Putative serine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase - Clan SC - Family S9D

Species:

Leishmania infantum

UniProt:

A4I8Q4_LEIIN

TriTrypDb:

LINF_330010400

Length:

406

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I8Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8Q4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008474	palmitoyl-(protein) hydrolase activity	3	1
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016790	thiolester hydrolase activity	4	1
GO:0098599	palmitoyl hydrolase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	204	206	PF00675	0.387
CLV_NRD_NRD_1	240	242	PF00675	0.385
CLV_NRD_NRD_1	27	29	PF00675	0.490
CLV_NRD_NRD_1	309	311	PF00675	0.536
CLV_NRD_NRD_1	320	322	PF00675	0.393
CLV_PCSK_KEX2_1	204	206	PF00082	0.387
CLV_PCSK_KEX2_1	240	242	PF00082	0.399
CLV_PCSK_KEX2_1	251	253	PF00082	0.514
CLV_PCSK_KEX2_1	261	263	PF00082	0.581
CLV_PCSK_KEX2_1	29	31	PF00082	0.465
CLV_PCSK_KEX2_1	309	311	PF00082	0.536
CLV_PCSK_KEX2_1	320	322	PF00082	0.393
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.539
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.490
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.444
CLV_PCSK_PC7_1	247	253	PF00082	0.533
CLV_PCSK_SKI1_1	247	251	PF00082	0.496
CLV_PCSK_SKI1_1	258	262	PF00082	0.477
CLV_PCSK_SKI1_1	368	372	PF00082	0.357
CLV_PCSK_SKI1_1	377	381	PF00082	0.526
CLV_PCSK_SKI1_1	384	388	PF00082	0.722
CLV_PCSK_SKI1_1	394	398	PF00082	0.548
DEG_Nend_Nbox_1	1	3	PF02207	0.450
DOC_MAPK_gen_1	164	174	PF00069	0.327
DOC_MAPK_gen_1	28	34	PF00069	0.468
DOC_MAPK_gen_1	62	72	PF00069	0.435
DOC_MAPK_MEF2A_6	65	72	PF00069	0.434
DOC_MAPK_NFAT4_5	65	73	PF00069	0.340
DOC_PP4_FxxP_1	11	14	PF00568	0.412
DOC_USP7_MATH_1	260	264	PF00917	0.656
DOC_USP7_MATH_1	332	336	PF00917	0.501
DOC_USP7_MATH_1	390	394	PF00917	0.668
DOC_USP7_UBL2_3	164	168	PF12436	0.365
DOC_USP7_UBL2_3	261	265	PF12436	0.497
DOC_USP7_UBL2_3	274	278	PF12436	0.511
DOC_WW_Pin1_4	113	118	PF00397	0.297
LIG_14-3-3_CanoR_1	183	193	PF00244	0.484
LIG_14-3-3_CanoR_1	240	249	PF00244	0.415
LIG_14-3-3_CanoR_1	30	35	PF00244	0.490
LIG_14-3-3_CanoR_1	368	375	PF00244	0.379
LIG_14-3-3_CanoR_1	42	46	PF00244	0.364
LIG_14-3-3_CanoR_1	62	72	PF00244	0.254
LIG_Actin_WH2_2	168	185	PF00022	0.337
LIG_AP2alpha_1	359	363	PF02296	0.382
LIG_BRCT_BRCA1_1	359	363	PF00533	0.455
LIG_BRCT_BRCA1_1	7	11	PF00533	0.418
LIG_FHA_1	177	183	PF00498	0.415
LIG_FHA_2	114	120	PF00498	0.423
LIG_FHA_2	356	362	PF00498	0.373
LIG_HCF-1_HBM_1	130	133	PF13415	0.413
LIG_LIR_Apic_2	8	14	PF02991	0.419
LIG_LIR_Gen_1	130	141	PF02991	0.479
LIG_LIR_Gen_1	358	367	PF02991	0.488
LIG_LIR_Nem_3	102	106	PF02991	0.337
LIG_LIR_Nem_3	130	136	PF02991	0.360
