Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8Q2_LEIIN

TriTrypDb:

LINF_330010200

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I8Q2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8Q2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	220	222	PF00675	0.508
CLV_PCSK_KEX2_1	219	221	PF00082	0.421
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.421
CLV_PCSK_SKI1_1	140	144	PF00082	0.455
CLV_PCSK_SKI1_1	208	212	PF00082	0.438
CLV_PCSK_SKI1_1	240	244	PF00082	0.509
CLV_PCSK_SKI1_1	288	292	PF00082	0.512
DEG_Nend_Nbox_1	1	3	PF02207	0.452
DOC_CYCLIN_RxL_1	299	310	PF00134	0.353
DOC_MAPK_DCC_7	24	34	PF00069	0.514
DOC_MAPK_gen_1	3	12	PF00069	0.508
DOC_MAPK_MEF2A_6	148	156	PF00069	0.424
DOC_PP1_RVXF_1	268	274	PF00149	0.318
DOC_PP2B_LxvP_1	179	182	PF13499	0.381
DOC_PP2B_LxvP_1	32	35	PF13499	0.494
DOC_PP2B_LxvP_1	42	45	PF13499	0.456
DOC_PP4_FxxP_1	273	276	PF00568	0.294
DOC_USP7_MATH_1	147	151	PF00917	0.390
DOC_USP7_UBL2_3	215	219	PF12436	0.415
DOC_WW_Pin1_4	158	163	PF00397	0.533
DOC_WW_Pin1_4	69	74	PF00397	0.655
LIG_14-3-3_CanoR_1	208	217	PF00244	0.426
LIG_14-3-3_CanoR_1	220	228	PF00244	0.383
LIG_14-3-3_CanoR_1	68	73	PF00244	0.647
LIG_14-3-3_CanoR_1	90	95	PF00244	0.552
LIG_Actin_WH2_2	126	142	PF00022	0.234
LIG_BIR_III_2	235	239	PF00653	0.472
LIG_CtBP_PxDLS_1	35	39	PF00389	0.300
LIG_deltaCOP1_diTrp_1	278	286	PF00928	0.380
LIG_eIF4E_1	4	10	PF01652	0.542
LIG_EVH1_1	179	183	PF00568	0.485
LIG_FHA_1	205	211	PF00498	0.557
LIG_FHA_1	257	263	PF00498	0.464
LIG_FHA_1	78	84	PF00498	0.680
LIG_FHA_1	91	97	PF00498	0.493
LIG_FHA_2	183	189	PF00498	0.381
LIG_FHA_2	220	226	PF00498	0.327
LIG_GBD_Chelix_1	300	308	PF00786	0.373
LIG_LIR_Apic_2	175	180	PF02991	0.374
LIG_LIR_Gen_1	188	197	PF02991	0.351
LIG_LIR_Gen_1	222	232	PF02991	0.349
LIG_LIR_Gen_1	295	306	PF02991	0.377
LIG_LIR_Gen_1	49	57	PF02991	0.483
LIG_LIR_Nem_3	188	193	PF02991	0.358
LIG_LIR_Nem_3	222	227	PF02991	0.346
LIG_LIR_Nem_3	278	284	PF02991	0.378
LIG_LIR_Nem_3	295	301	PF02991	0.477
LIG_LIR_Nem_3	315	320	PF02991	0.395
LIG_LIR_Nem_3	49	53	PF02991	0.454
LIG_PDZ_Class_2	321	326	PF00595	0.519
LIG_Pex14_2	227	231	PF04695	0.307
LIG_REV1ctd_RIR_1	228	237	PF16727	0.336
LIG_SH2_CRK	177	181	PF00017	0.365
LIG_SH2_CRK	298	302	PF00017	0.451
LIG_SH2_CRK	92	96	PF00017	0.485
LIG_SH2_GRB2like	50	53	PF00017	0.558
LIG_SH2_NCK_1	317	321	PF00017	0.493
LIG_SH2_PTP2	50	53	PF00017	0.471
LIG_SH2_SRC	50	53	PF00017	0.471
LIG_SH2_STAT3	4	7	PF00017	0.548
LIG_SH2_STAT5	118	121	PF00017	0.389
LIG_SH2_STAT5	171	174	PF00017	0.409
LIG_SH2_STAT5	229	232	PF00017	0.384
LIG_SH2_STAT5	307	310	PF00017	0.419
LIG_SH2_STAT5	50	53	PF00017	0.494
LIG_SH2_STAT5	92	95	PF00017	0.572
LIG_SH3_1	177	183	PF00018	0.491
LIG_SH3_2	238	243	PF14604	0.478
LIG_SH3_3	177	183	PF00018	0.468
LIG_SH3_3	23	29	PF00018	0.476
LIG_SH3_3	235	241	PF00018	0.456
LIG_SH3_3	317	323	PF00018	0.451
LIG_TYR_ITIM	296	301	PF00017	0.471
LIG_WW_1	276	279	PF00397	0.347
MOD_CDK_SPK_2	158	163	PF00069	0.524
MOD_CK1_1	64	70	PF00069	0.636
MOD_CK1_1	72	78	PF00069	0.782
MOD_CK2_1	182	188	PF00069	0.396
MOD_CK2_1	219	225	PF00069	0.360
MOD_GlcNHglycan	248	251	PF01048	0.387
MOD_GlcNHglycan	309	312	PF01048	0.382
MOD_GSK3_1	204	211	PF00069	0.405
MOD_GSK3_1	64	71	PF00069	0.607
MOD_GSK3_1	73	80	PF00069	0.773
MOD_N-GLC_1	204	209	PF02516	0.451
MOD_NEK2_1	112	117	PF00069	0.510
MOD_NEK2_1	306	311	PF00069	0.501
MOD_PIKK_1	219	225	PF00454	0.375
MOD_PIKK_1	244	250	PF00454	0.505
MOD_PKA_1	219	225	PF00069	0.375
MOD_PKA_2	113	119	PF00069	0.461
MOD_PKA_2	2	8	PF00069	0.456
MOD_PKA_2	219	225	PF00069	0.405
MOD_Plk_1	204	210	PF00069	0.461
MOD_Plk_4	134	140	PF00069	0.372
MOD_ProDKin_1	158	164	PF00069	0.528
MOD_ProDKin_1	69	75	PF00069	0.659
MOD_SUMO_rev_2	200	207	PF00179	0.445
TRG_AP2beta_CARGO_1	225	234	PF09066	0.302
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.428
TRG_ENDOCYTIC_2	280	283	PF00928	0.384
TRG_ENDOCYTIC_2	298	301	PF00928	0.316
TRG_ENDOCYTIC_2	317	320	PF00928	0.441
TRG_ENDOCYTIC_2	50	53	PF00928	0.531
TRG_ER_diArg_1	152	155	PF00400	0.391
TRG_ER_diArg_1	21	24	PF00400	0.483
TRG_NLS_MonoCore_2	217	222	PF00514	0.519
TRG_NLS_MonoExtN_4	215	222	PF00514	0.420
TRG_Pf-PMV_PEXEL_1	131	136	PF00026	0.300
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I000	Leptomonas seymouri	75%	70%
A0A0S4IZ12	Bodo saltans	43%	89%
A0A1X0P257	Trypanosomatidae	46%	93%
A0A3Q8IGF0	Leishmania donovani	99%	100%
A0A3R7L0A9	Trypanosoma rangeli	46%	93%
A4HL73	Leishmania braziliensis	86%	100%
D0A4N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	96%
E9B3L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q4G9	Leishmania major	95%	100%
V5BFU1	Trypanosoma cruzi	50%	94%