Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4I8Q1_LEIIN

TriTrypDb:

LINF_330010100

Length:

728

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	5
GO:0032991	protein-containing complex	1	5
GO:0043226	organelle	2	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:1990904	ribonucleoprotein complex	2	5
GO:0000151	ubiquitin ligase complex	3	1
GO:0000152	nuclear ubiquitin ligase complex	3	1
GO:0005680	anaphase-promoting complex	4	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4I8Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8Q1

Function

Biological processes
Term	Name	Level	Count
GO:0009893	positive regulation of metabolic process	4	7
GO:0010604	positive regulation of macromolecule metabolic process	5	7
GO:0019222	regulation of metabolic process	3	7
GO:0031396	regulation of protein ubiquitination	8	6
GO:0031398	positive regulation of protein ubiquitination	9	6
GO:0031399	regulation of protein modification process	6	6
GO:0031401	positive regulation of protein modification process	7	6
GO:0043085	positive regulation of catalytic activity	4	6
GO:0044093	positive regulation of molecular function	3	6
GO:0048518	positive regulation of biological process	3	7
GO:0050789	regulation of biological process	2	7
GO:0050790	regulation of catalytic activity	3	6
GO:0051171	regulation of nitrogen compound metabolic process	4	7
GO:0051173	positive regulation of nitrogen compound metabolic process	5	7
GO:0051246	regulation of protein metabolic process	5	7
GO:0051247	positive regulation of protein metabolic process	6	7
GO:0051338	regulation of transferase activity	4	6
GO:0051347	positive regulation of transferase activity	5	6
GO:0051438	regulation of ubiquitin-protein transferase activity	5	6
GO:0051443	positive regulation of ubiquitin-protein transferase activity	6	6
GO:0060255	regulation of macromolecule metabolic process	4	7
GO:0065007	biological regulation	1	7
GO:0065009	regulation of molecular function	2	6
GO:0080090	regulation of primary metabolic process	4	7
GO:1903320	regulation of protein modification by small protein conjugation or removal	7	6
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	8	6
GO:1904666	regulation of ubiquitin protein ligase activity	6	6
GO:1904668	positive regulation of ubiquitin protein ligase activity	7	6
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009896	positive regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030162	regulation of proteolysis	6	1
GO:0030163	protein catabolic process	4	1
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031331	positive regulation of cellular catabolic process	6	1
