POT_family_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

POT family - putative

Species:

Leishmania infantum

UniProt:

A4I8T7_LEIIN

TriTrypDb:

LINF_330014000

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4I8T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8T7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	10
GO:0022857	transmembrane transporter activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.614
CLV_PCSK_SKI1_1	114	118	PF00082	0.525
CLV_PCSK_SKI1_1	148	152	PF00082	0.336
CLV_PCSK_SKI1_1	232	236	PF00082	0.257
CLV_PCSK_SKI1_1	312	316	PF00082	0.262
DEG_APCC_DBOX_1	147	155	PF00400	0.557
DEG_MDM2_SWIB_1	472	480	PF02201	0.341
DEG_Nend_UBRbox_4	1	3	PF02207	0.617
DEG_SPOP_SBC_1	393	397	PF00917	0.441
DOC_AGCK_PIF_1	30	35	PF00069	0.393
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.288
DOC_CYCLIN_yCln2_LP_2	543	549	PF00134	0.276
DOC_MAPK_gen_1	421	431	PF00069	0.525
DOC_MAPK_gen_1	572	580	PF00069	0.525
DOC_MAPK_MEF2A_6	312	320	PF00069	0.464
DOC_MAPK_MEF2A_6	424	431	PF00069	0.300
DOC_MAPK_NFAT4_5	424	432	PF00069	0.335
DOC_PP2B_LxvP_1	450	453	PF13499	0.284
DOC_PP2B_LxvP_1	454	457	PF13499	0.284
DOC_PP2B_LxvP_1	5	8	PF13499	0.593
DOC_PP2B_LxvP_1	543	546	PF13499	0.276
DOC_PP4_FxxP_1	255	258	PF00568	0.300
DOC_PP4_FxxP_1	556	559	PF00568	0.383
DOC_USP7_MATH_1	165	169	PF00917	0.703
DOC_USP7_MATH_1	393	397	PF00917	0.489
DOC_USP7_MATH_1	407	411	PF00917	0.379
DOC_WW_Pin1_4	593	598	PF00397	0.256
DOC_WW_Pin1_4	95	100	PF00397	0.485
LIG_14-3-3_CanoR_1	181	187	PF00244	0.622
LIG_14-3-3_CanoR_1	317	321	PF00244	0.572
LIG_14-3-3_CanoR_1	417	421	PF00244	0.594
LIG_14-3-3_CanoR_1	77	86	PF00244	0.439
LIG_Actin_WH2_2	25	43	PF00022	0.281
LIG_Actin_WH2_2	316	333	PF00022	0.534
LIG_BIR_III_4	405	409	PF00653	0.516
LIG_BRCT_BRCA1_1	235	239	PF00533	0.442
LIG_BRCT_BRCA1_1	618	622	PF00533	0.372
LIG_Clathr_ClatBox_1	14	18	PF01394	0.473
LIG_eIF4E_1	279	285	PF01652	0.284
LIG_eIF4E_1	86	92	PF01652	0.379
LIG_FHA_1	133	139	PF00498	0.459
LIG_FHA_1	178	184	PF00498	0.669
LIG_FHA_1	220	226	PF00498	0.465
LIG_FHA_1	35	41	PF00498	0.361
LIG_FHA_1	417	423	PF00498	0.510
LIG_FHA_1	466	472	PF00498	0.337
LIG_FHA_1	85	91	PF00498	0.340
LIG_FHA_1	96	102	PF00498	0.387
LIG_FHA_2	154	160	PF00498	0.639
LIG_FHA_2	215	221	PF00498	0.614
LIG_FHA_2	453	459	PF00498	0.202
LIG_FHA_2	558	564	PF00498	0.442
LIG_LIR_Apic_2	477	482	PF02991	0.518
LIG_LIR_Apic_2	554	559	PF02991	0.387
LIG_LIR_Gen_1	34	40	PF02991	0.297
LIG_LIR_Gen_1	458	469	PF02991	0.242
LIG_LIR_Gen_1	539	549	PF02991	0.274
LIG_LIR_Gen_1	9	20	PF02991	0.483
LIG_LIR_Nem_3	277	283	PF02991	0.242
LIG_LIR_Nem_3	34	38	PF02991	0.317
LIG_LIR_Nem_3	349	353	PF02991	0.458
LIG_LIR_Nem_3	458	464	PF02991	0.242
LIG_LIR_Nem_3	506	512	PF02991	0.300
LIG_LIR_Nem_3	588	593	PF02991	0.329
LIG_LIR_Nem_3	619	625	PF02991	0.270
LIG_LIR_Nem_3	9	15	PF02991	0.510
LIG_Pex14_2	472	476	PF04695	0.385
LIG_Pex14_2	552	556	PF04695	0.357
LIG_PTB_Apo_2	49	56	PF02174	0.276
LIG_PTB_Phospho_1	49	55	PF10480	0.276
LIG_SH2_CRK	281	285	PF00017	0.335
LIG_SH2_CRK	35	39	PF00017	0.335
LIG_SH2_CRK	487	491	PF00017	0.441
LIG_SH2_NCK_1	26	30	PF00017	0.393
LIG_SH2_PTP2	55	58	PF00017	0.393
LIG_SH2_STAP1	208	212	PF00017	0.622
LIG_SH2_STAP1	241	245	PF00017	0.429
LIG_SH2_STAP1	26	30	PF00017	0.393
LIG_SH2_STAP1	281	285	PF00017	0.383
LIG_SH2_STAP1	86	90	PF00017	0.331
LIG_SH2_STAT3	547	550	PF00017	0.276
LIG_SH2_STAT5	102	105	PF00017	0.375
LIG_SH2_STAT5	35	38	PF00017	0.276
LIG_SH2_STAT5	529	532	PF00017	0.278
LIG_SH2_STAT5	547	550	PF00017	0.186
LIG_SH2_STAT5	55	58	PF00017	0.155
LIG_SH2_STAT5	623	626	PF00017	0.327
LIG_SH2_STAT5	86	89	PF00017	0.393
LIG_SH3_3	591	597	PF00018	0.315
LIG_SH3_3	70	76	PF00018	0.545
LIG_SUMO_SIM_anti_2	89	94	PF11976	0.393
LIG_SUMO_SIM_par_1	36	42	PF11976	0.422
LIG_SUMO_SIM_par_1	451	459	PF11976	0.218
LIG_TRFH_1	55	59	PF08558	0.300
LIG_TRFH_1	593	597	PF08558	0.297
LIG_TYR_ITIM	23	28	PF00017	0.365
LIG_TYR_ITIM	53	58	PF00017	0.365
LIG_WRC_WIRS_1	280	285	PF05994	0.383
LIG_WRC_WIRS_1	608	613	PF05994	0.341
MOD_CDK_SPxxK_3	593	600	PF00069	0.256
MOD_CK1_1	168	174	PF00069	0.598
MOD_CK1_1	31	37	PF00069	0.393
MOD_CK1_1	360	366	PF00069	0.496
MOD_CK1_1	383	389	PF00069	0.563
MOD_CK1_1	394	400	PF00069	0.470
MOD_CK1_1	516	522	PF00069	0.218
MOD_CK1_1	585	591	PF00069	0.276
MOD_CK1_1	610	616	PF00069	0.297
MOD_CK2_1	221	227	PF00069	0.534
MOD_CK2_1	452	458	PF00069	0.280
MOD_CK2_1	557	563	PF00069	0.276
MOD_CMANNOS	476	479	PF00535	0.318
MOD_GlcNHglycan	167	170	PF01048	0.387
MOD_GlcNHglycan	332	335	PF01048	0.299
MOD_GlcNHglycan	368	371	PF01048	0.299
MOD_GlcNHglycan	490	493	PF01048	0.288
MOD_GlcNHglycan	538	541	PF01048	0.485
MOD_GlcNHglycan	553	556	PF01048	0.155
MOD_GlcNHglycan	585	588	PF01048	0.282
MOD_GlcNHglycan	65	68	PF01048	0.307
MOD_GlcNHglycan	95	98	PF01048	0.420
MOD_GSK3_1	208	215	PF00069	0.729
MOD_GSK3_1	262	269	PF00069	0.247
MOD_GSK3_1	362	369	PF00069	0.454
MOD_GSK3_1	379	386	PF00069	0.471
MOD_GSK3_1	391	398	PF00069	0.484
MOD_NEK2_1	212	217	PF00069	0.627
MOD_NEK2_1	330	335	PF00069	0.510
MOD_NEK2_1	39	44	PF00069	0.304
MOD_NEK2_1	503	508	PF00069	0.276
MOD_NEK2_1	513	518	PF00069	0.276
MOD_NEK2_1	573	578	PF00069	0.504
MOD_NEK2_1	607	612	PF00069	0.288
MOD_NEK2_1	616	621	PF00069	0.246
MOD_NEK2_1	63	68	PF00069	0.375
MOD_NEK2_1	93	98	PF00069	0.311
MOD_NEK2_2	127	132	PF00069	0.393
MOD_NEK2_2	208	213	PF00069	0.638
MOD_NEK2_2	416	421	PF00069	0.525
MOD_PIKK_1	266	272	PF00454	0.202
MOD_PK_1	357	363	PF00069	0.457
MOD_PKA_2	266	272	PF00069	0.265
MOD_PKA_2	316	322	PF00069	0.569
MOD_PKA_2	330	336	PF00069	0.479
MOD_PKA_2	416	422	PF00069	0.525
MOD_PKB_1	486	494	PF00069	0.441
MOD_Plk_1	208	214	PF00069	0.748
MOD_Plk_1	383	389	PF00069	0.403
MOD_Plk_4	153	159	PF00069	0.629
MOD_Plk_4	208	214	PF00069	0.698
MOD_Plk_4	221	227	PF00069	0.472
MOD_Plk_4	279	285	PF00069	0.273
MOD_Plk_4	316	322	PF00069	0.483
MOD_Plk_4	34	40	PF00069	0.306
MOD_Plk_4	407	413	PF00069	0.470
MOD_Plk_4	465	471	PF00069	0.301
MOD_Plk_4	503	509	PF00069	0.344
MOD_Plk_4	557	563	PF00069	0.276
MOD_Plk_4	573	579	PF00069	0.442
MOD_Plk_4	616	622	PF00069	0.286
MOD_Plk_4	7	13	PF00069	0.625
MOD_Plk_4	86	92	PF00069	0.344
MOD_ProDKin_1	593	599	PF00069	0.256
MOD_ProDKin_1	95	101	PF00069	0.484
MOD_SUMO_rev_2	224	234	PF00179	0.402
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.276
TRG_ENDOCYTIC_2	102	105	PF00928	0.295
TRG_ENDOCYTIC_2	128	131	PF00928	0.276
TRG_ENDOCYTIC_2	25	28	PF00928	0.360
TRG_ENDOCYTIC_2	280	283	PF00928	0.276
TRG_ENDOCYTIC_2	298	301	PF00928	0.276
TRG_ENDOCYTIC_2	35	38	PF00928	0.300
TRG_ENDOCYTIC_2	432	435	PF00928	0.276
TRG_ENDOCYTIC_2	55	58	PF00928	0.155
TRG_ER_diArg_1	75	78	PF00400	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C4	Leptomonas seymouri	59%	96%
A0A1X0P0R8	Trypanosomatidae	40%	95%
A0A3S7X6J4	Leishmania donovani	100%	100%
A0A422P2J5	Trypanosoma rangeli	38%	99%
A4HLB1	Leishmania braziliensis	75%	100%
E9B3Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q4D4	Leishmania major	91%	100%
V5BPE7	Trypanosoma cruzi	38%	100%