Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8N4_LEIIN

TriTrypDb:

LINF_330006900

Length:

160

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8N4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.539
CLV_PCSK_SKI1_1	135	139	PF00082	0.735
DEG_APCC_DBOX_1	1	9	PF00400	0.513
DEG_Nend_UBRbox_1	1	4	PF02207	0.562
DOC_CYCLIN_RxL_1	129	141	PF00134	0.658
DOC_MAPK_gen_1	18	25	PF00069	0.393
DOC_MAPK_HePTP_8	11	23	PF00069	0.390
DOC_MAPK_MEF2A_6	14	23	PF00069	0.455
DOC_MAPK_NFAT4_5	18	26	PF00069	0.469
DOC_USP7_MATH_1	118	122	PF00917	0.725
DOC_USP7_MATH_1	144	148	PF00917	0.598
DOC_WW_Pin1_4	105	110	PF00397	0.599
LIG_14-3-3_CanoR_1	18	24	PF00244	0.475
LIG_14-3-3_CanoR_1	2	12	PF00244	0.590
LIG_14-3-3_CanoR_1	26	32	PF00244	0.396
LIG_Actin_WH2_2	5	22	PF00022	0.396
LIG_EH1_1	54	62	PF00400	0.569
LIG_FHA_1	41	47	PF00498	0.515
LIG_FHA_1	51	57	PF00498	0.429
LIG_FHA_1	98	104	PF00498	0.598
LIG_FHA_2	73	79	PF00498	0.515
LIG_LIR_Gen_1	15	23	PF02991	0.464
LIG_LIR_Gen_1	90	98	PF02991	0.589
LIG_LIR_Nem_3	15	19	PF02991	0.528
LIG_LIR_Nem_3	90	95	PF02991	0.576
LIG_SH2_CRK	92	96	PF00017	0.660
LIG_SH2_STAP1	98	102	PF00017	0.605
LIG_SH2_STAT5	66	69	PF00017	0.576
LIG_SH2_STAT5	98	101	PF00017	0.611
LIG_SH3_3	67	73	PF00018	0.606
LIG_TYR_ITIM	64	69	PF00017	0.435
LIG_WRC_WIRS_1	119	124	PF05994	0.624
LIG_WRC_WIRS_1	98	103	PF05994	0.596
MOD_CDC14_SPxK_1	108	111	PF00782	0.603
MOD_CDK_SPxK_1	105	111	PF00069	0.600
MOD_CK1_1	121	127	PF00069	0.695
MOD_GlcNHglycan	129	132	PF01048	0.692
MOD_GlcNHglycan	150	153	PF01048	0.783
MOD_GlcNHglycan	45	49	PF01048	0.564
MOD_GSK3_1	123	130	PF00069	0.631
MOD_GSK3_1	144	151	PF00069	0.553
MOD_GSK3_1	21	28	PF00069	0.461
MOD_GSK3_1	40	47	PF00069	0.500
MOD_GSK3_1	77	84	PF00069	0.624
MOD_NEK2_1	19	24	PF00069	0.474
MOD_NEK2_1	3	8	PF00069	0.498
MOD_NEK2_1	32	37	PF00069	0.352
MOD_NEK2_2	87	92	PF00069	0.582
MOD_PKA_2	19	25	PF00069	0.437
MOD_PKA_2	3	9	PF00069	0.493
MOD_PKB_1	146	154	PF00069	0.684
MOD_PKB_1	2	10	PF00069	0.504
MOD_Plk_1	28	34	PF00069	0.449
MOD_Plk_1	77	83	PF00069	0.627
MOD_Plk_4	55	61	PF00069	0.534
MOD_Plk_4	77	83	PF00069	0.557
MOD_Plk_4	87	93	PF00069	0.623
MOD_Plk_4	97	103	PF00069	0.573
MOD_ProDKin_1	105	111	PF00069	0.600
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.467
TRG_ENDOCYTIC_2	66	69	PF00928	0.576
TRG_ENDOCYTIC_2	92	95	PF00928	0.654
TRG_ENDOCYTIC_2	98	101	PF00928	0.594
TRG_ER_diArg_1	1	4	PF00400	0.562
TRG_ER_diArg_1	145	148	PF00400	0.592
TRG_ER_diArg_1	18	21	PF00400	0.410
TRG_NES_CRM1_1	54	68	PF08389	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6D8	Leishmania donovani	100%	100%
Q4Q4K5	Leishmania major	82%	100%