LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8M1_LEIIN

TriTrypDb:

LINF_330005500

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I8M1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8M1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	114	118	PF00082	0.585
CLV_PCSK_SKI1_1	70	74	PF00082	0.523
DEG_Nend_UBRbox_2	1	3	PF02207	0.648
DEG_SPOP_SBC_1	175	179	PF00917	0.706
DOC_ANK_TNKS_1	122	129	PF00023	0.610
DOC_CYCLIN_RxL_1	67	76	PF00134	0.520
DOC_MIT_MIM_1	127	137	PF04212	0.519
DOC_PP4_FxxP_1	68	71	PF00568	0.570
DOC_USP7_MATH_1	161	165	PF00917	0.590
DOC_USP7_MATH_1	174	178	PF00917	0.551
DOC_USP7_MATH_1	28	32	PF00917	0.543
DOC_WW_Pin1_4	170	175	PF00397	0.617
LIG_14-3-3_CanoR_1	47	54	PF00244	0.569
LIG_14-3-3_CanoR_1	70	75	PF00244	0.607
LIG_14-3-3_CterR_2	229	232	PF00244	0.701
LIG_BIR_III_4	213	217	PF00653	0.646
LIG_BRCT_BRCA1_1	207	211	PF00533	0.608
LIG_FHA_1	139	145	PF00498	0.639
LIG_FHA_1	160	166	PF00498	0.663
LIG_FHA_1	185	191	PF00498	0.687
LIG_FHA_1	7	13	PF00498	0.689
LIG_FHA_1	95	101	PF00498	0.483
LIG_FHA_2	8	14	PF00498	0.715
LIG_Integrin_RGD_1	55	57	PF01839	0.555
LIG_SH2_SRC	205	208	PF00017	0.562
LIG_SH2_STAP1	205	209	PF00017	0.575
LIG_SH2_STAT3	92	95	PF00017	0.515
LIG_SH3_3	160	166	PF00018	0.641
LIG_SH3_3	168	174	PF00018	0.568
LIG_SH3_3	187	193	PF00018	0.598
LIG_SUMO_SIM_anti_2	49	55	PF11976	0.574
LIG_SUMO_SIM_par_1	70	76	PF11976	0.508
LIG_SUMO_SIM_par_1	81	87	PF11976	0.449
LIG_SUMO_SIM_par_1	99	106	PF11976	0.323
LIG_TRAF2_1	182	185	PF00917	0.720
MOD_CK1_1	150	156	PF00069	0.701
MOD_CK1_1	159	165	PF00069	0.697
MOD_CK1_1	177	183	PF00069	0.687
MOD_CK1_1	31	37	PF00069	0.530
MOD_CK2_1	126	132	PF00069	0.479
MOD_CK2_1	209	215	PF00069	0.671
MOD_CK2_1	7	13	PF00069	0.725
MOD_GlcNHglycan	113	117	PF01048	0.606
MOD_GlcNHglycan	180	183	PF01048	0.732
MOD_GlcNHglycan	30	33	PF01048	0.502
MOD_GlcNHglycan	35	38	PF01048	0.491
MOD_GSK3_1	146	153	PF00069	0.702
MOD_GSK3_1	170	177	PF00069	0.630
MOD_GSK3_1	180	187	PF00069	0.581
MOD_GSK3_1	205	212	PF00069	0.531
MOD_N-GLC_1	150	155	PF02516	0.693
MOD_NEK2_1	33	38	PF00069	0.467
MOD_NEK2_1	46	51	PF00069	0.490
MOD_NEK2_1	72	77	PF00069	0.574
MOD_NEK2_1	94	99	PF00069	0.466
MOD_PIKK_1	156	162	PF00454	0.748
MOD_PIKK_1	180	186	PF00454	0.768
MOD_PIKK_1	7	13	PF00454	0.663
MOD_PKA_2	46	52	PF00069	0.544
MOD_Plk_1	103	109	PF00069	0.498
MOD_Plk_1	112	118	PF00069	0.515
MOD_Plk_1	150	156	PF00069	0.567
MOD_Plk_1	184	190	PF00069	0.646
MOD_Plk_1	205	211	PF00069	0.551
MOD_Plk_1	7	13	PF00069	0.692
MOD_Plk_4	126	132	PF00069	0.510
MOD_ProDKin_1	170	176	PF00069	0.621
TRG_DiLeu_BaEn_1	113	118	PF01217	0.502
TRG_DiLeu_BaEn_4	225	231	PF01217	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX52	Leptomonas seymouri	53%	100%
A0A0S4JQ70	Bodo saltans	33%	90%
A0A3Q8ILV2	Leishmania donovani	100%	100%
A4HL41	Leishmania braziliensis	73%	100%
C9ZPU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	96%
E9B3I2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q4L8	Leishmania major	92%	100%
V5BAE5	Trypanosoma cruzi	34%	100%