LeishMANIAdb
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Putative enolase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative enolase
Gene product:
enolase - putative
Species:
Leishmania infantum
UniProt:
A4I8J4_LEIIN
TriTrypDb:
LINF_320044800
Length:
608

Annotations

Annotations by Jardim et al.

Glycolysis Proteins, enolase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1
GO:0000015 phosphopyruvate hydratase complex 3 4
GO:0032991 protein-containing complex 1 4
GO:1902494 catalytic complex 2 4

Expansion

Sequence features

A4I8J4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8J4

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 4
GO:0006082 organic acid metabolic process 3 4
GO:0006090 pyruvate metabolic process 7 4
GO:0006091 generation of precursor metabolites and energy 3 4
GO:0006096 glycolytic process 5 4
GO:0006139 nucleobase-containing compound metabolic process 3 4
GO:0006163 purine nucleotide metabolic process 5 4
GO:0006165 obsolete nucleoside diphosphate phosphorylation 6 4
GO:0006725 cellular aromatic compound metabolic process 3 4
GO:0006753 nucleoside phosphate metabolic process 4 4
GO:0006757 obsolete ATP generation from ADP 4 4
GO:0006793 phosphorus metabolic process 3 4
GO:0006796 phosphate-containing compound metabolic process 4 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0008152 metabolic process 1 4
GO:0009056 catabolic process 2 4
GO:0009117 nucleotide metabolic process 5 4
GO:0009132 nucleoside diphosphate metabolic process 5 4
GO:0009135 purine nucleoside diphosphate metabolic process 6 4
GO:0009141 nucleoside triphosphate metabolic process 5 4
GO:0009144 purine nucleoside triphosphate metabolic process 6 4
GO:0009150 purine ribonucleotide metabolic process 6 4
GO:0009179 purine ribonucleoside diphosphate metabolic process 7 4
GO:0009185 ribonucleoside diphosphate metabolic process 6 4
GO:0009199 ribonucleoside triphosphate metabolic process 6 4
GO:0009205 purine ribonucleoside triphosphate metabolic process 7 4
GO:0009259 ribonucleotide metabolic process 5 4
GO:0009987 cellular process 1 4
GO:0016052 carbohydrate catabolic process 4 4
GO:0016310 phosphorylation 5 4
GO:0019637 organophosphate metabolic process 3 4
GO:0019693 ribose phosphate metabolic process 4 4
GO:0019752 carboxylic acid metabolic process 5 4
GO:0032787 monocarboxylic acid metabolic process 6 4
GO:0034641 cellular nitrogen compound metabolic process 3 4
GO:0043436 oxoacid metabolic process 4 4
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 4
GO:0044281 small molecule metabolic process 2 4
GO:0046031 ADP metabolic process 7 4
GO:0046034 ATP metabolic process 7 4
GO:0046483 heterocycle metabolic process 3 4
GO:0046939 obsolete nucleotide phosphorylation 6 4
GO:0055086 nucleobase-containing small molecule metabolic process 3 4
GO:0071704 organic substance metabolic process 2 4
GO:0072521 purine-containing compound metabolic process 4 4
GO:1901135 carbohydrate derivative metabolic process 3 4
GO:1901360 organic cyclic compound metabolic process 3 4
GO:1901564 organonitrogen compound metabolic process 3 4
GO:1901575 organic substance catabolic process 3 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0004634 phosphopyruvate hydratase activity 5 9
GO:0016829 lyase activity 2 9
GO:0016835 carbon-oxygen lyase activity 3 9
GO:0016836 hydro-lyase activity 4 9
GO:0000287 magnesium ion binding 5 4
GO:0005488 binding 1 4
GO:0043167 ion binding 2 4
GO:0043169 cation binding 3 4
GO:0046872 metal ion binding 4 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 84 88 PF00656 0.344
CLV_NRD_NRD_1 195 197 PF00675 0.540
CLV_NRD_NRD_1 501 503 PF00675 0.546
CLV_NRD_NRD_1 590 592 PF00675 0.518
CLV_NRD_NRD_1 606 608 PF00675 0.617
CLV_PCSK_KEX2_1 195 197 PF00082 0.608
CLV_PCSK_KEX2_1 501 503 PF00082 0.516
CLV_PCSK_KEX2_1 590 592 PF00082 0.514
CLV_PCSK_KEX2_1 606 608 PF00082 0.636
CLV_PCSK_PC1ET2_1 606 608 PF00082 0.693
CLV_PCSK_SKI1_1 332 336 PF00082 0.442
CLV_PCSK_SKI1_1 36 40 PF00082 0.600
CLV_PCSK_SKI1_1 502 506 PF00082 0.552
DEG_SIAH_1 581 589 PF03145 0.481
DEG_SPOP_SBC_1 151 155 PF00917 0.386
DEG_SPOP_SBC_1 308 312 PF00917 0.512
DOC_CYCLIN_RxL_1 128 139 PF00134 0.492
DOC_MAPK_DCC_7 229 238 PF00069 0.482
DOC_MAPK_gen_1 430 437 PF00069 0.482
DOC_MAPK_gen_1 501 508 PF00069 0.454
DOC_MAPK_MEF2A_6 229 238 PF00069 0.482
DOC_MAPK_MEF2A_6 257 265 PF00069 0.471
DOC_MAPK_MEF2A_6 501 508 PF00069 0.454
DOC_PP2B_LxvP_1 464 467 PF13499 0.493
DOC_USP7_MATH_1 100 104 PF00917 0.522
DOC_USP7_MATH_1 127 131 PF00917 0.530
DOC_USP7_MATH_1 244 248 PF00917 0.643
DOC_USP7_MATH_1 26 30 PF00917 0.432
DOC_USP7_MATH_1 308 312 PF00917 0.499
DOC_USP7_MATH_1 455 459 PF00917 0.516
DOC_USP7_MATH_1 546 550 PF00917 0.482
DOC_USP7_MATH_1 566 570 PF00917 0.307
DOC_USP7_MATH_1 79 83 PF00917 0.457
DOC_USP7_UBL2_3 404 408 PF12436 0.417
DOC_USP7_UBL2_3 592 596 PF12436 0.524
DOC_USP7_UBL2_3 598 602 PF12436 0.580
DOC_WW_Pin1_4 152 157 PF00397 0.496
DOC_WW_Pin1_4 267 272 PF00397 0.394
LIG_14-3-3_CanoR_1 117 121 PF00244 0.507
LIG_14-3-3_CanoR_1 149 157 PF00244 0.493
LIG_14-3-3_CanoR_1 229 234 PF00244 0.376
LIG_14-3-3_CanoR_1 25 35 PF00244 0.477
LIG_14-3-3_CanoR_1 257 265 PF00244 0.333
LIG_14-3-3_CanoR_1 302 308 PF00244 0.487
LIG_14-3-3_CanoR_1 356 363 PF00244 0.552
LIG_14-3-3_CanoR_1 381 387 PF00244 0.371
LIG_14-3-3_CanoR_1 501 507 PF00244 0.481
LIG_APCC_ABBAyCdc20_2 316 322 PF00400 0.327
LIG_BIR_II_1 1 5 PF00653 0.638
LIG_BIR_III_4 112 116 PF00653 0.483
LIG_BIR_III_4 274 278 PF00653 0.570
LIG_BRCT_BRCA1_1 39 43 PF00533 0.427
LIG_BRCT_BRCA1_1 87 91 PF00533 0.450
LIG_CaM_NSCaTE_8 144 151 PF13499 0.406
LIG_EH1_1 185 193 PF00400 0.276
LIG_eIF4E_1 231 237 PF01652 0.438
LIG_EVH1_1 578 582 PF00568 0.507
LIG_FHA_1 152 158 PF00498 0.444
LIG_FHA_1 237 243 PF00498 0.416
LIG_FHA_1 267 273 PF00498 0.644
LIG_FHA_1 326 332 PF00498 0.443
LIG_FHA_1 333 339 PF00498 0.457
LIG_FHA_1 357 363 PF00498 0.624
LIG_FHA_1 503 509 PF00498 0.411
LIG_FHA_1 553 559 PF00498 0.549
LIG_FHA_1 581 587 PF00498 0.535
LIG_FHA_1 68 74 PF00498 0.384
LIG_FHA_2 109 115 PF00498 0.560
LIG_FHA_2 483 489 PF00498 0.383
LIG_FHA_2 494 500 PF00498 0.373
LIG_FHA_2 82 88 PF00498 0.508
LIG_LIR_Gen_1 224 233 PF02991 0.376
LIG_LIR_Gen_1 259 268 PF02991 0.428
LIG_LIR_Gen_1 531 540 PF02991 0.448
LIG_LIR_Nem_3 224 228 PF02991 0.458
LIG_LIR_Nem_3 259 265 PF02991 0.446
LIG_LIR_Nem_3 37 42 PF02991 0.525
LIG_LIR_Nem_3 4 10 PF02991 0.433
LIG_LIR_Nem_3 470 476 PF02991 0.389
LIG_LIR_Nem_3 531 535 PF02991 0.509
LIG_LIR_Nem_3 577 581 PF02991 0.547
LIG_MLH1_MIPbox_1 39 43 PF16413 0.427
LIG_Pex14_2 39 43 PF04695 0.531
LIG_REV1ctd_RIR_1 36 45 PF16727 0.482
LIG_SH2_CRK 118 122 PF00017 0.463
LIG_SH2_CRK 225 229 PF00017 0.597
LIG_SH2_CRK 231 235 PF00017 0.404
LIG_SH2_NCK_1 118 122 PF00017 0.463
LIG_SH2_NCK_1 231 235 PF00017 0.322
LIG_SH2_PTP2 262 265 PF00017 0.442
LIG_SH2_PTP2 532 535 PF00017 0.332
LIG_SH2_STAP1 10 14 PF00017 0.548
LIG_SH2_STAT5 187 190 PF00017 0.343
LIG_SH2_STAT5 225 228 PF00017 0.449
LIG_SH2_STAT5 262 265 PF00017 0.442
LIG_SH2_STAT5 402 405 PF00017 0.399
LIG_SH2_STAT5 42 45 PF00017 0.428
LIG_SH2_STAT5 532 535 PF00017 0.433
LIG_SH3_1 576 582 PF00018 0.586
LIG_SH3_3 474 480 PF00018 0.428
LIG_SH3_3 576 582 PF00018 0.479
LIG_SUMO_SIM_par_1 504 510 PF11976 0.438
LIG_UBA3_1 170 178 PF00899 0.439
LIG_WRC_WIRS_1 237 242 PF05994 0.480
LIG_WW_2 579 582 PF00397 0.598
MOD_CK1_1 215 221 PF00069 0.630
MOD_CK1_1 224 230 PF00069 0.463
MOD_CK1_1 3 9 PF00069 0.552
MOD_CK1_1 306 312 PF00069 0.549
MOD_CK1_1 541 547 PF00069 0.424
MOD_CK1_1 82 88 PF00069 0.447
MOD_CK2_1 108 114 PF00069 0.572
MOD_GlcNHglycan 145 148 PF01048 0.504
MOD_GlcNHglycan 16 19 PF01048 0.405
MOD_GlcNHglycan 161 164 PF01048 0.338
MOD_GlcNHglycan 196 199 PF01048 0.525
MOD_GlcNHglycan 214 217 PF01048 0.736
MOD_GlcNHglycan 28 31 PF01048 0.463
MOD_GlcNHglycan 284 287 PF01048 0.474
MOD_GlcNHglycan 376 379 PF01048 0.564
MOD_GlcNHglycan 452 455 PF01048 0.598
