ATP-binding cassette protein subfamily F, member 3

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette sub-family F member 1 - putative

Species:

Leishmania infantum

UniProt:

A4I8P8_LEIIN

TriTrypDb:

LINF_330008900

Length:

668

Annotations

Annotations by Jardim et al.

Transporters, ATP-binding cassette F, member 3 ABCF2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I8P8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8P8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0005215	transporter activity	1	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0042626	ATPase-coupled transmembrane transporter activity	2	1
GO:0140657	ATP-dependent activity	1	1
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.452
CLV_C14_Caspase3-7	379	383	PF00656	0.472
CLV_C14_Caspase3-7	537	541	PF00656	0.518
CLV_NRD_NRD_1	18	20	PF00675	0.605
CLV_NRD_NRD_1	198	200	PF00675	0.346
CLV_NRD_NRD_1	21	23	PF00675	0.579
CLV_NRD_NRD_1	222	224	PF00675	0.320
CLV_NRD_NRD_1	269	271	PF00675	0.469
CLV_NRD_NRD_1	365	367	PF00675	0.478
CLV_NRD_NRD_1	484	486	PF00675	0.350
CLV_NRD_NRD_1	606	608	PF00675	0.553
CLV_PCSK_FUR_1	196	200	PF00082	0.354
CLV_PCSK_KEX2_1	198	200	PF00082	0.346
CLV_PCSK_KEX2_1	224	226	PF00082	0.335
CLV_PCSK_KEX2_1	269	271	PF00082	0.476
CLV_PCSK_KEX2_1	335	337	PF00082	0.484
CLV_PCSK_KEX2_1	364	366	PF00082	0.476
CLV_PCSK_KEX2_1	484	486	PF00082	0.350
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.325
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.484
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.489
CLV_PCSK_SKI1_1	198	202	PF00082	0.325
CLV_PCSK_SKI1_1	225	229	PF00082	0.325
CLV_PCSK_SKI1_1	484	488	PF00082	0.413
CLV_PCSK_SKI1_1	511	515	PF00082	0.325
CLV_PCSK_SKI1_1	547	551	PF00082	0.441
CLV_PCSK_SKI1_1	608	612	PF00082	0.622
CLV_PCSK_SKI1_1	618	622	PF00082	0.570
CLV_PCSK_SKI1_1	661	665	PF00082	0.665
CLV_PCSK_SKI1_1	67	71	PF00082	0.529
CLV_PCSK_SKI1_1	81	85	PF00082	0.375
DEG_APCC_DBOX_1	197	205	PF00400	0.325
DEG_MDM2_SWIB_1	218	226	PF02201	0.338
DEG_Nend_UBRbox_2	1	3	PF02207	0.755
DOC_CYCLIN_RxL_1	481	489	PF00134	0.393
DOC_MAPK_FxFP_2	372	375	PF00069	0.511
DOC_MAPK_FxFP_2	393	396	PF00069	0.424
DOC_MAPK_gen_1	105	113	PF00069	0.338
DOC_MAPK_gen_1	196	206	PF00069	0.354
DOC_MAPK_gen_1	269	277	PF00069	0.426
DOC_MAPK_gen_1	364	372	PF00069	0.496
DOC_MAPK_gen_1	547	556	PF00069	0.400
DOC_MAPK_JIP1_4	270	276	PF00069	0.406
DOC_PP1_RVXF_1	175	181	PF00149	0.338
DOC_PP1_RVXF_1	196	203	PF00149	0.338
DOC_PP1_RVXF_1	509	515	PF00149	0.393
DOC_PP1_RVXF_1	65	72	PF00149	0.547
DOC_PP2B_LxvP_1	475	478	PF13499	0.452
DOC_PP4_FxxP_1	233	236	PF00568	0.354
DOC_PP4_FxxP_1	372	375	PF00568	0.423
DOC_PP4_FxxP_1	393	396	PF00568	0.498
DOC_PP4_FxxP_1	527	530	PF00568	0.325
DOC_USP7_MATH_1	120	124	PF00917	0.354
DOC_USP7_MATH_1	214	218	PF00917	0.338
DOC_USP7_MATH_1	227	231	PF00917	0.338
DOC_USP7_MATH_1	63	67	PF00917	0.561
DOC_USP7_UBL2_3	20	24	PF12436	0.593
DOC_USP7_UBL2_3	657	661	PF12436	0.615
DOC_USP7_UBL2_3	81	85	PF12436	0.488
DOC_WW_Pin1_4	464	469	PF00397	0.393
DOC_WW_Pin1_4	518	523	PF00397	0.452
LIG_14-3-3_CanoR_1	105	114	PF00244	0.350
LIG_14-3-3_CanoR_1	213	219	PF00244	0.333
LIG_14-3-3_CanoR_1	269	275	PF00244	0.428
LIG_14-3-3_CanoR_1	303	313	PF00244	0.491
LIG_14-3-3_CanoR_1	414	418	PF00244	0.338
LIG_14-3-3_CanoR_1	67	72	PF00244	0.497
LIG_APCC_ABBA_1	524	529	PF00400	0.325
LIG_BRCT_BRCA1_1	229	233	PF00533	0.393
LIG_BRCT_BRCA1_1	389	393	PF00533	0.454
LIG_BRCT_BRCA1_1	520	524	PF00533	0.452
LIG_Clathr_ClatBox_1	127	131	PF01394	0.354
LIG_CtBP_PxDLS_1	377	381	PF00389	0.551
LIG_EH_1	50	54	PF12763	0.592
LIG_EVH1_1	374	378	PF00568	0.526
LIG_FHA_1	243	249	PF00498	0.321
LIG_FHA_1	271	277	PF00498	0.382
LIG_FHA_1	287	293	PF00498	0.364
LIG_FHA_1	431	437	PF00498	0.325
LIG_FHA_1	529	535	PF00498	0.325
LIG_FHA_1	57	63	PF00498	0.624
LIG_FHA_1	627	633	PF00498	0.597
LIG_FHA_1	86	92	PF00498	0.474
LIG_FHA_2	135	141	PF00498	0.452
LIG_FHA_2	16	22	PF00498	0.691
LIG_FHA_2	328	334	PF00498	0.477
LIG_FHA_2	465	471	PF00498	0.325
LIG_Integrin_isoDGR_2	103	105	PF01839	0.325
LIG_LIR_Apic_2	230	236	PF02991	0.372
LIG_LIR_Apic_2	369	375	PF02991	0.585
LIG_LIR_Apic_2	390	396	PF02991	0.400
LIG_LIR_Gen_1	305	313	PF02991	0.494
LIG_LIR_Gen_1	321	331	PF02991	0.392
LIG_LIR_Gen_1	439	449	PF02991	0.440
LIG_LIR_Gen_1	521	530	PF02991	0.452
LIG_LIR_Gen_1	70	78	PF02991	0.551
LIG_LIR_Nem_3	305	309	PF02991	0.467
LIG_LIR_Nem_3	321	327	PF02991	0.347
LIG_LIR_Nem_3	439	445	PF02991	0.440
LIG_LIR_Nem_3	521	527	PF02991	0.452
LIG_LIR_Nem_3	586	591	PF02991	0.525
LIG_LIR_Nem_3	70	74	PF02991	0.560
LIG_MAD2	199	207	PF02301	0.354
LIG_NRBOX	124	130	PF00104	0.338
LIG_Pex14_1	255	259	PF04695	0.368
LIG_Pex14_2	202	206	PF04695	0.338
LIG_Pex14_2	218	222	PF04695	0.338
LIG_SH2_CRK	588	592	PF00017	0.543
LIG_SH2_NCK_1	324	328	PF00017	0.489
LIG_SH2_PTP2	442	445	PF00017	0.452
LIG_SH2_STAP1	264	268	PF00017	0.499
LIG_SH2_STAP1	324	328	PF00017	0.570
LIG_SH2_STAP1	368	372	PF00017	0.598
LIG_SH2_STAT5	259	262	PF00017	0.406
LIG_SH2_STAT5	368	371	PF00017	0.489
LIG_SH2_STAT5	442	445	PF00017	0.452
LIG_SH3_3	367	373	PF00018	0.454
LIG_SH3_3	393	399	PF00018	0.487
LIG_SH3_3	432	438	PF00018	0.452
LIG_SUMO_SIM_anti_2	123	129	PF11976	0.338
LIG_SUMO_SIM_anti_2	182	189	PF11976	0.372
LIG_SUMO_SIM_anti_2	273	278	PF11976	0.369
LIG_SUMO_SIM_par_1	126	131	PF11976	0.338
LIG_SUMO_SIM_par_1	237	243	PF11976	0.338
LIG_SUMO_SIM_par_1	272	278	PF11976	0.373
LIG_SUMO_SIM_par_1	552	557	PF11976	0.363
LIG_TRAF2_1	631	634	PF00917	0.572
LIG_TRAF2_1	663	666	PF00917	0.709
LIG_WRC_WIRS_1	306	311	PF05994	0.521
LIG_WRC_WIRS_1	487	492	PF05994	0.325
MOD_CK1_1	139	145	PF00069	0.338
MOD_CK1_1	15	21	PF00069	0.711
MOD_CK1_1	216	222	PF00069	0.396
MOD_CK1_1	258	264	PF00069	0.518
MOD_CK1_1	305	311	PF00069	0.482
MOD_CK1_1	413	419	PF00069	0.338
MOD_CK1_1	518	524	PF00069	0.452
MOD_CK1_1	92	98	PF00069	0.393
MOD_CK2_1	134	140	PF00069	0.418
MOD_CK2_1	15	21	PF00069	0.653
MOD_CK2_1	168	174	PF00069	0.353
MOD_CK2_1	305	311	PF00069	0.527
MOD_CK2_1	464	470	PF00069	0.325
MOD_GlcNHglycan	12	15	PF01048	0.729
MOD_GlcNHglycan	140	144	PF01048	0.337
MOD_GlcNHglycan	218	221	PF01048	0.325
MOD_GlcNHglycan	229	232	PF01048	0.224
MOD_GlcNHglycan	353	356	PF01048	0.606
MOD_GlcNHglycan	504	507	PF01048	0.325
MOD_GlcNHglycan	517	520	PF01048	0.323
