Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8H7_LEIIN

TriTrypDb:

LINF_320042900

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8H7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.502
CLV_NRD_NRD_1	146	148	PF00675	0.532
CLV_NRD_NRD_1	298	300	PF00675	0.471
CLV_NRD_NRD_1	445	447	PF00675	0.613
CLV_NRD_NRD_1	50	52	PF00675	0.584
CLV_NRD_NRD_1	567	569	PF00675	0.708
CLV_PCSK_FUR_1	443	447	PF00082	0.565
CLV_PCSK_KEX2_1	143	145	PF00082	0.615
CLV_PCSK_KEX2_1	298	300	PF00082	0.471
CLV_PCSK_KEX2_1	445	447	PF00082	0.590
CLV_PCSK_KEX2_1	50	52	PF00082	0.584
CLV_PCSK_SKI1_1	143	147	PF00082	0.562
CLV_PCSK_SKI1_1	151	155	PF00082	0.496
CLV_PCSK_SKI1_1	243	247	PF00082	0.381
CLV_PCSK_SKI1_1	6	10	PF00082	0.691
CLV_Separin_Metazoa	93	97	PF03568	0.529
DEG_APCC_DBOX_1	242	250	PF00400	0.399
DEG_Nend_UBRbox_1	1	4	PF02207	0.550
DOC_CYCLIN_RxL_1	32	43	PF00134	0.328
DOC_CYCLIN_RxL_1	422	432	PF00134	0.559
DOC_CYCLIN_RxL_1	473	485	PF00134	0.583
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.459
DOC_CYCLIN_yCln2_LP_2	483	489	PF00134	0.519
DOC_MAPK_DCC_7	474	482	PF00069	0.540
DOC_MAPK_gen_1	240	248	PF00069	0.518
DOC_MAPK_RevD_3	37	51	PF00069	0.418
DOC_PP2B_LxvP_1	106	109	PF13499	0.591
DOC_PP2B_LxvP_1	124	127	PF13499	0.318
DOC_PP2B_LxvP_1	533	536	PF13499	0.591
DOC_PP4_FxxP_1	139	142	PF00568	0.416
DOC_PP4_FxxP_1	233	236	PF00568	0.503
DOC_PP4_FxxP_1	301	304	PF00568	0.400
DOC_USP7_MATH_1	135	139	PF00917	0.576
DOC_USP7_MATH_1	260	264	PF00917	0.405
DOC_USP7_MATH_1	364	368	PF00917	0.565
DOC_USP7_MATH_1	468	472	PF00917	0.741
DOC_USP7_MATH_1	522	526	PF00917	0.555
DOC_USP7_MATH_1	53	57	PF00917	0.793
DOC_USP7_MATH_1	65	69	PF00917	0.741
DOC_USP7_UBL2_3	148	152	PF12436	0.490
DOC_WW_Pin1_4	253	258	PF00397	0.485
DOC_WW_Pin1_4	393	398	PF00397	0.642
DOC_WW_Pin1_4	431	436	PF00397	0.492
DOC_WW_Pin1_4	472	477	PF00397	0.626
DOC_WW_Pin1_4	482	487	PF00397	0.550
DOC_WW_Pin1_4	505	510	PF00397	0.476
DOC_WW_Pin1_4	557	562	PF00397	0.533
DOC_WW_Pin1_4	61	66	PF00397	0.621
LIG_14-3-3_CanoR_1	2	9	PF00244	0.525
LIG_14-3-3_CanoR_1	220	225	PF00244	0.472
LIG_14-3-3_CanoR_1	298	302	PF00244	0.465
LIG_14-3-3_CanoR_1	481	486	PF00244	0.590
LIG_AP2alpha_2	231	233	PF02296	0.514
LIG_BRCT_BRCA1_1	255	259	PF00533	0.426
LIG_BRCT_BRCA1_1	366	370	PF00533	0.491
LIG_FHA_1	2	8	PF00498	0.716
LIG_FHA_1	209	215	PF00498	0.462
