Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8Q9_LEIIN

TriTrypDb:

LINF_330011100

Length:

288

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8Q9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8Q9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.607
CLV_C14_Caspase3-7	99	103	PF00656	0.417
CLV_NRD_NRD_1	133	135	PF00675	0.644
CLV_NRD_NRD_1	138	140	PF00675	0.600
CLV_NRD_NRD_1	248	250	PF00675	0.533
CLV_NRD_NRD_1	53	55	PF00675	0.681
CLV_PCSK_KEX2_1	133	135	PF00082	0.651
CLV_PCSK_KEX2_1	137	139	PF00082	0.609
CLV_PCSK_KEX2_1	148	150	PF00082	0.421
CLV_PCSK_KEX2_1	225	227	PF00082	0.476
CLV_PCSK_KEX2_1	248	250	PF00082	0.533
CLV_PCSK_KEX2_1	53	55	PF00082	0.639
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.509
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.476
CLV_PCSK_PC7_1	133	139	PF00082	0.562
CLV_PCSK_SKI1_1	267	271	PF00082	0.408
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.642
DOC_MAPK_gen_1	225	231	PF00069	0.488
DOC_PP1_RVXF_1	265	272	PF00149	0.482
DOC_PP2B_LxvP_1	112	115	PF13499	0.562
DOC_PP2B_LxvP_1	80	83	PF13499	0.647
DOC_USP7_MATH_1	197	201	PF00917	0.561
DOC_WW_Pin1_4	203	208	PF00397	0.646
LIG_14-3-3_CanoR_1	274	283	PF00244	0.548
LIG_14-3-3_CanoR_1	53	62	PF00244	0.651
LIG_APCC_ABBAyCdc20_2	272	278	PF00400	0.494
LIG_FAT_LD_1	150	158	PF03623	0.465
LIG_FHA_1	186	192	PF00498	0.714
LIG_FHA_1	264	270	PF00498	0.412
LIG_FHA_1	69	75	PF00498	0.650
LIG_FHA_2	185	191	PF00498	0.630
LIG_LIR_Apic_2	155	159	PF02991	0.456
LIG_LIR_Gen_1	6	14	PF02991	0.549
LIG_LIR_Nem_3	6	10	PF02991	0.614
LIG_PCNA_yPIPBox_3	145	154	PF02747	0.473
LIG_PCNA_yPIPBox_3	234	245	PF02747	0.504
LIG_PDZ_Class_3	283	288	PF00595	0.618
LIG_SH2_STAT5	156	159	PF00017	0.474
LIG_SH2_STAT5	9	12	PF00017	0.601
LIG_SH3_1	29	35	PF00018	0.585
LIG_SH3_3	204	210	PF00018	0.633
LIG_SH3_3	29	35	PF00018	0.585
LIG_SUMO_SIM_par_1	69	75	PF11976	0.606
LIG_TRAF2_1	230	233	PF00917	0.531
LIG_WRC_WIRS_1	4	9	PF05994	0.622
MOD_CDK_SPK_2	208	213	PF00069	0.598
MOD_CDK_SPxxK_3	208	215	PF00069	0.592
MOD_CK1_1	200	206	PF00069	0.672
MOD_CK1_1	208	214	PF00069	0.515
MOD_CK1_1	263	269	PF00069	0.542
MOD_GlcNHglycan	193	196	PF01048	0.614
MOD_GlcNHglycan	198	202	PF01048	0.593
MOD_GSK3_1	256	263	PF00069	0.484
MOD_GSK3_1	49	56	PF00069	0.662
MOD_GSK3_1	68	75	PF00069	0.470
MOD_NEK2_1	68	73	PF00069	0.517
MOD_PKA_1	53	59	PF00069	0.677
MOD_PKA_2	260	266	PF00069	0.497
MOD_PKA_2	53	59	PF00069	0.630
MOD_PKB_1	272	280	PF00069	0.501
MOD_Plk_1	256	262	PF00069	0.599
MOD_Plk_1	58	64	PF00069	0.657
MOD_Plk_1	68	74	PF00069	0.586
MOD_Plk_4	152	158	PF00069	0.465
MOD_ProDKin_1	203	209	PF00069	0.639
MOD_SUMO_rev_2	186	194	PF00179	0.603
TRG_DiLeu_BaEn_4	69	75	PF01217	0.508
TRG_ER_diArg_1	133	135	PF00400	0.643
TRG_ER_diArg_1	137	139	PF00400	0.618
TRG_ER_diArg_1	212	215	PF00400	0.582
TRG_ER_diArg_1	248	250	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IHC5	Leishmania donovani	97%	100%
A4HL81	Leishmania braziliensis	66%	100%
E9B3M4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q4G3	Leishmania major	91%	100%