MOD_GlcNHglycan 457 460 PF01048 0.693
MOD_GlcNHglycan 535 538 PF01048 0.529
MOD_GlcNHglycan 540 543 PF01048 0.362
MOD_GlcNHglycan 568 571 PF01048 0.497
MOD_GlcNHglycan 61 64 PF01048 0.517
MOD_GSK3_1 100 107 PF00069 0.672
MOD_GSK3_1 116 123 PF00069 0.563
MOD_GSK3_1 14 21 PF00069 0.396
MOD_GSK3_1 166 173 PF00069 0.347
MOD_GSK3_1 212 219 PF00069 0.559
MOD_GSK3_1 26 33 PF00069 0.402
MOD_GSK3_1 303 310 PF00069 0.517
MOD_GSK3_1 332 339 PF00069 0.567
MOD_GSK3_1 351 358 PF00069 0.507
MOD_GSK3_1 437 444 PF00069 0.416
MOD_GSK3_1 455 462 PF00069 0.598
MOD_GSK3_1 493 500 PF00069 0.537
MOD_GSK3_1 546 553 PF00069 0.480
MOD_GSK3_1 598 605 PF00069 0.521
MOD_GSK3_1 81 88 PF00069 0.351
MOD_N-GLC_1 325 330 PF02516 0.446
MOD_N-GLC_1 374 379 PF02516 0.518
MOD_NEK2_1 1 6 PF00069 0.623
MOD_NEK2_1 14 19 PF00069 0.572
MOD_NEK2_1 207 212 PF00069 0.483
MOD_NEK2_1 236 241 PF00069 0.346
MOD_NEK2_1 303 308 PF00069 0.545
MOD_NEK2_1 355 360 PF00069 0.568
MOD_NEK2_1 418 423 PF00069 0.465
MOD_NEK2_1 437 442 PF00069 0.265
MOD_NEK2_1 460 465 PF00069 0.542
MOD_NEK2_1 507 512 PF00069 0.563
MOD_NEK2_2 48 53 PF00069 0.484
MOD_PIKK_1 207 213 PF00454 0.469
MOD_PIKK_1 357 363 PF00454 0.374
MOD_PK_1 229 235 PF00069 0.367
MOD_PKA_2 116 122 PF00069 0.502
MOD_PKA_2 194 200 PF00069 0.581
MOD_PKA_2 256 262 PF00069 0.515
MOD_PKA_2 355 361 PF00069 0.617
MOD_PKA_2 450 456 PF00069 0.630
MOD_PKA_2 566 572 PF00069 0.472
MOD_Plk_1 556 562 PF00069 0.544
MOD_Plk_1 79 85 PF00069 0.435
MOD_Plk_2-3 108 114 PF00069 0.524
MOD_Plk_2-3 482 488 PF00069 0.450
MOD_Plk_2-3 87 93 PF00069 0.618
MOD_Plk_4 116 122 PF00069 0.468
MOD_Plk_4 166 172 PF00069 0.340
MOD_Plk_4 236 242 PF00069 0.442
MOD_Plk_4 382 388 PF00069 0.464
MOD_Plk_4 437 443 PF00069 0.453
MOD_Plk_4 502 508 PF00069 0.503
MOD_Plk_4 528 534 PF00069 0.459
MOD_ProDKin_1 152 158 PF00069 0.497
MOD_ProDKin_1 267 273 PF00069 0.405
MOD_SUMO_rev_2 29 38 PF00179 0.475
TRG_ENDOCYTIC_2 118 121 PF00928 0.608
TRG_ENDOCYTIC_2 225 228 PF00928 0.449
TRG_ENDOCYTIC_2 262 265 PF00928 0.442
TRG_ENDOCYTIC_2 384 387 PF00928 0.358
TRG_ENDOCYTIC_2 532 535 PF00928 0.518
TRG_ER_diArg_1 289 292 PF00400 0.461
TRG_ER_diArg_1 430 433 PF00400 0.370
TRG_ER_diArg_1 589 591 PF00400 0.500

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4A1 Leptomonas seymouri 39% 94%
A0A0S4IQJ6 Bodo saltans 23% 100%
A0A1X0NS02 Trypanosomatidae 26% 100%
A0A3Q8IJR5 Leishmania donovani 100% 100%
A4HL13 Leishmania braziliensis 72% 100%
D0AAM4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
E9B3F4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q4P6 Leishmania major 89% 100%
V5DME2 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS