	200	PF00917	0.696
DOC_USP7_MATH_1	212	216	PF00917	0.595
DOC_USP7_MATH_1	230	234	PF00917	0.663
DOC_USP7_MATH_1	241	245	PF00917	0.704
DOC_USP7_MATH_1	257	261	PF00917	0.737
DOC_USP7_MATH_1	45	49	PF00917	0.625
DOC_USP7_MATH_1	494	498	PF00917	0.665
DOC_USP7_MATH_1	504	508	PF00917	0.726
DOC_USP7_MATH_1	530	534	PF00917	0.656
DOC_USP7_MATH_1	555	559	PF00917	0.507
DOC_USP7_MATH_1	592	596	PF00917	0.438
DOC_USP7_MATH_1	731	735	PF00917	0.587
DOC_USP7_MATH_1	753	757	PF00917	0.466
DOC_USP7_UBL2_3	514	518	PF12436	0.651
DOC_WW_Pin1_4	226	231	PF00397	0.723
DOC_WW_Pin1_4	29	34	PF00397	0.573
DOC_WW_Pin1_4	307	312	PF00397	0.480
DOC_WW_Pin1_4	325	330	PF00397	0.505
DOC_WW_Pin1_4	41	46	PF00397	0.587
DOC_WW_Pin1_4	588	593	PF00397	0.363
DOC_WW_Pin1_4	595	600	PF00397	0.348
DOC_WW_Pin1_4	619	624	PF00397	0.387
DOC_WW_Pin1_4	64	69	PF00397	0.504
DOC_WW_Pin1_4	694	699	PF00397	0.583
DOC_WW_Pin1_4	712	717	PF00397	0.483
LIG_14-3-3_CanoR_1	10	15	PF00244	0.483
LIG_14-3-3_CanoR_1	19	25	PF00244	0.479
LIG_14-3-3_CanoR_1	198	204	PF00244	0.674
LIG_14-3-3_CanoR_1	213	220	PF00244	0.600
LIG_14-3-3_CanoR_1	51	57	PF00244	0.650
LIG_14-3-3_CanoR_1	567	575	PF00244	0.473
LIG_14-3-3_CanoR_1	582	590	PF00244	0.349
LIG_14-3-3_CanoR_1	668	677	PF00244	0.501
LIG_14-3-3_CanoR_1	709	714	PF00244	0.480
LIG_BIR_III_2	719	723	PF00653	0.577
LIG_BIR_III_4	472	476	PF00653	0.468
LIG_BIR_III_4	725	729	PF00653	0.575
LIG_BRCT_BRCA1_1	264	268	PF00533	0.700
LIG_BRCT_BRCA1_1	352	356	PF00533	0.400
LIG_CSL_BTD_1	316	319	PF09270	0.304
LIG_DLG_GKlike_1	10	17	PF00625	0.328
LIG_FHA_1	10	16	PF00498	0.367
LIG_FHA_1	179	185	PF00498	0.666
LIG_FHA_1	281	287	PF00498	0.568
LIG_FHA_1	410	416	PF00498	0.376
LIG_FHA_1	485	491	PF00498	0.700
LIG_FHA_1	567	573	PF00498	0.358
LIG_FHA_1	583	589	PF00498	0.333
LIG_FHA_1	662	668	PF00498	0.606
LIG_FHA_2	170	176	PF00498	0.663
LIG_FHA_2	333	339	PF00498	0.447
LIG_FHA_2	576	582	PF00498	0.492
LIG_Integrin_RGD_1	684	686	PF01839	0.547
LIG_LIR_Apic_2	551	555	PF02991	0.525
LIG_LIR_Apic_2	625	631	PF02991	0.338
LIG_LIR_Gen_1	312	322	PF02991	0.514
LIG_LIR_Gen_1	385	394	PF02991	0.361
LIG_LIR_Gen_1	621	631	PF02991	0.477
LIG_LIR_Gen_1	9	17	PF02991	0.409
LIG_LIR_Nem_3	312	318	PF02991	0.522
LIG_LIR_Nem_3	385	390	PF02991	0.365
LIG_LIR_Nem_3	621	627	PF02991	0.469
LIG_LIR_Nem_3	9	14	PF02991	0.409
LIG_MAD2	615	623	PF02301	0.391
LIG_NRBOX	90	96	PF00104	0.442
LIG_PDZ_Class_2	766	771	PF00595	0.409
LIG_REV1ctd_RIR_1	766	771	PF16727	0.542
