Transmembrane protein 18

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transmembrane protein 18 - putative

Species:

Leishmania infantum

UniProt:

A4I8J1_LEIIN

TriTrypDb:

LINF_320044500

Length:

205

Annotations

LeishMANIAdb annotations

Part of the eukaryotic TMEM18 family, consisting of conserved 3TM nuclear membrane proteins.. Localization: Perinuclear (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	1
GO:0031965	nuclear membrane	4	1
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

A4I8J1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8J1

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.298
CLV_NRD_NRD_1	185	187	PF00675	0.408
CLV_PCSK_KEX2_1	172	174	PF00082	0.275
CLV_PCSK_KEX2_1	177	179	PF00082	0.279
CLV_PCSK_KEX2_1	185	187	PF00082	0.402
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.267
CLV_PCSK_PC7_1	173	179	PF00082	0.310
CLV_PCSK_PC7_1	181	187	PF00082	0.418
DOC_MAPK_MEF2A_6	163	171	PF00069	0.546
DOC_PP4_FxxP_1	126	129	PF00568	0.346

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIZ0	Leptomonas seymouri	48%	100%
A0A1X0NRY6	Trypanosomatidae	42%	100%
A0A3R7KYB3	Trypanosoma rangeli	38%	100%
A0A3S7X686	Leishmania donovani	100%	100%
A4HL10	Leishmania braziliensis	79%	100%
D0AAM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B3F1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4P9	Leishmania major	94%	100%

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