TOG domain-containing protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8M3_LEIIN

TriTrypDb:

LINF_330005700

Length:

695

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0097542	ciliary tip	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Phosphorylation

Promastigote: 363

Expansion

Sequence features

A4I8M3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8M3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.457
CLV_NRD_NRD_1	185	187	PF00675	0.774
CLV_NRD_NRD_1	274	276	PF00675	0.355
CLV_NRD_NRD_1	600	602	PF00675	0.526
CLV_PCSK_KEX2_1	184	186	PF00082	0.721
CLV_PCSK_KEX2_1	199	201	PF00082	0.643
CLV_PCSK_KEX2_1	274	276	PF00082	0.356
CLV_PCSK_KEX2_1	600	602	PF00082	0.482
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.595
CLV_PCSK_SKI1_1	102	106	PF00082	0.561
CLV_PCSK_SKI1_1	137	141	PF00082	0.382
CLV_PCSK_SKI1_1	301	305	PF00082	0.395
CLV_PCSK_SKI1_1	473	477	PF00082	0.445
CLV_PCSK_SKI1_1	553	557	PF00082	0.335
CLV_PCSK_SKI1_1	642	646	PF00082	0.395
CLV_PCSK_SKI1_1	74	78	PF00082	0.447
CLV_PCSK_SKI1_1	82	86	PF00082	0.484
DEG_APCC_DBOX_1	298	306	PF00400	0.432
DEG_APCC_DBOX_1	608	616	PF00400	0.454
DOC_CKS1_1	179	184	PF01111	0.807
DOC_CKS1_1	381	386	PF01111	0.524
DOC_CYCLIN_RxL_1	134	141	PF00134	0.446
DOC_CYCLIN_RxL_1	639	647	PF00134	0.365
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.393
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	492	498	PF00134	0.371
DOC_MAPK_gen_1	102	111	PF00069	0.469
DOC_MAPK_gen_1	120	129	PF00069	0.433
DOC_MAPK_gen_1	274	282	PF00069	0.360
DOC_MAPK_gen_1	45	55	PF00069	0.498
DOC_MAPK_gen_1	476	485	PF00069	0.405
DOC_MAPK_gen_1	598	605	PF00069	0.560
DOC_MAPK_MEF2A_6	48	57	PF00069	0.475
DOC_MAPK_MEF2A_6	74	83	PF00069	0.388
DOC_PP1_RVXF_1	135	141	PF00149	0.435
DOC_PP1_RVXF_1	262	269	PF00149	0.497
DOC_PP1_RVXF_1	97	104	PF00149	0.514
DOC_PP2B_LxvP_1	643	646	PF13499	0.477
DOC_PP4_FxxP_1	140	143	PF00568	0.455
DOC_USP7_MATH_1	208	212	PF00917	0.574
DOC_USP7_MATH_1	232	236	PF00917	0.735
DOC_USP7_MATH_1	254	258	PF00917	0.648
DOC_USP7_MATH_1	461	465	PF00917	0.392
DOC_USP7_MATH_1	581	585	PF00917	0.459
DOC_USP7_UBL2_3	677	681	PF12436	0.553
DOC_USP7_UBL2_3	74	78	PF12436	0.451
DOC_WW_Pin1_4	178	183	PF00397	0.799
DOC_WW_Pin1_4	202	207	PF00397	0.534
DOC_WW_Pin1_4	235	240	PF00397	0.675
DOC_WW_Pin1_4	32	37	PF00397	0.712
DOC_WW_Pin1_4	350	355	PF00397	0.528
DOC_WW_Pin1_4	380	385	PF00397	0.554
DOC_WW_Pin1_4	387	392	PF00397	0.581
DOC_WW_Pin1_4	399	404	PF00397	0.468
DOC_WW_Pin1_4	46	51	PF00397	0.458
DOC_WW_Pin1_4	491	496	PF00397	0.434
DOC_WW_Pin1_4	542	547	PF00397	0.393
LIG_14-3-3_CanoR_1	124	128	PF00244	0.499
LIG_14-3-3_CanoR_1	184	192	PF00244	0.770
LIG_14-3-3_CanoR_1	200	207	PF00244	0.606
LIG_14-3-3_CanoR_1	243	247	PF00244	0.586
LIG_14-3-3_CanoR_1	274	282	PF00244	0.481
LIG_14-3-3_CanoR_1	337	342	PF00244	0.400
LIG_14-3-3_CanoR_1	375	381	PF00244	0.772
LIG_14-3-3_CanoR_1	557	565	PF00244	0.447
LIG_14-3-3_CanoR_1	614	618	PF00244	0.485
