Mitochondrial pyruvate carrier

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8I1_LEIIN

TriTrypDb:

LINF_320043300

Length:

147

Annotations

LeishMANIAdb annotations

This small protein family has no close known relatives. They might not even be membrane proteins.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I8I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8I1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	142	146	PF00082	0.615
DEG_APCC_DBOX_1	59	67	PF00400	0.630
DOC_PP1_RVXF_1	22	28	PF00149	0.529
DOC_PP4_FxxP_1	96	99	PF00568	0.389
DOC_PP4_MxPP_1	1	4	PF00568	0.558
DOC_USP7_MATH_1	4	8	PF00917	0.552
LIG_14-3-3_CanoR_1	24	28	PF00244	0.633
LIG_14-3-3_CanoR_1	46	52	PF00244	0.552
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_BIR_III_1	1	5	PF00653	0.554
LIG_BIR_III_3	1	5	PF00653	0.554
LIG_deltaCOP1_diTrp_1	114	120	PF00928	0.411
LIG_FHA_1	132	138	PF00498	0.434
LIG_LIR_Apic_2	119	123	PF02991	0.347
LIG_LIR_Apic_2	26	30	PF02991	0.539
LIG_LIR_Gen_1	87	97	PF02991	0.299
LIG_LIR_Nem_3	16	20	PF02991	0.515
LIG_LIR_Nem_3	49	54	PF02991	0.577
LIG_NRBOX	76	82	PF00104	0.384
LIG_Pex14_1	27	31	PF04695	0.551
LIG_Pex14_2	13	17	PF04695	0.615
LIG_SH2_SRC	97	100	PF00017	0.368
LIG_SH2_STAP1	111	115	PF00017	0.339
LIG_SH2_STAT5	143	146	PF00017	0.460
LIG_SH2_STAT5	97	100	PF00017	0.342
LIG_SH3_3	132	138	PF00018	0.372
MOD_CMANNOS	117	120	PF00535	0.615
MOD_GSK3_1	133	140	PF00069	0.354
MOD_NEK2_1	47	52	PF00069	0.567
MOD_PKA_2	23	29	PF00069	0.630
MOD_Plk_4	23	29	PF00069	0.545
MOD_Plk_4	47	53	PF00069	0.567
TRG_ENDOCYTIC_2	31	34	PF00928	0.549
TRG_ENDOCYTIC_2	54	57	PF00928	0.576
TRG_ENDOCYTIC_2	89	92	PF00928	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJP5	Leptomonas seymouri	86%	100%
A0A0S4JRP2	Bodo saltans	67%	100%
A0A1X0NRX4	Trypanosomatidae	65%	100%
A0A3S7X678	Leishmania donovani	100%	100%
A0A422P365	Trypanosoma rangeli	66%	100%
A4HL00	Leishmania braziliensis	93%	100%
D0AAN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9B3E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q4R1	Leishmania major	97%	100%
V5B5U3	Trypanosoma cruzi	67%	100%