LIG_FHA_1	424	430	PF00498	0.437
LIG_FHA_2	152	158	PF00498	0.528
LIG_FHA_2	373	379	PF00498	0.521
LIG_FHA_2	41	47	PF00498	0.391
LIG_FHA_2	515	521	PF00498	0.490
LIG_FHA_2	526	532	PF00498	0.391
LIG_FHA_2	558	564	PF00498	0.569
LIG_FHA_2	74	80	PF00498	0.600
LIG_FHA_2	83	89	PF00498	0.539
LIG_GBD_Chelix_1	213	221	PF00786	0.437
LIG_LIR_Apic_2	138	142	PF02991	0.419
LIG_LIR_Apic_2	231	236	PF02991	0.382
LIG_LIR_Apic_2	247	253	PF02991	0.398
LIG_LIR_Apic_2	300	304	PF02991	0.383
LIG_LIR_Gen_1	22	33	PF02991	0.520
LIG_LIR_Gen_1	305	315	PF02991	0.350
LIG_LIR_LC3C_4	211	214	PF02991	0.471
LIG_LIR_Nem_3	22	28	PF02991	0.497
LIG_LIR_Nem_3	305	311	PF02991	0.350
LIG_LIR_Nem_3	336	341	PF02991	0.614
LIG_MAD2	6	14	PF02301	0.699
LIG_NRBOX	292	298	PF00104	0.503
LIG_REV1ctd_RIR_1	224	231	PF16727	0.427
LIG_SH2_CRK	250	254	PF00017	0.543
LIG_SH2_CRK	279	283	PF00017	0.392
LIG_SH2_SRC	413	416	PF00017	0.500
LIG_SH2_STAP1	19	23	PF00017	0.397
LIG_SH2_STAP1	308	312	PF00017	0.383
LIG_SH2_STAT5	25	28	PF00017	0.510
LIG_SH2_STAT5	284	287	PF00017	0.336
LIG_SH2_STAT5	33	36	PF00017	0.381
LIG_SH2_STAT5	413	416	PF00017	0.500
LIG_SH3_2	476	481	PF14604	0.658
LIG_SH3_3	10	16	PF00018	0.533
LIG_SH3_3	251	257	PF00018	0.475
LIG_SH3_3	388	394	PF00018	0.602
LIG_SH3_3	473	479	PF00018	0.717
LIG_SH3_3	506	512	PF00018	0.651
LIG_SH3_3	67	73	PF00018	0.723
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.508
LIG_SUMO_SIM_anti_2	36	41	PF11976	0.499
LIG_SUMO_SIM_par_1	210	216	PF11976	0.391
LIG_TRAF2_1	120	123	PF00917	0.556
LIG_TRAF2_1	154	157	PF00917	0.556
LIG_UBA3_1	107	113	PF00899	0.481
LIG_UBA3_1	515	521	PF00899	0.577
LIG_WRC_WIRS_1	136	141	PF05994	0.581
LIG_WW_3	14	18	PF00397	0.544
LIG_WW_3	475	479	PF00397	0.635
MOD_CDK_SPK_2	505	510	PF00069	0.594
MOD_CDK_SPxK_1	472	478	PF00069	0.633
MOD_CK1_1	396	402	PF00069	0.655
MOD_CK1_1	405	411	PF00069	0.447
MOD_CK1_1	418	424	PF00069	0.429
MOD_CK1_1	514	520	PF00069	0.579
MOD_CK1_1	525	531	PF00069	0.408
MOD_CK1_1	64	70	PF00069	0.700
MOD_CK2_1	151	157	PF00069	0.532
MOD_CK2_1	169	175	PF00069	0.487
MOD_CK2_1	313	319	PF00069	0.492
MOD_CK2_1	396	402	PF00069	0.655
MOD_CK2_1	40	46	PF00069	0.371
MOD_CK2_1	482	488	PF00069	0.492
MOD_CK2_1	514	520	PF00069	0.579
MOD_CK2_1	525	531	PF00069	0.408
MOD_CK2_1	557	563	PF00069	0.552
MOD_CK2_1	73	79	PF00069	0.551
MOD_CK2_1	82	88	PF00069	0.557
MOD_CMANNOS	307	310	PF00535	0.376
MOD_Cter_Amidation	149	152	PF01082	0.555
MOD_Cter_Amidation	443	446	PF01082	0.607
MOD_Cter_Amidation	566	569	PF01082	0.592
MOD_DYRK1A_RPxSP_1	61	65	PF00069	0.759
MOD_GlcNHglycan	170	174	PF01048	0.639
MOD_GlcNHglycan	304	307	PF01048	0.349
MOD_GlcNHglycan	335	338	PF01048	0.588
MOD_GlcNHglycan	358	361	PF01048	0.697
MOD_GlcNHglycan	398	401	PF01048	0.765
MOD_GlcNHglycan	470	473	PF01048	0.681
MOD_GlcNHglycan	533	536	PF01048	0.631
MOD_GSK3_1	169	176	PF00069	0.664
MOD_GSK3_1	204	211	PF00069	0.462
MOD_GSK3_1	29	36	PF00069	0.536
MOD_GSK3_1	302	309	PF00069	0.397
MOD_GSK3_1	414	421	PF00069	0.408
MOD_GSK3_1	468	475	PF00069	0.715
MOD_GSK3_1	61	68	PF00069	0.768
MOD_N-GLC_1	65	70	PF02516	0.564
MOD_NEK2_1	1	6	PF00069	0.606
MOD_NEK2_1	363	368	PF00069	0.573
MOD_NEK2_1	370	375	PF00069	0.499
MOD_NEK2_1	423	428	PF00069	0.433
MOD_NEK2_1	429	434	PF00069	0.481
MOD_PIKK_1	260	266	PF00454	0.387
MOD_PKA_1	151	157	PF00069	0.576
MOD_PKA_2	1	7	PF00069	0.539
MOD_PKA_2	219	225	PF00069	0.504
MOD_PKA_2	297	303	PF00069	0.459
MOD_PKA_2	342	348	PF00069	0.636
MOD_Plk_1	418	424	PF00069	0.471
MOD_Plk_1	65	71	PF00069	0.706
MOD_Plk_2-3	372	378	PF00069	0.527
MOD_Plk_4	135	141	PF00069	0.516
MOD_Plk_4	208	214	PF00069	0.420
MOD_Plk_4	29	35	PF00069	0.402
MOD_Plk_4	306	312	PF00069	0.400
MOD_Plk_4	418	424	PF00069	0.471
MOD_Plk_4	511	517	PF00069	0.592
MOD_Plk_4	82	88	PF00069	0.600
MOD_ProDKin_1	253	259	PF00069	0.478
MOD_ProDKin_1	393	399	PF00069	0.644
MOD_ProDKin_1	431	437	PF00069	0.495
MOD_ProDKin_1	472	478	PF00069	0.627
MOD_ProDKin_1	482	488	PF00069	0.539
MOD_ProDKin_1	505	511	PF00069	0.480
MOD_ProDKin_1	557	563	PF00069	0.552
MOD_ProDKin_1	61	67	PF00069	0.617
TRG_DiLeu_BaEn_1	244	249	PF01217	0.510
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.611
TRG_ENDOCYTIC_2	25	28	PF00928	0.510
TRG_ENDOCYTIC_2	279	282	PF00928	0.395
TRG_ENDOCYTIC_2	308	311	PF00928	0.376
TRG_ER_diArg_1	142	144	PF00400	0.616
TRG_ER_diArg_1	297	299	PF00400	0.466
TRG_ER_diArg_1	443	446	PF00400	0.543
TRG_ER_diArg_1	50	52	PF00400	0.606
TRG_Pf-PMV_PEXEL_1	144	149	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P3	Leptomonas seymouri	38%	100%
A0A3Q8IFU0	Leishmania donovani	100%	100%
A4HKZ7	Leishmania braziliensis	72%	100%
E9B3D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q4R5	Leishmania major	87%	100%