Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8S6_LEIIN

TriTrypDb:

LINF_330012900

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8S6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	215	217	PF00675	0.397
CLV_NRD_NRD_1	29	31	PF00675	0.521
CLV_NRD_NRD_1	324	326	PF00675	0.490
CLV_PCSK_KEX2_1	193	195	PF00082	0.630
CLV_PCSK_KEX2_1	215	217	PF00082	0.427
CLV_PCSK_KEX2_1	29	31	PF00082	0.542
CLV_PCSK_KEX2_1	62	64	PF00082	0.536
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.469
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.398
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.536
CLV_PCSK_SKI1_1	254	258	PF00082	0.361
CLV_PCSK_SKI1_1	29	33	PF00082	0.403
CLV_PCSK_SKI1_1	8	12	PF00082	0.482
DEG_Nend_Nbox_1	1	3	PF02207	0.545
DOC_CYCLIN_RxL_1	26	37	PF00134	0.431
DOC_CYCLIN_RxL_1	91	102	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.463
DOC_MAPK_gen_1	193	202	PF00069	0.444
DOC_MAPK_gen_1	239	246	PF00069	0.426
DOC_PP1_RVXF_1	418	425	PF00149	0.474
DOC_PP2B_LxvP_1	340	343	PF13499	0.479
DOC_USP7_MATH_1	353	357	PF00917	0.603
DOC_USP7_MATH_1	398	402	PF00917	0.468
DOC_USP7_UBL2_3	193	197	PF12436	0.565
DOC_WW_Pin1_4	246	251	PF00397	0.475
DOC_WW_Pin1_4	34	39	PF00397	0.544
LIG_14-3-3_CanoR_1	176	180	PF00244	0.494
LIG_14-3-3_CanoR_1	294	303	PF00244	0.473
LIG_14-3-3_CanoR_1	373	379	PF00244	0.379
LIG_14-3-3_CanoR_1	412	422	PF00244	0.386
LIG_Actin_WH2_2	114	129	PF00022	0.360
LIG_Clathr_ClatBox_1	308	312	PF01394	0.396
LIG_EH1_1	220	228	PF00400	0.477
LIG_eIF4E_1	221	227	PF01652	0.477
LIG_FHA_1	123	129	PF00498	0.392
LIG_FHA_1	148	154	PF00498	0.589
LIG_FHA_1	56	62	PF00498	0.456
LIG_FHA_1	73	79	PF00498	0.263
LIG_FHA_2	302	308	PF00498	0.550
LIG_FHA_2	367	373	PF00498	0.349
LIG_GBD_Chelix_1	104	112	PF00786	0.480
LIG_LIR_Nem_3	178	182	PF02991	0.443
LIG_NBox_RRM_1	182	192	PF00076	0.309
LIG_Pex14_1	64	68	PF04695	0.367
LIG_PTB_Apo_2	164	171	PF02174	0.609
LIG_SH2_CRK	233	237	PF00017	0.357
LIG_SH2_STAP1	219	223	PF00017	0.392
LIG_SH2_STAP1	338	342	PF00017	0.417
LIG_SH2_STAT5	179	182	PF00017	0.479
LIG_SH3_3	356	362	PF00018	0.482
LIG_SUMO_SIM_par_1	37	42	PF11976	0.462
LIG_TRAF2_1	172	175	PF00917	0.412
LIG_UBA3_1	95	100	PF00899	0.416
LIG_WRC_WIRS_1	276	281	PF05994	0.404
MOD_CK1_1	148	154	PF00069	0.612
MOD_CK1_1	264	270	PF00069	0.456
MOD_CK1_1	299	305	PF00069	0.513
MOD_CK1_1	347	353	PF00069	0.527
MOD_CK1_1	355	361	PF00069	0.621
MOD_CK1_1	414	420	PF00069	0.430
