Thiol-dependent reductase 1

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thiol-dependent reductase 1

Species:

Leishmania infantum

UniProt:

A4I8P2_LEIIN

TriTrypDb:

LINF_330007600

Length:

450

Annotations

Annotations by Jardim et al.

Redox homeostasis, Thiol-dependent reductase 1 TDR1 PE=1 SV=1 - [A4I8P2_LEIIN]

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I8P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8P2

PDB structure(s): 4ags_A , 4ags_B , 4ags_C

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	3
GO:0005515	protein binding	2	2
GO:0015035	protein-disulfide reductase activity	3	6
GO:0015036	disulfide oxidoreductase activity	4	6
GO:0016491	oxidoreductase activity	2	6
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	6
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	4	6
GO:0019153	protein-disulfide reductase (glutathione) activity	4	6
GO:0042802	identical protein binding	3	2
GO:0140096	catalytic activity, acting on a protein	2	6
GO:0000166	nucleotide binding	3	1
GO:0015038	glutathione disulfide oxidoreductase activity	5	2
GO:0016209	antioxidant activity	1	2
GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	4	2
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0045174	glutathione dehydrogenase (ascorbate) activity	2	2
GO:0050661	NADP binding	4	1
GO:0070402	NADPH binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1
GO:0016740	transferase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.327
CLV_NRD_NRD_1	252	254	PF00675	0.470
CLV_NRD_NRD_1	440	442	PF00675	0.545
CLV_NRD_NRD_1	445	447	PF00675	0.628
CLV_PCSK_FUR_1	443	447	PF00082	0.558
CLV_PCSK_KEX2_1	125	127	PF00082	0.350
CLV_PCSK_KEX2_1	377	379	PF00082	0.390
CLV_PCSK_KEX2_1	442	444	PF00082	0.597
CLV_PCSK_KEX2_1	445	447	PF00082	0.635
CLV_PCSK_KEX2_1	65	67	PF00082	0.429
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.366
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.390
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.450
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.412
CLV_PCSK_PC7_1	441	447	PF00082	0.610
CLV_PCSK_SKI1_1	170	174	PF00082	0.344
CLV_PCSK_SKI1_1	4	8	PF00082	0.414
CLV_PCSK_SKI1_1	427	431	PF00082	0.345
CLV_PCSK_SKI1_1	66	70	PF00082	0.429
DEG_SCF_FBW7_2	283	289	PF00400	0.468
DOC_CKS1_1	283	288	PF01111	0.366
DOC_CKS1_1	421	426	PF01111	0.371
DOC_CYCLIN_RxL_1	1	11	PF00134	0.438
DOC_MAPK_DCC_7	52	60	PF00069	0.366
DOC_MAPK_gen_1	253	259	PF00069	0.337
DOC_MAPK_MEF2A_6	52	60	PF00069	0.366
DOC_WW_Pin1_4	202	207	PF00397	0.518
DOC_WW_Pin1_4	282	287	PF00397	0.354
DOC_WW_Pin1_4	420	425	PF00397	0.371
LIG_14-3-3_CanoR_1	198	202	PF00244	0.435
LIG_14-3-3_CanoR_1	247	255	PF00244	0.301
LIG_14-3-3_CterR_2	445	450	PF00244	0.461
LIG_Actin_WH2_2	156	172	PF00022	0.429
LIG_APCC_ABBA_1	239	244	PF00400	0.435
LIG_BIR_II_1	1	5	PF00653	0.510
LIG_BRCT_BRCA1_1	235	239	PF00533	0.390
LIG_EH1_1	331	339	PF00400	0.468
LIG_eIF4E_1	332	338	PF01652	0.468
LIG_FHA_1	55	61	PF00498	0.396
LIG_FHA_2	154	160	PF00498	0.468
LIG_FHA_2	430	436	PF00498	0.558
LIG_GBD_Chelix_1	34	42	PF00786	0.429
LIG_Integrin_RGD_1	314	316	PF01839	0.539
LIG_LIR_Gen_1	30	38	PF02991	0.456
LIG_LIR_Gen_1	401	412	PF02991	0.372
LIG_LIR_Nem_3	213	218	PF02991	0.512
LIG_LIR_Nem_3	236	242	PF02991	0.390
LIG_LIR_Nem_3	269	274	PF02991	0.368
LIG_LIR_Nem_3	30	34	PF02991	0.411