LIG_SH2_NCK_1	123	127	PF00017	0.492
LIG_SH2_NCK_1	590	594	PF00017	0.364
LIG_SH2_STAP1	425	429	PF00017	0.461
LIG_SH2_STAP1	584	588	PF00017	0.363
LIG_SH2_STAP1	83	87	PF00017	0.504
LIG_SH2_STAT3	455	458	PF00017	0.482
LIG_SH2_STAT5	23	26	PF00017	0.498
LIG_SH2_STAT5	343	346	PF00017	0.407
LIG_SH2_STAT5	374	377	PF00017	0.341
LIG_SH2_STAT5	421	424	PF00017	0.511
LIG_SH2_STAT5	455	458	PF00017	0.427
LIG_SH2_STAT5	584	587	PF00017	0.415
LIG_SH2_STAT5	628	631	PF00017	0.368
LIG_SH2_STAT5	751	754	PF00017	0.421
LIG_SH3_3	107	113	PF00018	0.638
LIG_SH3_3	114	120	PF00018	0.591
LIG_SH3_3	400	406	PF00018	0.391
LIG_SH3_3	412	418	PF00018	0.307
LIG_SH3_3	483	489	PF00018	0.466
LIG_SUMO_SIM_anti_2	389	395	PF11976	0.461
LIG_SUMO_SIM_anti_2	412	418	PF11976	0.343
LIG_SUMO_SIM_par_1	277	284	PF11976	0.591
LIG_WRC_WIRS_1	534	539	PF05994	0.514
LIG_WRPW_2	401	404	PF00400	0.496
LIG_WW_1	418	421	PF00397	0.293
MOD_CDK_SPxK_1	595	601	PF00069	0.428
MOD_CK1_1	199	205	PF00069	0.737
MOD_CK1_1	252	258	PF00069	0.634
MOD_CK1_1	270	276	PF00069	0.645
MOD_CK1_1	280	286	PF00069	0.570
MOD_CK1_1	40	46	PF00069	0.583
MOD_CK1_1	497	503	PF00069	0.625
MOD_CK1_1	533	539	PF00069	0.642
MOD_CK1_1	542	548	PF00069	0.614
MOD_CK1_1	558	564	PF00069	0.480
MOD_CK1_1	566	572	PF00069	0.585
MOD_CK1_1	595	601	PF00069	0.431
MOD_CK1_1	661	667	PF00069	0.569
MOD_CK1_1	712	718	PF00069	0.680
MOD_CK1_1	756	762	PF00069	0.419
MOD_CK2_1	151	157	PF00069	0.520
MOD_CK2_1	332	338	PF00069	0.462
MOD_CK2_1	731	737	PF00069	0.648
MOD_Cter_Amidation	17	20	PF01082	0.359
MOD_GlcNHglycan	148	151	PF01048	0.512
MOD_GlcNHglycan	198	201	PF01048	0.642
MOD_GlcNHglycan	20	23	PF01048	0.480
MOD_GlcNHglycan	214	217	PF01048	0.638
MOD_GlcNHglycan	230	233	PF01048	0.683
MOD_GlcNHglycan	254	257	PF01048	0.691
MOD_GlcNHglycan	259	262	PF01048	0.716
MOD_GlcNHglycan	323	326	PF01048	0.585
MOD_GlcNHglycan	33	36	PF01048	0.579
MOD_GlcNHglycan	38	42	PF01048	0.584
MOD_GlcNHglycan	425	428	PF01048	0.542
MOD_GlcNHglycan	496	499	PF01048	0.612
MOD_GlcNHglycan	52	55	PF01048	0.615
MOD_GlcNHglycan	58	61	PF01048	0.585
MOD_GlcNHglycan	689	692	PF01048	0.578
MOD_GlcNHglycan	732	736	PF01048	0.669
MOD_GlcNHglycan	91	94	PF01048	0.379
MOD_GSK3_1	139	146	PF00069	0.455
MOD_GSK3_1	222	229	PF00069	0.613
MOD_GSK3_1	252	259	PF00069	0.650
MOD_GSK3_1	321	328	PF00069	0.445
MOD_GSK3_1	37	44	PF00069	0.668
MOD_GSK3_1	52	59	PF00069	0.674
MOD_GSK3_1	532	539	PF00069	0.671
MOD_GSK3_1	554	561	PF00069	0.521
MOD_GSK3_1	562	569	PF00069	0.381
