Robl_LC7 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Roadblock/LC7 domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I8H6_LEIIN

TriTrypDb:

LINF_320042800

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4I8H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8H6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	142	146	PF00082	0.302
CLV_PCSK_SKI1_1	207	211	PF00082	0.587
CLV_PCSK_SKI1_1	228	232	PF00082	0.392
DEG_APCC_DBOX_1	227	235	PF00400	0.369
DEG_SCF_FBW7_1	185	192	PF00400	0.466
DEG_SPOP_SBC_1	33	37	PF00917	0.449
DOC_CKS1_1	186	191	PF01111	0.464
DOC_CYCLIN_RxL_1	225	233	PF00134	0.370
DOC_MAPK_MEF2A_6	142	149	PF00069	0.302
DOC_PP2B_LxvP_1	113	116	PF13499	0.508
DOC_PP2B_LxvP_1	5	8	PF13499	0.484
DOC_USP7_MATH_1	189	193	PF00917	0.547
DOC_USP7_MATH_1	196	200	PF00917	0.669
DOC_USP7_MATH_1	22	26	PF00917	0.557
DOC_WW_Pin1_4	12	17	PF00397	0.517
DOC_WW_Pin1_4	152	157	PF00397	0.338
DOC_WW_Pin1_4	185	190	PF00397	0.463
DOC_WW_Pin1_4	197	202	PF00397	0.646
DOC_WW_Pin1_4	209	214	PF00397	0.729
LIG_14-3-3_CanoR_1	137	141	PF00244	0.302
LIG_14-3-3_CanoR_1	194	203	PF00244	0.561
LIG_14-3-3_CanoR_1	226	231	PF00244	0.585
LIG_14-3-3_CanoR_1	237	244	PF00244	0.416
LIG_14-3-3_CanoR_1	93	100	PF00244	0.518
LIG_BRCT_BRCA1_1	110	114	PF00533	0.506
LIG_BRCT_BRCA1_1	238	242	PF00533	0.397
LIG_BRCT_BRCA1_1	34	38	PF00533	0.460
LIG_BRCT_BRCA1_1	52	56	PF00533	0.522
LIG_FHA_1	105	111	PF00498	0.532
LIG_FHA_1	139	145	PF00498	0.376
LIG_FHA_1	76	82	PF00498	0.649
LIG_LIR_Gen_1	111	118	PF02991	0.652
LIG_LIR_Gen_1	159	169	PF02991	0.302
LIG_LIR_Gen_1	171	180	PF02991	0.215
LIG_LIR_Nem_3	111	115	PF02991	0.655
LIG_LIR_Nem_3	159	164	PF02991	0.302
LIG_LIR_Nem_3	35	41	PF02991	0.473
LIG_SH2_STAP1	172	176	PF00017	0.354
LIG_SH2_STAT5	140	143	PF00017	0.302
LIG_SH2_STAT5	88	91	PF00017	0.525
LIG_SH3_3	210	216	PF00018	0.575
LIG_SH3_3	244	250	PF00018	0.350
LIG_SUMO_SIM_anti_2	219	226	PF11976	0.428
LIG_SUMO_SIM_par_1	1	6	PF11976	0.476
LIG_SUMO_SIM_par_1	78	85	PF11976	0.494
LIG_TRAF2_1	216	219	PF00917	0.565
MOD_CDC14_SPxK_1	15	18	PF00782	0.512
MOD_CDK_SPxK_1	12	18	PF00069	0.511
MOD_CDK_SPxK_1	152	158	PF00069	0.338
MOD_CDK_SPxK_1	185	191	PF00069	0.474
MOD_CK1_1	152	158	PF00069	0.282
MOD_CK1_1	197	203	PF00069	0.761
MOD_CK1_1	6	12	PF00069	0.647
MOD_CK1_1	75	81	PF00069	0.560
MOD_CK1_1	91	97	PF00069	0.650
MOD_CK2_1	217	223	PF00069	0.502
MOD_GlcNHglycan	100	103	PF01048	0.558
MOD_GlcNHglycan	126	129	PF01048	0.652
MOD_GlcNHglycan	24	27	PF01048	0.498
MOD_GlcNHglycan	5	8	PF01048	0.505
MOD_GlcNHglycan	90	93	PF01048	0.606
MOD_GSK3_1	104	111	PF00069	0.525
MOD_GSK3_1	148	155	PF00069	0.470
MOD_GSK3_1	164	171	PF00069	0.243
MOD_GSK3_1	185	192	PF00069	0.540
MOD_GSK3_1	22	29	PF00069	0.519
MOD_GSK3_1	3	10	PF00069	0.529
MOD_GSK3_1	39	46	PF00069	0.645
MOD_GSK3_1	47	54	PF00069	0.656
MOD_GSK3_1	72	79	PF00069	0.518
MOD_N-GLC_1	75	80	PF02516	0.512
MOD_NEK2_1	164	169	PF00069	0.302
MOD_NEK2_1	3	8	PF00069	0.511
MOD_NEK2_1	81	86	PF00069	0.575
MOD_NEK2_2	51	56	PF00069	0.501
MOD_OFUCOSY	59	66	PF10250	0.496
MOD_PIKK_1	43	49	PF00454	0.498
MOD_PIKK_1	93	99	PF00454	0.517
MOD_PKA_2	136	142	PF00069	0.375
MOD_PKA_2	157	163	PF00069	0.386
MOD_PKA_2	236	242	PF00069	0.382
MOD_PKA_2	98	104	PF00069	0.513
MOD_Plk_1	164	170	PF00069	0.302
MOD_Plk_1	218	224	PF00069	0.470
MOD_Plk_1	43	49	PF00069	0.580
MOD_Plk_1	75	81	PF00069	0.514
MOD_Plk_4	108	114	PF00069	0.506
MOD_Plk_4	51	57	PF00069	0.500
MOD_Plk_4	76	82	PF00069	0.559
MOD_ProDKin_1	12	18	PF00069	0.519
MOD_ProDKin_1	152	158	PF00069	0.338
MOD_ProDKin_1	185	191	PF00069	0.474
MOD_ProDKin_1	197	203	PF00069	0.651
MOD_ProDKin_1	209	215	PF00069	0.724
TRG_ENDOCYTIC_2	172	175	PF00928	0.302
TRG_ER_diArg_1	225	228	PF00400	0.559
TRG_ER_diArg_1	27	30	PF00400	0.635
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.302
TRG_Pf-PMV_PEXEL_1	228	233	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X636	Leishmania donovani	99%	100%
Q4Q4R6	Leishmania major	86%	100%