LIG_14-3-3_CanoR_1	67	75	PF00244	0.355
LIG_Actin_WH2_2	259	276	PF00022	0.511
LIG_Actin_WH2_2	463	480	PF00022	0.440
LIG_AP2alpha_1	268	272	PF02296	0.471
LIG_BIR_II_1	1	5	PF00653	0.510
LIG_BRCT_BRCA1_1	107	111	PF00533	0.429
LIG_BRCT_BRCA1_1	256	260	PF00533	0.549
LIG_BRCT_BRCA1_1	471	475	PF00533	0.409
LIG_BRCT_BRCA1_1	630	634	PF00533	0.438
LIG_Clathr_ClatBox_1	209	213	PF01394	0.606
LIG_CtBP_PxDLS_1	384	388	PF00389	0.537
LIG_deltaCOP1_diTrp_1	90	98	PF00928	0.527
LIG_eIF4E_1	134	140	PF01652	0.419
LIG_FHA_1	124	130	PF00498	0.424
LIG_FHA_1	50	56	PF00498	0.475
LIG_FHA_1	570	576	PF00498	0.457
LIG_FHA_1	577	583	PF00498	0.476
LIG_FHA_2	11	17	PF00498	0.491
LIG_FHA_2	338	344	PF00498	0.350
LIG_FHA_2	594	600	PF00498	0.567
LIG_FHA_2	75	81	PF00498	0.373
LIG_GBD_Chelix_1	658	666	PF00786	0.462
LIG_HP1_1	546	550	PF01393	0.435
LIG_Integrin_isoDGR_2	624	626	PF01839	0.354
LIG_LIR_Apic_2	90	95	PF02991	0.542
LIG_LIR_Gen_1	132	143	PF02991	0.421
LIG_LIR_Gen_1	267	273	PF02991	0.523
LIG_LIR_Gen_1	527	533	PF02991	0.281
LIG_LIR_Gen_1	616	622	PF02991	0.326
LIG_LIR_Nem_3	132	138	PF02991	0.415
LIG_LIR_Nem_3	257	263	PF02991	0.537
LIG_LIR_Nem_3	267	271	PF02991	0.492
LIG_LIR_Nem_3	616	621	PF02991	0.417
LIG_LIR_Nem_3	97	101	PF02991	0.383
LIG_NRBOX	616	622	PF00104	0.311
LIG_NRBOX	639	645	PF00104	0.474
LIG_NRP_CendR_1	694	695	PF00754	0.446
LIG_PCNA_PIPBox_1	321	330	PF02747	0.384
LIG_PCNA_yPIPBox_3	333	346	PF02747	0.387
LIG_Pex14_2	140	144	PF04695	0.346
LIG_Pex14_2	268	272	PF04695	0.471
LIG_Pex14_2	453	457	PF04695	0.496
LIG_Pex14_2	471	475	PF04695	0.466
LIG_PTB_Apo_2	447	454	PF02174	0.381
LIG_PTB_Apo_2	517	524	PF02174	0.443
LIG_PTB_Apo_2	97	104	PF02174	0.429
LIG_Rb_pABgroove_1	134	142	PF01858	0.329
LIG_REV1ctd_RIR_1	269	279	PF16727	0.490
LIG_SH2_CRK	7	11	PF00017	0.464
LIG_SH2_STAP1	7	11	PF00017	0.464
LIG_SH2_STAT3	512	515	PF00017	0.425
LIG_SH2_STAT5	134	137	PF00017	0.347
LIG_SH2_STAT5	164	167	PF00017	0.379
LIG_SH2_STAT5	576	579	PF00017	0.447
LIG_SH3_3	14	20	PF00018	0.511
LIG_SH3_3	176	182	PF00018	0.582
LIG_SH3_3	30	36	PF00018	0.655
LIG_SH3_3	375	381	PF00018	0.552
LIG_SH3_3	397	403	PF00018	0.773
LIG_SH3_3	540	546	PF00018	0.349
LIG_SH3_3	645	651	PF00018	0.475
LIG_SUMO_SIM_anti_2	300	307	PF11976	0.494
LIG_SUMO_SIM_par_1	208	213	PF11976	0.575
LIG_SUMO_SIM_par_1	481	487	PF11976	0.420
LIG_SxIP_EBH_1	32	43	PF03271	0.442
LIG_TYR_ITIM	5	10	PF00017	0.459
LIG_UBA3_1	482	488	PF00899	0.313
LIG_WRC_WIRS_1	462	467	PF05994	0.286
LIG_WW_3	181	185	PF00397	0.541
MOD_CDK_SPxK_1	178	184	PF00069	0.781
MOD_CDK_SPxxK_3	178	185	PF00069	0.600
MOD_CK1_1	202	208	PF00069	0.673
MOD_CK1_1	235	241	PF00069	0.609
MOD_CK1_1	350	356	PF00069	0.645
MOD_CK1_1	360	366	PF00069	0.677
MOD_CK1_1	379	385	PF00069	0.604
MOD_CK1_1	586	592	PF00069	0.408
MOD_CK2_1	337	343	PF00069	0.527
MOD_CK2_1	593	599	PF00069	0.537
MOD_CK2_1	74	80	PF00069	0.328
MOD_GlcNHglycan	160	164	PF01048	0.458
MOD_GlcNHglycan	187	190	PF01048	0.733
MOD_GlcNHglycan	202	205	PF01048	0.761