MOD_GSK3_1	588	595	PF00069	0.402
MOD_GSK3_1	64	71	PF00069	0.484
MOD_N-GLC_1	152	157	PF02516	0.494
MOD_N-GLC_1	619	624	PF02516	0.459
MOD_N-GLC_1	737	742	PF02516	0.502
MOD_NEK2_1	224	229	PF00069	0.770
MOD_NEK2_1	89	94	PF00069	0.336
MOD_PIKK_1	634	640	PF00454	0.549
MOD_PIKK_1	669	675	PF00454	0.540
MOD_PKA_1	675	681	PF00069	0.589
MOD_PKA_2	18	24	PF00069	0.474
MOD_PKA_2	196	202	PF00069	0.602
MOD_PKA_2	212	218	PF00069	0.516
MOD_PKA_2	222	228	PF00069	0.589
MOD_PKA_2	494	500	PF00069	0.726
MOD_PKA_2	50	56	PF00069	0.662
MOD_PKA_2	566	572	PF00069	0.381
MOD_PKA_2	575	581	PF00069	0.359
MOD_PKA_2	675	681	PF00069	0.615
MOD_PKA_2	9	15	PF00069	0.505
MOD_PKB_1	237	245	PF00069	0.613
MOD_Plk_1	178	184	PF00069	0.636
MOD_Plk_1	539	545	PF00069	0.512
MOD_Plk_1	649	655	PF00069	0.473
MOD_Plk_1	745	751	PF00069	0.388
MOD_Plk_4	10	16	PF00069	0.337
MOD_Plk_4	199	205	PF00069	0.599
MOD_Plk_4	351	357	PF00069	0.337
MOD_Plk_4	388	394	PF00069	0.424
MOD_Plk_4	441	447	PF00069	0.369
MOD_Plk_4	52	58	PF00069	0.681
MOD_Plk_4	533	539	PF00069	0.516
MOD_ProDKin_1	226	232	PF00069	0.725
MOD_ProDKin_1	29	35	PF00069	0.575
MOD_ProDKin_1	307	313	PF00069	0.480
MOD_ProDKin_1	325	331	PF00069	0.504
MOD_ProDKin_1	41	47	PF00069	0.586
MOD_ProDKin_1	588	594	PF00069	0.366
MOD_ProDKin_1	595	601	PF00069	0.354
MOD_ProDKin_1	619	625	PF00069	0.386
MOD_ProDKin_1	64	70	PF00069	0.495
MOD_ProDKin_1	694	700	PF00069	0.582
MOD_ProDKin_1	712	718	PF00069	0.484
MOD_SUMO_for_1	459	462	PF00179	0.474
MOD_SUMO_rev_2	515	520	PF00179	0.594
MOD_SUMO_rev_2	55	64	PF00179	0.505
TRG_DiLeu_BaEn_1	336	341	PF01217	0.432
TRG_DiLeu_BaEn_1	461	466	PF01217	0.444
TRG_DiLeu_BaEn_4	461	467	PF01217	0.440
TRG_DiLeu_LyEn_5	461	466	PF01217	0.333
TRG_ENDOCYTIC_2	343	346	PF00928	0.442
TRG_ENDOCYTIC_2	646	649	PF00928	0.398
TRG_ER_diArg_1	109	112	PF00400	0.529
TRG_ER_diArg_1	117	119	PF00400	0.419
TRG_ER_diArg_1	234	237	PF00400	0.651
TRG_ER_diArg_1	238	240	PF00400	0.654
TRG_ER_diArg_1	679	681	PF00400	0.616
TRG_ER_diArg_1	682	684	PF00400	0.623
TRG_ER_diArg_1	704	706	PF00400	0.447
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P467	Leptomonas seymouri	57%	89%
A0A0S4IVX1	Bodo saltans	28%	100%
A0A1X0P116	Trypanosomatidae	33%	100%
A0A3Q8IGR5	Leishmania donovani	100%	100%
A4HLB5	Leishmania braziliensis	77%	100%
D0A4T7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B3Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4D0	Leishmania major	93%	100%
V5BFB4	Trypanosoma cruzi	39%	100%