TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8T6_LEIIN

TriTrypDb:

LINF_330013900

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I8T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8T6

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0005515	protein binding	2	4
GO:0030544	Hsp70 protein binding	4	1
GO:0031072	heat shock protein binding	3	4
GO:0051879	Hsp90 protein binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.443
CLV_NRD_NRD_1	162	164	PF00675	0.459
CLV_NRD_NRD_1	190	192	PF00675	0.481
CLV_NRD_NRD_1	227	229	PF00675	0.605
CLV_NRD_NRD_1	32	34	PF00675	0.535
CLV_NRD_NRD_1	83	85	PF00675	0.449
CLV_PCSK_KEX2_1	102	104	PF00082	0.543
CLV_PCSK_KEX2_1	190	192	PF00082	0.481
CLV_PCSK_KEX2_1	227	229	PF00082	0.571
CLV_PCSK_KEX2_1	32	34	PF00082	0.535
CLV_PCSK_SKI1_1	168	172	PF00082	0.449
CLV_PCSK_SKI1_1	242	246	PF00082	0.405
DEG_Nend_Nbox_1	1	3	PF02207	0.576
DEG_SPOP_SBC_1	243	247	PF00917	0.558
DOC_CDC14_PxL_1	277	285	PF14671	0.351
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.344
DOC_MAPK_gen_1	177	185	PF00069	0.393
DOC_MAPK_gen_1	321	331	PF00069	0.398
DOC_MAPK_MEF2A_6	177	185	PF00069	0.387
DOC_MAPK_MEF2A_6	324	332	PF00069	0.452
DOC_MAPK_NFAT4_5	178	186	PF00069	0.403
DOC_PP2B_LxvP_1	278	281	PF13499	0.346
DOC_USP7_MATH_1	10	14	PF00917	0.566
DOC_USP7_MATH_1	133	137	PF00917	0.354
DOC_USP7_MATH_1	152	156	PF00917	0.384
DOC_USP7_MATH_1	229	233	PF00917	0.511
DOC_USP7_MATH_1	235	239	PF00917	0.451
DOC_USP7_MATH_1	243	247	PF00917	0.311
DOC_USP7_MATH_1	66	70	PF00917	0.459
LIG_14-3-3_CanoR_1	228	237	PF00244	0.515
LIG_14-3-3_CanoR_1	242	251	PF00244	0.332
LIG_14-3-3_CanoR_1	90	95	PF00244	0.468
LIG_APCC_ABBA_1	283	288	PF00400	0.361
LIG_APCC_ABBA_1	353	358	PF00400	0.442
LIG_deltaCOP1_diTrp_1	347	356	PF00928	0.428
LIG_deltaCOP1_diTrp_1	41	49	PF00928	0.496
LIG_eIF4E_1	361	367	PF01652	0.369
LIG_FHA_1	113	119	PF00498	0.386
LIG_FHA_2	218	224	PF00498	0.441
LIG_FHA_2	52	58	PF00498	0.490
LIG_LIR_Apic_2	358	364	PF02991	0.380
LIG_LIR_Gen_1	204	213	PF02991	0.414
LIG_LIR_Gen_1	41	50	PF02991	0.491
LIG_LIR_Gen_1	69	80	PF02991	0.477
LIG_LIR_Nem_3	340	346	PF02991	0.395
LIG_LIR_Nem_3	347	353	PF02991	0.390
LIG_LIR_Nem_3	69	75	PF02991	0.492
LIG_MYND_1	364	368	PF01753	0.368
LIG_REV1ctd_RIR_1	329	337	PF16727	0.446
LIG_RPA_C_Fungi	130	142	PF08784	0.364
LIG_SH2_CRK	265	269	PF00017	0.521
LIG_SH2_GRB2like	132	135	PF00017	0.364
LIG_SH2_NCK_1	361	365	PF00017	0.482
LIG_SH2_NCK_1	72	76	PF00017	0.488
LIG_SH2_SRC	72	75	PF00017	0.521
LIG_SH2_STAP1	114	118	PF00017	0.479
LIG_SH2_STAT5	114	117	PF00017	0.378
LIG_SH2_STAT5	271	274	PF00017	0.477
LIG_SH3_3	189	195	PF00018	0.575
LIG_TRAF2_1	220	223	PF00917	0.573
LIG_TRAF2_1	98	101	PF00917	0.569
LIG_TYR_ITIM	70	75	PF00017	0.496
LIG_UBA3_1	366	375	PF00899	0.374
MOD_CK2_1	110	116	PF00069	0.482
MOD_CK2_1	217	223	PF00069	0.433
MOD_CK2_1	250	256	PF00069	0.459
MOD_Cter_Amidation	188	191	PF01082	0.514
MOD_GlcNHglycan	246	249	PF01048	0.451
MOD_GSK3_1	122	129	PF00069	0.560
MOD_N-GLC_1	133	138	PF02516	0.361
MOD_N-GLC_1	51	56	PF02516	0.499
MOD_NEK2_1	127	132	PF00069	0.464
MOD_PIKK_1	229	235	PF00454	0.618
MOD_Plk_1	133	139	PF00069	0.353
MOD_Plk_1	346	352	PF00069	0.379
MOD_Plk_2-3	51	57	PF00069	0.452
MOD_Plk_4	127	133	PF00069	0.474
MOD_Plk_4	66	72	PF00069	0.573
MOD_SUMO_rev_2	204	213	PF00179	0.483
TRG_DiLeu_BaEn_1	362	367	PF01217	0.514
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.444
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.481
TRG_ENDOCYTIC_2	322	325	PF00928	0.378
TRG_ENDOCYTIC_2	343	346	PF00928	0.353
TRG_ENDOCYTIC_2	72	75	PF00928	0.496
TRG_ER_diArg_1	190	192	PF00400	0.534
TRG_ER_diArg_1	319	322	PF00400	0.420
TRG_NES_CRM1_1	323	336	PF08389	0.461
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R4	Leptomonas seymouri	79%	100%
A0A1X0P0Q3	Trypanosomatidae	61%	100%
A0A3S7X6F2	Leishmania donovani	99%	100%
A0A422P2K3	Trypanosoma rangeli	60%	100%
A1Z6M6	Drosophila melanogaster	28%	98%
A4HLB0	Leishmania braziliensis	85%	100%
D0A4T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	90%
E9B3Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O13754	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
O95801	Homo sapiens	28%	100%
P33313	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q4Q4D5	Leishmania major	95%	100%
Q54M20	Dictyostelium discoideum	24%	98%
Q5EA11	Bos taurus	30%	100%
Q8R3H9	Mus musculus	28%	100%