Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8M0_LEIIN

TriTrypDb:

LINF_330005400

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8M0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.520
CLV_NRD_NRD_1	2	4	PF00675	0.599
CLV_NRD_NRD_1	339	341	PF00675	0.635
CLV_NRD_NRD_1	412	414	PF00675	0.752
CLV_NRD_NRD_1	88	90	PF00675	0.581
CLV_PCSK_KEX2_1	2	4	PF00082	0.599
CLV_PCSK_KEX2_1	338	340	PF00082	0.648
CLV_PCSK_KEX2_1	412	414	PF00082	0.718
CLV_PCSK_KEX2_1	88	90	PF00082	0.581
CLV_PCSK_SKI1_1	18	22	PF00082	0.484
CLV_PCSK_SKI1_1	217	221	PF00082	0.547
CLV_PCSK_SKI1_1	307	311	PF00082	0.652
CLV_PCSK_SKI1_1	451	455	PF00082	0.566
CLV_PCSK_SKI1_1	89	93	PF00082	0.594
DEG_APCC_DBOX_1	17	25	PF00400	0.509
DEG_APCC_DBOX_1	216	224	PF00400	0.522
DEG_Nend_UBRbox_1	1	4	PF02207	0.716
DEG_SPOP_SBC_1	359	363	PF00917	0.708
DOC_CYCLIN_RxL_1	112	121	PF00134	0.426
DOC_CYCLIN_RxL_1	213	224	PF00134	0.543
DOC_PP1_RVXF_1	114	121	PF00149	0.416
DOC_PP4_FxxP_1	452	455	PF00568	0.551
DOC_USP7_MATH_1	159	163	PF00917	0.578
DOC_USP7_MATH_1	253	257	PF00917	0.716
DOC_USP7_MATH_1	319	323	PF00917	0.686
DOC_USP7_MATH_1	359	363	PF00917	0.708
DOC_USP7_MATH_1	486	490	PF00917	0.444
DOC_WW_Pin1_4	138	143	PF00397	0.708
DOC_WW_Pin1_4	147	152	PF00397	0.647
DOC_WW_Pin1_4	297	302	PF00397	0.613
DOC_WW_Pin1_4	315	320	PF00397	0.643
DOC_WW_Pin1_4	36	41	PF00397	0.557
DOC_WW_Pin1_4	390	395	PF00397	0.662
DOC_WW_Pin1_4	43	48	PF00397	0.511
DOC_WW_Pin1_4	49	54	PF00397	0.445
LIG_14-3-3_CanoR_1	11	21	PF00244	0.502
LIG_14-3-3_CanoR_1	338	345	PF00244	0.621
LIG_14-3-3_CanoR_1	88	94	PF00244	0.581
LIG_Actin_WH2_2	457	475	PF00022	0.532
LIG_BIR_III_4	121	125	PF00653	0.493
LIG_BIR_III_4	289	293	PF00653	0.534
LIG_BRCT_BRCA1_1	51	55	PF00533	0.494
LIG_FHA_1	148	154	PF00498	0.676
LIG_FHA_1	194	200	PF00498	0.451
LIG_FHA_1	339	345	PF00498	0.656
LIG_FHA_1	444	450	PF00498	0.671
LIG_FHA_2	124	130	PF00498	0.652
LIG_FHA_2	438	444	PF00498	0.626
LIG_FHA_2	483	489	PF00498	0.574
LIG_FHA_2	55	61	PF00498	0.590
LIG_FHA_2	66	72	PF00498	0.381
LIG_HCF-1_HBM_1	200	203	PF13415	0.532
LIG_LIR_Apic_2	450	455	PF02991	0.546
LIG_LIR_Gen_1	117	125	PF02991	0.454
LIG_LIR_Gen_1	393	400	PF02991	0.529
LIG_LIR_Nem_3	14	20	PF02991	0.551
LIG_LIR_Nem_3	393	399	PF02991	0.544
LIG_Pex14_2	51	55	PF04695	0.413
LIG_SH2_NCK_1	262	266	PF00017	0.601
LIG_SH2_SRC	31	34	PF00017	0.532
LIG_SH2_STAP1	262	266	PF00017	0.601
LIG_SH2_STAT5	245	248	PF00017	0.566
LIG_SH2_STAT5	262	265	PF00017	0.672
LIG_SH2_STAT5	448	451	PF00017	0.529
LIG_SH2_STAT5	483	486	PF00017	0.474
LIG_SH2_STAT5	77	80	PF00017	0.469
LIG_SH2_STAT5	85	88	PF00017	0.500
LIG_SH3_2	33	38	PF14604	0.416
LIG_SH3_3	30	36	PF00018	0.571
LIG_SH3_3	417	423	PF00018	0.631
LIG_SH3_3	44	50	PF00018	0.593
LIG_SUMO_SIM_anti_2	291	297	PF11976	0.621
LIG_TRAF2_1	126	129	PF00917	0.714
LIG_TRAF2_1	371	374	PF00917	0.638
MOD_CDK_SPxxK_3	147	154	PF00069	0.635
MOD_CK1_1	135	141	PF00069	0.700
MOD_CK1_1	256	262	PF00069	0.709
MOD_CK1_1	323	329	PF00069	0.696
MOD_CK1_1	392	398	PF00069	0.620
MOD_CK2_1	123	129	PF00069	0.627
MOD_CK2_1	368	374	PF00069	0.633
MOD_CK2_1	400	406	PF00069	0.677
MOD_CK2_1	437	443	PF00069	0.573
MOD_CK2_1	482	488	PF00069	0.546
MOD_GlcNHglycan	136	140	PF01048	0.698
MOD_GlcNHglycan	257	261	PF01048	0.722
MOD_GlcNHglycan	325	328	PF01048	0.694
MOD_GlcNHglycan	370	373	PF01048	0.606
MOD_GlcNHglycan	465	468	PF01048	0.534
MOD_GlcNHglycan	488	491	PF01048	0.449
MOD_GlcNHglycan	78	81	PF01048	0.511
MOD_GSK3_1	131	138	PF00069	0.680
MOD_GSK3_1	239	246	PF00069	0.513
MOD_GSK3_1	256	263	PF00069	0.568
MOD_GSK3_1	297	304	PF00069	0.658
MOD_GSK3_1	315	322	PF00069	0.510
MOD_GSK3_1	359	366	PF00069	0.741
MOD_GSK3_1	39	46	PF00069	0.556
MOD_GSK3_1	477	484	PF00069	0.502
MOD_GSK3_1	486	493	PF00069	0.453
MOD_GSK3_1	49	56	PF00069	0.384
MOD_GSK3_1	7	14	PF00069	0.602
MOD_GSK3_1	92	99	PF00069	0.492
MOD_N-GLC_1	12	17	PF02516	0.355
MOD_NEK2_1	460	465	PF00069	0.478
MOD_NEK2_1	54	59	PF00069	0.484
MOD_NEK2_1	7	12	PF00069	0.614
MOD_PIKK_1	152	158	PF00454	0.624
MOD_PIKK_1	338	344	PF00454	0.624
MOD_PIKK_1	400	406	PF00454	0.638
MOD_PIKK_1	54	60	PF00454	0.606
MOD_PKA_1	338	344	PF00069	0.665
MOD_PKA_2	338	344	PF00069	0.632
MOD_PKA_2	411	417	PF00069	0.711
MOD_PKA_2	481	487	PF00069	0.465
MOD_PKA_2	7	13	PF00069	0.613
MOD_Plk_1	12	18	PF00069	0.360
MOD_Plk_1	307	313	PF00069	0.624
MOD_Plk_1	460	466	PF00069	0.480
MOD_ProDKin_1	138	144	PF00069	0.710
MOD_ProDKin_1	147	153	PF00069	0.645
MOD_ProDKin_1	297	303	PF00069	0.621
MOD_ProDKin_1	315	321	PF00069	0.645
MOD_ProDKin_1	36	42	PF00069	0.554
MOD_ProDKin_1	390	396	PF00069	0.650
MOD_ProDKin_1	43	49	PF00069	0.508
MOD_SUMO_rev_2	466	475	PF00179	0.443
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.639
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.507
TRG_ENDOCYTIC_2	17	20	PF00928	0.508
TRG_ENDOCYTIC_2	426	429	PF00928	0.693
TRG_ER_diArg_1	1	3	PF00400	0.609
TRG_ER_diArg_1	248	251	PF00400	0.656
TRG_ER_diArg_1	337	340	PF00400	0.612
TRG_ER_diArg_1	411	413	PF00400	0.749

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKK4	Leptomonas seymouri	58%	99%
A0A0S4JPU3	Bodo saltans	34%	95%
A0A3S7X6B5	Leishmania donovani	100%	100%
A0A422NYF9	Trypanosoma rangeli	44%	100%
A4HL40	Leishmania braziliensis	79%	100%
C9ZPU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	98%
E9B3I1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4L9	Leishmania major	92%	100%
V5AUZ3	Trypanosoma cruzi	47%	100%