MOD_GlcNHglycan	622	625	PF01048	0.639
MOD_GlcNHglycan	91	94	PF01048	0.354
MOD_GSK3_1	212	219	PF00069	0.335
MOD_GSK3_1	258	265	PF00069	0.520
MOD_GSK3_1	323	330	PF00069	0.542
MOD_GSK3_1	63	70	PF00069	0.518
MOD_GSK3_1	85	92	PF00069	0.452
MOD_LATS_1	211	217	PF00433	0.393
MOD_N-GLC_1	403	408	PF02516	0.460
MOD_N-GLC_1	581	586	PF02516	0.487
MOD_N-GLC_1	67	72	PF02516	0.507
MOD_N-GLC_2	155	157	PF02516	0.357
MOD_NEK2_1	486	491	PF00069	0.393
MOD_NEK2_1	620	625	PF00069	0.633
MOD_NEK2_1	84	89	PF00069	0.373
MOD_PK_1	323	329	PF00069	0.576
MOD_PK_1	387	393	PF00069	0.458
MOD_PKA_2	212	218	PF00069	0.329
MOD_PKA_2	302	308	PF00069	0.512
MOD_PKA_2	413	419	PF00069	0.338
MOD_Plk_1	139	145	PF00069	0.354
MOD_Plk_1	366	372	PF00069	0.614
MOD_Plk_1	67	73	PF00069	0.489
MOD_Plk_1	85	91	PF00069	0.278
MOD_Plk_2-3	535	541	PF00069	0.414
MOD_Plk_4	106	112	PF00069	0.334
MOD_Plk_4	255	261	PF00069	0.370
MOD_Plk_4	270	276	PF00069	0.371
MOD_Plk_4	424	430	PF00069	0.325
MOD_Plk_4	79	85	PF00069	0.505
MOD_ProDKin_1	464	470	PF00069	0.393
MOD_ProDKin_1	518	524	PF00069	0.452
MOD_SUMO_for_1	166	169	PF00179	0.452
MOD_SUMO_for_1	663	666	PF00179	0.771
MOD_SUMO_rev_2	15	25	PF00179	0.668
MOD_SUMO_rev_2	159	164	PF00179	0.454
MOD_SUMO_rev_2	479	483	PF00179	0.393
MOD_SUMO_rev_2	584	591	PF00179	0.514
MOD_SUMO_rev_2	600	610	PF00179	0.549
TRG_DiLeu_BaEn_1	235	240	PF01217	0.338
TRG_DiLeu_BaEn_1	606	611	PF01217	0.572
TRG_DiLeu_BaEn_2	175	181	PF01217	0.375
TRG_DiLeu_BaEn_2	519	525	PF01217	0.338
TRG_DiLeu_BaEn_3	182	188	PF01217	0.420
TRG_DiLeu_BaEn_4	33	39	PF01217	0.607
TRG_DiLeu_BaEn_4	599	605	PF01217	0.592
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.335
TRG_DiLeu_BaLyEn_6	482	487	PF01217	0.452
TRG_DiLeu_BaLyEn_6	558	563	PF01217	0.391
TRG_ENDOCYTIC_2	306	309	PF00928	0.439
TRG_ENDOCYTIC_2	324	327	PF00928	0.316
TRG_ENDOCYTIC_2	442	445	PF00928	0.452
TRG_ENDOCYTIC_2	588	591	PF00928	0.548
TRG_ENDOCYTIC_2	97	100	PF00928	0.338
TRG_ER_diArg_1	196	199	PF00400	0.354
TRG_ER_diArg_1	222	225	PF00400	0.325
TRG_ER_diArg_1	269	271	PF00400	0.469
TRG_ER_diArg_1	484	486	PF00400	0.447
TRG_NLS_MonoCore_2	655	660	PF00514	0.671
TRG_NLS_MonoExtC_3	655	660	PF00514	0.625
TRG_NLS_MonoExtN_4	656	662	PF00514	0.644
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	608	612	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VBH0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	35%	100%
A0A0H2VFI8	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	28%	100%
A0A0N0P4L2	Leptomonas seymouri	38%	92%
A0A0N1I593	Leptomonas seymouri	89%	100%
A0A0N1PAH6	Leptomonas seymouri	40%	100%
A0A0S4IYK6	Bodo saltans	48%	100%
A0A0S4JRN6	Bodo saltans	72%	98%
A0A0S4JUD9	Bodo saltans	33%	100%
A0A1X0P0L3	Trypanosomatidae	80%	99%
A0A1X0P688	Trypanosomatidae	39%	100%
A0A1X0P8V9	Trypanosomatidae	38%	92%
A0A3Q8IHB5	Leishmania donovani	100%	100%
A0A3R7LWT1	Trypanosoma rangeli	38%	100%
A0A3S5H525	Leishmania donovani	37%	92%
A0A3S7WVI6	Leishmania donovani	42%	100%
A0A422N7J4	Trypanosoma rangeli	36%	92%
A0A422NHP3	Trypanosoma rangeli	78%	99%
A4H3I8	Leishmania braziliensis	36%	100%
A4HA37	Leishmania braziliensis	41%	100%
A4HL68	Leishmania braziliensis	94%	100%
A4HRS7	Leishmania infantum	36%	100%
A4HYA0	Leishmania infantum	42%	100%
D0A0N6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A223	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	92%
D0A4N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	98%
E9ACG3	Leishmania major	36%	100%
E9AJQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AS32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B3L1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O05519	Bacillus subtilis (strain 168)	29%	100%
O06476	Bacillus subtilis (strain 168)	28%	100%
O31716	Bacillus subtilis (strain 168)	30%	100%
O34362	Bacillus subtilis (strain 168)	25%	100%
O34512	Bacillus subtilis (strain 168)	25%	100%
O42943	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
O59672	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	91%
P0A9U3	Escherichia coli (strain K12)	31%	100%
P0A9U4	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	31%	100%
P0A9U5	Escherichia coli O157:H7	31%	100%
P0A9W3	Escherichia coli (strain K12)	28%	100%
P0A9W4	Escherichia coli O157:H7	28%	100%
P0A9W5	Shigella flexneri	28%	100%
P23212	Staphylococcus epidermidis	23%	100%
P25256	Streptomyces fradiae	26%	100%
P39115	Bacillus subtilis (strain 168)	26%	100%
P40024	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
P43535	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	89%
P43672	Escherichia coli (strain K12)	29%	100%
P44808	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	34%	100%
P45127	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	100%
P63389	Escherichia coli (strain K12)	34%	100%
P63390	Escherichia coli O157:H7	34%	100%
P9WQK2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	28%	100%
P9WQK3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
Q2KJA2	Bos taurus	37%	100%
Q4Q4I8	Leishmania major	99%	100%
Q4QDE1	Leishmania major	41%	100%
Q57242	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	26%	100%
Q58129	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
Q5R9Z5	Pongo abelii	38%	94%
Q66H39	Rattus norvegicus	38%	94%
Q6MG08	Rattus norvegicus	46%	80%
Q6P542	Mus musculus	45%	80%
Q73R11	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	24%	100%
Q767L0	Sus scrofa	45%	83%
Q7YR37	Pan troglodytes	45%	83%
Q87G35	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	23%	100%
Q8G838	Bifidobacterium longum (strain NCC 2705)	25%	86%
Q8H0V6	Arabidopsis thaliana	37%	93%
Q8K268	Mus musculus	38%	94%
Q8K9I3	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	26%	100%
Q8NE71	Homo sapiens	45%	79%
Q8SRV5	Encephalitozoon cuniculi (strain GB-M1)	33%	100%
Q8T6B7	Dictyostelium discoideum	36%	100%
Q8TQ05	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	25%	100%
Q99LE6	Mus musculus	37%	100%
Q9FIB4	Arabidopsis thaliana	29%	99%
Q9FJH6	Arabidopsis thaliana	37%	100%
Q9LV93	Arabidopsis thaliana	29%	97%
Q9M1H3	Arabidopsis thaliana	42%	92%
Q9NUQ8	Homo sapiens	38%	94%
Q9UG63	Homo sapiens	37%	100%
Q9USH9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	81%
V5AVV7	Trypanosoma cruzi	77%	100%
V5BD93	Trypanosoma cruzi	37%	100%
V5DFD4	Trypanosoma cruzi	38%	100%