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	8	1
GO:0042176	regulation of protein catabolic process	5	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0045732	positive regulation of protein catabolic process	6	1
GO:0045862	positive regulation of proteolysis	7	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050794	regulation of cellular process	3	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0061136	regulation of proteasomal protein catabolic process	6	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901800	positive regulation of proteasomal protein catabolic process	7	1
GO:1903050	regulation of proteolysis involved in protein catabolic process	7	1
GO:1903052	positive regulation of proteolysis involved in protein catabolic process	8	1
GO:1905784	regulation of anaphase-promoting complex-dependent catabolic process	8	1
GO:1905786	positive regulation of anaphase-promoting complex-dependent catabolic process	9	1
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	6	1
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0008047	enzyme activator activity	3	7
GO:0010997	anaphase-promoting complex binding	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0044877	protein-containing complex binding	2	7
GO:0055106	ubiquitin-protein transferase regulator activity	3	7
GO:0097027	ubiquitin-protein transferase activator activity	4	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7
GO:1990757	ubiquitin ligase activator activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	436	440	PF00656	0.567
CLV_MEL_PAP_1	85	91	PF00089	0.729
CLV_NRD_NRD_1	273	275	PF00675	0.799
CLV_NRD_NRD_1	37	39	PF00675	0.734
CLV_NRD_NRD_1	45	47	PF00675	0.734
CLV_NRD_NRD_1	535	537	PF00675	0.521
CLV_NRD_NRD_1	644	646	PF00675	0.488
CLV_NRD_NRD_1	706	708	PF00675	0.818
CLV_NRD_NRD_1	74	76	PF00675	0.761
CLV_PCSK_KEX2_1	273	275	PF00082	0.799
CLV_PCSK_KEX2_1	37	39	PF00082	0.734
CLV_PCSK_KEX2_1	45	47	PF00082	0.734
CLV_PCSK_KEX2_1	535	537	PF00082	0.521
CLV_PCSK_KEX2_1	561	563	PF00082	0.527
CLV_PCSK_KEX2_1	583	585	PF00082	0.640
CLV_PCSK_KEX2_1	706	708	PF00082	0.653
CLV_PCSK_KEX2_1	74	76	PF00082	0.761
CLV_PCSK_PC1ET2_1	561	563	PF00082	0.527
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.640
CLV_PCSK_PC7_1	41	47	PF00082	0.731
CLV_PCSK_PC7_1	702	708	PF00082	0.639
CLV_PCSK_SKI1_1	139	143	PF00082	0.814
CLV_PCSK_SKI1_1	225	229	PF00082	0.659
CLV_PCSK_SKI1_1	27	31	PF00082	0.655
CLV_PCSK_SKI1_1	308	312	PF00082	0.711
CLV_PCSK_SKI1_1	49	53	PF00082	0.829
CLV_PCSK_SKI1_1	493	497	PF00082	0.511
CLV_PCSK_SKI1_1	541	545	PF00082	0.500
CLV_PCSK_SKI1_1	564	568	PF00082	0.466
CLV_Separin_Metazoa	279	283	PF03568	0.773
