Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8S3_LEIIN

TriTrypDb:

LINF_330012600

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8S3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.634
CLV_C14_Caspase3-7	173	177	PF00656	0.608
CLV_C14_Caspase3-7	194	198	PF00656	0.670
CLV_C14_Caspase3-7	525	529	PF00656	0.662
CLV_C14_Caspase3-7	531	535	PF00656	0.595
CLV_C14_Caspase3-7	540	544	PF00656	0.531
CLV_C14_Caspase3-7	668	672	PF00656	0.659
CLV_NRD_NRD_1	119	121	PF00675	0.742
CLV_NRD_NRD_1	478	480	PF00675	0.675
CLV_NRD_NRD_1	548	550	PF00675	0.662
CLV_NRD_NRD_1	594	596	PF00675	0.782
CLV_NRD_NRD_1	639	641	PF00675	0.635
CLV_PCSK_FUR_1	478	482	PF00082	0.645
CLV_PCSK_KEX2_1	119	121	PF00082	0.729
CLV_PCSK_KEX2_1	478	480	PF00082	0.640
CLV_PCSK_KEX2_1	556	558	PF00082	0.680
CLV_PCSK_KEX2_1	593	595	PF00082	0.807
CLV_PCSK_KEX2_1	615	617	PF00082	0.646
CLV_PCSK_KEX2_1	639	641	PF00082	0.593
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.648
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.680
CLV_PCSK_PC1ET2_1	593	595	PF00082	0.807
CLV_PCSK_PC1ET2_1	615	617	PF00082	0.646
CLV_PCSK_SKI1_1	590	594	PF00082	0.667
CLV_PCSK_SKI1_1	639	643	PF00082	0.594
DEG_Nend_Nbox_1	1	3	PF02207	0.663
DEG_SCF_FBW7_2	512	519	PF00400	0.669
DEG_SPOP_SBC_1	236	240	PF00917	0.578
DEG_SPOP_SBC_1	606	610	PF00917	0.645
DOC_ANK_TNKS_1	326	333	PF00023	0.567
DOC_CYCLIN_yClb5_NLxxxL_5	486	492	PF00134	0.663
DOC_MAPK_gen_1	613	620	PF00069	0.547
DOC_PP2B_LxvP_1	221	224	PF13499	0.644
DOC_PP2B_LxvP_1	492	495	PF13499	0.665
DOC_PP2B_LxvP_1	632	635	PF13499	0.401
DOC_PP4_FxxP_1	165	168	PF00568	0.551
DOC_USP7_MATH_1	140	144	PF00917	0.661
DOC_USP7_MATH_1	224	228	PF00917	0.582
DOC_USP7_MATH_1	241	245	PF00917	0.511
DOC_USP7_MATH_1	258	262	PF00917	0.546
DOC_USP7_MATH_1	276	280	PF00917	0.502
DOC_USP7_MATH_1	347	351	PF00917	0.667
DOC_USP7_MATH_1	555	559	PF00917	0.680
DOC_USP7_MATH_1	599	603	PF00917	0.705
DOC_USP7_MATH_1	606	610	PF00917	0.630
DOC_USP7_MATH_1	670	674	PF00917	0.635
DOC_USP7_MATH_1	91	95	PF00917	0.650
DOC_WW_Pin1_4	118	123	PF00397	0.566
DOC_WW_Pin1_4	256	261	PF00397	0.691
DOC_WW_Pin1_4	274	279	PF00397	0.499
DOC_WW_Pin1_4	335	340	PF00397	0.535
DOC_WW_Pin1_4	497	502	PF00397	0.659
DOC_WW_Pin1_4	512	517	PF00397	0.552
DOC_WW_Pin1_4	607	612	PF00397	0.667
DOC_WW_Pin1_4	645	650	PF00397	0.599
DOC_WW_Pin1_4	656	661	PF00397	0.614
LIG_14-3-3_CanoR_1	342	347	PF00244	0.609
LIG_14-3-3_CanoR_1	395	400	PF00244	0.651
LIG_14-3-3_CanoR_1	557	563	PF00244	0.647
LIG_14-3-3_CanoR_1	582	588	PF00244	0.589
LIG_14-3-3_CanoR_1	607	611	PF00244	0.671
LIG_14-3-3_CanoR_1	619	626	PF00244	0.578
LIG_Actin_WH2_2	625	641	PF00022	0.589
LIG_BIR_III_2	543	547	PF00653	0.578
LIG_BIR_III_4	534	538	PF00653	0.659
LIG_Clathr_ClatBox_1	280	284	PF01394	0.680
LIG_deltaCOP1_diTrp_1	382	392	PF00928	0.704
LIG_FHA_1	111	117	PF00498	0.551
LIG_FHA_1	237	243	PF00498	0.553
LIG_FHA_1	440	446	PF00498	0.718
LIG_FHA_1	506	512	PF00498	0.704
LIG_FHA_1	583	589	PF00498	0.590
LIG_FHA_1	612	618	PF00498	0.693
LIG_FHA_1	646	652	PF00498	0.586
LIG_FHA_2	102	108	PF00498	0.502
LIG_FHA_2	458	464	PF00498	0.659
LIG_FHA_2	513	519	PF00498	0.670
LIG_FHA_2	573	579	PF00498	0.718
LIG_FHA_2	582	588	PF00498	0.746
LIG_FHA_2	599	605	PF00498	0.569
LIG_LIR_Apic_2	164	168	PF02991	0.555
LIG_MYND_1	278	282	PF01753	0.685
LIG_MYND_1	501	505	PF01753	0.576
LIG_PCNA_yPIPBox_3	615	629	PF02747	0.621
LIG_PDZ_Class_3	672	677	PF00595	0.581
LIG_Pex14_2	161	165	PF04695	0.557
LIG_SH2_CRK	141	145	PF00017	0.669
LIG_SH2_NCK_1	105	109	PF00017	0.509
LIG_SH2_NCK_1	532	536	PF00017	0.679
LIG_SH2_SRC	105	108	PF00017	0.557
LIG_SH2_SRC	532	535	PF00017	0.657
LIG_SH2_STAP1	301	305	PF00017	0.634
LIG_SH2_STAP1	532	536	PF00017	0.631
LIG_SH2_STAT5	141	144	PF00017	0.671
LIG_SH2_STAT5	301	304	PF00017	0.588
LIG_SH3_1	333	339	PF00018	0.523
LIG_SH3_3	217	223	PF00018	0.622
LIG_SH3_3	333	339	PF00018	0.523
LIG_SH3_3	435	441	PF00018	0.702
LIG_SH3_3	654	660	PF00018	0.646
LIG_TRAF2_1	326	329	PF00917	0.604
LIG_TRAF2_1	409	412	PF00917	0.658
LIG_TRAF2_1	621	624	PF00917	0.590
LIG_TRFH_1	219	223	PF08558	0.584
MOD_CDC14_SPxK_1	121	124	PF00782	0.600
MOD_CDK_SPxK_1	118	124	PF00069	0.573
MOD_CDK_SPxK_1	607	613	PF00069	0.581
MOD_CDK_SPxxK_3	335	342	PF00069	0.545
MOD_CK1_1	235	241	PF00069	0.676
MOD_CK1_1	244	250	PF00069	0.606
MOD_CK1_1	261	267	PF00069	0.539
MOD_CK1_1	349	355	PF00069	0.760
MOD_CK1_1	387	393	PF00069	0.753
MOD_CK1_1	394	400	PF00069	0.669
MOD_CK1_1	493	499	PF00069	0.653
MOD_CK1_1	506	512	PF00069	0.610
MOD_CK1_1	524	530	PF00069	0.583
MOD_CK1_1	558	564	PF00069	0.701
MOD_CK1_1	85	91	PF00069	0.693
MOD_CK1_1	99	105	PF00069	0.493
MOD_CK2_1	301	307	PF00069	0.621
MOD_CK2_1	323	329	PF00069	0.662
MOD_CK2_1	393	399	PF00069	0.724
MOD_CK2_1	572	578	PF00069	0.720
MOD_CK2_1	581	587	PF00069	0.751
MOD_CK2_1	598	604	PF00069	0.611
MOD_CK2_1	618	624	PF00069	0.620
MOD_Cter_Amidation	547	550	PF01082	0.664
MOD_GlcNHglycan	202	205	PF01048	0.605
MOD_GlcNHglycan	234	237	PF01048	0.630
MOD_GlcNHglycan	239	242	PF01048	0.614
MOD_GlcNHglycan	24	27	PF01048	0.569
MOD_GlcNHglycan	246	249	PF01048	0.573
MOD_GlcNHglycan	260	263	PF01048	0.579
MOD_GlcNHglycan	30	33	PF01048	0.599
MOD_GlcNHglycan	303	306	PF01048	0.612
MOD_GlcNHglycan	344	347	PF01048	0.815
MOD_GlcNHglycan	349	352	PF01048	0.761
MOD_GlcNHglycan	369	372	PF01048	0.609
MOD_GlcNHglycan	389	392	PF01048	0.601
MOD_GlcNHglycan	524	527	PF01048	0.682
MOD_GlcNHglycan	564	567	PF01048	0.699
MOD_GlcNHglycan	575	578	PF01048	0.613
MOD_GSK3_1	140	147	PF00069	0.783
MOD_GSK3_1	232	239	PF00069	0.671
MOD_GSK3_1	24	31	PF00069	0.584
MOD_GSK3_1	342	349	PF00069	0.707
MOD_GSK3_1	386	393	PF00069	0.787
MOD_GSK3_1	395	402	PF00069	0.690
MOD_GSK3_1	451	458	PF00069	0.657
MOD_GSK3_1	493	500	PF00069	0.696
MOD_GSK3_1	503	510	PF00069	0.627
MOD_GSK3_1	520	527	PF00069	0.574
MOD_GSK3_1	558	565	PF00069	0.694
MOD_GSK3_1	607	614	PF00069	0.769
MOD_GSK3_1	81	88	PF00069	0.691
MOD_GSK3_1	92	99	PF00069	0.562
MOD_N-GLC_1	28	33	PF02516	0.606
MOD_N-GLC_1	512	517	PF02516	0.718
MOD_NEK2_1	21	26	PF00069	0.555
MOD_NEK2_1	232	237	PF00069	0.599
MOD_NEK2_1	311	316	PF00069	0.648
MOD_NEK2_1	507	512	PF00069	0.673
MOD_NEK2_1	522	527	PF00069	0.562
MOD_NEK2_1	562	567	PF00069	0.654
MOD_NEK2_1	75	80	PF00069	0.655
MOD_PIKK_1	411	417	PF00454	0.614
MOD_PIKK_1	618	624	PF00454	0.620
MOD_PK_1	222	228	PF00069	0.666
MOD_PKA_2	170	176	PF00069	0.558
MOD_PKA_2	341	347	PF00069	0.582
MOD_PKA_2	394	400	PF00069	0.650
MOD_PKA_2	558	564	PF00069	0.701
MOD_PKA_2	581	587	PF00069	0.587
MOD_PKA_2	606	612	PF00069	0.669
MOD_PKA_2	618	624	PF00069	0.596
MOD_Plk_2-3	665	671	PF00069	0.718
MOD_Plk_4	266	272	PF00069	0.698
MOD_Plk_4	276	282	PF00069	0.582
MOD_Plk_4	457	463	PF00069	0.576
MOD_Plk_4	46	52	PF00069	0.578
MOD_Plk_4	507	513	PF00069	0.692
MOD_ProDKin_1	118	124	PF00069	0.578
MOD_ProDKin_1	256	262	PF00069	0.692
MOD_ProDKin_1	274	280	PF00069	0.502
MOD_ProDKin_1	335	341	PF00069	0.540
MOD_ProDKin_1	497	503	PF00069	0.660
MOD_ProDKin_1	512	518	PF00069	0.552
MOD_ProDKin_1	607	613	PF00069	0.666
MOD_ProDKin_1	645	651	PF00069	0.603
MOD_ProDKin_1	656	662	PF00069	0.615
MOD_SUMO_for_1	409	412	PF00179	0.658
MOD_SUMO_rev_2	131	140	PF00179	0.657
MOD_SUMO_rev_2	659	668	PF00179	0.672
TRG_DiLeu_BaEn_1	307	312	PF01217	0.621
TRG_DiLeu_BaEn_3	623	629	PF01217	0.582
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.575
TRG_ENDOCYTIC_2	141	144	PF00928	0.671
TRG_ER_diArg_1	118	120	PF00400	0.717
TRG_ER_diArg_1	477	479	PF00400	0.632
TRG_ER_diArg_1	481	484	PF00400	0.644
TRG_ER_diArg_1	638	640	PF00400	0.592
TRG_NES_CRM1_1	623	636	PF08389	0.583
TRG_NLS_MonoExtC_3	478	483	PF00514	0.697
TRG_NLS_MonoExtN_4	478	484	PF00514	0.697
TRG_NLS_MonoExtN_4	590	597	PF00514	0.672
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ITV4	Leishmania donovani	100%	100%
A4HL97	Leishmania braziliensis	69%	100%
E9B3N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q4E8	Leishmania major	89%	100%