Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8P3_LEIIN

TriTrypDb:

LINF_330007700

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I8P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8P3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.516
CLV_C14_Caspase3-7	295	299	PF00656	0.500
CLV_C14_Caspase3-7	309	313	PF00656	0.447
CLV_MEL_PAP_1	38	44	PF00089	0.411
CLV_NRD_NRD_1	283	285	PF00675	0.543
CLV_NRD_NRD_1	329	331	PF00675	0.496
CLV_NRD_NRD_1	86	88	PF00675	0.596
CLV_PCSK_FUR_1	84	88	PF00082	0.624
CLV_PCSK_KEX2_1	283	285	PF00082	0.546
CLV_PCSK_KEX2_1	329	331	PF00082	0.496
CLV_PCSK_KEX2_1	86	88	PF00082	0.612
CLV_PCSK_SKI1_1	117	121	PF00082	0.308
CLV_PCSK_SKI1_1	128	132	PF00082	0.320
CLV_PCSK_SKI1_1	206	210	PF00082	0.553
DEG_Nend_UBRbox_1	1	4	PF02207	0.548
DOC_MAPK_gen_1	13	21	PF00069	0.398
DOC_MAPK_MEF2A_6	15	23	PF00069	0.439
DOC_PP1_RVXF_1	4	10	PF00149	0.428
DOC_PP2B_LxvP_1	193	196	PF13499	0.598
DOC_PP4_FxxP_1	243	246	PF00568	0.404
DOC_SPAK_OSR1_1	242	246	PF12202	0.418
DOC_USP7_MATH_1	180	184	PF00917	0.550
DOC_USP7_MATH_1	246	250	PF00917	0.358
DOC_USP7_MATH_1	31	35	PF00917	0.475
DOC_USP7_MATH_1	52	56	PF00917	0.440
DOC_WW_Pin1_4	234	239	PF00397	0.512
DOC_WW_Pin1_4	255	260	PF00397	0.378
DOC_WW_Pin1_4	269	274	PF00397	0.432
DOC_WW_Pin1_4	50	55	PF00397	0.484
DOC_WW_Pin1_4	95	100	PF00397	0.630
LIG_14-3-3_CanoR_1	147	155	PF00244	0.479
LIG_14-3-3_CanoR_1	210	218	PF00244	0.367
LIG_14-3-3_CanoR_1	284	290	PF00244	0.407
LIG_14-3-3_CanoR_1	41	48	PF00244	0.399
LIG_14-3-3_CanoR_1	6	12	PF00244	0.477
LIG_14-3-3_CanoR_1	89	99	PF00244	0.599
LIG_eIF4E_1	322	328	PF01652	0.382
LIG_FHA_1	156	162	PF00498	0.387
LIG_FHA_1	188	194	PF00498	0.562
LIG_FHA_1	235	241	PF00498	0.406
LIG_FHA_1	318	324	PF00498	0.424
LIG_FHA_1	91	97	PF00498	0.633
LIG_FHA_2	198	204	PF00498	0.449
LIG_FHA_2	273	279	PF00498	0.426
LIG_GBD_Chelix_1	323	331	PF00786	0.403
LIG_LIR_LC3C_4	158	163	PF02991	0.425
LIG_LIR_Nem_3	109	113	PF02991	0.357
LIG_PDZ_Class_1	333	338	PF00595	0.444
LIG_PTB_Apo_2	300	307	PF02174	0.428
LIG_PTB_Phospho_1	300	306	PF10480	0.422
LIG_RPA_C_Fungi	30	42	PF08784	0.433
LIG_SH2_STAP1	81	85	PF00017	0.416
LIG_SH2_STAT5	265	268	PF00017	0.396
LIG_SH2_STAT5	322	325	PF00017	0.385
LIG_SH2_STAT5	81	84	PF00017	0.584
LIG_SH3_3	131	137	PF00018	0.367
LIG_SH3_3	54	60	PF00018	0.492
LIG_SUMO_SIM_anti_2	156	164	PF11976	0.479
LIG_SUMO_SIM_par_1	156	164	PF11976	0.435
LIG_TYR_ITIM	108	113	PF00017	0.427
LIG_WRC_WIRS_1	247	252	PF05994	0.309
MOD_CDC14_SPxK_1	258	261	PF00782	0.302
MOD_CDK_SPxK_1	255	261	PF00069	0.285
MOD_CK1_1	213	219	PF00069	0.450
MOD_CK1_1	292	298	PF00069	0.370
MOD_CK1_1	98	104	PF00069	0.655
MOD_CK2_1	272	278	PF00069	0.420
MOD_GlcNHglycan	163	166	PF01048	0.458
MOD_GlcNHglycan	182	185	PF01048	0.510
MOD_GlcNHglycan	212	215	PF01048	0.488
MOD_GlcNHglycan	298	301	PF01048	0.435
MOD_GlcNHglycan	333	338	PF01048	0.505
MOD_GSK3_1	206	213	PF00069	0.456
MOD_GSK3_1	221	228	PF00069	0.541
MOD_GSK3_1	265	272	PF00069	0.526
MOD_GSK3_1	285	292	PF00069	0.363
MOD_GSK3_1	313	320	PF00069	0.439
MOD_GSK3_1	98	105	PF00069	0.653
MOD_N-GLC_1	317	322	PF02516	0.534
MOD_NEK2_1	161	166	PF00069	0.367
MOD_NEK2_1	208	213	PF00069	0.544
MOD_NEK2_1	285	290	PF00069	0.377
MOD_NEK2_1	323	328	PF00069	0.376
MOD_NEK2_1	77	82	PF00069	0.476
MOD_NEK2_1	9	14	PF00069	0.486
MOD_PIKK_1	40	46	PF00454	0.475
MOD_PKA_2	209	215	PF00069	0.547
MOD_PKA_2	296	302	PF00069	0.399
MOD_PKA_2	31	37	PF00069	0.517
MOD_PKA_2	313	319	PF00069	0.375
MOD_PKA_2	40	46	PF00069	0.498
MOD_Plk_1	102	108	PF00069	0.606
MOD_Plk_1	317	323	PF00069	0.530
MOD_Plk_4	246	252	PF00069	0.448
MOD_Plk_4	289	295	PF00069	0.356
MOD_Plk_4	323	329	PF00069	0.381
MOD_ProDKin_1	234	240	PF00069	0.501
MOD_ProDKin_1	255	261	PF00069	0.385
MOD_ProDKin_1	269	275	PF00069	0.431
MOD_ProDKin_1	50	56	PF00069	0.480
MOD_ProDKin_1	95	101	PF00069	0.630
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.312
TRG_ENDOCYTIC_2	110	113	PF00928	0.400
TRG_ER_diArg_1	283	285	PF00400	0.539
TRG_ER_diArg_1	328	330	PF00400	0.510
TRG_ER_diArg_1	83	86	PF00400	0.604
TRG_ER_diArg_1	87	90	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRG0	Leptomonas seymouri	54%	98%
A0A0S4JMI8	Bodo saltans	29%	100%
A0A1X0P0V8	Trypanosomatidae	43%	100%
A0A3Q8IJV7	Leishmania donovani	100%	100%
A0A422NG71	Trypanosoma rangeli	47%	100%
A4HJ17	Leishmania braziliensis	83%	100%
D0A4L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B3K4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4J5	Leishmania major	92%	100%
V5BFZ0	Trypanosoma cruzi	43%	100%