LeishMANIAdb
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Coiled-coil domain-containing protein 176

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Coiled-coil domain-containing protein 176
Gene product:
BRE1 E3 ubiquitin ligase - putative
Species:
Leishmania infantum
UniProt:
A4I8S4_LEIIN
TriTrypDb:
LINF_330012700
Length:
875

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I8S4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8S4

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 12
GO:0001578 microtubule bundle formation 4 12
GO:0006996 organelle organization 4 12
GO:0007010 cytoskeleton organization 5 12
GO:0007017 microtubule-based process 2 12
GO:0009987 cellular process 1 12
GO:0016043 cellular component organization 3 12
GO:0022607 cellular component assembly 4 12
GO:0035082 axoneme assembly 5 12
GO:0071840 cellular component organization or biogenesis 2 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016874 ligase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 215 219 PF00656 0.537
CLV_C14_Caspase3-7 294 298 PF00656 0.375
CLV_NRD_NRD_1 157 159 PF00675 0.556
CLV_NRD_NRD_1 246 248 PF00675 0.403
CLV_NRD_NRD_1 251 253 PF00675 0.403
CLV_NRD_NRD_1 31 33 PF00675 0.486
CLV_NRD_NRD_1 334 336 PF00675 0.551
CLV_NRD_NRD_1 37 39 PF00675 0.438
CLV_NRD_NRD_1 391 393 PF00675 0.497
CLV_NRD_NRD_1 456 458 PF00675 0.418
CLV_NRD_NRD_1 462 464 PF00675 0.427
CLV_NRD_NRD_1 611 613 PF00675 0.253
CLV_NRD_NRD_1 615 617 PF00675 0.247
CLV_NRD_NRD_1 652 654 PF00675 0.444
CLV_NRD_NRD_1 754 756 PF00675 0.554
CLV_NRD_NRD_1 847 849 PF00675 0.417
CLV_PCSK_KEX2_1 157 159 PF00082 0.556
CLV_PCSK_KEX2_1 186 188 PF00082 0.465
CLV_PCSK_KEX2_1 210 212 PF00082 0.555
CLV_PCSK_KEX2_1 246 248 PF00082 0.403
CLV_PCSK_KEX2_1 31 33 PF00082 0.523
CLV_PCSK_KEX2_1 455 457 PF00082 0.425
CLV_PCSK_KEX2_1 582 584 PF00082 0.285
CLV_PCSK_KEX2_1 611 613 PF00082 0.250
CLV_PCSK_KEX2_1 617 619 PF00082 0.250
CLV_PCSK_KEX2_1 749 751 PF00082 0.430
CLV_PCSK_KEX2_1 754 756 PF00082 0.440
CLV_PCSK_KEX2_1 809 811 PF00082 0.510
CLV_PCSK_KEX2_1 847 849 PF00082 0.399
CLV_PCSK_PC1ET2_1 186 188 PF00082 0.465
CLV_PCSK_PC1ET2_1 210 212 PF00082 0.555
CLV_PCSK_PC1ET2_1 582 584 PF00082 0.286
CLV_PCSK_PC1ET2_1 617 619 PF00082 0.255
CLV_PCSK_PC1ET2_1 749 751 PF00082 0.430
CLV_PCSK_PC1ET2_1 809 811 PF00082 0.495
CLV_PCSK_PC7_1 206 212 PF00082 0.556
CLV_PCSK_PC7_1 750 756 PF00082 0.441
CLV_PCSK_SKI1_1 358 362 PF00082 0.480
CLV_PCSK_SKI1_1 385 389 PF00082 0.501
CLV_PCSK_SKI1_1 392 396 PF00082 0.437
CLV_PCSK_SKI1_1 679 683 PF00082 0.624
CLV_PCSK_SKI1_1 741 745 PF00082 0.477
CLV_PCSK_SKI1_1 758 762 PF00082 0.369
DEG_APCC_DBOX_1 237 245 PF00400 0.521
DEG_APCC_DBOX_1 37 45 PF00400 0.463
DEG_APCC_KENBOX_2 736 740 PF00400 0.552
DEG_Nend_UBRbox_1 1 4 PF02207 0.599
DOC_MAPK_gen_1 174 182 PF00069 0.538
DOC_MAPK_gen_1 60 69 PF00069 0.435
DOC_MAPK_gen_1 616 623 PF00069 0.393
DOC_MAPK_gen_1 676 683 PF00069 0.490
DOC_MAPK_gen_1 713 721 PF00069 0.518
DOC_MAPK_gen_1 847 853 PF00069 0.389
DOC_MAPK_MEF2A_6 176 184 PF00069 0.535
DOC_MAPK_MEF2A_6 573 581 PF00069 0.265
DOC_PP1_RVXF_1 644 651 PF00149 0.430
DOC_PP1_RVXF_1 677 684 PF00149 0.632
DOC_USP7_MATH_1 110 114 PF00917 0.547
DOC_USP7_MATH_1 291 295 PF00917 0.536
DOC_USP7_MATH_1 4 8 PF00917 0.698
DOC_USP7_MATH_1 505 509 PF00917 0.434
DOC_USP7_MATH_1 594 598 PF00917 0.278
DOC_USP7_MATH_1 9 13 PF00917 0.654
DOC_USP7_UBL2_3 341 345 PF12436 0.556
DOC_USP7_UBL2_3 354 358 PF12436 0.386
DOC_USP7_UBL2_3 381 385 PF12436 0.514
LIG_14-3-3_CanoR_1 238 242 PF00244 0.505
LIG_14-3-3_CanoR_1 252 258 PF00244 0.428
LIG_14-3-3_CanoR_1 520 528 PF00244 0.393
LIG_14-3-3_CanoR_1 583 588 PF00244 0.465
LIG_14-3-3_CanoR_1 631 641 PF00244 0.455
LIG_APCC_ABBA_1 740 745 PF00400 0.437
LIG_APCC_ABBAyCdc20_2 646 652 PF00400 0.435
LIG_BRCT_BRCA1_1 857 861 PF00533 0.544
LIG_Clathr_ClatBox_1 139 143 PF01394 0.576
LIG_Clathr_ClatBox_1 265 269 PF01394 0.522
LIG_DLG_GKlike_1 176 184 PF00625 0.444
LIG_FHA_1 134 140 PF00498 0.456
LIG_FHA_1 521 527 PF00498 0.280
LIG_FHA_2 161 167 PF00498 0.521
LIG_FHA_2 213 219 PF00498 0.486
LIG_FHA_2 404 410 PF00498 0.540
LIG_FHA_2 430 436 PF00498 0.365
LIG_FHA_2 49 55 PF00498 0.532
LIG_FHA_2 680 686 PF00498 0.554
LIG_FHA_2 775 781 PF00498 0.442
LIG_LIR_Gen_1 318 329 PF02991 0.399
LIG_LIR_Gen_1 517 526 PF02991 0.250
LIG_LIR_Nem_3 318 324 PF02991 0.397
LIG_LIR_Nem_3 517 521 PF02991 0.374
LIG_LIR_Nem_3 858 864 PF02991 0.430
LIG_MYND_1 862 866 PF01753 0.564
LIG_PCNA_yPIPBox_3 280 293 PF02747 0.530
LIG_PDZ_Class_1 870 875 PF00595 0.461
LIG_Rb_LxCxE_1 666 685 PF01857 0.580
LIG_REV1ctd_RIR_1 601 611 PF16727 0.193
LIG_SH2_GRB2like 128 131 PF00017 0.445
LIG_SH2_STAP1 475 479 PF00017 0.502
LIG_SH2_STAT3 70 73 PF00017 0.423
LIG_SH2_STAT5 125 128 PF00017 0.500
LIG_SH3_3 22 28 PF00018 0.504
LIG_SUMO_SIM_anti_2 264 269 PF11976 0.525
LIG_SUMO_SIM_anti_2 299 304 PF11976 0.372
LIG_SUMO_SIM_par_1 264 269 PF11976 0.525
LIG_SUMO_SIM_par_1 299 304 PF11976 0.451
LIG_TRAF2_1 103 106 PF00917 0.578
LIG_TRAF2_1 331 334 PF00917 0.543
LIG_TRAF2_1 387 390 PF00917 0.468
LIG_UBA3_1 180 186 PF00899 0.424
LIG_UBA3_1 556 564 PF00899 0.285
LIG_UBA3_1 698 704 PF00899 0.469
LIG_UBA3_1 742 749 PF00899 0.427
MOD_CK1_1 14 20 PF00069 0.566
MOD_CK1_1 327 333 PF00069 0.506
MOD_CK1_1 375 381 PF00069 0.532
MOD_CK2_1 106 112 PF00069 0.585
MOD_CK2_1 165 171 PF00069 0.481
MOD_CK2_1 201 207 PF00069 0.452
MOD_CK2_1 218 224 PF00069 0.416
MOD_CK2_1 279 285 PF00069 0.562
MOD_CK2_1 327 333 PF00069 0.374
MOD_CK2_1 347 353 PF00069 0.327
MOD_CK2_1 403 409 PF00069 0.533
MOD_CK2_1 48 54 PF00069 0.533
MOD_CK2_1 506 512 PF00069 0.476
MOD_CK2_1 679 685 PF00069 0.559
MOD_CK2_1 760 766 PF00069 0.445
MOD_CK2_1 774 780 PF00069 0.349
MOD_Cter_Amidation 845 848 PF01082 0.532
MOD_GlcNHglycan 108 111 PF01048 0.563
MOD_GlcNHglycan 112 115 PF01048 0.561
MOD_GlcNHglycan 194 197 PF01048 0.504
MOD_GlcNHglycan 443 446 PF01048 0.443
MOD_GlcNHglycan 54 58 PF01048 0.504
MOD_GlcNHglycan 596 599 PF01048 0.278
MOD_GlcNHglycan 855 860 PF01048 0.510
MOD_GSK3_1 106 113 PF00069 0.468
MOD_GSK3_1 176 183 PF00069 0.581
MOD_GSK3_1 287 294 PF00069 0.445
MOD_GSK3_1 324 331 PF00069 0.452
MOD_GSK3_1 372 379 PF00069 0.534
MOD_GSK3_1 425 432 PF00069 0.416
MOD_GSK3_1 75 82 PF00069 0.492
MOD_N-GLC_1 192 197 PF02516 0.529
MOD_N-GLC_1 4 9 PF02516 0.633
MOD_N-GLC_1 425 430 PF02516 0.404
MOD_N-GLC_1 558 563 PF02516 0.374
MOD_N-GLC_1 571 576 PF02516 0.285
MOD_NEK2_1 135 140 PF00069 0.437
MOD_NEK2_1 180 185 PF00069 0.531
MOD_NEK2_1 324 329 PF00069 0.470
MOD_NEK2_1 429 434 PF00069 0.400
MOD_NEK2_1 493 498 PF00069 0.418
MOD_NEK2_1 630 635 PF00069 0.427
MOD_PIKK_1 201 207 PF00454 0.437
MOD_PIKK_1 279 285 PF00454 0.548
MOD_PIKK_1 403 409 PF00454 0.463
MOD_PIKK_1 42 48 PF00454 0.484
MOD_PIKK_1 586 592 PF00454 0.266
MOD_PIKK_1 686 692 PF00454 0.592
MOD_PIKK_1 720 726 PF00454 0.494
MOD_PIKK_1 774 780 PF00454 0.486
MOD_PKA_2 212 218 PF00069 0.521
MOD_PKA_2 237 243 PF00069 0.502
MOD_PKA_2 251 257 PF00069 0.428
MOD_PKA_2 279 285 PF00069 0.419
MOD_PKA_2 375 381 PF00069 0.463
MOD_PKA_2 61 67 PF00069 0.563
MOD_PKA_2 630 636 PF00069 0.456
MOD_PKA_2 658 664 PF00069 0.637
MOD_PKA_2 686 692 PF00069 0.483
MOD_PKB_1 414 422 PF00069 0.411
MOD_Plk_1 192 198 PF00069 0.466
MOD_Plk_1 324 330 PF00069 0.468
MOD_Plk_1 376 382 PF00069 0.576
MOD_Plk_1 4 10 PF00069 0.754
MOD_Plk_1 425 431 PF00069 0.404
MOD_Plk_1 493 499 PF00069 0.416
MOD_Plk_1 679 685 PF00069 0.559
MOD_Plk_2-3 218 224 PF00069 0.492
MOD_Plk_4 135 141 PF00069 0.456
MOD_Plk_4 176 182 PF00069 0.444
MOD_Plk_4 237 243 PF00069 0.391
MOD_Plk_4 544 550 PF00069 0.250
MOD_Plk_4 583 589 PF00069 0.393
MOD_SUMO_for_1 140 143 PF00179 0.473
MOD_SUMO_for_1 149 152 PF00179 0.449
MOD_SUMO_for_1 312 315 PF00179 0.495
MOD_SUMO_for_1 380 383 PF00179 0.544
MOD_SUMO_for_1 677 680 PF00179 0.635
MOD_SUMO_for_1 798 801 PF00179 0.495
MOD_SUMO_rev_2 204 212 PF00179 0.505
MOD_SUMO_rev_2 224 233 PF00179 0.320
MOD_SUMO_rev_2 330 338 PF00179 0.411
MOD_SUMO_rev_2 377 387 PF00179 0.509
MOD_SUMO_rev_2 396 406 PF00179 0.288
MOD_SUMO_rev_2 574 584 PF00179 0.307
MOD_SUMO_rev_2 619 627 PF00179 0.401
MOD_SUMO_rev_2 647 655 PF00179 0.416
MOD_SUMO_rev_2 689 698 PF00179 0.508
MOD_SUMO_rev_2 801 811 PF00179 0.461
TRG_DiLeu_BaEn_1 229 234 PF01217 0.405
TRG_DiLeu_BaEn_1 367 372 PF01217 0.580
TRG_DiLeu_BaEn_1 694 699 PF01217 0.444
TRG_DiLeu_BaEn_3 700 706 PF01217 0.481
TRG_DiLeu_BaLyEn_6 552 557 PF01217 0.265
TRG_ENDOCYTIC_2 321 324 PF00928 0.410
TRG_ENDOCYTIC_2 475 478 PF00928 0.475
TRG_ENDOCYTIC_2 827 830 PF00928 0.609
TRG_ER_diArg_1 101 104 PF00400 0.566
TRG_ER_diArg_1 31 33 PF00400 0.572
TRG_ER_diArg_1 414 417 PF00400 0.404
TRG_ER_diArg_1 454 457 PF00400 0.448
TRG_ER_diArg_1 610 612 PF00400 0.265
TRG_Pf-PMV_PEXEL_1 31 35 PF00026 0.493
TRG_Pf-PMV_PEXEL_1 39 43 PF00026 0.424
TRG_Pf-PMV_PEXEL_1 392 396 PF00026 0.492
TRG_Pf-PMV_PEXEL_1 611 615 PF00026 0.250
TRG_Pf-PMV_PEXEL_1 696 700 PF00026 0.462

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I582 Leptomonas seymouri 82% 100%
A0A0S4JM03 Bodo saltans 50% 99%
A0A1X0P1D5 Trypanosomatidae 59% 100%
A0A3R7RFG2 Trypanosoma rangeli 59% 100%
A0A3S7X6D9 Leishmania donovani 100% 100%
A4HL98 Leishmania braziliensis 91% 100%
D0A4R8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 100%
E9B3P0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4G0X9 Homo sapiens 25% 77%
Q4Q4E7 Leishmania major 98% 100%
Q56A40 Danio rerio 24% 93%
Q8BI79 Mus musculus 25% 73%
V5BJZ2 Trypanosoma cruzi 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS