Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2A regulatory subunit - putative

Species:

Leishmania infantum

UniProt:

A4I8T3_LEIIN

TriTrypDb:

LINF_330013600

Length:

918

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	8
GO:0008287	protein serine/threonine phosphatase complex	4	8
GO:0016020	membrane	2	2
GO:0032991	protein-containing complex	1	8
GO:0110165	cellular anatomical entity	1	3
GO:1902494	catalytic complex	2	8
GO:1903293	phosphatase complex	3	8
GO:0005829	cytosol	2	1

Expansion

Sequence features

A4I8T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8T3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	8
GO:0019888	protein phosphatase regulator activity	4	8
GO:0030234	enzyme regulator activity	2	8
GO:0098772	molecular function regulator activity	1	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.472
CLV_NRD_NRD_1	271	273	PF00675	0.692
CLV_NRD_NRD_1	329	331	PF00675	0.718
CLV_NRD_NRD_1	466	468	PF00675	0.610
CLV_NRD_NRD_1	47	49	PF00675	0.569
CLV_NRD_NRD_1	766	768	PF00675	0.762
CLV_NRD_NRD_1	785	787	PF00675	0.558
CLV_NRD_NRD_1	860	862	PF00675	0.661
CLV_PCSK_KEX2_1	107	109	PF00082	0.472
CLV_PCSK_KEX2_1	270	272	PF00082	0.708
CLV_PCSK_KEX2_1	328	330	PF00082	0.720
CLV_PCSK_KEX2_1	466	468	PF00082	0.610
CLV_PCSK_KEX2_1	47	49	PF00082	0.569
CLV_PCSK_KEX2_1	486	488	PF00082	0.563
CLV_PCSK_KEX2_1	766	768	PF00082	0.762
CLV_PCSK_KEX2_1	785	787	PF00082	0.541
CLV_PCSK_KEX2_1	860	862	PF00082	0.661
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.708
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.720
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.726
CLV_PCSK_SKI1_1	467	471	PF00082	0.646
CLV_PCSK_SKI1_1	51	55	PF00082	0.561
CLV_PCSK_SKI1_1	75	79	PF00082	0.258
CLV_PCSK_SKI1_1	786	790	PF00082	0.579
DEG_APCC_DBOX_1	465	473	PF00400	0.437
DEG_APCC_DBOX_1	793	801	PF00400	0.359
DEG_SPOP_SBC_1	319	323	PF00917	0.505
DOC_CKS1_1	762	767	PF01111	0.516
DOC_CYCLIN_RxL_1	464	471	PF00134	0.432
DOC_CYCLIN_yClb5_NLxxxL_5	140	149	PF00134	0.493
DOC_MAPK_gen_1	466	472	PF00069	0.450
DOC_MAPK_gen_1	561	571	PF00069	0.321
DOC_MAPK_gen_1	82	91	PF00069	0.594
DOC_MAPK_MEF2A_6	32	39	PF00069	0.304
DOC_MAPK_MEF2A_6	740	747	PF00069	0.285
DOC_MAPK_MEF2A_6	82	91	PF00069	0.593
DOC_PP2B_LxvP_1	119	122	PF13499	0.233
DOC_PP2B_LxvP_1	210	213	PF13499	0.508
DOC_PP2B_LxvP_1	358	361	PF13499	0.473
DOC_PP2B_LxvP_1	78	81	PF13499	0.258
DOC_PP2B_LxvP_1	89	92	PF13499	0.597
DOC_PP2B_PxIxI_1	67	73	PF00149	0.221
DOC_PP4_FxxP_1	377	380	PF00568	0.447
DOC_PP4_FxxP_1	499	502	PF00568	0.447
DOC_PP4_FxxP_1	707	710	PF00568	0.373
DOC_SPAK_OSR1_1	82	86	PF12202	0.592
DOC_USP7_MATH_1	132	136	PF00917	0.529
DOC_USP7_MATH_1	240	244	PF00917	0.485
DOC_USP7_MATH_1	290	294	PF00917	0.516
DOC_USP7_MATH_1	332	336	PF00917	0.524
DOC_USP7_MATH_1	349	353	PF00917	0.515
DOC_USP7_MATH_1	361	365	PF00917	0.475
DOC_USP7_MATH_1	383	387	PF00917	0.452
DOC_USP7_MATH_1	402	406	PF00917	0.394
DOC_USP7_MATH_1	415	419	PF00917	0.497
DOC_USP7_MATH_1	436	440	PF00917	0.362
DOC_USP7_MATH_1	494	498	PF00917	0.523
DOC_USP7_MATH_1	645	649	PF00917	0.333
DOC_USP7_MATH_1	779	783	PF00917	0.415
DOC_USP7_MATH_1	890	894	PF00917	0.357
DOC_USP7_MATH_1	92	96	PF00917	0.626
DOC_USP7_UBL2_3	583	587	PF12436	0.451
DOC_WW_Pin1_4	167	172	PF00397	0.500
DOC_WW_Pin1_4	208	213	PF00397	0.513
DOC_WW_Pin1_4	248	253	PF00397	0.535
DOC_WW_Pin1_4	311	316	PF00397	0.527
DOC_WW_Pin1_4	320	325	PF00397	0.550
DOC_WW_Pin1_4	330	335	PF00397	0.514
DOC_WW_Pin1_4	497	502	PF00397	0.524
DOC_WW_Pin1_4	534	539	PF00397	0.322
DOC_WW_Pin1_4	653	658	PF00397	0.443
DOC_WW_Pin1_4	728	733	PF00397	0.327
DOC_WW_Pin1_4	761	766	PF00397	0.527
DOC_WW_Pin1_4	775	780	PF00397	0.488
LIG_14-3-3_CanoR_1	152	157	PF00244	0.523
LIG_14-3-3_CanoR_1	172	182	PF00244	0.497
LIG_14-3-3_CanoR_1	195	201	PF00244	0.583
LIG_14-3-3_CanoR_1	318	324	PF00244	0.516
LIG_14-3-3_CanoR_1	32	38	PF00244	0.300
LIG_14-3-3_CanoR_1	391	401	PF00244	0.515
LIG_14-3-3_CanoR_1	466	470	PF00244	0.430
LIG_14-3-3_CanoR_1	487	491	PF00244	0.512
LIG_14-3-3_CanoR_1	503	511	PF00244	0.496
LIG_14-3-3_CanoR_1	51	57	PF00244	0.347
LIG_14-3-3_CanoR_1	59	68	PF00244	0.210
LIG_14-3-3_CanoR_1	597	602	PF00244	0.368
LIG_14-3-3_CanoR_1	694	698	PF00244	0.409
LIG_14-3-3_CanoR_1	82	88	PF00244	0.590
LIG_14-3-3_CanoR_1	860	865	PF00244	0.468
LIG_14-3-3_CanoR_1	873	880	PF00244	0.503
LIG_14-3-3_CanoR_1	883	887	PF00244	0.333
LIG_14-3-3_CanoR_1	889	895	PF00244	0.330
LIG_Actin_WH2_2	684	700	PF00022	0.375
LIG_APCC_ABBAyCdc20_2	608	614	PF00400	0.273
LIG_BRCT_BRCA1_1	495	499	PF00533	0.494
LIG_BRCT_BRCA1_1	625	629	PF00533	0.335
LIG_DLG_GKlike_1	250	257	PF00625	0.456
LIG_EH_1	575	579	PF12763	0.450
LIG_eIF4E_1	801	807	PF01652	0.373
LIG_FHA_1	205	211	PF00498	0.583
LIG_FHA_1	34	40	PF00498	0.313
LIG_FHA_1	363	369	PF00498	0.444
LIG_FHA_1	448	454	PF00498	0.372
LIG_FHA_1	503	509	PF00498	0.466
LIG_FHA_1	52	58	PF00498	0.355
LIG_FHA_1	550	556	PF00498	0.357
LIG_FHA_1	584	590	PF00498	0.454
LIG_FHA_1	596	602	PF00498	0.412
LIG_FHA_1	634	640	PF00498	0.301
LIG_FHA_1	649	655	PF00498	0.352
LIG_FHA_1	720	726	PF00498	0.360
LIG_FHA_1	829	835	PF00498	0.309
LIG_FHA_1	845	851	PF00498	0.362
LIG_FHA_2	276	282	PF00498	0.441
LIG_FHA_2	466	472	PF00498	0.454
LIG_FHA_2	629	635	PF00498	0.315
LIG_FHA_2	645	651	PF00498	0.281
LIG_FHA_2	835	841	PF00498	0.427
LIG_LIR_Apic_2	496	502	PF02991	0.451
LIG_LIR_Gen_1	442	448	PF02991	0.349
LIG_LIR_Gen_1	675	682	PF02991	0.332
LIG_LIR_Gen_1	715	725	PF02991	0.374
LIG_LIR_Gen_1	741	750	PF02991	0.312
LIG_LIR_Gen_1	8	18	PF02991	0.398
LIG_LIR_Gen_1	847	856	PF02991	0.438
LIG_LIR_LC3C_4	69	73	PF02991	0.233
LIG_LIR_Nem_3	442	446	PF02991	0.350
LIG_LIR_Nem_3	513	518	PF02991	0.470
LIG_LIR_Nem_3	675	680	PF02991	0.337
LIG_LIR_Nem_3	715	721	PF02991	0.388
LIG_LIR_Nem_3	741	745	PF02991	0.307
LIG_LIR_Nem_3	8	13	PF02991	0.398
LIG_LIR_Nem_3	847	851	PF02991	0.440
LIG_LIR_Nem_3	912	916	PF02991	0.388
LIG_LYPXL_SIV_4	523	531	PF13949	0.374
LIG_Pex14_1	640	644	PF04695	0.384
LIG_Pex14_2	377	381	PF04695	0.433
LIG_Pex14_2	810	814	PF04695	0.291
LIG_PTB_Apo_2	824	831	PF02174	0.356
LIG_PTB_Phospho_1	824	830	PF10480	0.357
LIG_Rb_LxCxE_1	634	653	PF01857	0.320
LIG_SH2_CRK	913	917	PF00017	0.362
LIG_SH2_PTP2	524	527	PF00017	0.364
LIG_SH2_SRC	524	527	PF00017	0.364
LIG_SH2_SRC	658	661	PF00017	0.470
LIG_SH2_STAP1	515	519	PF00017	0.361
LIG_SH2_STAP1	625	629	PF00017	0.415
LIG_SH2_STAP1	830	834	PF00017	0.356
LIG_SH2_STAT3	518	521	PF00017	0.371
LIG_SH2_STAT3	625	628	PF00017	0.406
LIG_SH2_STAT5	12	15	PF00017	0.208
LIG_SH2_STAT5	375	378	PF00017	0.410
LIG_SH2_STAT5	433	436	PF00017	0.368
LIG_SH2_STAT5	518	521	PF00017	0.367
LIG_SH2_STAT5	524	527	PF00017	0.302
LIG_SH2_STAT5	554	557	PF00017	0.347
LIG_SH2_STAT5	736	739	PF00017	0.338
LIG_SH2_STAT5	830	833	PF00017	0.298
LIG_SH2_STAT5	90	93	PF00017	0.607
LIG_SH3_1	670	676	PF00018	0.324
LIG_SH3_1	759	765	PF00018	0.531
LIG_SH3_2	762	767	PF14604	0.537
LIG_SH3_3	508	514	PF00018	0.417
LIG_SH3_3	670	676	PF00018	0.324
LIG_SH3_3	759	765	PF00018	0.490
LIG_Sin3_3	116	123	PF02671	0.221
LIG_SUMO_SIM_anti_2	19	24	PF11976	0.177
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.492
LIG_SUMO_SIM_anti_2	219	225	PF11976	0.548
LIG_SUMO_SIM_anti_2	364	370	PF11976	0.468
LIG_SUMO_SIM_anti_2	468	474	PF11976	0.451
LIG_SUMO_SIM_anti_2	69	75	PF11976	0.233
LIG_SUMO_SIM_par_1	33	38	PF11976	0.300
LIG_SUMO_SIM_par_1	364	370	PF11976	0.432
LIG_TRAF2_1	155	158	PF00917	0.525
LIG_TRAF2_1	479	482	PF00917	0.395
LIG_TRAF2_1	711	714	PF00917	0.430
LIG_TYR_ITIM	911	916	PF00017	0.323
LIG_WRC_WIRS_1	53	58	PF05994	0.379
LIG_WRC_WIRS_1	845	850	PF05994	0.381
LIG_WW_3	500	504	PF00397	0.419
LIG_WW_3	709	713	PF00397	0.424
MOD_CDC14_SPxK_1	500	503	PF00782	0.484
MOD_CDK_SPK_2	167	172	PF00069	0.500
MOD_CDK_SPK_2	761	766	PF00069	0.532
MOD_CDK_SPxK_1	497	503	PF00069	0.488
MOD_CDK_SPxK_1	761	767	PF00069	0.535
MOD_CDK_SPxxK_3	311	318	PF00069	0.521
MOD_CDK_SPxxK_3	728	735	PF00069	0.311
MOD_CK1_1	135	141	PF00069	0.427
MOD_CK1_1	199	205	PF00069	0.597
MOD_CK1_1	266	272	PF00069	0.621
MOD_CK1_1	310	316	PF00069	0.574
MOD_CK1_1	335	341	PF00069	0.619
MOD_CK1_1	359	365	PF00069	0.456
MOD_CK1_1	367	373	PF00069	0.402
MOD_CK1_1	386	392	PF00069	0.397
MOD_CK1_1	394	400	PF00069	0.506
MOD_CK1_1	435	441	PF00069	0.353
MOD_CK1_1	489	495	PF00069	0.531
MOD_CK1_1	497	503	PF00069	0.488
MOD_CK1_1	549	555	PF00069	0.385
MOD_CK1_1	595	601	PF00069	0.426
MOD_CK1_1	648	654	PF00069	0.343
MOD_CK1_1	684	690	PF00069	0.353
MOD_CK1_1	719	725	PF00069	0.355
MOD_CK1_1	838	844	PF00069	0.382
MOD_CK1_1	882	888	PF00069	0.447
MOD_CK2_1	152	158	PF00069	0.522
MOD_CK2_1	213	219	PF00069	0.521
MOD_CK2_1	228	234	PF00069	0.527
MOD_CK2_1	567	573	PF00069	0.436
MOD_CK2_1	644	650	PF00069	0.379
MOD_CK2_1	653	659	PF00069	0.448
MOD_DYRK1A_RPxSP_1	208	212	PF00069	0.466
MOD_GlcNHglycan	198	201	PF01048	0.721
MOD_GlcNHglycan	246	249	PF01048	0.725
MOD_GlcNHglycan	257	260	PF01048	0.713
MOD_GlcNHglycan	334	337	PF01048	0.796
MOD_GlcNHglycan	343	346	PF01048	0.681
MOD_GlcNHglycan	358	361	PF01048	0.613
MOD_GlcNHglycan	385	388	PF01048	0.651
MOD_GlcNHglycan	404	407	PF01048	0.777
MOD_GlcNHglycan	417	420	PF01048	0.783
MOD_GlcNHglycan	434	437	PF01048	0.450
MOD_GlcNHglycan	475	478	PF01048	0.686
MOD_GlcNHglycan	492	495	PF01048	0.640
MOD_GlcNHglycan	548	551	PF01048	0.627
MOD_GlcNHglycan	62	65	PF01048	0.221
MOD_GlcNHglycan	683	686	PF01048	0.551
MOD_GlcNHglycan	732	735	PF01048	0.598
MOD_GlcNHglycan	754	757	PF01048	0.695
MOD_GlcNHglycan	837	840	PF01048	0.636
MOD_GlcNHglycan	864	867	PF01048	0.635
MOD_GlcNHglycan	894	897	PF01048	0.584
MOD_GSK3_1	147	154	PF00069	0.505
MOD_GSK3_1	190	197	PF00069	0.577
MOD_GSK3_1	204	211	PF00069	0.529
MOD_GSK3_1	214	221	PF00069	0.542
MOD_GSK3_1	240	247	PF00069	0.483
MOD_GSK3_1	306	313	PF00069	0.511
MOD_GSK3_1	383	390	PF00069	0.469
MOD_GSK3_1	397	404	PF00069	0.535
MOD_GSK3_1	428	435	PF00069	0.353
MOD_GSK3_1	486	493	PF00069	0.522
MOD_GSK3_1	530	537	PF00069	0.385
MOD_GSK3_1	546	553	PF00069	0.347
MOD_GSK3_1	567	574	PF00069	0.392
MOD_GSK3_1	592	599	PF00069	0.447
MOD_GSK3_1	62	69	PF00069	0.221
MOD_GSK3_1	644	651	PF00069	0.334
MOD_GSK3_1	680	687	PF00069	0.318
MOD_GSK3_1	775	782	PF00069	0.405
MOD_GSK3_1	796	803	PF00069	0.379
MOD_GSK3_1	834	841	PF00069	0.404
MOD_GSK3_1	850	857	PF00069	0.402
MOD_GSK3_1	99	106	PF00069	0.639
MOD_N-GLC_1	341	346	PF02516	0.679
MOD_N-GLC_1	719	724	PF02516	0.568
MOD_N-GLC_1	825	830	PF02516	0.560
MOD_NEK2_1	126	131	PF00069	0.481
MOD_NEK2_1	145	150	PF00069	0.473
MOD_NEK2_1	173	178	PF00069	0.448
MOD_NEK2_1	196	201	PF00069	0.582
MOD_NEK2_1	204	209	PF00069	0.506
MOD_NEK2_1	385	390	PF00069	0.463
MOD_NEK2_1	401	406	PF00069	0.476
MOD_NEK2_1	490	495	PF00069	0.548
MOD_NEK2_1	5	10	PF00069	0.485
MOD_NEK2_1	52	57	PF00069	0.377
MOD_NEK2_1	592	597	PF00069	0.458
MOD_NEK2_1	62	67	PF00069	0.202
MOD_NEK2_1	680	685	PF00069	0.302
MOD_NEK2_1	752	757	PF00069	0.456
MOD_NEK2_1	814	819	PF00069	0.360
MOD_NEK2_1	825	830	PF00069	0.277
MOD_NEK2_1	83	88	PF00069	0.635
MOD_NEK2_1	859	864	PF00069	0.422
MOD_NEK2_1	892	897	PF00069	0.389
MOD_NEK2_1	909	914	PF00069	0.274
MOD_NEK2_2	494	499	PF00069	0.475
MOD_NEK2_2	662	667	PF00069	0.366
MOD_PIKK_1	173	179	PF00454	0.532
MOD_PIKK_1	359	365	PF00454	0.479
MOD_PIKK_1	394	400	PF00454	0.498
MOD_PIKK_1	428	434	PF00454	0.422
MOD_PIKK_1	436	442	PF00454	0.378
MOD_PIKK_1	648	654	PF00454	0.302
MOD_PK_1	152	158	PF00069	0.512
MOD_PK_1	567	573	PF00069	0.388
MOD_PKA_1	486	492	PF00069	0.524
MOD_PKA_1	860	866	PF00069	0.467
MOD_PKA_2	109	115	PF00069	0.622
MOD_PKA_2	151	157	PF00069	0.529
MOD_PKA_2	194	200	PF00069	0.581
MOD_PKA_2	255	261	PF00069	0.580
MOD_PKA_2	390	396	PF00069	0.548
MOD_PKA_2	41	47	PF00069	0.366
MOD_PKA_2	465	471	PF00069	0.412
MOD_PKA_2	486	492	PF00069	0.487
MOD_PKA_2	502	508	PF00069	0.492
MOD_PKA_2	571	577	PF00069	0.418
MOD_PKA_2	596	602	PF00069	0.374
MOD_PKA_2	662	668	PF00069	0.404
MOD_PKA_2	693	699	PF00069	0.401
MOD_PKA_2	83	89	PF00069	0.588
MOD_PKA_2	859	865	PF00069	0.450
MOD_PKA_2	872	878	PF00069	0.394
MOD_PKA_2	882	888	PF00069	0.328
MOD_Plk_1	218	224	PF00069	0.535
MOD_Plk_1	633	639	PF00069	0.298
MOD_Plk_1	645	651	PF00069	0.334
MOD_Plk_1	779	785	PF00069	0.482
MOD_Plk_1	825	831	PF00069	0.359
MOD_Plk_4	109	115	PF00069	0.646
MOD_Plk_4	135	141	PF00069	0.414
MOD_Plk_4	25	31	PF00069	0.208
MOD_Plk_4	494	500	PF00069	0.486
MOD_Plk_4	52	58	PF00069	0.379
MOD_Plk_4	550	556	PF00069	0.318
MOD_Plk_4	633	639	PF00069	0.334
MOD_Plk_4	66	72	PF00069	0.205
MOD_Plk_4	779	785	PF00069	0.506
MOD_Plk_4	796	802	PF00069	0.289
MOD_Plk_4	825	831	PF00069	0.322
MOD_Plk_4	882	888	PF00069	0.367
MOD_ProDKin_1	167	173	PF00069	0.500
MOD_ProDKin_1	208	214	PF00069	0.515
MOD_ProDKin_1	248	254	PF00069	0.536
MOD_ProDKin_1	311	317	PF00069	0.527
MOD_ProDKin_1	320	326	PF00069	0.550
MOD_ProDKin_1	330	336	PF00069	0.513
MOD_ProDKin_1	497	503	PF00069	0.525
MOD_ProDKin_1	534	540	PF00069	0.319
MOD_ProDKin_1	653	659	PF00069	0.450
MOD_ProDKin_1	728	734	PF00069	0.329
MOD_ProDKin_1	761	767	PF00069	0.530
MOD_ProDKin_1	775	781	PF00069	0.478
MOD_SUMO_for_1	851	854	PF00179	0.422
MOD_SUMO_rev_2	99	106	PF00179	0.650
TRG_ENDOCYTIC_2	524	527	PF00928	0.330
TRG_ENDOCYTIC_2	566	569	PF00928	0.334
TRG_ENDOCYTIC_2	913	916	PF00928	0.352
TRG_ER_diArg_1	107	110	PF00400	0.679
TRG_ER_diArg_1	456	459	PF00400	0.364
TRG_ER_diArg_1	465	467	PF00400	0.392
TRG_ER_diArg_1	765	767	PF00400	0.561
TRG_ER_diArg_1	784	786	PF00400	0.360
TRG_ER_diArg_1	859	861	PF00400	0.462
TRG_ER_FFAT_2	431	439	PF00635	0.364
TRG_Pf-PMV_PEXEL_1	467	471	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP1	Leptomonas seymouri	64%	100%
A0A3S7X6D7	Leishmania donovani	100%	100%
A4HLA7	Leishmania braziliensis	78%	100%
E9B3P9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4D8	Leishmania major	92%	100%
V5BFC1	Trypanosoma cruzi	39%	100%