LIG_LIR_Nem_3	401	407	PF02991	0.340
LIG_LIR_Nem_3	428	433	PF02991	0.345
LIG_MYND_3	55	59	PF01753	0.468
LIG_PCNA_TLS_4	96	103	PF02747	0.468
LIG_Pex14_2	396	400	PF04695	0.451
LIG_PTB_Apo_2	326	333	PF02174	0.468
LIG_PTB_Phospho_1	326	332	PF10480	0.468
LIG_REV1ctd_RIR_1	371	382	PF16727	0.468
LIG_SH2_CRK	235	239	PF00017	0.351
LIG_SH2_CRK	271	275	PF00017	0.390
LIG_SH2_CRK	31	35	PF00017	0.439
LIG_SH2_CRK	46	50	PF00017	0.249
LIG_SH2_GRB2like	235	238	PF00017	0.396
LIG_SH2_GRB2like	273	276	PF00017	0.390
LIG_SH2_NCK_1	31	35	PF00017	0.465
LIG_SH2_PTP2	273	276	PF00017	0.390
LIG_SH2_SRC	135	138	PF00017	0.344
LIG_SH2_SRC	273	276	PF00017	0.390
LIG_SH2_STAP1	235	239	PF00017	0.468
LIG_SH2_STAP1	31	35	PF00017	0.471
LIG_SH2_STAP1	404	408	PF00017	0.396
LIG_SH2_STAT5	135	138	PF00017	0.331
LIG_SH2_STAT5	150	153	PF00017	0.370
LIG_SH2_STAT5	273	276	PF00017	0.480
LIG_SH2_STAT5	300	303	PF00017	0.333
LIG_SH2_STAT5	332	335	PF00017	0.393
LIG_SH2_STAT5	77	80	PF00017	0.323
LIG_SH2_STAT5	9	12	PF00017	0.447
LIG_SH3_3	257	263	PF00018	0.447
LIG_SUMO_SIM_anti_2	159	164	PF11976	0.313
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.343
LIG_TRAF2_1	432	435	PF00917	0.541
LIG_TYR_ITIM	233	238	PF00017	0.351
LIG_TYR_ITIM	29	34	PF00017	0.403
LIG_UBA3_1	386	394	PF00899	0.375
MOD_CDK_SPxxK_3	420	427	PF00069	0.371
MOD_CK2_1	197	203	PF00069	0.356
MOD_CK2_1	429	435	PF00069	0.524
MOD_Cter_Amidation	375	378	PF01082	0.390
MOD_GlcNHglycan	10	13	PF01048	0.351
MOD_GlcNHglycan	121	124	PF01048	0.457
MOD_GlcNHglycan	221	224	PF01048	0.549
MOD_GlcNHglycan	286	289	PF01048	0.468
MOD_GlcNHglycan	308	311	PF01048	0.466
MOD_GlcNHglycan	399	403	PF01048	0.402
MOD_GlcNHglycan	79	83	PF01048	0.514
MOD_GlcNHglycan	91	94	PF01048	0.451
MOD_GSK3_1	197	204	PF00069	0.331
MOD_GSK3_1	425	432	PF00069	0.397
MOD_N-GLC_1	142	147	PF02516	0.468
MOD_NEK2_1	68	73	PF00069	0.361
MOD_NEK2_1	78	83	PF00069	0.468
MOD_NEK2_1	8	13	PF00069	0.381
MOD_NEK2_1	88	93	PF00069	0.358
MOD_PIKK_1	291	297	PF00454	0.396
MOD_PKA_2	197	203	PF00069	0.323
MOD_PKA_2	276	282	PF00069	0.312
MOD_PKA_2	51	57	PF00069	0.323
MOD_PKB_1	245	253	PF00069	0.254
MOD_Plk_1	153	159	PF00069	0.403
MOD_Plk_4	336	342	PF00069	0.468
MOD_Plk_4	425	431	PF00069	0.308
MOD_Plk_4	68	74	PF00069	0.464
MOD_ProDKin_1	202	208	PF00069	0.518
MOD_ProDKin_1	282	288	PF00069	0.354
MOD_ProDKin_1	420	426	PF00069	0.371
MOD_SUMO_for_1	348	351	PF00179	0.396
MOD_SUMO_rev_2	346	350	PF00179	0.464
TRG_DiLeu_BaEn_2	321	327	PF01217	0.468
TRG_DiLeu_BaLyEn_6	408	413	PF01217	0.468
TRG_ENDOCYTIC_2	179	182	PF00928	0.323
TRG_ENDOCYTIC_2	215	218	PF00928	0.492
TRG_ENDOCYTIC_2	235	238	PF00928	0.138
TRG_ENDOCYTIC_2	271	274	PF00928	0.396
TRG_ENDOCYTIC_2	31	34	PF00928	0.378
TRG_ENDOCYTIC_2	404	407	PF00928	0.329
TRG_ENDOCYTIC_2	46	49	PF00928	0.253
TRG_ER_diArg_1	245	248	PF00400	0.366
TRG_ER_diArg_1	440	443	PF00400	0.475
TRG_NLS_MonoExtC_3	440	445	PF00514	0.389
TRG_NLS_MonoExtN_4	441	446	PF00514	0.403
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IX62	Bodo saltans	40%	94%
A0A0S4KHM5	Bodo saltans	40%	93%
A0A1X0P247	Trypanosomatidae	46%	100%
A0A3S7X699	Leishmania donovani	100%	100%
A0A422NGA2	Trypanosoma rangeli	51%	100%
A4HJ18	Leishmania braziliensis	80%	100%
E9B3K3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q70GE8	Leishmania major	96%	100%
V5DBY4	Trypanosoma cruzi	48%	100%