Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8R1_LEIIN

TriTrypDb:

LINF_330011300

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8R1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8R1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.768
CLV_C14_Caspase3-7	176	180	PF00656	0.730
CLV_C14_Caspase3-7	435	439	PF00656	0.698
CLV_C14_Caspase3-7	767	771	PF00656	0.454
CLV_NRD_NRD_1	127	129	PF00675	0.659
CLV_NRD_NRD_1	172	174	PF00675	0.607
CLV_NRD_NRD_1	198	200	PF00675	0.577
CLV_NRD_NRD_1	260	262	PF00675	0.582
CLV_NRD_NRD_1	317	319	PF00675	0.589
CLV_NRD_NRD_1	323	325	PF00675	0.495
CLV_NRD_NRD_1	327	329	PF00675	0.435
CLV_NRD_NRD_1	344	346	PF00675	0.379
CLV_NRD_NRD_1	427	429	PF00675	0.545
CLV_NRD_NRD_1	433	435	PF00675	0.481
CLV_NRD_NRD_1	487	489	PF00675	0.567
CLV_NRD_NRD_1	583	585	PF00675	0.597
CLV_NRD_NRD_1	607	609	PF00675	0.538
CLV_PCSK_FUR_1	251	255	PF00082	0.554
CLV_PCSK_FUR_1	315	319	PF00082	0.534
CLV_PCSK_KEX2_1	126	128	PF00082	0.653
CLV_PCSK_KEX2_1	172	174	PF00082	0.498
CLV_PCSK_KEX2_1	253	255	PF00082	0.563
CLV_PCSK_KEX2_1	262	264	PF00082	0.486
CLV_PCSK_KEX2_1	289	291	PF00082	0.591
CLV_PCSK_KEX2_1	296	298	PF00082	0.581
CLV_PCSK_KEX2_1	317	319	PF00082	0.589
CLV_PCSK_KEX2_1	322	324	PF00082	0.519
CLV_PCSK_KEX2_1	344	346	PF00082	0.554
CLV_PCSK_KEX2_1	422	424	PF00082	0.570
CLV_PCSK_KEX2_1	427	429	PF00082	0.486
CLV_PCSK_KEX2_1	433	435	PF00082	0.422
CLV_PCSK_KEX2_1	448	450	PF00082	0.526
CLV_PCSK_KEX2_1	487	489	PF00082	0.567
CLV_PCSK_KEX2_1	583	585	PF00082	0.597
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.563
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.486
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.591
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.581
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.570
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.662
CLV_PCSK_PC7_1	292	298	PF00082	0.619
CLV_PCSK_PC7_1	318	324	PF00082	0.583
CLV_PCSK_PC7_1	423	429	PF00082	0.557
CLV_PCSK_SKI1_1	328	332	PF00082	0.535
CLV_PCSK_SKI1_1	423	427	PF00082	0.509
CLV_PCSK_SKI1_1	45	49	PF00082	0.450
CLV_PCSK_SKI1_1	495	499	PF00082	0.530
CLV_PCSK_SKI1_1	692	696	PF00082	0.526
DEG_APCC_DBOX_1	422	430	PF00400	0.703
DEG_SCF_FBW7_1	698	704	PF00400	0.769
DEG_SCF_FBW7_1	710	715	PF00400	0.691
DOC_CKS1_1	695	700	PF01111	0.817
DOC_CKS1_1	721	726	PF01111	0.413
DOC_CYCLIN_RxL_1	16	28	PF00134	0.626
DOC_CYCLIN_RxL_1	689	699	PF00134	0.729
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.618
DOC_CYCLIN_yCln2_LP_2	624	627	PF00134	0.663
DOC_MAPK_gen_1	16	25	PF00069	0.627
DOC_MAPK_MEF2A_6	147	156	PF00069	0.801
DOC_MAPK_MEF2A_6	406	413	PF00069	0.785
DOC_MAPK_MEF2A_6	597	604	PF00069	0.733
DOC_PP2B_LxvP_1	23	26	PF13499	0.619
DOC_PP2B_LxvP_1	623	626	PF13499	0.706
DOC_USP7_MATH_1	390	394	PF00917	0.800
DOC_USP7_MATH_1	432	436	PF00917	0.736
DOC_USP7_MATH_1	439	443	PF00917	0.719
DOC_USP7_MATH_1	538	542	PF00917	0.572
DOC_USP7_MATH_1	652	656	PF00917	0.819
DOC_USP7_MATH_1	680	684	PF00917	0.800
DOC_USP7_MATH_1	701	705	PF00917	0.783
DOC_USP7_MATH_1	712	716	PF00917	0.726
DOC_USP7_MATH_1	764	768	PF00917	0.501
DOC_USP7_UBL2_3	170	174	PF12436	0.672
DOC_USP7_UBL2_3	285	289	PF12436	0.843
DOC_USP7_UBL2_3	394	398	PF12436	0.791
DOC_WW_Pin1_4	194	199	PF00397	0.742
DOC_WW_Pin1_4	397	402	PF00397	0.833
DOC_WW_Pin1_4	405	410	PF00397	0.762
DOC_WW_Pin1_4	459	464	PF00397	0.762
DOC_WW_Pin1_4	666	671	PF00397	0.756
DOC_WW_Pin1_4	694	699	PF00397	0.802
DOC_WW_Pin1_4	708	713	PF00397	0.707
DOC_WW_Pin1_4	720	725	PF00397	0.460
LIG_14-3-3_CanoR_1	128	138	PF00244	0.825
LIG_14-3-3_CanoR_1	190	198	PF00244	0.806
LIG_14-3-3_CanoR_1	206	215	PF00244	0.669
LIG_14-3-3_CanoR_1	263	272	PF00244	0.724
LIG_14-3-3_CanoR_1	290	299	PF00244	0.757
LIG_14-3-3_CanoR_1	322	331	PF00244	0.679
LIG_14-3-3_CanoR_1	339	347	PF00244	0.600
LIG_14-3-3_CanoR_1	433	437	PF00244	0.690
LIG_14-3-3_CanoR_1	495	501	PF00244	0.530
LIG_14-3-3_CanoR_1	665	670	PF00244	0.726
LIG_Actin_WH2_2	563	579	PF00022	0.493
LIG_BIR_II_1	1	5	PF00653	0.659
LIG_BIR_III_2	770	774	PF00653	0.547
LIG_BIR_III_4	438	442	PF00653	0.639
LIG_BRCT_BRCA1_1	53	57	PF00533	0.665
LIG_BRCT_BRCA1_1	682	686	PF00533	0.791
LIG_CtBP_PxDLS_1	548	552	PF00389	0.530
LIG_EH1_1	29	37	PF00400	0.621
LIG_eIF4E_1	772	778	PF01652	0.601
LIG_FHA_1	266	272	PF00498	0.679
LIG_FHA_1	325	331	PF00498	0.748
LIG_FHA_1	406	412	PF00498	0.786
LIG_FHA_1	463	469	PF00498	0.821
LIG_FHA_1	569	575	PF00498	0.722
LIG_FHA_1	617	623	PF00498	0.732
LIG_FHA_1	635	641	PF00498	0.518
LIG_FHA_1	75	81	PF00498	0.651
LIG_FHA_1	89	95	PF00498	0.721
LIG_FHA_2	314	320	PF00498	0.766
LIG_FHA_2	371	377	PF00498	0.764
LIG_Integrin_RGD_1	449	451	PF01839	0.635
LIG_Integrin_RGD_1	656	658	PF01839	0.573
LIG_LIR_Gen_1	244	252	PF02991	0.643
LIG_LIR_Gen_1	54	64	PF02991	0.673
LIG_LIR_Gen_1	683	694	PF02991	0.774
LIG_LIR_Nem_3	17	23	PF02991	0.629
LIG_LIR_Nem_3	244	250	PF02991	0.641
LIG_LIR_Nem_3	28	32	PF02991	0.602
LIG_LIR_Nem_3	54	60	PF02991	0.671
LIG_LIR_Nem_3	683	689	PF02991	0.780
LIG_NRBOX	101	107	PF00104	0.786
LIG_NRBOX	619	625	PF00104	0.713
LIG_NRBOX	689	695	PF00104	0.767
LIG_SH2_CRK	348	352	PF00017	0.812
LIG_SH2_STAP1	616	620	PF00017	0.748
LIG_SH2_STAT5	348	351	PF00017	0.809
LIG_SH3_3	110	116	PF00018	0.755
LIG_SH3_3	181	187	PF00018	0.782
LIG_SH3_3	220	226	PF00018	0.787
LIG_SH3_3	463	469	PF00018	0.776
LIG_SH3_3	670	676	PF00018	0.751
LIG_SH3_3	695	701	PF00018	0.766
LIG_SH3_3	718	724	PF00018	0.552
LIG_SH3_CIN85_PxpxPR_1	187	192	PF14604	0.728
LIG_SUMO_SIM_anti_2	566	571	PF11976	0.577
LIG_SUMO_SIM_anti_2	685	691	PF11976	0.677
LIG_SUMO_SIM_par_1	560	566	PF11976	0.452
LIG_WRC_WIRS_1	497	502	PF05994	0.413
MOD_CDC14_SPxK_1	197	200	PF00782	0.804
MOD_CDK_SPK_2	194	199	PF00069	0.799
MOD_CDK_SPxK_1	194	200	PF00069	0.762
MOD_CK1_1	131	137	PF00069	0.834
MOD_CK1_1	202	208	PF00069	0.738
MOD_CK1_1	28	34	PF00069	0.502
MOD_CK1_1	338	344	PF00069	0.695
MOD_CK1_1	397	403	PF00069	0.760
MOD_CK1_1	482	488	PF00069	0.743
MOD_CK1_1	501	507	PF00069	0.293
MOD_CK1_1	668	674	PF00069	0.623
MOD_CK1_1	7	13	PF00069	0.653
MOD_CK1_1	715	721	PF00069	0.787
MOD_CK2_1	278	284	PF00069	0.717
MOD_CK2_1	682	688	PF00069	0.744
MOD_GlcNHglycan	133	136	PF01048	0.708
MOD_GlcNHglycan	162	165	PF01048	0.744
MOD_GlcNHglycan	208	211	PF01048	0.778
MOD_GlcNHglycan	239	242	PF01048	0.689
MOD_GlcNHglycan	273	276	PF01048	0.750
MOD_GlcNHglycan	284	288	PF01048	0.629
MOD_GlcNHglycan	340	343	PF01048	0.681
MOD_GlcNHglycan	351	354	PF01048	0.608
MOD_GlcNHglycan	375	379	PF01048	0.763
MOD_GlcNHglycan	474	477	PF01048	0.770
MOD_GlcNHglycan	534	537	PF01048	0.642
MOD_GlcNHglycan	588	591	PF01048	0.629
MOD_GlcNHglycan	6	9	PF01048	0.534
MOD_GlcNHglycan	649	653	PF01048	0.535
MOD_GlcNHglycan	682	685	PF01048	0.596
MOD_GSK3_1	178	185	PF00069	0.778
MOD_GSK3_1	190	197	PF00069	0.639
MOD_GSK3_1	198	205	PF00069	0.694
MOD_GSK3_1	211	218	PF00069	0.664
MOD_GSK3_1	237	244	PF00069	0.692
MOD_GSK3_1	261	268	PF00069	0.681
MOD_GSK3_1	307	314	PF00069	0.807
MOD_GSK3_1	370	377	PF00069	0.649
MOD_GSK3_1	39	46	PF00069	0.533
MOD_GSK3_1	390	397	PF00069	0.712
MOD_GSK3_1	405	412	PF00069	0.609
MOD_GSK3_1	439	446	PF00069	0.712
MOD_GSK3_1	47	54	PF00069	0.510
MOD_GSK3_1	479	486	PF00069	0.622
MOD_GSK3_1	528	535	PF00069	0.764
MOD_GSK3_1	634	641	PF00069	0.492
MOD_GSK3_1	648	655	PF00069	0.493
MOD_GSK3_1	696	703	PF00069	0.797
MOD_GSK3_1	708	715	PF00069	0.671
MOD_LATS_1	288	294	PF00433	0.648
MOD_N-GLC_1	202	207	PF02516	0.837
MOD_N-GLC_1	416	421	PF02516	0.667
MOD_NEK2_1	178	183	PF00069	0.858
MOD_NEK2_1	307	312	PF00069	0.820
MOD_NEK2_1	404	409	PF00069	0.805
MOD_NEK2_1	43	48	PF00069	0.547
MOD_NEK2_1	453	458	PF00069	0.626
MOD_NEK2_1	498	503	PF00069	0.530
MOD_NEK2_1	528	533	PF00069	0.684
MOD_NEK2_1	576	581	PF00069	0.677
MOD_PIKK_1	217	223	PF00454	0.730
MOD_PIKK_1	440	446	PF00454	0.682
MOD_PIKK_1	518	524	PF00454	0.623
MOD_PKA_1	173	179	PF00069	0.733
MOD_PKA_1	199	205	PF00069	0.709
MOD_PKA_1	261	267	PF00069	0.718
MOD_PKA_1	323	329	PF00069	0.701
MOD_PKA_2	182	188	PF00069	0.816
MOD_PKA_2	198	204	PF00069	0.583
MOD_PKA_2	323	329	PF00069	0.631
MOD_PKA_2	338	344	PF00069	0.447
MOD_PKA_2	39	45	PF00069	0.532
MOD_PKA_2	390	396	PF00069	0.672
MOD_PKA_2	432	438	PF00069	0.606
MOD_PKA_2	480	486	PF00069	0.756
MOD_PKA_2	52	58	PF00069	0.506
MOD_PKA_2	576	582	PF00069	0.766
MOD_PKA_2	74	80	PF00069	0.636
MOD_PKB_1	126	134	PF00069	0.723
MOD_PKB_1	190	198	PF00069	0.707
MOD_PKB_1	261	269	PF00069	0.719
MOD_PKB_1	322	330	PF00069	0.701
MOD_PKB_1	584	592	PF00069	0.616
MOD_Plk_1	638	644	PF00069	0.458
MOD_Plk_2-3	97	103	PF00069	0.728
MOD_Plk_4	211	217	PF00069	0.836
MOD_Plk_4	25	31	PF00069	0.503
MOD_Plk_4	267	273	PF00069	0.561
MOD_Plk_4	409	415	PF00069	0.796
MOD_Plk_4	501	507	PF00069	0.475
MOD_Plk_4	668	674	PF00069	0.698
MOD_Plk_4	682	688	PF00069	0.512
MOD_Plk_4	97	103	PF00069	0.728
MOD_ProDKin_1	194	200	PF00069	0.680
MOD_ProDKin_1	397	403	PF00069	0.806
MOD_ProDKin_1	405	411	PF00069	0.704
MOD_ProDKin_1	459	465	PF00069	0.705
MOD_ProDKin_1	666	672	PF00069	0.701
MOD_ProDKin_1	694	700	PF00069	0.773
MOD_ProDKin_1	708	714	PF00069	0.627
MOD_ProDKin_1	720	726	PF00069	0.285
MOD_SUMO_rev_2	257	264	PF00179	0.692
MOD_SUMO_rev_2	451	459	PF00179	0.723
TRG_DiLeu_BaLyEn_6	689	694	PF01217	0.631
TRG_DiLeu_BaLyEn_6	773	778	PF01217	0.760
TRG_DiLeu_LyEn_5	659	664	PF01217	0.623
TRG_ENDOCYTIC_2	20	23	PF00928	0.523
TRG_ENDOCYTIC_2	247	250	PF00928	0.538
TRG_ENDOCYTIC_2	348	351	PF00928	0.773
TRG_ER_diArg_1	125	128	PF00400	0.712
TRG_ER_diArg_1	13	16	PF00400	0.492
TRG_ER_diArg_1	315	318	PF00400	0.638
TRG_ER_diArg_1	321	324	PF00400	0.569
TRG_ER_diArg_1	343	345	PF00400	0.719
TRG_ER_diArg_1	426	428	PF00400	0.694
TRG_ER_diArg_1	487	490	PF00400	0.707
TRG_ER_diArg_1	574	577	PF00400	0.788
TRG_ER_diArg_1	583	586	PF00400	0.629
TRG_NES_CRM1_1	515	526	PF08389	0.702
TRG_NLS_MonoExtC_3	261	267	PF00514	0.718
TRG_NLS_MonoExtC_3	288	294	PF00514	0.687
TRG_NLS_MonoExtN_4	261	266	PF00514	0.702
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.703
TRG_Pf-PMV_PEXEL_1	642	646	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6F7	Leishmania donovani	99%	100%
A4HL83	Leishmania braziliensis	65%	99%
E9B3M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	97%
Q4Q4G1	Leishmania major	88%	99%