LIG_LIR_Nem_3	198	203	PF02991	0.451
LIG_LIR_Nem_3	303	308	PF02991	0.403
LIG_LIR_Nem_3	360	366	PF02991	0.461
LIG_LIR_Nem_3	44	48	PF02991	0.358
LIG_MAD2	183	191	PF02301	0.473
LIG_NRBOX	244	250	PF00104	0.514
LIG_PCNA_yPIPBox_3	240	249	PF02747	0.426
LIG_Pex14_2	339	343	PF04695	0.387
LIG_Pex14_2	359	363	PF04695	0.249
LIG_Pex14_2	369	373	PF04695	0.243
LIG_RPA_C_Fungi	236	248	PF08784	0.494
LIG_SH2_CRK	312	316	PF00017	0.443
LIG_SH2_NCK_1	126	130	PF00017	0.337
LIG_SH2_STAP1	133	137	PF00017	0.491
LIG_SH2_STAP1	86	90	PF00017	0.414
LIG_SH2_STAT5	103	106	PF00017	0.486
LIG_SH2_STAT5	160	163	PF00017	0.337
LIG_SH2_STAT5	365	368	PF00017	0.457
LIG_SH2_STAT5	45	48	PF00017	0.396
LIG_SH3_3	7	13	PF00018	0.425
LIG_SUMO_SIM_par_1	171	177	PF11976	0.337
LIG_WRC_WIRS_1	175	180	PF05994	0.337
LIG_WW_3	12	16	PF00397	0.466
MOD_CK1_1	124	130	PF00069	0.388
MOD_CK1_1	176	182	PF00069	0.359
MOD_CK1_1	33	39	PF00069	0.506
MOD_CK2_1	113	119	PF00069	0.352
MOD_GlcNHglycan	108	111	PF01048	0.376
MOD_GlcNHglycan	242	245	PF01048	0.355
MOD_GlcNHglycan	279	282	PF01048	0.636
MOD_GlcNHglycan	38	41	PF01048	0.520
MOD_GlcNHglycan	381	384	PF01048	0.524
MOD_GSK3_1	1	8	PF00069	0.417
MOD_GSK3_1	173	180	PF00069	0.353
MOD_GSK3_1	273	280	PF00069	0.727
MOD_GSK3_1	32	39	PF00069	0.505
MOD_GSK3_1	82	89	PF00069	0.413
MOD_N-GLC_1	274	279	PF02516	0.641
MOD_N-GLC_1	332	337	PF02516	0.346
MOD_NEK2_1	1	6	PF00069	0.454
MOD_NEK2_1	174	179	PF00069	0.373
MOD_NEK2_1	32	37	PF00069	0.492
MOD_NEK2_1	327	332	PF00069	0.602
MOD_OFUCOSY	181	188	PF10250	0.522
MOD_PKA_1	240	246	PF00069	0.358
MOD_PKA_1	261	267	PF00069	0.554
MOD_PKA_2	240	246	PF00069	0.416
MOD_PKA_2	261	267	PF00069	0.668
MOD_PKA_2	41	47	PF00069	0.446
MOD_PKA_2	64	70	PF00069	0.444
MOD_PKB_1	28	36	PF00069	0.440
MOD_Plk_1	121	127	PF00069	0.337
MOD_Plk_1	332	338	PF00069	0.452
MOD_Plk_2-3	300	306	PF00069	0.436
MOD_Plk_2-3	355	361	PF00069	0.385
MOD_Plk_4	1	7	PF00069	0.444
MOD_Plk_4	121	127	PF00069	0.337
MOD_Plk_4	300	306	PF00069	0.568
MOD_Plk_4	64	70	PF00069	0.391
MOD_ProDKin_1	113	119	PF00069	0.297
TRG_DiLeu_BaEn_1	211	216	PF01217	0.378
TRG_DiLeu_BaEn_1	376	381	PF01217	0.513
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.505
TRG_ENDOCYTIC_2	133	136	PF00928	0.351
TRG_ENDOCYTIC_2	203	206	PF00928	0.459
TRG_ENDOCYTIC_2	312	315	PF00928	0.436
TRG_ENDOCYTIC_2	45	48	PF00928	0.471
TRG_ER_diArg_1	203	205	PF00400	0.398
TRG_ER_diArg_1	308	310	PF00400	0.598
TRG_ER_diArg_1	319	321	PF00400	0.382
TRG_NES_CRM1_1	88	102	PF08389	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M6	Leptomonas seymouri	56%	100%
A0A3S7X6G6	Leishmania donovani	100%	100%
A4HL75	Leishmania braziliensis	74%	100%
E9B3L8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q4J7	Leishmania major	92%	100%