Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1762) - putative

Species:

Leishmania infantum

UniProt:

A4I8N1_LEIIN

TriTrypDb:

LINF_330006600

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I8N1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8N1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.613
CLV_C14_Caspase3-7	168	172	PF00656	0.691
CLV_C14_Caspase3-7	223	227	PF00656	0.749
CLV_C14_Caspase3-7	68	72	PF00656	0.600
CLV_NRD_NRD_1	139	141	PF00675	0.682
CLV_NRD_NRD_1	203	205	PF00675	0.346
CLV_NRD_NRD_1	21	23	PF00675	0.576
CLV_NRD_NRD_1	248	250	PF00675	0.667
CLV_PCSK_KEX2_1	121	123	PF00082	0.644
CLV_PCSK_KEX2_1	139	141	PF00082	0.581
CLV_PCSK_KEX2_1	21	23	PF00082	0.576
CLV_PCSK_KEX2_1	247	249	PF00082	0.682
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.686
CLV_PCSK_PC7_1	117	123	PF00082	0.718
CLV_PCSK_SKI1_1	17	21	PF00082	0.572
DOC_PP4_FxxP_1	135	138	PF00568	0.700
DOC_PP4_FxxP_1	51	54	PF00568	0.652
DOC_USP7_MATH_1	158	162	PF00917	0.745
DOC_USP7_MATH_1	240	244	PF00917	0.745
DOC_USP7_MATH_1	253	257	PF00917	0.602
DOC_USP7_MATH_1	28	32	PF00917	0.667
DOC_USP7_MATH_1	40	44	PF00917	0.644
DOC_WW_Pin1_4	156	161	PF00397	0.753
DOC_WW_Pin1_4	50	55	PF00397	0.633
LIG_14-3-3_CanoR_1	117	121	PF00244	0.656
LIG_14-3-3_CanoR_1	140	146	PF00244	0.698
LIG_14-3-3_CanoR_1	255	259	PF00244	0.655
LIG_14-3-3_CanoR_1	57	65	PF00244	0.583
LIG_BIR_III_4	169	173	PF00653	0.678
LIG_BIR_III_4	224	228	PF00653	0.639
LIG_Clathr_ClatBox_1	184	188	PF01394	0.573
LIG_Clathr_ClatBox_1	85	89	PF01394	0.750
LIG_FHA_1	14	20	PF00498	0.582
LIG_FHA_1	140	146	PF00498	0.721
LIG_FHA_1	192	198	PF00498	0.677
LIG_FHA_2	106	112	PF00498	0.453
LIG_FHA_2	166	172	PF00498	0.721
LIG_FHA_2	91	97	PF00498	0.669
LIG_LIR_Apic_2	195	201	PF02991	0.662
LIG_LIR_Apic_2	48	54	PF02991	0.674
LIG_LIR_Gen_1	180	189	PF02991	0.704
LIG_LIR_Nem_3	100	105	PF02991	0.592
LIG_LIR_Nem_3	161	166	PF02991	0.675
LIG_LIR_Nem_3	180	184	PF02991	0.441
LIG_LIR_Nem_3	256	261	PF02991	0.563
LIG_Rb_LxCxE_1	180	202	PF01857	0.618
LIG_SH2_CRK	258	262	PF00017	0.524
LIG_SH2_STAP1	181	185	PF00017	0.618
LIG_SH2_STAT5	134	137	PF00017	0.580
LIG_SH2_STAT5	198	201	PF00017	0.670
LIG_SUMO_SIM_par_1	81	87	PF11976	0.541
LIG_TRAF2_1	92	95	PF00917	0.633
LIG_TRFH_1	134	138	PF08558	0.702
MOD_CDC14_SPxK_1	159	162	PF00782	0.804
MOD_CDK_SPxK_1	156	162	PF00069	0.802
MOD_CDK_SPxxK_3	50	57	PF00069	0.643
MOD_CK1_1	13	19	PF00069	0.695
MOD_CK1_1	229	235	PF00069	0.770
MOD_CK1_1	241	247	PF00069	0.638
MOD_CK1_1	254	260	PF00069	0.646
MOD_CK1_1	267	273	PF00069	0.476
MOD_CK1_1	90	96	PF00069	0.732
MOD_CK2_1	208	214	PF00069	0.546
MOD_CK2_1	50	56	PF00069	0.653
MOD_CK2_1	94	100	PF00069	0.576
MOD_Cter_Amidation	245	248	PF01082	0.660
MOD_GlcNHglycan	149	152	PF01048	0.663
MOD_GlcNHglycan	156	159	PF01048	0.690
MOD_GlcNHglycan	214	219	PF01048	0.355
MOD_GlcNHglycan	228	231	PF01048	0.625
MOD_GlcNHglycan	237	243	PF01048	0.685
MOD_GlcNHglycan	272	275	PF01048	0.623
MOD_GlcNHglycan	60	63	PF01048	0.693
MOD_GSK3_1	154	161	PF00069	0.697
MOD_GSK3_1	238	245	PF00069	0.768
MOD_GSK3_1	270	277	PF00069	0.653
MOD_GSK3_1	41	48	PF00069	0.805
MOD_GSK3_1	90	97	PF00069	0.521
MOD_NEK2_1	8	13	PF00069	0.656
MOD_NEK2_2	10	15	PF00069	0.658
MOD_PKA_1	139	145	PF00069	0.619
MOD_PKA_2	116	122	PF00069	0.745
MOD_PKA_2	139	145	PF00069	0.619
MOD_PKA_2	254	260	PF00069	0.643
MOD_PKA_2	45	51	PF00069	0.743
MOD_PKA_2	56	62	PF00069	0.534
MOD_PKB_1	249	257	PF00069	0.565
MOD_Plk_1	267	273	PF00069	0.628
MOD_Plk_1	94	100	PF00069	0.529
MOD_Plk_2-3	84	90	PF00069	0.533
MOD_Plk_2-3	94	100	PF00069	0.412
MOD_Plk_4	94	100	PF00069	0.651
MOD_ProDKin_1	156	162	PF00069	0.755
MOD_ProDKin_1	50	56	PF00069	0.630
TRG_DiLeu_BaEn_1	180	185	PF01217	0.661
TRG_DiLeu_BaEn_4	126	132	PF01217	0.761
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.665
TRG_ENDOCYTIC_2	181	184	PF00928	0.626
TRG_ENDOCYTIC_2	258	261	PF00928	0.628
TRG_ER_diArg_1	122	125	PF00400	0.626
TRG_ER_diArg_1	138	140	PF00400	0.596
TRG_ER_diArg_1	20	22	PF00400	0.519
TRG_ER_diArg_1	247	249	PF00400	0.639
TRG_NES_CRM1_1	96	111	PF08389	0.611
TRG_NLS_MonoExtC_3	120	126	PF00514	0.683
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U4	Leptomonas seymouri	44%	82%
A0A3S7X690	Leishmania donovani	100%	100%
A4HL52	Leishmania braziliensis	69%	100%
E9B3J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q4K8	Leishmania major	88%	100%