Putative glucose transporter/membrane transporter D2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glucose transporter/membrane transporter D2 - putative

Species:

Leishmania infantum

UniProt:

A4I8N6_LEIIN

TriTrypDb:

LINF_330008300

Length:

594

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Annotations by Jardim et al.

Transporters, glucose transporter/membrane transporter D2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 39
NetGPI	no	yes: 0, no: 39

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	40
GO:0110165	cellular anatomical entity	1	40
GO:0005886	plasma membrane	3	3
GO:0051286	cell tip	3	3
GO:0060187	cell pole	2	3

Expansion

Sequence features

A4I8N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8N6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	17
GO:0008643	carbohydrate transport	5	17
GO:0051179	localization	1	17
GO:0051234	establishment of localization	2	17
GO:0071702	organic substance transport	4	17
GO:0009987	cellular process	1	1
GO:0015749	monosaccharide transmembrane transport	4	1
GO:0034219	carbohydrate transmembrane transport	3	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	40
GO:0022857	transmembrane transporter activity	2	40
GO:0015144	carbohydrate transmembrane transporter activity	3	14
GO:0015145	monosaccharide transmembrane transporter activity	5	2
GO:0015149	hexose transmembrane transporter activity	6	2
GO:0051119	sugar transmembrane transporter activity	4	2
GO:0005353	fructose transmembrane transporter activity	7	1
GO:0005354	galactose transmembrane transporter activity	7	1
GO:0015578	mannose transmembrane transporter activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	581	585	PF00656	0.741
CLV_MEL_PAP_1	430	436	PF00089	0.300
CLV_NRD_NRD_1	347	349	PF00675	0.319
CLV_NRD_NRD_1	360	362	PF00675	0.322
CLV_NRD_NRD_1	432	434	PF00675	0.255
CLV_PCSK_KEX2_1	210	212	PF00082	0.306
CLV_PCSK_KEX2_1	347	349	PF00082	0.328
CLV_PCSK_KEX2_1	41	43	PF00082	0.493
CLV_PCSK_KEX2_1	432	434	PF00082	0.240
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.337
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.551
CLV_PCSK_SKI1_1	16	20	PF00082	0.354
CLV_PCSK_SKI1_1	216	220	PF00082	0.238
CLV_PCSK_SKI1_1	248	252	PF00082	0.286
CLV_PCSK_SKI1_1	437	441	PF00082	0.260
DEG_Nend_Nbox_1	1	3	PF02207	0.537
DEG_SCF_FBW7_1	64	71	PF00400	0.484
DOC_CKS1_1	77	82	PF01111	0.179
DOC_MAPK_gen_1	465	475	PF00069	0.284
DOC_MAPK_MEF2A_6	216	223	PF00069	0.336
DOC_PP4_FxxP_1	568	571	PF00568	0.341
DOC_PP4_FxxP_1	94	97	PF00568	0.359
DOC_USP7_MATH_1	113	117	PF00917	0.181
DOC_USP7_MATH_1	507	511	PF00917	0.393
DOC_USP7_MATH_2	8	14	PF00917	0.562
DOC_WW_Pin1_4	31	36	PF00397	0.579
DOC_WW_Pin1_4	4	9	PF00397	0.755
DOC_WW_Pin1_4	57	62	PF00397	0.694
DOC_WW_Pin1_4	64	69	PF00397	0.589
DOC_WW_Pin1_4	76	81	PF00397	0.326
LIG_14-3-3_CanoR_1	148	155	PF00244	0.345
LIG_14-3-3_CanoR_1	42	46	PF00244	0.759
LIG_14-3-3_CanoR_1	432	437	PF00244	0.419
LIG_APCC_ABBA_1	498	503	PF00400	0.526
LIG_BRCT_BRCA1_1	186	190	PF00533	0.272
LIG_BRCT_BRCA1_1	216	220	PF00533	0.468
LIG_BRCT_BRCA1_1	430	434	PF00533	0.410
LIG_DLG_GKlike_1	432	439	PF00625	0.376
LIG_EH1_1	366	374	PF00400	0.376
LIG_EH1_1	69	77	PF00400	0.443
LIG_eIF4E_1	214	220	PF01652	0.508
LIG_FHA_1	148	154	PF00498	0.267
LIG_FHA_1	207	213	PF00498	0.268
LIG_FHA_1	368	374	PF00498	0.475
LIG_FHA_1	422	428	PF00498	0.257
LIG_FHA_1	436	442	PF00498	0.385
LIG_FHA_1	511	517	PF00498	0.361
LIG_FHA_1	530	536	PF00498	0.262
LIG_FHA_1	578	584	PF00498	0.740
LIG_FHA_1	77	83	PF00498	0.279
LIG_FHA_2	136	142	PF00498	0.354
LIG_FHA_2	462	468	PF00498	0.307
LIG_FHA_2	48	54	PF00498	0.754
LIG_Integrin_RGD_1	348	350	PF01839	0.166
LIG_LIR_Apic_2	565	571	PF02991	0.281
LIG_LIR_Gen_1	217	226	PF02991	0.331
LIG_LIR_Gen_1	329	338	PF02991	0.387
LIG_LIR_Gen_1	424	430	PF02991	0.329
LIG_LIR_Nem_3	137	142	PF02991	0.251
LIG_LIR_Nem_3	149	155	PF02991	0.231
LIG_LIR_Nem_3	217	223	PF02991	0.333
LIG_LIR_Nem_3	293	299	PF02991	0.290
LIG_LIR_Nem_3	329	334	PF02991	0.367
LIG_LIR_Nem_3	424	428	PF02991	0.325
LIG_LIR_Nem_3	503	508	PF02991	0.480
LIG_LIR_Nem_3	565	569	PF02991	0.285
LIG_LYPXL_S_1	459	463	PF13949	0.320
LIG_LYPXL_yS_3	460	463	PF13949	0.260
LIG_Pex14_2	253	257	PF04695	0.406
LIG_Pex14_2	291	295	PF04695	0.297
LIG_Pex14_2	501	505	PF04695	0.469
LIG_Pex14_2	568	572	PF04695	0.365
LIG_PTB_Apo_2	133	140	PF02174	0.166
LIG_PTB_Apo_2	522	529	PF02174	0.307
LIG_PTB_Apo_2	63	70	PF02174	0.501
LIG_PTB_Phospho_1	133	139	PF10480	0.166
LIG_PTB_Phospho_1	522	528	PF10480	0.351
LIG_REV1ctd_RIR_1	67	77	PF16727	0.601
LIG_SH2_CRK	182	186	PF00017	0.177
LIG_SH2_NCK_1	182	186	PF00017	0.192
LIG_SH2_NCK_1	306	310	PF00017	0.160
LIG_SH2_STAP1	155	159	PF00017	0.344
LIG_SH2_STAP1	265	269	PF00017	0.526
LIG_SH2_STAP1	98	102	PF00017	0.302
LIG_SH2_STAT5	133	136	PF00017	0.321
LIG_SH2_STAT5	207	210	PF00017	0.367
LIG_SH2_STAT5	214	217	PF00017	0.483
LIG_SH2_STAT5	265	268	PF00017	0.438
LIG_SH2_STAT5	367	370	PF00017	0.550
LIG_SH2_STAT5	494	497	PF00017	0.362
LIG_SH2_STAT5	566	569	PF00017	0.239
LIG_SH3_3	330	336	PF00018	0.182
LIG_SH3_3	43	49	PF00018	0.752
LIG_SH3_3	455	461	PF00018	0.296
LIG_SH3_3	74	80	PF00018	0.573
LIG_SUMO_SIM_par_1	320	326	PF11976	0.370
LIG_SUMO_SIM_par_1	494	499	PF11976	0.406
LIG_SUMO_SIM_par_1	79	84	PF11976	0.195
LIG_TRAF2_1	363	366	PF00917	0.366
LIG_TRFH_1	567	571	PF08558	0.341
LIG_TYR_ITIM	180	185	PF00017	0.226
LIG_TYR_ITIM	564	569	PF00017	0.294
LIG_TYR_ITSM	135	142	PF00017	0.176
LIG_WRC_WIRS_1	292	297	PF05994	0.265
LIG_WRC_WIRS_1	422	427	PF05994	0.412
MOD_CDK_SPK_2	4	9	PF00069	0.547
MOD_CK1_1	116	122	PF00069	0.281
MOD_CK1_1	135	141	PF00069	0.260
MOD_CK1_1	172	178	PF00069	0.280
MOD_CK1_1	184	190	PF00069	0.282
MOD_CK1_1	259	265	PF00069	0.448
MOD_CK1_1	285	291	PF00069	0.460
MOD_CK1_1	323	329	PF00069	0.391
MOD_CK1_1	435	441	PF00069	0.460
MOD_CK1_1	510	516	PF00069	0.234
MOD_CK2_1	135	141	PF00069	0.300
MOD_CK2_1	4	10	PF00069	0.570
MOD_CK2_1	41	47	PF00069	0.769
MOD_CK2_1	48	54	PF00069	0.750
MOD_GlcNHglycan	164	167	PF01048	0.508
MOD_GlcNHglycan	171	174	PF01048	0.488
MOD_GlcNHglycan	186	189	PF01048	0.418
MOD_GlcNHglycan	28	31	PF01048	0.457
MOD_GlcNHglycan	43	46	PF01048	0.444
MOD_GlcNHglycan	470	473	PF01048	0.439
MOD_GlcNHglycan	535	538	PF01048	0.439
MOD_GlcNHglycan	539	542	PF01048	0.438
MOD_GSK3_1	10	17	PF00069	0.758
MOD_GSK3_1	128	135	PF00069	0.216
MOD_GSK3_1	180	187	PF00069	0.256
MOD_GSK3_1	229	236	PF00069	0.244
MOD_GSK3_1	256	263	PF00069	0.393
MOD_GSK3_1	307	314	PF00069	0.290
MOD_GSK3_1	31	38	PF00069	0.741
MOD_GSK3_1	322	329	PF00069	0.356
MOD_GSK3_1	353	360	PF00069	0.462
MOD_GSK3_1	428	435	PF00069	0.309
MOD_GSK3_1	529	536	PF00069	0.308
MOD_GSK3_1	64	71	PF00069	0.581
MOD_N-GLC_1	128	133	PF02516	0.503
MOD_N-GLC_1	135	140	PF02516	0.487
MOD_N-GLC_1	4	9	PF02516	0.370
MOD_N-GLC_2	174	176	PF02516	0.526
MOD_N-GLC_2	525	527	PF02516	0.370
MOD_NEK2_1	1	6	PF00069	0.697
MOD_NEK2_1	128	133	PF00069	0.375
MOD_NEK2_1	162	167	PF00069	0.269
MOD_NEK2_1	190	195	PF00069	0.313
MOD_NEK2_1	282	287	PF00069	0.322
MOD_NEK2_1	291	296	PF00069	0.309
MOD_NEK2_1	300	305	PF00069	0.264
MOD_NEK2_1	421	426	PF00069	0.338
MOD_NEK2_1	445	450	PF00069	0.316
MOD_NEK2_2	35	40	PF00069	0.571
MOD_NEK2_2	68	73	PF00069	0.472
MOD_NEK2_2	97	102	PF00069	0.326
MOD_PIKK_1	16	22	PF00454	0.567
MOD_PIKK_1	367	373	PF00454	0.556
MOD_PIKK_1	383	389	PF00454	0.194
MOD_PKA_1	40	46	PF00069	0.619
MOD_PKA_1	432	438	PF00069	0.526
MOD_PKA_2	147	153	PF00069	0.344
MOD_PKA_2	41	47	PF00069	0.758
MOD_PKA_2	432	438	PF00069	0.417
MOD_Plk_1	128	134	PF00069	0.279
MOD_Plk_1	135	141	PF00069	0.236
MOD_Plk_1	365	371	PF00069	0.439
MOD_Plk_4	129	135	PF00069	0.157
MOD_Plk_4	190	196	PF00069	0.330
MOD_Plk_4	214	220	PF00069	0.444
MOD_Plk_4	222	228	PF00069	0.295
MOD_Plk_4	277	283	PF00069	0.478
MOD_Plk_4	291	297	PF00069	0.363
MOD_Plk_4	323	329	PF00069	0.321
MOD_Plk_4	397	403	PF00069	0.273
MOD_Plk_4	97	103	PF00069	0.264
MOD_ProDKin_1	31	37	PF00069	0.581
MOD_ProDKin_1	4	10	PF00069	0.755
MOD_ProDKin_1	57	63	PF00069	0.692
MOD_ProDKin_1	64	70	PF00069	0.585
MOD_ProDKin_1	76	82	PF00069	0.323
MOD_SUMO_rev_2	574	580	PF00179	0.556
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.568
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.196
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.196
TRG_ENDOCYTIC_2	139	142	PF00928	0.320
TRG_ENDOCYTIC_2	182	185	PF00928	0.199
TRG_ENDOCYTIC_2	241	244	PF00928	0.202
TRG_ENDOCYTIC_2	460	463	PF00928	0.260
TRG_ENDOCYTIC_2	566	569	PF00928	0.264
TRG_ENDOCYTIC_2	98	101	PF00928	0.259
TRG_ER_diArg_1	432	434	PF00400	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VG78	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	24%	100%
A0A0N0P2E1	Leptomonas seymouri	40%	100%
A0A0N0P3Z7	Leptomonas seymouri	35%	78%
A0A0N0P4D8	Leptomonas seymouri	37%	80%
A0A0N1IG16	Leptomonas seymouri	43%	100%
A0A0N1P9H5	Leptomonas seymouri	63%	100%
A0A0S4J363	Bodo saltans	27%	100%
A0A0S4JDF9	Bodo saltans	37%	100%
A0A0S4JEY7	Bodo saltans	36%	100%
A0A0S4JH90	Bodo saltans	35%	100%
A0A0S4JS00	Bodo saltans	31%	100%
A0A1X0NLE0	Trypanosomatidae	43%	100%
A0A1X0NM05	Trypanosomatidae	43%	100%
A0A1X0NN62	Trypanosomatidae	43%	100%
A0A1X0P9L7	Trypanosomatidae	32%	100%
A0A381N054	Leishmania infantum	43%	99%
A0A3Q8IDK1	Leishmania donovani	100%	100%
A0A3Q8IK60	Leishmania donovani	43%	100%
A0A3Q8IWJ4	Leishmania donovani	43%	91%
A0A3R7KPU3	Trypanosoma rangeli	32%	100%
A0A3R7MGQ7	Trypanosoma rangeli	21%	100%
A0A3S7WY58	Leishmania donovani	22%	100%
A0A3S7XC27	Leishmania donovani	43%	100%
A0A422MNQ4	Trypanosoma rangeli	43%	100%
A4HDC6	Leishmania braziliensis	21%	100%
A4HL65	Leishmania braziliensis	84%	100%
A4HQD6	Leishmania braziliensis	45%	98%
A4HQD7	Leishmania braziliensis	46%	97%
A4HQE7	Leishmania braziliensis	50%	100%
A4I0Q6	Leishmania infantum	22%	100%
A4IC83	Leishmania infantum	43%	91%
C0SPB2	Bacillus subtilis (strain 168)	24%	100%
C9ZMM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A3U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A3U2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A3U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AU62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AU63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AU64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AWQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B3K8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O34718	Bacillus subtilis (strain 168)	23%	100%
O62787	Sus scrofa	23%	100%
P0AE24	Escherichia coli (strain K12)	25%	100%
P0AE25	Escherichia coli O157:H7	25%	100%
P0AEP1	Escherichia coli (strain K12)	24%	100%
P0AEP2	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	24%	100%
P0AGF4	Escherichia coli (strain K12)	23%	100%
P0AGF5	Escherichia coli O157:H7	23%	100%
P12336	Rattus norvegicus	25%	100%
P13865	Leishmania enriettii	44%	100%
P14246	Mus musculus	24%	100%
P14672	Homo sapiens	24%	100%
P15729	Synechocystis sp. (strain PCC 6803 / Kazusa)	23%	100%
P23585	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P40885	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P43427	Rattus norvegicus	22%	100%
P45598	Klebsiella oxytoca	25%	100%
P46333	Bacillus subtilis (strain 168)	23%	100%
P54723	Bacillus subtilis (strain 168)	23%	100%
P54862	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P58353	Bos taurus	24%	100%
P78831	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
P94493	Bacillus subtilis (strain 168)	22%	100%
Q01441	Leishmania donovani	100%	100%
Q06221	Trypanosoma brucei brucei	35%	100%
Q06222	Trypanosoma brucei brucei	37%	100%
Q09037	Trypanosoma brucei brucei	35%	100%
Q10710	Ricinus communis	24%	100%
Q27115	Trypanosoma vivax	38%	100%
Q4Q0D0	Leishmania major	42%	100%
Q4Q0D1	Leishmania major	44%	100%
Q4Q0D2	Leishmania major	44%	100%
Q4Q4J1	Leishmania major	95%	100%
Q4QAR5	Leishmania major	22%	100%
Q5RET7	Pongo abelii	21%	100%
Q8VZ80	Arabidopsis thaliana	22%	100%
Q8WMN1	Ovis aries	24%	100%
Q94EC4	Oryza sativa subsp. japonica	24%	100%
Q9P3U6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
Q9P3U7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q9SFG0	Arabidopsis thaliana	23%	100%
Q9SX48	Arabidopsis thaliana	24%	100%
Q9WV38	Mus musculus	23%	100%
Q9XIH6	Arabidopsis thaliana	24%	100%
Q9XIH7	Arabidopsis thaliana	23%	100%