HNRNPA

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

HNRNPA

Gene product:

RGG-containing protein 2 - putative

Species:

Leishmania infantum

UniProt:

A4I8P4_LEIIN

TriTrypDb:

LINF_330007800

Length:

327

Annotations

Annotations by Jardim et al.

Nucleic acid binding, HNRNPA

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0032473	cytoplasmic side of mitochondrial outer membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098552	side of membrane	2	1
GO:0098562	cytoplasmic side of membrane	3	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I8P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8P4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.756
CLV_C14_Caspase3-7	292	296	PF00656	0.610
CLV_C14_Caspase3-7	56	60	PF00656	0.481
CLV_NRD_NRD_1	151	153	PF00675	0.752
CLV_NRD_NRD_1	185	187	PF00675	0.720
CLV_NRD_NRD_1	287	289	PF00675	0.658
CLV_NRD_NRD_1	3	5	PF00675	0.690
CLV_NRD_NRD_1	300	302	PF00675	0.417
CLV_NRD_NRD_1	309	311	PF00675	0.502
CLV_PCSK_KEX2_1	151	153	PF00082	0.752
CLV_PCSK_KEX2_1	185	187	PF00082	0.720
CLV_PCSK_KEX2_1	287	289	PF00082	0.658
CLV_PCSK_KEX2_1	3	5	PF00082	0.690
CLV_PCSK_KEX2_1	309	311	PF00082	0.648
CLV_PCSK_PC7_1	147	153	PF00082	0.760
CLV_PCSK_SKI1_1	257	261	PF00082	0.355
DEG_Nend_Nbox_1	1	3	PF02207	0.702
DOC_MAPK_gen_1	185	192	PF00069	0.709
DOC_MAPK_gen_1	275	284	PF00069	0.621
DOC_PP4_FxxP_1	180	183	PF00568	0.707
DOC_PP4_FxxP_1	249	252	PF00568	0.555
DOC_USP7_MATH_1	110	114	PF00917	0.758
DOC_USP7_MATH_1	305	309	PF00917	0.613
DOC_USP7_MATH_1	320	324	PF00917	0.445
DOC_USP7_MATH_1	33	37	PF00917	0.705
DOC_USP7_MATH_1	57	61	PF00917	0.492
DOC_USP7_MATH_1	81	85	PF00917	0.519
LIG_14-3-3_CanoR_1	12	18	PF00244	0.544
LIG_14-3-3_CanoR_1	3	7	PF00244	0.536
LIG_deltaCOP1_diTrp_1	169	180	PF00928	0.706
LIG_FHA_1	269	275	PF00498	0.555
LIG_FHA_1	279	285	PF00498	0.476
LIG_FHA_2	191	197	PF00498	0.670
LIG_FHA_2	221	227	PF00498	0.555
LIG_LIR_Apic_2	179	183	PF02991	0.707
LIG_LIR_Apic_2	248	252	PF02991	0.555
LIG_LIR_Gen_1	218	228	PF02991	0.555
LIG_LIR_Gen_1	233	240	PF02991	0.381
LIG_LIR_Nem_3	218	224	PF02991	0.555
LIG_LIR_Nem_3	233	239	PF02991	0.381
LIG_LIR_Nem_3	5	9	PF02991	0.681
LIG_Pex14_2	236	240	PF04695	0.555
LIG_SH2_STAT5	273	276	PF00017	0.426
LIG_SUMO_SIM_par_1	188	193	PF11976	0.702
LIG_SUMO_SIM_par_1	279	286	PF11976	0.636
LIG_TRAF2_1	168	171	PF00917	0.520
MOD_CK1_1	213	219	PF00069	0.555
MOD_CK2_1	190	196	PF00069	0.686
MOD_CK2_1	262	268	PF00069	0.512
MOD_CK2_1	305	311	PF00069	0.634
MOD_GlcNHglycan	105	108	PF01048	0.538
MOD_GlcNHglycan	125	128	PF01048	0.764
MOD_GlcNHglycan	156	159	PF01048	0.753
MOD_GlcNHglycan	212	215	PF01048	0.355
MOD_GlcNHglycan	240	243	PF01048	0.286
MOD_GlcNHglycan	31	34	PF01048	0.543
MOD_GlcNHglycan	322	325	PF01048	0.703
MOD_GlcNHglycan	37	40	PF01048	0.568
MOD_GlcNHglycan	43	46	PF01048	0.443
MOD_GlcNHglycan	49	52	PF01048	0.395
MOD_GlcNHglycan	55	58	PF01048	0.378
MOD_GlcNHglycan	61	64	PF01048	0.521
MOD_GlcNHglycan	67	70	PF01048	0.512
MOD_GlcNHglycan	73	76	PF01048	0.500
MOD_GlcNHglycan	79	82	PF01048	0.446
MOD_GlcNHglycan	85	88	PF01048	0.449
MOD_GlcNHglycan	91	94	PF01048	0.430
MOD_GSK3_1	213	220	PF00069	0.555
MOD_GSK3_1	29	36	PF00069	0.668
MOD_GSK3_1	41	48	PF00069	0.444
MOD_GSK3_1	53	60	PF00069	0.488
MOD_GSK3_1	65	72	PF00069	0.487
MOD_GSK3_1	77	84	PF00069	0.552
MOD_GSK3_1	99	106	PF00069	0.701
MOD_N-GLC_1	320	325	PF02516	0.697
MOD_N-GLC_1	34	39	PF02516	0.519
MOD_N-GLC_1	82	87	PF02516	0.438
MOD_NEK2_1	190	195	PF00069	0.690
MOD_NEK2_1	2	7	PF00069	0.558
MOD_NEK2_1	283	288	PF00069	0.500
MOD_PKA_2	11	17	PF00069	0.511
MOD_PKA_2	2	8	PF00069	0.686
MOD_PKB_1	152	160	PF00069	0.749
MOD_Plk_1	216	222	PF00069	0.555
MOD_Plk_1	232	238	PF00069	0.555
MOD_Plk_1	278	284	PF00069	0.637
MOD_Plk_4	268	274	PF00069	0.555
MOD_Plk_4	278	284	PF00069	0.541
TRG_DiLeu_BaEn_1	279	284	PF01217	0.635
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.683
TRG_ER_diArg_1	150	152	PF00400	0.762
TRG_ER_diArg_1	184	186	PF00400	0.726
TRG_ER_diArg_1	2	4	PF00400	0.698
TRG_ER_diArg_1	298	301	PF00400	0.629
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	288	292	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6A5	Leishmania donovani	96%	96%
E9B3K5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q4J4	Leishmania major	87%	100%