Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8Q3_LEIIN

TriTrypDb:

LINF_330010300

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8Q3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	166	168	PF00675	0.675
CLV_NRD_NRD_1	228	230	PF00675	0.484
CLV_NRD_NRD_1	40	42	PF00675	0.500
CLV_NRD_NRD_1	79	81	PF00675	0.651
CLV_PCSK_KEX2_1	166	168	PF00082	0.675
CLV_PCSK_KEX2_1	228	230	PF00082	0.552
CLV_PCSK_KEX2_1	238	240	PF00082	0.542
CLV_PCSK_KEX2_1	353	355	PF00082	0.498
CLV_PCSK_KEX2_1	39	41	PF00082	0.495
CLV_PCSK_KEX2_1	79	81	PF00082	0.651
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.542
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.498
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.480
CLV_PCSK_SKI1_1	257	261	PF00082	0.423
CLV_PCSK_SKI1_1	302	306	PF00082	0.462
CLV_PCSK_SKI1_1	353	357	PF00082	0.485
DEG_ODPH_VHL_1	271	283	PF01847	0.500
DEG_SPOP_SBC_1	62	66	PF00917	0.695
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	54	60	PF00134	0.602
DOC_MAPK_gen_1	39	48	PF00069	0.594
DOC_MAPK_MEF2A_6	29	37	PF00069	0.588
DOC_PP2B_LxvP_1	252	255	PF13499	0.475
DOC_PP2B_LxvP_1	54	57	PF13499	0.626
DOC_PP4_FxxP_1	346	349	PF00568	0.366
DOC_USP7_MATH_1	128	132	PF00917	0.761
DOC_USP7_MATH_1	160	164	PF00917	0.663
DOC_USP7_MATH_1	169	173	PF00917	0.754
DOC_USP7_MATH_1	215	219	PF00917	0.499
DOC_USP7_MATH_1	246	250	PF00917	0.539
DOC_USP7_MATH_1	62	66	PF00917	0.762
DOC_USP7_UBL2_3	238	242	PF12436	0.539
DOC_USP7_UBL2_3	298	302	PF12436	0.467
DOC_WW_Pin1_4	150	155	PF00397	0.698
DOC_WW_Pin1_4	167	172	PF00397	0.588
DOC_WW_Pin1_4	179	184	PF00397	0.679
DOC_WW_Pin1_4	213	218	PF00397	0.597
DOC_WW_Pin1_4	359	364	PF00397	0.600
DOC_WW_Pin1_4	86	91	PF00397	0.698
LIG_14-3-3_CanoR_1	102	108	PF00244	0.612
LIG_14-3-3_CanoR_1	129	138	PF00244	0.553
LIG_14-3-3_CanoR_1	141	149	PF00244	0.653
LIG_14-3-3_CanoR_1	232	240	PF00244	0.556
LIG_14-3-3_CanoR_1	91	97	PF00244	0.596
LIG_BIR_II_1	1	5	PF00653	0.654
LIG_BIR_III_4	6	10	PF00653	0.470
LIG_eIF4E_1	21	27	PF01652	0.500
LIG_FHA_1	303	309	PF00498	0.399
LIG_FHA_1	49	55	PF00498	0.526
LIG_FHA_1	62	68	PF00498	0.660
LIG_FHA_2	10	16	PF00498	0.581
LIG_FHA_2	130	136	PF00498	0.601
LIG_FHA_2	214	220	PF00498	0.608
LIG_FHA_2	283	289	PF00498	0.397
LIG_IRF3_LxIS_1	184	191	PF10401	0.626
LIG_LIR_Apic_2	345	349	PF02991	0.364
LIG_LIR_Gen_1	28	37	PF02991	0.479
LIG_LIR_Gen_1	330	339	PF02991	0.433
LIG_LIR_Nem_3	28	33	PF02991	0.536
LIG_LIR_Nem_3	330	336	PF02991	0.422
LIG_LIR_Nem_3	42	48	PF02991	0.489
LIG_Pex14_2	346	350	PF04695	0.377
LIG_SH2_CRK	204	208	PF00017	0.543
LIG_SH2_CRK	268	272	PF00017	0.384
LIG_SH2_CRK	30	34	PF00017	0.462
LIG_SH2_CRK	58	62	PF00017	0.610
LIG_SH2_GRB2like	310	313	PF00017	0.389
LIG_SH2_NCK_1	221	225	PF00017	0.632
LIG_SH2_SRC	21	24	PF00017	0.638
LIG_SH2_STAP1	17	21	PF00017	0.521
LIG_SH2_STAP1	221	225	PF00017	0.632
LIG_SH2_STAP1	58	62	PF00017	0.640
LIG_SH2_STAT5	21	24	PF00017	0.535
LIG_SH2_STAT5	293	296	PF00017	0.377
LIG_SH2_STAT5	344	347	PF00017	0.364
LIG_SH3_3	214	220	PF00018	0.602
LIG_SH3_3	240	246	PF00018	0.533
LIG_SH3_3	274	280	PF00018	0.506
LIG_SH3_3	358	364	PF00018	0.547
LIG_SUMO_SIM_par_1	279	285	PF11976	0.530
LIG_TYR_ITIM	56	61	PF00017	0.635
LIG_UBA3_1	307	316	PF00899	0.502
LIG_WRC_WIRS_1	343	348	PF05994	0.354
MOD_CDK_SPK_2	86	91	PF00069	0.658
MOD_CK1_1	103	109	PF00069	0.638
MOD_CK1_1	172	178	PF00069	0.802
MOD_CK1_1	49	55	PF00069	0.652
MOD_CK1_1	75	81	PF00069	0.757
MOD_CK1_1	89	95	PF00069	0.599
MOD_CK2_1	129	135	PF00069	0.629
MOD_CK2_1	281	287	PF00069	0.405
MOD_CK2_1	324	330	PF00069	0.518
MOD_GlcNHglycan	1	4	PF01048	0.588
MOD_GlcNHglycan	109	112	PF01048	0.747
MOD_GlcNHglycan	121	124	PF01048	0.578
MOD_GlcNHglycan	163	166	PF01048	0.675
MOD_GlcNHglycan	171	174	PF01048	0.753
MOD_GlcNHglycan	190	193	PF01048	0.623
MOD_GlcNHglycan	246	249	PF01048	0.543
MOD_GlcNHglycan	51	54	PF01048	0.599
MOD_GlcNHglycan	74	77	PF01048	0.611
MOD_GSK3_1	103	110	PF00069	0.684
MOD_GSK3_1	115	122	PF00069	0.612
MOD_GSK3_1	161	168	PF00069	0.698
MOD_GSK3_1	44	51	PF00069	0.494
MOD_GSK3_1	68	75	PF00069	0.764
MOD_N-GLC_2	124	126	PF02516	0.644
MOD_N-GLC_2	312	314	PF02516	0.439
MOD_NEK2_1	100	105	PF00069	0.780
MOD_NEK2_1	107	112	PF00069	0.684
MOD_NEK2_1	155	160	PF00069	0.615
MOD_NEK2_1	234	239	PF00069	0.505
MOD_NEK2_1	267	272	PF00069	0.399
MOD_NEK2_1	324	329	PF00069	0.464
MOD_NEK2_1	46	51	PF00069	0.536
MOD_NEK2_1	61	66	PF00069	0.570
MOD_NEK2_2	9	14	PF00069	0.569
MOD_PIKK_1	46	52	PF00454	0.588
MOD_PKA_2	103	109	PF00069	0.652
MOD_PKA_2	128	134	PF00069	0.530
MOD_PKA_2	160	166	PF00069	0.675
MOD_Plk_1	322	328	PF00069	0.461
MOD_Plk_2-3	334	340	PF00069	0.457
MOD_ProDKin_1	150	156	PF00069	0.696
MOD_ProDKin_1	167	173	PF00069	0.590
MOD_ProDKin_1	179	185	PF00069	0.680
MOD_ProDKin_1	213	219	PF00069	0.591
MOD_ProDKin_1	359	365	PF00069	0.601
MOD_ProDKin_1	86	92	PF00069	0.696
MOD_SUMO_rev_2	231	240	PF00179	0.504
TRG_ENDOCYTIC_2	10	13	PF00928	0.597
TRG_ENDOCYTIC_2	204	207	PF00928	0.541
TRG_ENDOCYTIC_2	268	271	PF00928	0.388
TRG_ENDOCYTIC_2	293	296	PF00928	0.377
TRG_ENDOCYTIC_2	30	33	PF00928	0.335
TRG_ENDOCYTIC_2	58	61	PF00928	0.640
TRG_ER_diArg_1	140	143	PF00400	0.610
TRG_ER_diArg_1	195	198	PF00400	0.715
TRG_NLS_MonoExtN_4	349	356	PF00514	0.459
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P717	Leptomonas seymouri	52%	100%
A0A3Q8IJX1	Leishmania donovani	100%	100%
A4HL74	Leishmania braziliensis	67%	100%
E9B3L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q4G8	Leishmania major	90%	100%