MOD_GlcNHglycan	218	221	PF01048	0.538
MOD_GlcNHglycan	256	259	PF01048	0.645
MOD_GlcNHglycan	359	362	PF01048	0.689
MOD_GlcNHglycan	367	370	PF01048	0.599
MOD_GlcNHglycan	42	45	PF01048	0.449
MOD_GlcNHglycan	588	591	PF01048	0.333
MOD_GlcNHglycan	630	633	PF01048	0.639
MOD_GSK3_1	110	117	PF00069	0.455
MOD_GSK3_1	155	162	PF00069	0.374
MOD_GSK3_1	195	202	PF00069	0.675
MOD_GSK3_1	346	353	PF00069	0.558
MOD_GSK3_1	365	372	PF00069	0.644
MOD_GSK3_1	376	383	PF00069	0.576
MOD_GSK3_1	433	440	PF00069	0.399
MOD_GSK3_1	582	589	PF00069	0.445
MOD_N-GLC_1	376	381	PF02516	0.619
MOD_NEK2_1	159	164	PF00069	0.381
MOD_NEK2_1	304	309	PF00069	0.463
MOD_NEK2_1	346	351	PF00069	0.495
MOD_NEK2_1	471	476	PF00069	0.326
MOD_NEK2_1	514	519	PF00069	0.395
MOD_NEK2_1	533	538	PF00069	0.410
MOD_NEK2_1	658	663	PF00069	0.346
MOD_NEK2_2	613	618	PF00069	0.312
MOD_PK_1	105	111	PF00069	0.503
MOD_PKA_1	185	191	PF00069	0.782
MOD_PKA_1	199	205	PF00069	0.633
MOD_PKA_2	123	129	PF00069	0.468
MOD_PKA_2	185	191	PF00069	0.730
MOD_PKA_2	199	205	PF00069	0.625
MOD_PKA_2	242	248	PF00069	0.583
MOD_PKA_2	273	279	PF00069	0.464
MOD_PKA_2	556	562	PF00069	0.437
MOD_PKA_2	613	619	PF00069	0.343
MOD_PKA_2	687	693	PF00069	0.602
MOD_Plk_1	114	120	PF00069	0.451
MOD_Plk_1	346	352	PF00069	0.405
MOD_Plk_1	376	382	PF00069	0.746
MOD_Plk_4	337	343	PF00069	0.527
MOD_Plk_4	49	55	PF00069	0.474
MOD_Plk_4	524	530	PF00069	0.392
MOD_Plk_4	571	577	PF00069	0.346
MOD_Plk_4	583	589	PF00069	0.492
MOD_Plk_4	613	619	PF00069	0.397
MOD_Plk_4	658	664	PF00069	0.344
MOD_ProDKin_1	178	184	PF00069	0.802
MOD_ProDKin_1	202	208	PF00069	0.534
MOD_ProDKin_1	235	241	PF00069	0.676
MOD_ProDKin_1	32	38	PF00069	0.701
MOD_ProDKin_1	350	356	PF00069	0.540
MOD_ProDKin_1	380	386	PF00069	0.557
MOD_ProDKin_1	387	393	PF00069	0.581
MOD_ProDKin_1	399	405	PF00069	0.468
MOD_ProDKin_1	46	52	PF00069	0.449
MOD_ProDKin_1	491	497	PF00069	0.434
MOD_ProDKin_1	542	548	PF00069	0.394
MOD_SUMO_for_1	129	132	PF00179	0.436
MOD_SUMO_for_1	282	285	PF00179	0.502
MOD_SUMO_rev_2	117	127	PF00179	0.500
MOD_SUMO_rev_2	70	76	PF00179	0.326
TRG_AP2beta_CARGO_1	132	142	PF09066	0.444
TRG_DiLeu_BaEn_4	277	283	PF01217	0.496
TRG_DiLeu_BaLyEn_6	550	555	PF01217	0.317
TRG_ENDOCYTIC_2	7	10	PF00928	0.461
TRG_ER_diArg_1	183	186	PF00400	0.723
TRG_ER_diArg_1	273	275	PF00400	0.376
TRG_NES_CRM1_1	611	623	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U7	Leptomonas seymouri	61%	98%
A0A0S4ILQ6	Bodo saltans	22%	70%
A0A1X0P6E5	Trypanosomatidae	25%	82%
A0A3R7MW28	Trypanosoma rangeli	27%	81%
A0A3S7WVF9	Leishmania donovani	24%	79%
A0A3S7X6A2	Leishmania donovani	100%	100%
A4HL43	Leishmania braziliensis	75%	99%
A4HY47	Leishmania infantum	24%	79%
D0A0E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	77%
E9ARX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	79%
E9B3I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4L6	Leishmania major	94%	100%
Q4QDJ6	Leishmania major	24%	79%
V5DTJ3	Trypanosoma cruzi	27%	82%