LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I8S1_LEIIN
TriTrypDb:
LINF_330012400
Length:
578

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005829 cytosol 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032991 protein-containing complex 1 1
GO:0034708 methyltransferase complex 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043233 organelle lumen 3 1
GO:0043527 tRNA methyltransferase complex 5 1
GO:0070013 intracellular organelle lumen 4 1
GO:0110165 cellular anatomical entity 1 1
GO:1902494 catalytic complex 2 1
GO:1990234 transferase complex 3 1

Phosphorylation

Promastigote: 123

Expansion

Sequence features

A4I8S1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8S1

Function

Biological processes
Term Name Level Count
GO:0001510 RNA methylation 4 11
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006396 RNA processing 6 10
GO:0006399 tRNA metabolic process 7 10
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008033 tRNA processing 8 10
GO:0008152 metabolic process 1 11
GO:0009451 RNA modification 5 11
GO:0009987 cellular process 1 11
GO:0016070 RNA metabolic process 5 11
GO:0032259 methylation 2 11
GO:0034470 ncRNA processing 7 10
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034660 ncRNA metabolic process 6 10
GO:0036265 RNA (guanine-N7)-methylation 5 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0043414 macromolecule methylation 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044260 obsolete cellular macromolecule metabolic process 3 11
GO:0046483 heterocycle metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:0006400 tRNA modification 6 1
GO:0030488 tRNA methylation 5 1
GO:0106004 tRNA (guanine-N7)-methylation 6 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 419 423 PF00656 0.468
CLV_C14_Caspase3-7 73 77 PF00656 0.392
CLV_MEL_PAP_1 368 374 PF00089 0.422
CLV_NRD_NRD_1 120 122 PF00675 0.710
CLV_NRD_NRD_1 235 237 PF00675 0.384
CLV_NRD_NRD_1 535 537 PF00675 0.653
CLV_PCSK_FUR_1 532 536 PF00082 0.679
CLV_PCSK_KEX2_1 120 122 PF00082 0.712
CLV_PCSK_KEX2_1 153 155 PF00082 0.419
CLV_PCSK_KEX2_1 235 237 PF00082 0.383
CLV_PCSK_KEX2_1 440 442 PF00082 0.448
CLV_PCSK_KEX2_1 534 536 PF00082 0.662
CLV_PCSK_PC1ET2_1 153 155 PF00082 0.419
CLV_PCSK_PC1ET2_1 440 442 PF00082 0.448
CLV_PCSK_SKI1_1 153 157 PF00082 0.436
CLV_PCSK_SKI1_1 196 200 PF00082 0.532
CLV_PCSK_SKI1_1 235 239 PF00082 0.385
CLV_PCSK_SKI1_1 383 387 PF00082 0.422
DOC_ANK_TNKS_1 344 351 PF00023 0.484
DOC_CDC14_PxL_1 5 13 PF14671 0.538
DOC_CYCLIN_RxL_1 229 241 PF00134 0.532
DOC_CYCLIN_yCln2_LP_2 304 310 PF00134 0.582
DOC_MAPK_gen_1 440 447 PF00069 0.392
DOC_PP1_RVXF_1 177 183 PF00149 0.506
DOC_PP1_RVXF_1 55 62 PF00149 0.428
DOC_PP2B_LxvP_1 213 216 PF13499 0.482
DOC_PP2B_LxvP_1 304 307 PF13499 0.610
DOC_PP2B_LxvP_1 62 65 PF13499 0.451
DOC_PP4_FxxP_1 372 375 PF00568 0.515
DOC_PP4_FxxP_1 396 399 PF00568 0.464
DOC_USP7_MATH_1 246 250 PF00917 0.402
DOC_USP7_MATH_1 330 334 PF00917 0.523
DOC_USP7_MATH_1 412 416 PF00917 0.585
DOC_USP7_MATH_1 44 48 PF00917 0.560
DOC_USP7_UBL2_3 564 568 PF12436 0.782
DOC_WW_Pin1_4 180 185 PF00397 0.504
DOC_WW_Pin1_4 38 43 PF00397 0.661
LIG_14-3-3_CanoR_1 154 159 PF00244 0.464
LIG_14-3-3_CanoR_1 177 183 PF00244 0.467
LIG_14-3-3_CanoR_1 264 268 PF00244 0.529
LIG_14-3-3_CanoR_1 3 11 PF00244 0.540
LIG_14-3-3_CanoR_1 418 422 PF00244 0.514
LIG_14-3-3_CanoR_1 424 430 PF00244 0.487
LIG_14-3-3_CanoR_1 511 518 PF00244 0.546
LIG_AP2alpha_1 168 172 PF02296 0.364
LIG_BIR_III_2 422 426 PF00653 0.564
LIG_BRCT_BRCA1_1 392 396 PF00533 0.507
LIG_FHA_1 109 115 PF00498 0.762
LIG_FHA_1 150 156 PF00498 0.452
LIG_FHA_1 185 191 PF00498 0.529
LIG_FHA_1 197 203 PF00498 0.311
LIG_FHA_1 208 214 PF00498 0.405
LIG_FHA_1 252 258 PF00498 0.477
LIG_FHA_1 335 341 PF00498 0.525
LIG_FHA_1 433 439 PF00498 0.468
LIG_FHA_2 158 164 PF00498 0.480
LIG_FHA_2 417 423 PF00498 0.453
LIG_FHA_2 505 511 PF00498 0.690
LIG_LIR_Apic_2 140 144 PF02991 0.575
LIG_LIR_Apic_2 370 375 PF02991 0.508
LIG_LIR_Apic_2 393 399 PF02991 0.473
LIG_LIR_Gen_1 336 346 PF02991 0.436
LIG_LIR_Gen_1 446 455 PF02991 0.517
LIG_LIR_Gen_1 523 531 PF02991 0.669
LIG_LIR_Gen_1 76 85 PF02991 0.490
LIG_LIR_Nem_3 170 175 PF02991 0.387
LIG_LIR_Nem_3 336 341 PF02991 0.432
LIG_LIR_Nem_3 354 359 PF02991 0.566
LIG_LIR_Nem_3 394 400 PF02991 0.354
LIG_LIR_Nem_3 446 450 PF02991 0.483
LIG_LIR_Nem_3 523 529 PF02991 0.658
LIG_LIR_Nem_3 76 82 PF02991 0.487
LIG_MYND_3 482 486 PF01753 0.533
LIG_Pex14_1 142 146 PF04695 0.582
LIG_Pex14_2 168 172 PF04695 0.364
LIG_SH2_CRK 401 405 PF00017 0.559
LIG_SH2_GRB2like 401 404 PF00017 0.470
LIG_SH2_NCK_1 401 405 PF00017 0.491
LIG_SH2_NCK_1 526 530 PF00017 0.546
LIG_SH2_SRC 146 149 PF00017 0.574
LIG_SH2_SRC 401 404 PF00017 0.490
LIG_SH2_STAP1 286 290 PF00017 0.628
LIG_SH2_STAP1 308 312 PF00017 0.460
LIG_SH2_STAT5 255 258 PF00017 0.497
LIG_SH2_STAT5 279 282 PF00017 0.555
LIG_SH2_STAT5 311 314 PF00017 0.343
LIG_SH2_STAT5 484 487 PF00017 0.495
LIG_SH3_3 343 349 PF00018 0.516
LIG_SH3_3 450 456 PF00018 0.484
LIG_SH3_3 477 483 PF00018 0.558
LIG_SH3_3 525 531 PF00018 0.611
LIG_SH3_3 62 68 PF00018 0.529
LIG_SH3_4 143 150 PF00018 0.555
LIG_SUMO_SIM_par_1 185 191 PF11976 0.567
LIG_TRAF2_1 225 228 PF00917 0.665
LIG_TRAF2_1 498 501 PF00917 0.743
LIG_WRC_WIRS_1 341 346 PF05994 0.530
MOD_CK1_1 157 163 PF00069 0.523
MOD_CK1_1 206 212 PF00069 0.393
MOD_CK1_1 266 272 PF00069 0.406
MOD_CK1_1 417 423 PF00069 0.525
MOD_CK1_1 547 553 PF00069 0.706
MOD_CK1_1 555 561 PF00069 0.733
MOD_CK2_1 157 163 PF00069 0.523
MOD_CK2_1 275 281 PF00069 0.466
MOD_CK2_1 330 336 PF00069 0.524
MOD_CK2_1 510 516 PF00069 0.572
MOD_Cter_Amidation 566 569 PF01082 0.703
MOD_GlcNHglycan 227 232 PF01048 0.562
MOD_GlcNHglycan 268 271 PF01048 0.523
MOD_GlcNHglycan 414 417 PF01048 0.560
MOD_GlcNHglycan 549 552 PF01048 0.750
MOD_GlcNHglycan 559 562 PF01048 0.635
MOD_GlcNHglycan 72 75 PF01048 0.393
MOD_GSK3_1 149 156 PF00069 0.440
MOD_GSK3_1 178 185 PF00069 0.495
MOD_GSK3_1 192 199 PF00069 0.273
MOD_GSK3_1 203 210 PF00069 0.377
MOD_GSK3_1 223 230 PF00069 0.337
MOD_GSK3_1 3 10 PF00069 0.621
MOD_GSK3_1 306 313 PF00069 0.437
MOD_GSK3_1 330 337 PF00069 0.505
MOD_GSK3_1 360 367 PF00069 0.542
MOD_GSK3_1 40 47 PF00069 0.618
MOD_GSK3_1 412 419 PF00069 0.465
MOD_GSK3_1 459 466 PF00069 0.596
MOD_LATS_1 151 157 PF00433 0.424
MOD_N-GLC_1 3 8 PF02516 0.654
MOD_N-GLC_1 300 305 PF02516 0.668
MOD_N-GLC_1 334 339 PF02516 0.546
MOD_N-GLC_1 547 552 PF02516 0.742
MOD_N-GLC_1 83 88 PF02516 0.536
MOD_N-GLC_1 97 102 PF02516 0.646
MOD_NEK2_1 211 216 PF00069 0.400
MOD_NEK2_1 260 265 PF00069 0.550
MOD_NEK2_1 340 345 PF00069 0.484
MOD_NEK2_1 520 525 PF00069 0.561
MOD_NEK2_2 405 410 PF00069 0.404
MOD_OFUCOSY 234 240 PF10250 0.427
MOD_PKA_1 120 126 PF00069 0.719
MOD_PKA_1 153 159 PF00069 0.411
MOD_PKA_2 120 126 PF00069 0.719
MOD_PKA_2 153 159 PF00069 0.411
MOD_PKA_2 178 184 PF00069 0.488
MOD_PKA_2 246 252 PF00069 0.381
MOD_PKA_2 263 269 PF00069 0.439
MOD_PKA_2 417 423 PF00069 0.508
MOD_PKA_2 510 516 PF00069 0.575
MOD_Plk_1 275 281 PF00069 0.536
MOD_Plk_1 286 292 PF00069 0.644
MOD_Plk_1 300 306 PF00069 0.668
MOD_Plk_1 334 340 PF00069 0.504
MOD_Plk_1 432 438 PF00069 0.456
MOD_Plk_1 83 89 PF00069 0.534
MOD_Plk_2-3 510 516 PF00069 0.652
MOD_Plk_4 162 168 PF00069 0.356
MOD_Plk_4 196 202 PF00069 0.435
MOD_Plk_4 251 257 PF00069 0.483
MOD_Plk_4 306 312 PF00069 0.474
MOD_Plk_4 360 366 PF00069 0.432
MOD_Plk_4 44 50 PF00069 0.547
MOD_Plk_4 443 449 PF00069 0.470
MOD_ProDKin_1 180 186 PF00069 0.512
MOD_ProDKin_1 38 44 PF00069 0.654
MOD_SUMO_for_1 137 140 PF00179 0.598
MOD_SUMO_rev_2 73 80 PF00179 0.430
TRG_DiLeu_BaEn_1 336 341 PF01217 0.452
TRG_DiLeu_BaEn_2 432 438 PF01217 0.534
TRG_ENDOCYTIC_2 401 404 PF00928 0.476
TRG_ENDOCYTIC_2 526 529 PF00928 0.545
TRG_ER_diArg_1 176 179 PF00400 0.495
TRG_ER_diArg_1 235 237 PF00400 0.384
TRG_ER_diArg_1 344 347 PF00400 0.527
TRG_ER_diArg_1 531 534 PF00400 0.589
TRG_NES_CRM1_1 54 66 PF08389 0.546
TRG_NLS_MonoExtC_3 567 573 PF00514 0.724
TRG_NLS_MonoExtN_4 120 125 PF00514 0.670
TRG_Pf-PMV_PEXEL_1 3 7 PF00026 0.658

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL73 Leptomonas seymouri 67% 100%
A0A1X0P0S8 Trypanosomatidae 29% 100%
A0A3Q8IGQ7 Leishmania donovani 99% 100%
A0A422N539 Trypanosoma rangeli 32% 100%
A4HL95 Leishmania braziliensis 79% 99%
D0A4R4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9B3N7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q4F0 Leishmania major 94% 100%
V5D2Q1 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS