Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8N5_LEIIN

TriTrypDb:

LINF_330007000

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4I8N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8N5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.589
CLV_C14_Caspase3-7	165	169	PF00656	0.501
CLV_C14_Caspase3-7	510	514	PF00656	0.657
CLV_NRD_NRD_1	131	133	PF00675	0.477
CLV_NRD_NRD_1	248	250	PF00675	0.538
CLV_NRD_NRD_1	277	279	PF00675	0.441
CLV_NRD_NRD_1	340	342	PF00675	0.495
CLV_PCSK_KEX2_1	131	133	PF00082	0.477
CLV_PCSK_KEX2_1	188	190	PF00082	0.464
CLV_PCSK_KEX2_1	203	205	PF00082	0.312
CLV_PCSK_KEX2_1	248	250	PF00082	0.538
CLV_PCSK_KEX2_1	276	278	PF00082	0.476
CLV_PCSK_KEX2_1	340	342	PF00082	0.519
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.490
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.338
CLV_PCSK_PC7_1	184	190	PF00082	0.448
CLV_PCSK_SKI1_1	131	135	PF00082	0.463
CLV_PCSK_SKI1_1	162	166	PF00082	0.404
CLV_PCSK_SKI1_1	189	193	PF00082	0.377
CLV_PCSK_SKI1_1	268	272	PF00082	0.498
CLV_PCSK_SKI1_1	512	516	PF00082	0.593
CLV_PCSK_SKI1_1	77	81	PF00082	0.499
DEG_APCC_DBOX_1	76	84	PF00400	0.415
DEG_Nend_UBRbox_1	1	4	PF02207	0.574
DEG_SPOP_SBC_1	503	507	PF00917	0.641
DOC_AGCK_PIF_3	551	554	PF00069	0.553
DOC_CKS1_1	314	319	PF01111	0.651
DOC_CYCLIN_RxL_1	489	501	PF00134	0.570
DOC_MAPK_gen_1	27	36	PF00069	0.476
DOC_MAPK_gen_1	301	309	PF00069	0.392
DOC_MAPK_JIP1_4	424	430	PF00069	0.501
DOC_MAPK_MEF2A_6	268	275	PF00069	0.518
DOC_MAPK_MEF2A_6	27	36	PF00069	0.449
DOC_MAPK_MEF2A_6	427	436	PF00069	0.528
DOC_MAPK_NFAT4_5	268	276	PF00069	0.446
DOC_MIT_MIM_1	449	458	PF04212	0.396
DOC_PP2B_PxIxI_1	431	437	PF00149	0.482
DOC_USP7_MATH_1	266	270	PF00917	0.498
DOC_USP7_MATH_1	295	299	PF00917	0.331
DOC_USP7_MATH_1	352	356	PF00917	0.468
DOC_USP7_MATH_1	375	379	PF00917	0.538
DOC_USP7_MATH_1	380	384	PF00917	0.546
DOC_USP7_MATH_1	477	481	PF00917	0.629
DOC_USP7_MATH_1	503	507	PF00917	0.671
DOC_USP7_MATH_1	53	57	PF00917	0.613
DOC_WW_Pin1_4	258	263	PF00397	0.635
DOC_WW_Pin1_4	285	290	PF00397	0.407
DOC_WW_Pin1_4	313	318	PF00397	0.579
DOC_WW_Pin1_4	341	346	PF00397	0.618
DOC_WW_Pin1_4	401	406	PF00397	0.625
DOC_WW_Pin1_4	513	518	PF00397	0.689
LIG_14-3-3_CanoR_1	131	136	PF00244	0.385
LIG_14-3-3_CanoR_1	228	236	PF00244	0.630
LIG_14-3-3_CanoR_1	249	257	PF00244	0.611
LIG_14-3-3_CanoR_1	340	345	PF00244	0.530
LIG_14-3-3_CanoR_1	362	372	PF00244	0.521
LIG_14-3-3_CanoR_1	454	459	PF00244	0.379
LIG_14-3-3_CanoR_1	521	531	PF00244	0.675
LIG_BRCT_BRCA1_1	364	368	PF00533	0.512
LIG_DLG_GKlike_1	2	9	PF00625	0.535
LIG_DLG_GKlike_1	454	462	PF00625	0.460
LIG_eIF4E_1	42	48	PF01652	0.556
LIG_FHA_1	313	319	PF00498	0.624
LIG_FHA_1	341	347	PF00498	0.582
LIG_FHA_1	365	371	PF00498	0.490
LIG_FHA_1	380	386	PF00498	0.460
LIG_FHA_1	431	437	PF00498	0.595
LIG_FHA_1	479	485	PF00498	0.604
LIG_FHA_1	488	494	PF00498	0.653
LIG_FHA_1	535	541	PF00498	0.586
LIG_FHA_1	82	88	PF00498	0.512
LIG_FHA_2	111	117	PF00498	0.562
LIG_FHA_2	163	169	PF00498	0.485
LIG_FHA_2	506	512	PF00498	0.662
LIG_HP1_1	76	80	PF01393	0.475
LIG_LIR_Gen_1	134	141	PF02991	0.384
LIG_LIR_Gen_1	365	375	PF02991	0.472
LIG_LIR_Gen_1	449	458	PF02991	0.407
LIG_LIR_Gen_1	548	554	PF02991	0.536
LIG_LIR_Nem_3	106	112	PF02991	0.488
LIG_LIR_Nem_3	134	139	PF02991	0.386
LIG_LIR_Nem_3	365	371	PF02991	0.478
LIG_LIR_Nem_3	40	45	PF02991	0.455
LIG_LIR_Nem_3	449	453	PF02991	0.410
LIG_LIR_Nem_3	456	462	PF02991	0.428
LIG_LIR_Nem_3	548	554	PF02991	0.532
LIG_PDZ_Class_1	549	554	PF00595	0.521
LIG_SH2_CRK	239	243	PF00017	0.498
LIG_SH2_CRK	45	49	PF00017	0.505
LIG_SH2_NCK_1	302	306	PF00017	0.414
LIG_SH2_NCK_1	45	49	PF00017	0.557
LIG_SH2_STAT3	49	52	PF00017	0.612
LIG_SH2_STAT5	42	45	PF00017	0.496
LIG_SH3_3	18	24	PF00018	0.550
LIG_SH3_3	259	265	PF00018	0.621
LIG_SH3_3	469	475	PF00018	0.416
LIG_SH3_3	70	76	PF00018	0.457
LIG_SUMO_SIM_anti_2	365	373	PF11976	0.500
LIG_SUMO_SIM_par_1	365	373	PF11976	0.405
LIG_TYR_ITIM	43	48	PF00017	0.497
MOD_CDC14_SPxK_1	404	407	PF00782	0.608
MOD_CDK_SPxK_1	401	407	PF00069	0.589
MOD_CK1_1	243	249	PF00069	0.504
MOD_CK1_1	258	264	PF00069	0.672
MOD_CK1_1	325	331	PF00069	0.640
MOD_CK1_1	505	511	PF00069	0.635
MOD_CK2_1	110	116	PF00069	0.477
MOD_CK2_1	160	166	PF00069	0.454
MOD_CK2_1	370	376	PF00069	0.475
MOD_Cter_Amidation	186	189	PF01082	0.518
MOD_Cter_Amidation	201	204	PF01082	0.342
MOD_GlcNHglycan	242	245	PF01048	0.568
MOD_GlcNHglycan	252	255	PF01048	0.630
MOD_GlcNHglycan	322	325	PF01048	0.697
MOD_GlcNHglycan	327	330	PF01048	0.608
MOD_GlcNHglycan	354	357	PF01048	0.562
MOD_GlcNHglycan	376	380	PF01048	0.610
MOD_GlcNHglycan	39	42	PF01048	0.444
MOD_GlcNHglycan	500	503	PF01048	0.674
MOD_GlcNHglycan	550	554	PF01048	0.528
MOD_GSK3_1	318	325	PF00069	0.674
MOD_GSK3_1	375	382	PF00069	0.450
MOD_GSK3_1	498	505	PF00069	0.620
MOD_GSK3_1	513	520	PF00069	0.594
MOD_N-GLC_1	81	86	PF02516	0.474
MOD_NEK2_1	364	369	PF00069	0.524
MOD_NEK2_1	438	443	PF00069	0.534
MOD_NEK2_1	496	501	PF00069	0.715
MOD_NEK2_1	519	524	PF00069	0.611
MOD_PIKK_1	318	324	PF00454	0.694
MOD_PIKK_1	523	529	PF00454	0.695
MOD_PIKK_1	53	59	PF00454	0.542
MOD_PKA_1	131	137	PF00069	0.379
MOD_PKA_1	340	346	PF00069	0.591
MOD_PKA_2	131	137	PF00069	0.379
MOD_PKA_2	227	233	PF00069	0.543
MOD_PKA_2	340	346	PF00069	0.528
MOD_PKA_2	352	358	PF00069	0.540
MOD_PKA_2	453	459	PF00069	0.342
MOD_PKB_1	360	368	PF00069	0.598
MOD_Plk_4	110	116	PF00069	0.527
MOD_Plk_4	131	137	PF00069	0.379
MOD_Plk_4	266	272	PF00069	0.639
MOD_Plk_4	295	301	PF00069	0.489
MOD_Plk_4	327	333	PF00069	0.717
MOD_Plk_4	364	370	PF00069	0.522
MOD_Plk_4	441	447	PF00069	0.419
MOD_Plk_4	454	460	PF00069	0.438
MOD_Plk_4	479	485	PF00069	0.693
MOD_ProDKin_1	258	264	PF00069	0.629
MOD_ProDKin_1	285	291	PF00069	0.405
MOD_ProDKin_1	313	319	PF00069	0.585
MOD_ProDKin_1	341	347	PF00069	0.620
MOD_ProDKin_1	401	407	PF00069	0.631
MOD_ProDKin_1	513	519	PF00069	0.690
MOD_SUMO_rev_2	146	156	PF00179	0.409
MOD_SUMO_rev_2	199	205	PF00179	0.513
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.483
TRG_ENDOCYTIC_2	45	48	PF00928	0.513
TRG_ER_diArg_1	130	132	PF00400	0.475
TRG_ER_diArg_1	247	249	PF00400	0.513
TRG_ER_diArg_1	275	278	PF00400	0.601
TRG_ER_diArg_1	74	77	PF00400	0.535
TRG_NES_CRM1_1	363	377	PF08389	0.518
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Z6	Leptomonas seymouri	36%	100%
A0A3R7MER9	Trypanosoma rangeli	24%	100%
A0A3S5H7T7	Leishmania donovani	100%	82%
A4HL56	Leishmania braziliensis	70%	100%
E9B3J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q4K4	Leishmania major	89%	100%
V5AVX1	Trypanosoma cruzi	23%	87%