HIG1 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8Q8_LEIIN

TriTrypDb:

LINF_330011000

Length:

216

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4I8Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8Q8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.570
CLV_C14_Caspase3-7	130	134	PF00656	0.555
CLV_NRD_NRD_1	112	114	PF00675	0.608
CLV_NRD_NRD_1	81	83	PF00675	0.675
CLV_PCSK_KEX2_1	112	114	PF00082	0.536
CLV_PCSK_KEX2_1	81	83	PF00082	0.644
DEG_APCC_DBOX_1	136	144	PF00400	0.455
DEG_Nend_Nbox_1	1	3	PF02207	0.634
DOC_CKS1_1	104	109	PF01111	0.549
DOC_USP7_UBL2_3	148	152	PF12436	0.463
DOC_WW_Pin1_4	103	108	PF00397	0.648
DOC_WW_Pin1_4	56	61	PF00397	0.557
LIG_14-3-3_CanoR_1	113	121	PF00244	0.624
LIG_14-3-3_CanoR_1	137	141	PF00244	0.631
LIG_14-3-3_CanoR_1	210	216	PF00244	0.535
LIG_14-3-3_CanoR_1	81	90	PF00244	0.688
LIG_FHA_1	155	161	PF00498	0.536
LIG_FHA_1	32	38	PF00498	0.459
LIG_FHA_2	104	110	PF00498	0.538
LIG_FHA_2	118	124	PF00498	0.486
LIG_FHA_2	128	134	PF00498	0.453
LIG_FHA_2	84	90	PF00498	0.582
LIG_HCF-1_HBM_1	28	31	PF13415	0.425
LIG_LIR_Apic_2	212	216	PF02991	0.676
LIG_LIR_Gen_1	179	188	PF02991	0.507
LIG_LIR_Nem_3	179	185	PF02991	0.532
LIG_LIR_Nem_3	194	200	PF02991	0.491
LIG_Pex14_1	76	80	PF04695	0.614
LIG_SH2_STAP1	47	51	PF00017	0.447
LIG_SH2_STAT3	47	50	PF00017	0.592
LIG_SH3_3	165	171	PF00018	0.523
LIG_SH3_3	3	9	PF00018	0.467
LIG_TRAF2_1	106	109	PF00917	0.543
MOD_CK1_1	117	123	PF00069	0.546
MOD_CK1_1	183	189	PF00069	0.581
MOD_CK2_1	103	109	PF00069	0.582
MOD_CK2_1	71	77	PF00069	0.572
MOD_CMANNOS	76	79	PF00535	0.626
MOD_GlcNHglycan	14	18	PF01048	0.463
MOD_GlcNHglycan	162	165	PF01048	0.565
MOD_GSK3_1	19	26	PF00069	0.463
MOD_N-GLC_1	154	159	PF02516	0.550
MOD_N-GLC_1	180	185	PF02516	0.532
MOD_NEK2_1	127	132	PF00069	0.538
MOD_NEK2_1	160	165	PF00069	0.592
MOD_NEK2_1	19	24	PF00069	0.401
MOD_PIKK_1	114	120	PF00454	0.545
MOD_PIKK_1	83	89	PF00454	0.566
MOD_PK_1	180	186	PF00069	0.605
MOD_PKA_1	81	87	PF00069	0.550
MOD_PKA_2	114	120	PF00069	0.616
MOD_PKA_2	136	142	PF00069	0.635
MOD_PKA_2	20	26	PF00069	0.416
MOD_PKA_2	209	215	PF00069	0.522
MOD_PKA_2	31	37	PF00069	0.412
MOD_PKA_2	81	87	PF00069	0.562
MOD_Plk_1	154	160	PF00069	0.549
MOD_Plk_1	180	186	PF00069	0.529
MOD_Plk_1	71	77	PF00069	0.577
MOD_Plk_2-3	136	142	PF00069	0.608
MOD_Plk_4	155	161	PF00069	0.652
MOD_Plk_4	41	47	PF00069	0.438
MOD_Plk_4	71	77	PF00069	0.637
MOD_ProDKin_1	103	109	PF00069	0.642
MOD_ProDKin_1	56	62	PF00069	0.560
MOD_SUMO_for_1	90	93	PF00179	0.754
MOD_SUMO_rev_2	84	92	PF00179	0.674
TRG_DiLeu_BaEn_4	93	99	PF01217	0.613
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.549
TRG_ER_diArg_1	112	115	PF00400	0.489
TRG_ER_diArg_1	80	82	PF00400	0.677
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYD0	Leptomonas seymouri	75%	99%
A0A0S4KNW6	Bodo saltans	43%	100%
A0A1X0P0X4	Trypanosomatidae	59%	100%
A0A3Q8IHM0	Leishmania donovani	100%	100%
A0A3R7MM31	Trypanosoma rangeli	57%	100%
A4HL80	Leishmania braziliensis	84%	100%
D0A4P6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9B3M3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q4G4	Leishmania major	96%	100%
V5BKE3	Trypanosoma cruzi	53%	100%