Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8I2_LEIIN

TriTrypDb:

LINF_320043400

Length:

272

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8I2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.380
CLV_PCSK_SKI1_1	22	26	PF00082	0.448
DEG_Nend_Nbox_1	1	3	PF02207	0.463
DEG_SPOP_SBC_1	86	90	PF00917	0.586
DOC_CKS1_1	201	206	PF01111	0.434
DOC_PP2B_LxvP_1	180	183	PF13499	0.401
DOC_USP7_UBL2_3	190	194	PF12436	0.419
DOC_WW_Pin1_4	200	205	PF00397	0.573
DOC_WW_Pin1_4	214	219	PF00397	0.304
DOC_WW_Pin1_4	43	48	PF00397	0.719
DOC_WW_Pin1_4	72	77	PF00397	0.745
DOC_WW_Pin1_4	78	83	PF00397	0.653
DOC_WW_Pin1_4	87	92	PF00397	0.686
LIG_14-3-3_CanoR_1	52	61	PF00244	0.552
LIG_BRCT_BRCA1_1	113	117	PF00533	0.518
LIG_BRCT_BRCA1_1	120	124	PF00533	0.374
LIG_deltaCOP1_diTrp_1	158	164	PF00928	0.362
LIG_FHA_1	227	233	PF00498	0.330
LIG_FHA_1	56	62	PF00498	0.552
LIG_FHA_2	201	207	PF00498	0.389
LIG_FHA_2	72	78	PF00498	0.690
LIG_FHA_2	99	105	PF00498	0.484
LIG_LIR_Apic_2	200	204	PF02991	0.487
LIG_LIR_Apic_2	233	238	PF02991	0.474
LIG_LIR_Gen_1	222	232	PF02991	0.356
LIG_LIR_Nem_3	195	199	PF02991	0.370
LIG_LIR_Nem_3	222	227	PF02991	0.364
LIG_LIR_Nem_3	229	234	PF02991	0.312
LIG_Pex14_1	160	164	PF04695	0.465
LIG_SH2_NCK_1	54	58	PF00017	0.560
LIG_SH2_PTP2	128	131	PF00017	0.405
LIG_SH2_PTP2	231	234	PF00017	0.366
LIG_SH2_STAP1	140	144	PF00017	0.438
LIG_SH2_STAT5	128	131	PF00017	0.345
LIG_SH2_STAT5	196	199	PF00017	0.342
LIG_SH2_STAT5	202	205	PF00017	0.397
LIG_SH2_STAT5	231	234	PF00017	0.366
LIG_SH2_STAT5	235	238	PF00017	0.430
LIG_SH3_1	147	153	PF00018	0.490
LIG_SH3_2	47	52	PF14604	0.645
LIG_SH3_3	147	153	PF00018	0.472
LIG_SH3_3	173	179	PF00018	0.366
LIG_SH3_3	44	50	PF00018	0.618
LIG_SH3_3	60	66	PF00018	0.463
LIG_SH3_3	91	97	PF00018	0.701
LIG_SUMO_SIM_par_1	178	185	PF11976	0.364
LIG_SUMO_SIM_par_1	57	62	PF11976	0.479
LIG_TRAF2_1	3	6	PF00917	0.507
LIG_WRC_WIRS_1	161	166	PF05994	0.396
MOD_CDC14_SPxK_1	49	52	PF00782	0.594
MOD_CDC14_SPxK_1	75	78	PF00782	0.655
MOD_CDC14_SPxK_1	90	93	PF00782	0.472
MOD_CDK_SPxK_1	46	52	PF00069	0.795
MOD_CDK_SPxK_1	72	78	PF00069	0.658
MOD_CDK_SPxK_1	87	93	PF00069	0.482
MOD_CDK_SPxxK_3	214	221	PF00069	0.461
MOD_CK1_1	166	172	PF00069	0.378
MOD_CK1_1	46	52	PF00069	0.619
MOD_CK1_1	55	61	PF00069	0.552
MOD_CK1_1	67	73	PF00069	0.660
MOD_CK2_1	139	145	PF00069	0.432
MOD_CK2_1	200	206	PF00069	0.426
MOD_CK2_1	214	220	PF00069	0.319
MOD_CK2_1	98	104	PF00069	0.511
MOD_DYRK1A_RPxSP_1	78	82	PF00069	0.614
MOD_GlcNHglycan	113	116	PF01048	0.540
MOD_GlcNHglycan	131	134	PF01048	0.432
MOD_GlcNHglycan	258	261	PF01048	0.549
MOD_GlcNHglycan	54	57	PF01048	0.617
MOD_GlcNHglycan	82	85	PF01048	0.666
MOD_GSK3_1	131	138	PF00069	0.409
MOD_GSK3_1	42	49	PF00069	0.611
MOD_GSK3_1	55	62	PF00069	0.534
MOD_GSK3_1	64	71	PF00069	0.656
MOD_N-GLC_1	192	197	PF02516	0.575
MOD_NEK2_1	15	20	PF00069	0.533
MOD_NEK2_1	213	218	PF00069	0.527
MOD_NEK2_1	256	261	PF00069	0.500
MOD_PK_1	64	70	PF00069	0.761
MOD_PKA_2	111	117	PF00069	0.635
MOD_PKA_2	166	172	PF00069	0.382
MOD_Plk_1	192	198	PF00069	0.382
MOD_Plk_4	103	109	PF00069	0.470
MOD_Plk_4	192	198	PF00069	0.400
MOD_ProDKin_1	200	206	PF00069	0.576
MOD_ProDKin_1	214	220	PF00069	0.300
MOD_ProDKin_1	43	49	PF00069	0.719
MOD_ProDKin_1	72	78	PF00069	0.748
MOD_ProDKin_1	87	93	PF00069	0.689
MOD_SUMO_rev_2	184	192	PF00179	0.401
TRG_DiLeu_BaEn_1	6	11	PF01217	0.580
TRG_DiLeu_BaEn_4	6	12	PF01217	0.532
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.332
TRG_DiLeu_LyEn_5	6	11	PF01217	0.497
TRG_ENDOCYTIC_2	128	131	PF00928	0.370
TRG_ENDOCYTIC_2	196	199	PF00928	0.332
TRG_ENDOCYTIC_2	231	234	PF00928	0.366
TRG_Pf-PMV_PEXEL_1	9	14	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT8	Leptomonas seymouri	56%	95%
A0A0S4IRN5	Bodo saltans	37%	100%
A0A3Q8IG98	Leishmania donovani	99%	100%
A0A3R7P3C4	Trypanosoma rangeli	49%	100%
A4HL01	Leishmania braziliensis	78%	100%
E9B3E2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4R0	Leishmania major	94%	100%