DEG_Kelch_Keap1_1	403	408	PF01344	0.613
DEG_Nend_UBRbox_3	1	3	PF02207	0.701
DEG_SCF_FBW7_1	165	170	PF00400	0.708
DEG_SPOP_SBC_1	108	112	PF00917	0.681
DOC_ANK_TNKS_1	261	268	PF00023	0.679
DOC_CKS1_1	227	232	PF01111	0.706
DOC_CKS1_1	57	62	PF01111	0.744
DOC_MAPK_gen_1	454	464	PF00069	0.483
DOC_MAPK_gen_1	637	644	PF00069	0.498
DOC_PP1_RVXF_1	420	427	PF00149	0.423
DOC_PP2B_LxvP_1	370	373	PF13499	0.507
DOC_PP4_FxxP_1	656	659	PF00568	0.517
DOC_USP7_MATH_1	108	112	PF00917	0.763
DOC_USP7_MATH_1	13	17	PF00917	0.738
DOC_USP7_MATH_1	147	151	PF00917	0.627
DOC_USP7_MATH_1	215	219	PF00917	0.685
DOC_USP7_MATH_1	36	40	PF00917	0.629
DOC_USP7_MATH_1	475	479	PF00917	0.454
DOC_USP7_MATH_2	301	307	PF00917	0.728
DOC_WW_Pin1_4	111	116	PF00397	0.754
DOC_WW_Pin1_4	139	144	PF00397	0.813
DOC_WW_Pin1_4	163	168	PF00397	0.711
DOC_WW_Pin1_4	226	231	PF00397	0.712
DOC_WW_Pin1_4	248	253	PF00397	0.592
DOC_WW_Pin1_4	297	302	PF00397	0.676
DOC_WW_Pin1_4	362	367	PF00397	0.498
DOC_WW_Pin1_4	536	541	PF00397	0.527
DOC_WW_Pin1_4	56	61	PF00397	0.736
DOC_WW_Pin1_4	710	715	PF00397	0.738
DOC_WW_Pin1_4	9	14	PF00397	0.713
LIG_14-3-3_CanoR_1	225	230	PF00244	0.686
LIG_14-3-3_CanoR_1	262	269	PF00244	0.604
LIG_14-3-3_CanoR_1	308	313	PF00244	0.709
LIG_14-3-3_CanoR_1	360	366	PF00244	0.508
LIG_14-3-3_CanoR_1	448	453	PF00244	0.465
LIG_14-3-3_CanoR_1	535	540	PF00244	0.632
LIG_14-3-3_CanoR_1	612	620	PF00244	0.486
LIG_14-3-3_CanoR_1	645	651	PF00244	0.505
LIG_14-3-3_CanoR_1	74	78	PF00244	0.838
LIG_Actin_WH2_2	292	310	PF00022	0.683
LIG_BRCT_BRCA1_1	562	566	PF00533	0.492
LIG_EH1_1	617	625	PF00400	0.587
LIG_FHA_1	316	322	PF00498	0.686
LIG_FHA_1	378	384	PF00498	0.483
LIG_FHA_1	439	445	PF00498	0.403
LIG_FHA_1	52	58	PF00498	0.696
LIG_FHA_1	609	615	PF00498	0.505
LIG_FHA_1	647	653	PF00498	0.444
LIG_FHA_2	285	291	PF00498	0.699
LIG_FHA_2	362	368	PF00498	0.503
LIG_FHA_2	38	44	PF00498	0.832
LIG_FHA_2	565	571	PF00498	0.466
LIG_FHA_2	588	594	PF00498	0.784
LIG_IBAR_NPY_1	129	131	PF08397	0.792
LIG_LIR_Apic_2	655	659	PF02991	0.499
LIG_LIR_Gen_1	188	199	PF02991	0.604
LIG_LIR_Gen_1	449	459	PF02991	0.593
LIG_LIR_Gen_1	648	658	PF02991	0.494
LIG_LIR_Gen_1	96	105	PF02991	0.695
LIG_LIR_Nem_3	188	194	PF02991	0.599
LIG_LIR_Nem_3	449	455	PF02991	0.597
LIG_LIR_Nem_3	648	653	PF02991	0.512
LIG_LIR_Nem_3	685	691	PF02991	0.466
LIG_MAD2	368	376	PF02301	0.458
LIG_MAD2	707	715	PF02301	0.598
LIG_PCNA_yPIPBox_3	612	624	PF02747	0.595
LIG_Pex14_2	688	692	PF04695	0.474
LIG_PTB_Apo_2	506	513	PF02174	0.559
LIG_PTB_Phospho_1	506	512	PF10480	0.559
LIG_RPA_C_Fungi	443	455	PF08784	0.523
LIG_SH2_STAP1	159	163	PF00017	0.819
LIG_SH2_STAP1	223	227	PF00017	0.812
LIG_SH2_STAT5	347	350	PF00017	0.630
LIG_SH2_STAT5	512	515	PF00017	0.411
LIG_SH2_STAT5	519	522	PF00017	0.411
LIG_SH2_STAT5	609	612	PF00017	0.479
LIG_SH3_2	373	378	PF14604	0.644
LIG_SH3_3	162	168	PF00018	0.621
LIG_SH3_3	246	252	PF00018	0.596
LIG_SH3_3	295	301	PF00018	0.732
LIG_SH3_3	370	376	PF00018	0.516
LIG_SH3_3	453	459	PF00018	0.492
LIG_SH3_3	466	472	PF00018	0.472
LIG_SH3_3	50	56	PF00018	0.821
LIG_SUMO_SIM_par_1	410	416	PF11976	0.445
LIG_SUMO_SIM_par_1	472	478	PF11976	0.494
LIG_TRAF2_1	592	595	PF00917	0.682
LIG_TRAF2_1	672	675	PF00917	0.571
LIG_WRC_WIRS_1	172	177	PF05994	0.716
LIG_WRC_WIRS_1	653	658	PF05994	0.471
LIG_WRC_WIRS_1	95	100	PF05994	0.697
LIG_WW_3	291	295	PF00397	0.524
MOD_CDC14_SPxK_1	114	117	PF00782	0.727
MOD_CDK_SPK_2	536	541	PF00069	0.527
MOD_CDK_SPxK_1	111	117	PF00069	0.721
MOD_CDK_SPxK_1	362	368	PF00069	0.503
MOD_CDK_SPxK_1	56	62	PF00069	0.739
MOD_CK1_1	111	117	PF00069	0.799
MOD_CK1_1	12	18	PF00069	0.723
MOD_CK1_1	170	176	PF00069	0.754
MOD_CK1_1	178	184	PF00069	0.758
MOD_CK1_1	185	191	PF00069	0.633
MOD_CK1_1	20	26	PF00069	0.720
MOD_CK1_1	349	355	PF00069	0.533
MOD_CK1_1	377	383	PF00069	0.515
MOD_CK1_1	39	45	PF00069	0.519
MOD_CK1_1	398	404	PF00069	0.462
MOD_CK1_1	447	453	PF00069	0.543
MOD_CK1_1	525	531	PF00069	0.471
MOD_CK1_1	666	672	PF00069	0.536
MOD_CK2_1	171	177	PF00069	0.716
MOD_CK2_1	232	238	PF00069	0.760
MOD_CK2_1	284	290	PF00069	0.734
MOD_CK2_1	297	303	PF00069	0.657
MOD_CK2_1	361	367	PF00069	0.457
MOD_CK2_1	37	43	PF00069	0.832
MOD_CK2_1	457	463	PF00069	0.533
MOD_CK2_1	564	570	PF00069	0.469
MOD_CK2_1	588	594	PF00069	0.660
MOD_Cter_Amidation	72	75	PF01082	0.762
MOD_DYRK1A_RPxSP_1	536	540	PF00069	0.527
MOD_GlcNHglycan	14	18	PF01048	0.807
MOD_GlcNHglycan	149	152	PF01048	0.727
MOD_GlcNHglycan	19	22	PF01048	0.830
MOD_GlcNHglycan	216	220	PF01048	0.753
MOD_GlcNHglycan	238	242	PF01048	0.793
MOD_GlcNHglycan	258	261	PF01048	0.755
MOD_GlcNHglycan	263	266	PF01048	0.714
MOD_GlcNHglycan	270	273	PF01048	0.642
MOD_GlcNHglycan	312	315	PF01048	0.719
MOD_GlcNHglycan	335	338	PF01048	0.764
MOD_GlcNHglycan	34	37	PF01048	0.540
MOD_GlcNHglycan	348	351	PF01048	0.521
MOD_GlcNHglycan	402	405	PF01048	0.452
MOD_GlcNHglycan	459	462	PF01048	0.641
MOD_GlcNHglycan	477	480	PF01048	0.290
MOD_GlcNHglycan	693	697	PF01048	0.596
MOD_GlcNHglycan	701	705	PF01048	0.688
MOD_GlcNHglycan	75	78	PF01048	0.739
MOD_GSK3_1	107	114	PF00069	0.699
MOD_GSK3_1	147	154	PF00069	0.711
MOD_GSK3_1	159	166	PF00069	0.726
MOD_GSK3_1	167	174	PF00069	0.741
MOD_GSK3_1	178	185	PF00069	0.596
MOD_GSK3_1	207	214	PF00069	0.685
MOD_GSK3_1	232	239	PF00069	0.811
MOD_GSK3_1	299	306	PF00069	0.686
MOD_GSK3_1	32	39	PF00069	0.772
MOD_GSK3_1	321	328	PF00069	0.650
MOD_GSK3_1	342	349	PF00069	0.642
MOD_GSK3_1	444	451	PF00069	0.524
MOD_GSK3_1	51	58	PF00069	0.576
MOD_GSK3_1	560	567	PF00069	0.503
MOD_GSK3_1	9	16	PF00069	0.717
MOD_N-GLC_1	211	216	PF02516	0.544
MOD_N-GLC_1	232	237	PF02516	0.706
MOD_N-GLC_1	285	290	PF02516	0.607
MOD_N-GLC_1	362	367	PF02516	0.498
MOD_N-GLC_2	388	390	PF02516	0.570
MOD_NEK2_1	100	105	PF00069	0.695
MOD_NEK2_1	175	180	PF00069	0.706
MOD_NEK2_1	207	212	PF00069	0.756
MOD_NEK2_1	268	273	PF00069	0.740
MOD_NEK2_1	395	400	PF00069	0.457
MOD_NEK2_1	462	467	PF00069	0.502
MOD_NEK2_1	576	581	PF00069	0.488
MOD_NEK2_1	652	657	PF00069	0.515
MOD_NEK2_1	692	697	PF00069	0.553
MOD_NEK2_1	93	98	PF00069	0.697
MOD_NEK2_2	186	191	PF00069	0.630
MOD_NEK2_2	682	687	PF00069	0.481
MOD_OFUCOSY	661	667	PF10250	0.486
MOD_PIKK_1	377	383	PF00454	0.497
MOD_PIKK_1	613	619	PF00454	0.564
MOD_PKA_1	37	43	PF00069	0.832
MOD_PKA_1	45	51	PF00069	0.684
MOD_PKA_1	535	541	PF00069	0.632
MOD_PKA_1	645	651	PF00069	0.505
MOD_PKA_2	17	23	PF00069	0.755
MOD_PKA_2	261	267	PF00069	0.772
MOD_PKA_2	36	42	PF00069	0.728
MOD_PKA_2	447	453	PF00069	0.504
MOD_PKA_2	45	51	PF00069	0.713
MOD_PKA_2	535	541	PF00069	0.632
MOD_PKA_2	73	79	PF00069	0.765
MOD_PKB_1	340	348	PF00069	0.739
MOD_PKB_1	562	570	PF00069	0.480
MOD_Plk_1	181	187	PF00069	0.660
MOD_Plk_1	232	238	PF00069	0.710
MOD_Plk_1	302	308	PF00069	0.748
MOD_Plk_1	661	667	PF00069	0.586
MOD_Plk_1	682	688	PF00069	0.443
MOD_Plk_1	91	97	PF00069	0.697
MOD_Plk_4	167	173	PF00069	0.735
MOD_Plk_4	175	181	PF00069	0.671
MOD_Plk_4	182	188	PF00069	0.604
MOD_Plk_4	395	401	PF00069	0.457
MOD_Plk_4	448	454	PF00069	0.486
MOD_ProDKin_1	111	117	PF00069	0.757
MOD_ProDKin_1	139	145	PF00069	0.814
MOD_ProDKin_1	163	169	PF00069	0.711
MOD_ProDKin_1	226	232	PF00069	0.709
MOD_ProDKin_1	248	254	PF00069	0.592
MOD_ProDKin_1	297	303	PF00069	0.674
MOD_ProDKin_1	362	368	PF00069	0.503
MOD_ProDKin_1	536	542	PF00069	0.521
MOD_ProDKin_1	56	62	PF00069	0.739
MOD_ProDKin_1	710	716	PF00069	0.735
MOD_ProDKin_1	9	15	PF00069	0.712
MOD_SUMO_for_1	29	32	PF00179	0.650
TRG_ENDOCYTIC_2	191	194	PF00928	0.614
TRG_ER_diArg_1	339	342	PF00400	0.675
TRG_ER_diArg_1	419	422	PF00400	0.495
TRG_ER_diArg_1	534	536	PF00400	0.557
TRG_ER_diArg_1	562	565	PF00400	0.501
TRG_ER_diArg_1	706	708	PF00400	0.685
TRG_NLS_MonoExtN_4	559	565	PF00514	0.523
TRG_Pf-PMV_PEXEL_1	274	279	PF00026	0.688
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N4	Leptomonas seymouri	61%	98%
A0A3Q8ILY5	Leishmania donovani	99%	100%
A4HL72	Leishmania braziliensis	82%	100%
E9B3L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q4H0	Leishmania major	93%	100%