Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ras-induced vulval development antagonist - putative

Species:

Leishmania infantum

UniProt:

A4I8S2_LEIIN

TriTrypDb:

LINF_330012500

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I8S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8S2

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	8
GO:0005488	binding	1	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.637
CLV_C14_Caspase3-7	148	152	PF00656	0.683
CLV_C14_Caspase3-7	92	96	PF00656	0.670
CLV_NRD_NRD_1	141	143	PF00675	0.781
CLV_NRD_NRD_1	192	194	PF00675	0.807
CLV_NRD_NRD_1	206	208	PF00675	0.808
CLV_NRD_NRD_1	301	303	PF00675	0.376
CLV_NRD_NRD_1	32	34	PF00675	0.551
CLV_NRD_NRD_1	353	355	PF00675	0.387
CLV_NRD_NRD_1	38	40	PF00675	0.621
CLV_PCSK_FUR_1	30	34	PF00082	0.668
CLV_PCSK_FUR_1	36	40	PF00082	0.631
CLV_PCSK_KEX2_1	192	194	PF00082	0.807
CLV_PCSK_KEX2_1	208	210	PF00082	0.804
CLV_PCSK_KEX2_1	297	299	PF00082	0.376
CLV_PCSK_KEX2_1	30	32	PF00082	0.548
CLV_PCSK_KEX2_1	301	303	PF00082	0.376
CLV_PCSK_KEX2_1	35	37	PF00082	0.564
CLV_PCSK_KEX2_1	38	40	PF00082	0.601
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.804
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.376
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.549
CLV_PCSK_PC7_1	31	37	PF00082	0.559
CLV_Separin_Metazoa	139	143	PF03568	0.799
DEG_Nend_UBRbox_2	1	3	PF02207	0.644
DOC_MAPK_MEF2A_6	360	369	PF00069	0.501
DOC_PP1_RVXF_1	206	213	PF00149	0.734
DOC_PP4_FxxP_1	212	215	PF00568	0.577
DOC_USP7_MATH_1	101	105	PF00917	0.582
DOC_USP7_MATH_1	112	116	PF00917	0.677
DOC_USP7_MATH_1	134	138	PF00917	0.754
DOC_USP7_MATH_1	258	262	PF00917	0.750
DOC_USP7_MATH_1	87	91	PF00917	0.601
DOC_USP7_UBL2_3	166	170	PF12436	0.639
DOC_WW_Pin1_4	124	129	PF00397	0.785
LIG_CaM_IQ_9	346	362	PF13499	0.430
LIG_FHA_1	151	157	PF00498	0.713
LIG_FHA_1	159	165	PF00498	0.603
LIG_FHA_1	241	247	PF00498	0.717
LIG_FHA_2	106	112	PF00498	0.681
LIG_FHA_2	286	292	PF00498	0.674
LIG_FHA_2	306	312	PF00498	0.171
LIG_LIR_Nem_3	24	29	PF02991	0.618
LIG_Pex14_1	22	26	PF04695	0.618
LIG_Pex14_2	292	296	PF04695	0.376
LIG_PTAP_UEV_1	156	161	PF05743	0.508
LIG_SH2_STAT3	14	17	PF00017	0.561
LIG_SH2_STAT5	320	323	PF00017	0.352
LIG_SH2_STAT5	333	336	PF00017	0.376
LIG_SH2_STAT5	76	79	PF00017	0.508
LIG_SH3_1	249	255	PF00018	0.582
LIG_SH3_3	127	133	PF00018	0.757
LIG_SH3_3	154	160	PF00018	0.665
LIG_SH3_3	249	255	PF00018	0.625
LIG_TRAF2_1	308	311	PF00917	0.501
LIG_TRAF2_1	8	11	PF00917	0.590
LIG_WW_3	139	143	PF00397	0.799
MOD_CDK_SPxxK_3	124	131	PF00069	0.574
MOD_CK1_1	115	121	PF00069	0.753
MOD_CK1_1	158	164	PF00069	0.598
MOD_CK1_1	285	291	PF00069	0.549
MOD_CK1_1	327	333	PF00069	0.430
MOD_CK1_1	52	58	PF00069	0.711
MOD_CK1_1	90	96	PF00069	0.725
MOD_CK2_1	142	148	PF00069	0.777
MOD_CK2_1	285	291	PF00069	0.597
MOD_CK2_1	305	311	PF00069	0.171
MOD_CK2_1	43	49	PF00069	0.744
MOD_CK2_1	5	11	PF00069	0.596
MOD_CK2_1	57	63	PF00069	0.570
MOD_Cter_Amidation	205	208	PF01082	0.810
MOD_Cter_Amidation	374	377	PF01082	0.501
MOD_GlcNHglycan	102	106	PF01048	0.622
MOD_GlcNHglycan	114	117	PF01048	0.639
MOD_GlcNHglycan	122	125	PF01048	0.692
MOD_GlcNHglycan	136	139	PF01048	0.682
MOD_GlcNHglycan	157	160	PF01048	0.600
MOD_GlcNHglycan	161	164	PF01048	0.599
MOD_GlcNHglycan	260	263	PF01048	0.776
MOD_GlcNHglycan	322	325	PF01048	0.376
MOD_GlcNHglycan	49	54	PF01048	0.714
MOD_GlcNHglycan	77	80	PF01048	0.507
MOD_GlcNHglycan	89	92	PF01048	0.607
MOD_GSK3_1	101	108	PF00069	0.735
MOD_GSK3_1	111	118	PF00069	0.596
MOD_GSK3_1	120	127	PF00069	0.460
MOD_GSK3_1	147	154	PF00069	0.725
MOD_GSK3_1	155	162	PF00069	0.532
MOD_GSK3_1	228	235	PF00069	0.614
MOD_GSK3_1	320	327	PF00069	0.430
MOD_GSK3_1	45	52	PF00069	0.688
MOD_GSK3_1	55	62	PF00069	0.589
MOD_N-GLC_1	232	237	PF02516	0.589
MOD_NEK2_1	21	26	PF00069	0.545
MOD_NEK2_1	322	327	PF00069	0.376
MOD_NEK2_1	81	86	PF00069	0.536
MOD_PIKK_1	198	204	PF00454	0.772
MOD_PIKK_1	282	288	PF00454	0.555
MOD_PIKK_1	291	297	PF00454	0.376
MOD_PIKK_1	57	63	PF00454	0.723
MOD_PKA_1	142	148	PF00069	0.729
MOD_Plk_1	238	244	PF00069	0.711
MOD_Plk_1	63	69	PF00069	0.651
MOD_Plk_2-3	43	49	PF00069	0.693
MOD_ProDKin_1	124	130	PF00069	0.787
TRG_DiLeu_BaEn_2	367	373	PF01217	0.424
TRG_ER_diArg_1	207	210	PF00400	0.808
TRG_ER_diArg_1	29	32	PF00400	0.549
TRG_ER_diArg_1	300	302	PF00400	0.376
TRG_ER_diArg_1	36	39	PF00400	0.580
TRG_ER_diLys_1	376	379	PF00400	0.604
TRG_NLS_Bipartite_1	192	211	PF00514	0.802
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYC1	Leptomonas seymouri	50%	91%
A0A3S7X6H7	Leishmania donovani	100%	100%
A0A422N868	Trypanosoma rangeli	34%	100%
A4HL96	Leishmania braziliensis	76%	99%
E9B3N8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q4E9	Leishmania major	91%	100%