MOD_CK1_1	9	15	PF00069	0.619
MOD_CK2_1	151	157	PF00069	0.588
MOD_CK2_1	237	243	PF00069	0.529
MOD_CK2_1	295	301	PF00069	0.473
MOD_CK2_1	398	404	PF00069	0.395
MOD_GlcNHglycan	101	104	PF01048	0.439
MOD_GlcNHglycan	183	186	PF01048	0.420
MOD_GlcNHglycan	331	334	PF01048	0.533
MOD_GSK3_1	147	154	PF00069	0.643
MOD_GSK3_1	2	9	PF00069	0.545
MOD_GSK3_1	248	255	PF00069	0.372
MOD_GSK3_1	260	267	PF00069	0.378
MOD_GSK3_1	275	282	PF00069	0.295
MOD_GSK3_1	295	302	PF00069	0.402
MOD_GSK3_1	347	354	PF00069	0.432
MOD_GSK3_1	360	367	PF00069	0.453
MOD_GSK3_1	373	380	PF00069	0.388
MOD_GSK3_1	414	421	PF00069	0.596
MOD_N-GLC_1	148	153	PF02516	0.627
MOD_N-GLC_1	158	163	PF02516	0.591
MOD_NEK2_1	10	15	PF00069	0.558
MOD_NEK2_1	145	150	PF00069	0.642
MOD_NEK2_1	2	7	PF00069	0.583
MOD_NEK2_1	252	257	PF00069	0.328
MOD_NEK2_1	275	280	PF00069	0.364
MOD_NEK2_1	288	293	PF00069	0.395
MOD_NEK2_1	345	350	PF00069	0.463
MOD_NEK2_1	351	356	PF00069	0.522
MOD_NEK2_1	364	369	PF00069	0.464
MOD_NEK2_1	374	379	PF00069	0.422
MOD_NEK2_1	411	416	PF00069	0.428
MOD_NEK2_1	49	54	PF00069	0.480
MOD_NEK2_2	122	127	PF00069	0.449
MOD_PIKK_1	377	383	PF00454	0.529
MOD_PIKK_1	41	47	PF00454	0.445
MOD_PIKK_1	49	55	PF00454	0.464
MOD_PK_1	310	316	PF00069	0.338
MOD_PK_1	63	69	PF00069	0.515
MOD_PKA_2	175	181	PF00069	0.450
MOD_PKA_2	411	417	PF00069	0.411
MOD_PKB_1	156	164	PF00069	0.497
MOD_Plk_1	148	154	PF00069	0.665
MOD_Plk_1	264	270	PF00069	0.487
MOD_Plk_1	299	305	PF00069	0.439
MOD_Plk_4	148	154	PF00069	0.710
MOD_Plk_4	248	254	PF00069	0.418
MOD_Plk_4	310	316	PF00069	0.361
MOD_Plk_4	355	361	PF00069	0.526
MOD_Plk_4	374	380	PF00069	0.268
MOD_Plk_4	389	395	PF00069	0.398
MOD_Plk_4	414	420	PF00069	0.393
MOD_Plk_4	63	69	PF00069	0.463
MOD_ProDKin_1	246	252	PF00069	0.468
MOD_ProDKin_1	34	40	PF00069	0.542
MOD_SUMO_rev_2	337	343	PF00179	0.461
TRG_DiLeu_BaEn_1	317	322	PF01217	0.509
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.365
TRG_ENDOCYTIC_2	179	182	PF00928	0.479
TRG_ENDOCYTIC_2	233	236	PF00928	0.456
TRG_ER_diArg_1	28	30	PF00400	0.530
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R7	Leptomonas seymouri	54%	99%
A0A1X0P0P1	Trypanosomatidae	30%	98%
A0A3Q8IHM8	Leishmania donovani	99%	100%
A0A3S5IQQ0	Trypanosoma rangeli	27%	100%
A4HLA0	Leishmania braziliensis	79%	100%
D0A4S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	99%
E9B3P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q4E5	Leishmania major	91%	100%
V5BFC5	Trypanosoma cruzi	27%	98%