LeishMANIAdb
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Putative sterol C-24 reductase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative sterol C-24 reductase
Gene product:
sterol C-24 reductase - putative
Species:
Leishmania infantum
UniProt:
A4I8T4_LEIIN
TriTrypDb:
LINF_330013700
Length:
496

Annotations

LeishMANIAdb annotations

Related to both fungal ergosterol C-24 reductases and to a lesser extent, animal delta-14 lanosterol reductases (all preferentially ER-localized).. The highly changed Ser/Arg rich N-terminus might point to a mitochondrial transit signal (ergosterols are essential for Kinetoplastid mitochondria).. Localization: ER (by homology) / Mitochondrial (by feature)

Annotations by Jardim et al.

Sterol metabolism/biosynthesis, sterol C-24 reductase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I8T4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8T4

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 9
GO:0006694 steroid biosynthetic process 5 9
GO:0008152 metabolic process 1 9
GO:0008202 steroid metabolic process 4 9
GO:0008610 lipid biosynthetic process 4 9
GO:0009058 biosynthetic process 2 9
GO:0016125 sterol metabolic process 4 9
GO:0016126 sterol biosynthetic process 5 9
GO:0044238 primary metabolic process 2 9
GO:0071704 organic substance metabolic process 2 9
GO:1901360 organic cyclic compound metabolic process 3 9
GO:1901362 organic cyclic compound biosynthetic process 4 9
GO:1901576 organic substance biosynthetic process 3 9
GO:1901615 organic hydroxy compound metabolic process 3 9
GO:1901617 organic hydroxy compound biosynthetic process 4 9
GO:0006066 alcohol metabolic process 3 1
GO:0006696 ergosterol biosynthetic process 5 1
GO:0008204 ergosterol metabolic process 4 1
GO:0009987 cellular process 1 1
GO:0016128 phytosteroid metabolic process 4 1
GO:0016129 phytosteroid biosynthetic process 5 1
GO:0044107 obsolete cellular alcohol metabolic process 3 1
GO:0044108 obsolete cellular alcohol biosynthetic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0044283 small molecule biosynthetic process 3 1
GO:0046165 alcohol biosynthetic process 4 1
GO:0097384 cellular lipid biosynthetic process 4 1
GO:1902652 secondary alcohol metabolic process 4 1
GO:1902653 secondary alcohol biosynthetic process 5 1
Molecular functions
Term Name Level Count
GO:0000246 delta24(24-1) sterol reductase activity 5 7
GO:0003824 catalytic activity 1 9
GO:0016491 oxidoreductase activity 2 9
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 9
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 19 21 PF00675 0.498
CLV_NRD_NRD_1 193 195 PF00675 0.483
CLV_NRD_NRD_1 221 223 PF00675 0.241
CLV_NRD_NRD_1 380 382 PF00675 0.302
CLV_NRD_NRD_1 424 426 PF00675 0.259
CLV_NRD_NRD_1 466 468 PF00675 0.254
CLV_NRD_NRD_1 47 49 PF00675 0.367
CLV_PCSK_FUR_1 378 382 PF00082 0.263
CLV_PCSK_FUR_1 464 468 PF00082 0.283
CLV_PCSK_KEX2_1 193 195 PF00082 0.483
CLV_PCSK_KEX2_1 220 222 PF00082 0.260
CLV_PCSK_KEX2_1 380 382 PF00082 0.263
CLV_PCSK_KEX2_1 466 468 PF00082 0.283
CLV_PCSK_PC1ET2_1 220 222 PF00082 0.285
CLV_PCSK_SKI1_1 109 113 PF00082 0.506
CLV_PCSK_SKI1_1 34 38 PF00082 0.415
CLV_PCSK_SKI1_1 350 354 PF00082 0.425
CLV_PCSK_SKI1_1 406 410 PF00082 0.291
CLV_PCSK_SKI1_1 48 52 PF00082 0.298
DEG_APCC_DBOX_1 349 357 PF00400 0.450
DOC_CKS1_1 35 40 PF01111 0.636
DOC_CYCLIN_RxL_1 146 156 PF00134 0.518
DOC_CYCLIN_yCln2_LP_2 141 147 PF00134 0.374
DOC_MAPK_gen_1 103 112 PF00069 0.351
DOC_MAPK_gen_1 378 388 PF00069 0.518
DOC_MAPK_gen_1 425 433 PF00069 0.527
DOC_MAPK_HePTP_8 239 251 PF00069 0.483
DOC_MAPK_MEF2A_6 242 251 PF00069 0.475
DOC_MAPK_MEF2A_6 256 264 PF00069 0.265
DOC_MAPK_MEF2A_6 426 435 PF00069 0.443
DOC_PP1_RVXF_1 107 113 PF00149 0.301
DOC_PP2B_LxvP_1 141 144 PF13499 0.349
DOC_PP2B_LxvP_1 151 154 PF13499 0.428
DOC_PP4_FxxP_1 241 244 PF00568 0.443
DOC_PP4_FxxP_1 63 66 PF00568 0.483
DOC_USP7_MATH_1 12 16 PF00917 0.689
DOC_USP7_MATH_1 152 156 PF00917 0.459
DOC_USP7_MATH_1 369 373 PF00917 0.501
DOC_WW_Pin1_4 26 31 PF00397 0.653
DOC_WW_Pin1_4 34 39 PF00397 0.579
DOC_WW_Pin1_4 48 53 PF00397 0.476
LIG_14-3-3_CanoR_1 160 164 PF00244 0.518
LIG_14-3-3_CanoR_1 256 260 PF00244 0.315
LIG_14-3-3_CanoR_1 406 416 PF00244 0.464
LIG_AP2alpha_1 416 420 PF02296 0.502
LIG_APCC_ABBA_1 249 254 PF00400 0.459
LIG_deltaCOP1_diTrp_1 55 63 PF00928 0.517
LIG_eIF4E_1 84 90 PF01652 0.427
LIG_FHA_1 123 129 PF00498 0.304
LIG_FHA_1 306 312 PF00498 0.459
LIG_FHA_1 323 329 PF00498 0.315
LIG_FHA_1 410 416 PF00498 0.552
LIG_FHA_1 428 434 PF00498 0.348
LIG_FHA_2 305 311 PF00498 0.492
LIG_FHA_2 35 41 PF00498 0.566
LIG_LIR_Apic_2 39 45 PF02991 0.560
LIG_LIR_Apic_2 62 66 PF02991 0.485
LIG_LIR_Gen_1 125 134 PF02991 0.413
LIG_LIR_Gen_1 169 180 PF02991 0.450
LIG_LIR_Gen_1 258 267 PF02991 0.315
LIG_LIR_Gen_1 272 280 PF02991 0.259
LIG_LIR_Gen_1 310 321 PF02991 0.466
LIG_LIR_Gen_1 481 491 PF02991 0.483
LIG_LIR_Nem_3 125 129 PF02991 0.429
LIG_LIR_Nem_3 169 175 PF02991 0.415
LIG_LIR_Nem_3 258 262 PF02991 0.315
LIG_LIR_Nem_3 272 277 PF02991 0.259
LIG_LIR_Nem_3 307 312 PF02991 0.459
LIG_LIR_Nem_3 40 46 PF02991 0.599
LIG_LIR_Nem_3 418 423 PF02991 0.459
LIG_LIR_Nem_3 446 451 PF02991 0.263
LIG_LIR_Nem_3 481 486 PF02991 0.453
LIG_NRBOX 129 135 PF00104 0.397
LIG_Pex14_1 309 313 PF04695 0.459
LIG_Pex14_1 318 322 PF04695 0.315
LIG_Pex14_2 229 233 PF04695 0.552
LIG_Pex14_2 416 420 PF04695 0.438
LIG_Pex14_2 448 452 PF04695 0.315
LIG_PTB_Apo_2 388 395 PF02174 0.506
LIG_SH2_CRK 172 176 PF00017 0.352
LIG_SH2_CRK 489 493 PF00017 0.445
LIG_SH2_GRB2like 294 297 PF00017 0.315
LIG_SH2_GRB2like 322 325 PF00017 0.315
LIG_SH2_NCK_1 43 47 PF00017 0.612
LIG_SH2_PTP2 483 486 PF00017 0.556
LIG_SH2_PTP2 84 87 PF00017 0.397
LIG_SH2_SRC 294 297 PF00017 0.315
LIG_SH2_SRC 43 46 PF00017 0.526
LIG_SH2_STAP1 231 235 PF00017 0.459
LIG_SH2_STAP1 429 433 PF00017 0.315
LIG_SH2_STAT3 332 335 PF00017 0.315
LIG_SH2_STAT5 137 140 PF00017 0.349
LIG_SH2_STAT5 147 150 PF00017 0.483
LIG_SH2_STAT5 172 175 PF00017 0.332
LIG_SH2_STAT5 215 218 PF00017 0.413
LIG_SH2_STAT5 279 282 PF00017 0.259
LIG_SH2_STAT5 294 297 PF00017 0.315
LIG_SH2_STAT5 332 335 PF00017 0.324
LIG_SH2_STAT5 338 341 PF00017 0.251
LIG_SH2_STAT5 365 368 PF00017 0.315
LIG_SH2_STAT5 401 404 PF00017 0.506
LIG_SH2_STAT5 429 432 PF00017 0.315
LIG_SH2_STAT5 453 456 PF00017 0.307
LIG_SH2_STAT5 483 486 PF00017 0.456
LIG_SH2_STAT5 82 85 PF00017 0.315
LIG_SH3_3 32 38 PF00018 0.654
LIG_SH3_3 392 398 PF00018 0.459
LIG_SH3_3 94 100 PF00018 0.283
LIG_SUMO_SIM_anti_2 258 264 PF11976 0.315
LIG_SUMO_SIM_anti_2 430 435 PF11976 0.327
LIG_SUMO_SIM_par_1 263 268 PF11976 0.321
LIG_TRAF2_1 37 40 PF00917 0.561
LIG_TYR_ITIM 181 186 PF00017 0.349
LIG_TYR_ITIM 487 492 PF00017 0.459
LIG_TYR_ITIM 80 85 PF00017 0.315
LIG_WRC_WIRS_1 111 116 PF05994 0.356
LIG_WRC_WIRS_1 445 450 PF05994 0.259
MOD_CDK_SPxK_1 26 32 PF00069 0.672
MOD_CDK_SPxK_1 48 54 PF00069 0.514
MOD_CK1_1 4 10 PF00069 0.744
MOD_CK2_1 34 40 PF00069 0.574
MOD_Cter_Amidation 423 426 PF01082 0.259
MOD_DYRK1A_RPxSP_1 26 30 PF00069 0.678
MOD_DYRK1A_RPxSP_1 34 38 PF00069 0.595
MOD_GlcNHglycan 236 239 PF01048 0.259
MOD_GlcNHglycan 288 291 PF01048 0.237
MOD_GlcNHglycan 381 384 PF01048 0.274
MOD_GlcNHglycan 409 412 PF01048 0.356
MOD_GlcNHglycan 440 443 PF01048 0.380
MOD_GlcNHglycan 6 9 PF01048 0.488
MOD_GSK3_1 16 23 PF00069 0.716
MOD_GSK3_1 24 31 PF00069 0.678
MOD_GSK3_1 6 13 PF00069 0.673
MOD_N-GLC_2 324 326 PF02516 0.315
MOD_NEK2_1 234 239 PF00069 0.472
MOD_NEK2_1 263 268 PF00069 0.349
MOD_NEK2_1 286 291 PF00069 0.237
MOD_NEK2_1 379 384 PF00069 0.449
MOD_NEK2_1 438 443 PF00069 0.330
MOD_NEK2_1 73 78 PF00069 0.340
MOD_NEK2_1 90 95 PF00069 0.196
MOD_NEK2_2 333 338 PF00069 0.397
MOD_PIKK_1 369 375 PF00454 0.459
MOD_PKA_1 20 26 PF00069 0.730
MOD_PKA_2 159 165 PF00069 0.518
MOD_PKA_2 223 229 PF00069 0.459
MOD_PKA_2 255 261 PF00069 0.315
MOD_PKA_2 379 385 PF00069 0.487
MOD_PKB_1 14 22 PF00069 0.693
MOD_PKB_1 26 34 PF00069 0.638
MOD_Plk_4 201 207 PF00069 0.292
MOD_Plk_4 255 261 PF00069 0.315
MOD_Plk_4 333 339 PF00069 0.322
MOD_Plk_4 444 450 PF00069 0.315
MOD_Plk_4 90 96 PF00069 0.277
MOD_ProDKin_1 26 32 PF00069 0.651
MOD_ProDKin_1 34 40 PF00069 0.574
MOD_ProDKin_1 48 54 PF00069 0.479
MOD_SUMO_for_1 102 105 PF00179 0.258
TRG_DiLeu_BaEn_1 482 487 PF01217 0.556
TRG_ENDOCYTIC_2 172 175 PF00928 0.361
TRG_ENDOCYTIC_2 183 186 PF00928 0.315
TRG_ENDOCYTIC_2 196 199 PF00928 0.349
TRG_ENDOCYTIC_2 231 234 PF00928 0.459
TRG_ENDOCYTIC_2 274 277 PF00928 0.283
TRG_ENDOCYTIC_2 313 316 PF00928 0.459
TRG_ENDOCYTIC_2 43 46 PF00928 0.609
TRG_ENDOCYTIC_2 453 456 PF00928 0.315
TRG_ENDOCYTIC_2 476 479 PF00928 0.459
TRG_ENDOCYTIC_2 483 486 PF00928 0.459
TRG_ENDOCYTIC_2 489 492 PF00928 0.459
TRG_ENDOCYTIC_2 82 85 PF00928 0.316
TRG_ER_diArg_1 192 194 PF00400 0.283
TRG_ER_diArg_1 221 224 PF00400 0.442
TRG_ER_diArg_1 32 35 PF00400 0.709
TRG_ER_diArg_1 377 380 PF00400 0.512
TRG_NLS_MonoExtC_3 219 224 PF00514 0.463
TRG_Pf-PMV_PEXEL_1 34 39 PF00026 0.400

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3C6 Leptomonas seymouri 79% 99%
A0A0N1PBH8 Leptomonas seymouri 29% 100%
A0A0S4IS37 Bodo saltans 28% 100%
A0A0S4KLN5 Bodo saltans 28% 100%
A0A1D8PIC7 Candida albicans (strain SC5314 / ATCC MYA-2876) 28% 100%
A0A1D8PJ25 Candida albicans (strain SC5314 / ATCC MYA-2876) 37% 100%
A0A1X0NRH6 Trypanosomatidae 24% 100%
A0A1X0P0Q6 Trypanosomatidae 67% 100%
A0A3Q8IM20 Leishmania donovani 100% 100%
A0A3R7KUI7 Trypanosoma rangeli 65% 100%
A0A3R7N804 Trypanosoma rangeli 28% 100%
A0A3S7X5R0 Leishmania donovani 27% 100%
A4HKM3 Leishmania braziliensis 27% 100%
A4HLA8 Leishmania braziliensis 86% 100%
A4I855 Leishmania infantum 27% 100%
D0AAC2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
E9B312 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B3Q0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
G4SW86 Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z) 31% 100%
I1RF79 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 25% 100%
I1RR90 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 26% 100%
I1RZZ3 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 40% 83%
O08984 Rattus norvegicus 30% 80%
O13597 Septoria lycopersici 28% 97%
O76062 Homo sapiens 32% 100%
O88455 Mus musculus 26% 100%
P23913 Gallus gallus 29% 78%
P25340 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 100%
P32462 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 100%
P36209 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 36% 100%
P38670 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 26% 100%
P78575 Ascobolus immersus 28% 100%
Q01447 Fusarium vanettenii 27% 100%
Q09195 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 100%
Q14739 Homo sapiens 32% 81%
Q3U9G9 Mus musculus 32% 79%
Q4Q4D7 Leishmania major 96% 100%
Q4Q543 Leishmania major 27% 100%
Q4WJ59 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 39% 87%
Q4WJJ9 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 27% 96%
Q4WKA5 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 25% 100%
Q4WW43 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 41% 100%
Q54PP1 Dictyostelium discoideum 31% 100%
Q5E9J5 Bos taurus 26% 100%
Q5R7H4 Pongo abelii 32% 81%
Q5UQI4 Acanthamoeba polyphaga mimivirus 30% 100%
Q6P4M0 Xenopus tropicalis 26% 100%
Q71KT5 Mus musculus 32% 100%
Q7SXF1 Danio rerio 26% 100%
Q7ZXH1 Xenopus laevis 26% 100%
Q8WMV1 Bos taurus 32% 100%
Q9LDR4 Arabidopsis thaliana 27% 100%
Q9LDU6 Arabidopsis thaliana 28% 100%
Q9UBM7 Homo sapiens 25% 100%
Q9Z2Z8 Rattus norvegicus 25% 100%
V5BKN3 Trypanosoma cruzi 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS