HD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8R3_LEIIN

TriTrypDb:

LINF_330011500

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8R3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8R3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.375
CLV_NRD_NRD_1	32	34	PF00675	0.477
CLV_PCSK_KEX2_1	151	153	PF00082	0.409
CLV_PCSK_KEX2_1	254	256	PF00082	0.482
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.438
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.482
CLV_PCSK_SKI1_1	148	152	PF00082	0.447
CLV_PCSK_SKI1_1	254	258	PF00082	0.462
CLV_PCSK_SKI1_1	33	37	PF00082	0.426
CLV_PCSK_SKI1_1	62	66	PF00082	0.298
DEG_APCC_DBOX_1	61	69	PF00400	0.297
DEG_Nend_UBRbox_2	1	3	PF02207	0.392
DEG_SCF_FBW7_1	216	222	PF00400	0.397
DOC_CKS1_1	216	221	PF01111	0.395
DOC_MAPK_DCC_7	252	261	PF00069	0.393
DOC_MAPK_gen_1	252	261	PF00069	0.437
DOC_MAPK_MEF2A_6	252	261	PF00069	0.393
DOC_PP2B_LxvP_1	269	272	PF13499	0.382
DOC_PP4_FxxP_1	110	113	PF00568	0.566
DOC_USP7_MATH_1	168	172	PF00917	0.586
DOC_USP7_MATH_1	219	223	PF00917	0.648
DOC_WW_Pin1_4	215	220	PF00397	0.591
DOC_WW_Pin1_4	301	306	PF00397	0.431
LIG_14-3-3_CanoR_1	11	16	PF00244	0.401
LIG_14-3-3_CanoR_1	207	214	PF00244	0.449
LIG_14-3-3_CanoR_1	33	42	PF00244	0.412
LIG_14-3-3_CanoR_1	86	91	PF00244	0.421
LIG_Actin_WH2_2	230	245	PF00022	0.498
LIG_deltaCOP1_diTrp_1	7	15	PF00928	0.375
LIG_FHA_1	11	17	PF00498	0.419
LIG_FHA_2	137	143	PF00498	0.352
LIG_FHA_2	229	235	PF00498	0.489
LIG_GBD_Chelix_1	133	141	PF00786	0.308
LIG_HCF-1_HBM_1	74	77	PF13415	0.343
LIG_LIR_Gen_1	171	181	PF02991	0.332
LIG_LIR_Gen_1	200	208	PF02991	0.363
LIG_LIR_Nem_3	171	177	PF02991	0.344
LIG_LIR_Nem_3	200	204	PF02991	0.355
LIG_LIR_Nem_3	282	287	PF02991	0.529
LIG_Rb_LxCxE_1	192	209	PF01857	0.461
LIG_RPA_C_Fungi	81	93	PF08784	0.266
LIG_SH2_CRK	201	205	PF00017	0.469
LIG_SH2_CRK	287	291	PF00017	0.287
LIG_SH2_CRK	61	65	PF00017	0.442
LIG_SH2_NCK_1	201	205	PF00017	0.404
LIG_SH2_NCK_1	77	81	PF00017	0.422
LIG_SH2_STAP1	146	150	PF00017	0.446
LIG_SH2_STAT5	180	183	PF00017	0.446
LIG_SH2_STAT5	201	204	PF00017	0.330
LIG_SH2_STAT5	43	46	PF00017	0.480
LIG_SH3_3	109	115	PF00018	0.497
LIG_Sin3_3	95	102	PF02671	0.412
LIG_WRC_WIRS_1	87	92	PF05994	0.461
MOD_CDK_SPK_2	215	220	PF00069	0.444
MOD_CK1_1	222	228	PF00069	0.533
MOD_CK2_1	186	192	PF00069	0.250
MOD_CK2_1	228	234	PF00069	0.503
MOD_GlcNHglycan	123	127	PF01048	0.613
MOD_GlcNHglycan	17	20	PF01048	0.399
MOD_GlcNHglycan	208	211	PF01048	0.551
MOD_GlcNHglycan	221	224	PF01048	0.428
MOD_GlcNHglycan	264	267	PF01048	0.401
MOD_GlcNHglycan	46	50	PF01048	0.509
MOD_GSK3_1	11	18	PF00069	0.391
MOD_GSK3_1	166	173	PF00069	0.549
MOD_GSK3_1	215	222	PF00069	0.514
MOD_LATS_1	31	37	PF00433	0.467
MOD_NEK2_1	136	141	PF00069	0.393
MOD_NEK2_1	15	20	PF00069	0.358
MOD_NEK2_1	260	265	PF00069	0.414
MOD_NEK2_1	44	49	PF00069	0.511
MOD_OFUCOSY	198	203	PF10250	0.434
MOD_PK_1	186	192	PF00069	0.250
MOD_PKA_1	33	39	PF00069	0.460
MOD_PKA_2	10	16	PF00069	0.435
MOD_PKA_2	206	212	PF00069	0.508
MOD_PKA_2	219	225	PF00069	0.693
MOD_Plk_1	199	205	PF00069	0.509
MOD_Plk_2-3	179	185	PF00069	0.306
MOD_Plk_4	11	17	PF00069	0.385
MOD_Plk_4	170	176	PF00069	0.507
MOD_Plk_4	290	296	PF00069	0.486
MOD_ProDKin_1	215	221	PF00069	0.600
TRG_DiLeu_BaEn_1	276	281	PF01217	0.484
TRG_DiLeu_BaEn_1	37	42	PF01217	0.348
TRG_DiLeu_BaEn_1	94	99	PF01217	0.421
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.444
TRG_ENDOCYTIC_2	201	204	PF00928	0.445
TRG_ENDOCYTIC_2	61	64	PF00928	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I587	Leptomonas seymouri	61%	99%
A0A0S4KI40	Bodo saltans	42%	100%
A0A1X0P0R2	Trypanosomatidae	42%	100%
A0A3R7LX07	Trypanosoma rangeli	42%	100%
A0A3S7X6G1	Leishmania donovani	99%	100%
A4HL85	Leishmania braziliensis	78%	100%
D0A4Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B3M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q4F9	Leishmania major	94%	100%
V5BKA1	Trypanosoma cruzi	40%	100%