LeishMANIAdb
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Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanine nucleotide-binding protein subunit beta-like protein
Gene product:
WD domain - G-beta repeat - putative
Species:
Leishmania infantum
UniProt:
A4I8T9_LEIIN
TriTrypDb:
LINF_330014200 *
Length:
530

Annotations

Annotations by Jardim et al.

Phosphatase, phosphatase, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 2
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2
GO:0005840 ribosome 5 1
GO:0032991 protein-containing complex 1 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

A4I8T9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8T9

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0006356 regulation of transcription by RNA polymerase I 7 1
GO:0006364 rRNA processing 8 1
GO:0006396 RNA processing 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0009891 positive regulation of biosynthetic process 5 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010557 positive regulation of macromolecule biosynthetic process 6 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0016070 RNA metabolic process 5 1
GO:0016072 rRNA metabolic process 7 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031325 positive regulation of cellular metabolic process 5 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0031328 positive regulation of cellular biosynthetic process 6 1
GO:0034470 ncRNA processing 7 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034660 ncRNA metabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0045893 positive regulation of DNA-templated transcription 7 1
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 6 1
GO:0045943 positive regulation of transcription by RNA polymerase I 8 1
GO:0046483 heterocycle metabolic process 3 1
GO:0048518 positive regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051173 positive regulation of nitrogen compound metabolic process 5 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0051254 positive regulation of RNA metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1902680 positive regulation of RNA biosynthetic process 7 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:1903508 positive regulation of nucleic acid-templated transcription 8 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 374 378 PF00656 0.683
CLV_C14_Caspase3-7 463 467 PF00656 0.534
CLV_NRD_NRD_1 371 373 PF00675 0.459
CLV_PCSK_KEX2_1 371 373 PF00082 0.584
CLV_PCSK_SKI1_1 109 113 PF00082 0.370
CLV_PCSK_SKI1_1 147 151 PF00082 0.431
DEG_APCC_DBOX_1 438 446 PF00400 0.310
DEG_Nend_UBRbox_2 1 3 PF02207 0.461
DEG_SPOP_SBC_1 80 84 PF00917 0.672
DOC_CKS1_1 148 153 PF01111 0.423
DOC_CYCLIN_RxL_1 105 115 PF00134 0.585
DOC_MAPK_gen_1 105 113 PF00069 0.562
DOC_MAPK_RevD_3 357 372 PF00069 0.492
DOC_PP4_FxxP_1 134 137 PF00568 0.413
DOC_USP7_MATH_1 137 141 PF00917 0.429
DOC_USP7_MATH_1 166 170 PF00917 0.364
DOC_USP7_MATH_1 34 38 PF00917 0.712
DOC_USP7_MATH_1 346 350 PF00917 0.610
DOC_USP7_MATH_1 351 355 PF00917 0.550
DOC_USP7_MATH_1 67 71 PF00917 0.668
DOC_USP7_MATH_1 78 82 PF00917 0.670
DOC_WW_Pin1_4 147 152 PF00397 0.427
DOC_WW_Pin1_4 179 184 PF00397 0.417
DOC_WW_Pin1_4 32 37 PF00397 0.719
DOC_WW_Pin1_4 81 86 PF00397 0.765
LIG_14-3-3_CanoR_1 109 114 PF00244 0.502
LIG_14-3-3_CanoR_1 372 382 PF00244 0.478
LIG_14-3-3_CanoR_1 99 108 PF00244 0.395
LIG_Actin_WH2_2 35 53 PF00022 0.681
LIG_AP2alpha_2 328 330 PF02296 0.694
LIG_BRCT_BRCA1_1 242 246 PF00533 0.511
LIG_BRCT_BRCA1_1 9 13 PF00533 0.498
LIG_FHA_1 133 139 PF00498 0.477
LIG_FHA_1 144 150 PF00498 0.355
LIG_FHA_1 235 241 PF00498 0.496
LIG_FHA_1 262 268 PF00498 0.539
LIG_FHA_1 397 403 PF00498 0.463
LIG_LIR_Apic_2 133 137 PF02991 0.407
LIG_PDZ_Class_3 525 530 PF00595 0.610
LIG_SH2_CRK 195 199 PF00017 0.549
LIG_SH2_NCK_1 22 26 PF00017 0.622
LIG_SH2_NCK_1 314 318 PF00017 0.525
LIG_SH2_SRC 22 25 PF00017 0.596
LIG_SH2_SRC 434 437 PF00017 0.591
LIG_SH2_STAP1 314 318 PF00017 0.525
LIG_SH2_STAT3 141 144 PF00017 0.446
LIG_SH2_STAT5 173 176 PF00017 0.399
LIG_SH2_STAT5 195 198 PF00017 0.411
LIG_SH2_STAT5 432 435 PF00017 0.490
LIG_SH3_2 319 324 PF14604 0.722
LIG_SH3_3 145 151 PF00018 0.460
LIG_SH3_3 30 36 PF00018 0.659
LIG_SH3_3 316 322 PF00018 0.680
LIG_SH3_3 510 516 PF00018 0.653
LIG_SUMO_SIM_anti_2 441 446 PF11976 0.307
LIG_TRFH_1 141 145 PF08558 0.337
LIG_TYR_ITIM 193 198 PF00017 0.549
LIG_UBA3_1 203 210 PF00899 0.503
LIG_UBA3_1 338 344 PF00899 0.600
MOD_CDK_SPK_2 83 88 PF00069 0.560
MOD_CDK_SPxxK_3 81 88 PF00069 0.571
MOD_CK1_1 15 21 PF00069 0.705
MOD_CK1_1 169 175 PF00069 0.397
MOD_CK1_1 269 275 PF00069 0.514
MOD_CK1_1 349 355 PF00069 0.641
MOD_CK1_1 411 417 PF00069 0.320
MOD_CK1_1 58 64 PF00069 0.673
MOD_CK1_1 81 87 PF00069 0.700
MOD_CK2_1 15 21 PF00069 0.704
MOD_CK2_1 49 55 PF00069 0.738
MOD_DYRK1A_RPxSP_1 147 151 PF00069 0.462
MOD_GlcNHglycan 156 159 PF01048 0.473
MOD_GlcNHglycan 17 20 PF01048 0.734
MOD_GlcNHglycan 188 191 PF01048 0.448
MOD_GlcNHglycan 242 245 PF01048 0.427
MOD_GlcNHglycan 257 260 PF01048 0.490
MOD_GlcNHglycan 285 288 PF01048 0.350
MOD_GlcNHglycan 351 354 PF01048 0.650
MOD_GlcNHglycan 362 365 PF01048 0.448
MOD_GlcNHglycan 474 477 PF01048 0.488
MOD_GlcNHglycan 51 54 PF01048 0.644
MOD_GlcNHglycan 57 60 PF01048 0.584
MOD_GlcNHglycan 76 79 PF01048 0.636
MOD_GlcNHglycan 88 91 PF01048 0.712
MOD_GSK3_1 112 119 PF00069 0.522
MOD_GSK3_1 143 150 PF00069 0.420
MOD_GSK3_1 230 237 PF00069 0.532
MOD_GSK3_1 255 262 PF00069 0.604
MOD_GSK3_1 28 35 PF00069 0.681
MOD_GSK3_1 373 380 PF00069 0.628
MOD_GSK3_1 38 45 PF00069 0.655
MOD_GSK3_1 396 403 PF00069 0.567
MOD_GSK3_1 407 414 PF00069 0.516
MOD_GSK3_1 67 74 PF00069 0.690
MOD_GSK3_1 79 86 PF00069 0.694
MOD_N-GLC_1 55 60 PF02516 0.627
MOD_NEK2_1 12 17 PF00069 0.741
MOD_NEK2_1 240 245 PF00069 0.637
MOD_NEK2_1 261 266 PF00069 0.599
MOD_NEK2_1 38 43 PF00069 0.651
MOD_NEK2_1 397 402 PF00069 0.592
MOD_NEK2_1 413 418 PF00069 0.435
MOD_NEK2_1 440 445 PF00069 0.359
MOD_NEK2_1 49 54 PF00069 0.563
MOD_PIKK_1 230 236 PF00454 0.496
MOD_PK_1 247 253 PF00069 0.582
MOD_PKA_1 371 377 PF00069 0.571
MOD_PKA_1 7 13 PF00069 0.498
MOD_PKA_2 154 160 PF00069 0.474
MOD_PKA_2 186 192 PF00069 0.524
MOD_PKA_2 371 377 PF00069 0.630
MOD_PKA_2 421 427 PF00069 0.507
MOD_PKB_1 107 115 PF00069 0.555
MOD_Plk_1 132 138 PF00069 0.578
MOD_Plk_1 169 175 PF00069 0.398
MOD_Plk_1 397 403 PF00069 0.584
MOD_Plk_1 440 446 PF00069 0.421
MOD_Plk_4 169 175 PF00069 0.370
MOD_Plk_4 38 44 PF00069 0.723
MOD_Plk_4 408 414 PF00069 0.422
MOD_Plk_4 440 446 PF00069 0.427
MOD_ProDKin_1 147 153 PF00069 0.438
MOD_ProDKin_1 179 185 PF00069 0.412
MOD_ProDKin_1 32 38 PF00069 0.720
MOD_ProDKin_1 81 87 PF00069 0.765
TRG_ENDOCYTIC_2 195 198 PF00928 0.404
TRG_ER_diArg_1 370 372 PF00400 0.578
TRG_NLS_MonoExtN_4 4 10 PF00514 0.450
TRG_Pf-PMV_PEXEL_1 201 205 PF00026 0.537

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBT4 Leptomonas seymouri 61% 100%
A0A1X0P1X3 Trypanosomatidae 40% 96%
A0A3Q8IGG9 Leishmania donovani 99% 100%
A0A422P2K2 Trypanosoma rangeli 45% 100%
A4HLB3 Leishmania braziliensis 80% 100%
D0A4T5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9B3Q5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 98%
Q4Q4D2 Leishmania major 93% 100%
V5DG89 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS