LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
paraflagellar rod component - putative
Species:
Leishmania infantum
UniProt:
A4I8S7_LEIIN
TriTrypDb:
LINF_330013000
Length:
126

Annotations

Annotations by Jardim et al.

Flagella, paraflagellar rod component, putative (PFC16) Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 10
Silverman et al. no yes: 0
Pissara et al. yes yes: 30
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 31
NetGPI no yes: 0, no: 31
Cellular components
Term Name Level Count
GO:0005929 cilium 4 2
GO:0031514 motile cilium 5 2
GO:0042995 cell projection 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0110165 cellular anatomical entity 1 2
GO:0120025 plasma membrane bounded cell projection 3 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I8S7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8S7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 116 120 PF00082 0.371
DEG_SPOP_SBC_1 35 39 PF00917 0.386
DEG_SPOP_SBC_1 98 102 PF00917 0.340
DOC_PP1_RVXF_1 114 120 PF00149 0.374
DOC_PP2B_PxIxI_1 13 19 PF00149 0.346
DOC_PP4_FxxP_1 11 14 PF00568 0.356
DOC_USP7_MATH_1 98 102 PF00917 0.504
LIG_BIR_II_1 1 5 PF00653 0.470
LIG_FHA_1 39 45 PF00498 0.524
LIG_LIR_Apic_2 10 14 PF02991 0.344
LIG_LIR_Gen_1 65 74 PF02991 0.424
LIG_LIR_Gen_1 88 98 PF02991 0.563
LIG_LIR_Nem_3 113 118 PF02991 0.415
LIG_LIR_Nem_3 65 71 PF02991 0.436
LIG_LIR_Nem_3 88 94 PF02991 0.412
LIG_NRBOX 76 82 PF00104 0.367
LIG_PTB_Apo_2 5 12 PF02174 0.384
LIG_REV1ctd_RIR_1 116 125 PF16727 0.423
LIG_SH2_STAT5 53 56 PF00017 0.412
LIG_SUMO_SIM_anti_2 75 81 PF11976 0.367
LIG_SUMO_SIM_par_1 77 83 PF11976 0.392
LIG_TRAF2_1 21 24 PF00917 0.490
LIG_TRAF2_1 84 87 PF00917 0.414
MOD_CK1_1 37 43 PF00069 0.502
MOD_CK1_1 96 102 PF00069 0.418
MOD_CK2_1 22 28 PF00069 0.474
MOD_GSK3_1 34 41 PF00069 0.413
MOD_GSK3_1 89 96 PF00069 0.419
MOD_N-GLC_1 7 12 PF02516 0.352
MOD_NEK2_1 117 122 PF00069 0.478
MOD_NEK2_1 93 98 PF00069 0.447
MOD_PIKK_1 93 99 PF00454 0.499
MOD_Plk_1 23 29 PF00069 0.415
MOD_Plk_1 7 13 PF00069 0.347
MOD_SUMO_for_1 49 52 PF00179 0.531
TRG_DiLeu_BaLyEn_6 73 78 PF01217 0.244
TRG_ENDOCYTIC_2 115 118 PF00928 0.477
TRG_NES_CRM1_1 70 83 PF08389 0.344

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3C7 Leptomonas seymouri 82% 100%
A0A0N1HW96 Leptomonas seymouri 34% 100%
A0A0N1IHI7 Leptomonas seymouri 41% 100%
A0A0S4IPF2 Bodo saltans 36% 100%
A0A0S4IRP9 Bodo saltans 42% 100%
A0A0S4JBB4 Bodo saltans 35% 100%
A0A0S4JFI1 Bodo saltans 36% 100%
A0A1X0P0Q8 Trypanosomatidae 56% 100%
A0A1X0P259 Trypanosomatidae 39% 100%
A0A1X0P760 Trypanosomatidae 42% 100%
A0A3Q8IB96 Leishmania donovani 40% 100%
A0A3R7K0R9 Trypanosoma rangeli 33% 100%
A0A3S7X3W3 Leishmania donovani 34% 100%
A0A3S7X6I1 Leishmania donovani 100% 75%
A0A422N867 Trypanosoma rangeli 50% 100%
A0A422NFX4 Trypanosoma rangeli 33% 100%
A0A422NPM1 Trypanosoma rangeli 44% 100%
A4H9R6 Leishmania braziliensis 37% 97%
A4HIL9 Leishmania braziliensis 36% 100%
A4HLA1 Leishmania braziliensis 82% 100%
A4HY35 Leishmania infantum 39% 97%
A4I5W4 Leishmania infantum 40% 100%
C9ZR85 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
D0A4S3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9ARU9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 99%
E9B159 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9B3P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 99%
Q4Q707 Leishmania major 40% 100%
Q4QDM4 Leishmania major 39% 98%
V5BMX8 Trypanosoma cruzi 35% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS