LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I8K3_LEIIN
TriTrypDb:
LINF_320045700
Length:
291

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8K3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8K3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 132 136 PF00656 0.566
CLV_C14_Caspase3-7 225 229 PF00656 0.595
CLV_NRD_NRD_1 120 122 PF00675 0.486
CLV_NRD_NRD_1 213 215 PF00675 0.447
CLV_NRD_NRD_1 232 234 PF00675 0.509
CLV_NRD_NRD_1 278 280 PF00675 0.596
CLV_NRD_NRD_1 34 36 PF00675 0.662
CLV_NRD_NRD_1 82 84 PF00675 0.679
CLV_PCSK_FUR_1 80 84 PF00082 0.678
CLV_PCSK_KEX2_1 232 234 PF00082 0.620
CLV_PCSK_KEX2_1 278 280 PF00082 0.756
CLV_PCSK_KEX2_1 283 285 PF00082 0.784
CLV_PCSK_KEX2_1 34 36 PF00082 0.662
CLV_PCSK_KEX2_1 82 84 PF00082 0.679
CLV_PCSK_PC1ET2_1 283 285 PF00082 0.813
CLV_PCSK_PC7_1 279 285 PF00082 0.597
CLV_PCSK_SKI1_1 121 125 PF00082 0.679
CLV_PCSK_SKI1_1 185 189 PF00082 0.534
CLV_PCSK_SKI1_1 83 87 PF00082 0.677
CLV_Separin_Metazoa 180 184 PF03568 0.554
DEG_Nend_UBRbox_1 1 4 PF02207 0.740
DEG_SPOP_SBC_1 265 269 PF00917 0.716
DOC_MAPK_gen_1 183 190 PF00069 0.515
DOC_MAPK_MEF2A_6 158 167 PF00069 0.676
DOC_PP1_RVXF_1 107 113 PF00149 0.541
DOC_USP7_MATH_1 231 235 PF00917 0.693
DOC_USP7_MATH_1 38 42 PF00917 0.690
DOC_WW_Pin1_4 268 273 PF00397 0.742
LIG_Actin_WH2_2 71 89 PF00022 0.679
LIG_BIR_III_2 135 139 PF00653 0.590
LIG_FHA_1 190 196 PF00498 0.665
LIG_FHA_2 23 29 PF00498 0.700
LIG_LIR_Gen_1 271 280 PF02991 0.715
LIG_LIR_Nem_3 271 276 PF02991 0.667
LIG_MYND_3 174 178 PF01753 0.559
LIG_PTAP_UEV_1 146 151 PF05743 0.634
LIG_SH2_STAT5 208 211 PF00017 0.658
LIG_SH3_1 158 164 PF00018 0.688
LIG_SH3_3 135 141 PF00018 0.800
LIG_SH3_3 144 150 PF00018 0.696
LIG_SH3_3 158 164 PF00018 0.685
LIG_SUMO_SIM_anti_2 245 252 PF11976 0.572
LIG_SUMO_SIM_par_1 22 28 PF11976 0.587
LIG_SUMO_SIM_par_1 245 252 PF11976 0.595
LIG_TRAF2_1 129 132 PF00917 0.590
LIG_TRAF2_1 169 172 PF00917 0.655
MOD_CK1_1 249 255 PF00069 0.794
MOD_CK1_1 257 263 PF00069 0.699
MOD_CK1_1 46 52 PF00069 0.668
MOD_CK1_1 53 59 PF00069 0.590
MOD_CK2_1 126 132 PF00069 0.650
MOD_CK2_1 156 162 PF00069 0.727
MOD_CK2_1 53 59 PF00069 0.709
MOD_Cter_Amidation 276 279 PF01082 0.601
MOD_GlcNHglycan 128 131 PF01048 0.649
MOD_GlcNHglycan 238 241 PF01048 0.551
MOD_GlcNHglycan 257 260 PF01048 0.821
MOD_GlcNHglycan 40 43 PF01048 0.578
MOD_GlcNHglycan 6 9 PF01048 0.735
MOD_GlcNHglycan 87 90 PF01048 0.675
MOD_GSK3_1 260 267 PF00069 0.821
MOD_GSK3_1 268 275 PF00069 0.679
MOD_GSK3_1 43 50 PF00069 0.776
MOD_N-GLC_1 265 270 PF02516 0.659
MOD_NEK2_1 1 6 PF00069 0.602
MOD_NEK2_1 126 131 PF00069 0.642
MOD_NEK2_1 85 90 PF00069 0.676
MOD_NEK2_1 95 100 PF00069 0.505
MOD_PIKK_1 189 195 PF00454 0.661
MOD_PIKK_1 257 263 PF00454 0.754
MOD_PIKK_1 266 272 PF00454 0.640
MOD_PIKK_1 43 49 PF00454 0.722
MOD_PIKK_1 95 101 PF00454 0.592
MOD_PKA_2 1 7 PF00069 0.633
MOD_PKA_2 231 237 PF00069 0.701
MOD_Plk_4 246 252 PF00069 0.669
MOD_ProDKin_1 268 274 PF00069 0.738
TRG_ER_diArg_1 102 105 PF00400 0.609
TRG_ER_diArg_1 182 185 PF00400 0.560
TRG_NES_CRM1_1 242 255 PF08389 0.707
TRG_Pf-PMV_PEXEL_1 158 162 PF00026 0.740

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IEK8 Leishmania donovani 99% 100%
A4HL22 Leishmania braziliensis 57% 99%
E9B3G3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q4N7 Leishmania major 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS