Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8H5_LEIIN

TriTrypDb:

LINF_320042700

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8H5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.533
CLV_C14_Caspase3-7	320	324	PF00656	0.535
CLV_C14_Caspase3-7	374	378	PF00656	0.633
CLV_C14_Caspase3-7	416	420	PF00656	0.552
CLV_NRD_NRD_1	210	212	PF00675	0.415
CLV_NRD_NRD_1	243	245	PF00675	0.678
CLV_NRD_NRD_1	254	256	PF00675	0.593
CLV_NRD_NRD_1	353	355	PF00675	0.632
CLV_NRD_NRD_1	361	363	PF00675	0.594
CLV_NRD_NRD_1	366	368	PF00675	0.553
CLV_NRD_NRD_1	401	403	PF00675	0.621
CLV_NRD_NRD_1	58	60	PF00675	0.537
CLV_PCSK_KEX2_1	243	245	PF00082	0.576
CLV_PCSK_KEX2_1	317	319	PF00082	0.598
CLV_PCSK_KEX2_1	353	355	PF00082	0.670
CLV_PCSK_KEX2_1	361	363	PF00082	0.587
CLV_PCSK_KEX2_1	365	367	PF00082	0.557
CLV_PCSK_KEX2_1	400	402	PF00082	0.614
CLV_PCSK_KEX2_1	407	409	PF00082	0.618
CLV_PCSK_KEX2_1	411	413	PF00082	0.587
CLV_PCSK_KEX2_1	58	60	PF00082	0.503
CLV_PCSK_KEX2_1	73	75	PF00082	0.549
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.598
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.654
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.658
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.607
CLV_PCSK_PC7_1	361	367	PF00082	0.574
CLV_PCSK_SKI1_1	172	176	PF00082	0.536
CLV_PCSK_SKI1_1	412	416	PF00082	0.631
CLV_PCSK_SKI1_1	59	63	PF00082	0.466
DEG_MDM2_SWIB_1	220	228	PF02201	0.520
DEG_Nend_Nbox_1	1	3	PF02207	0.553
DEG_SPOP_SBC_1	371	375	PF00917	0.557
DEG_SPOP_SBC_1	67	71	PF00917	0.483
DEG_SPOP_SBC_1	97	101	PF00917	0.560
DOC_CKS1_1	267	272	PF01111	0.577
DOC_CYCLIN_RxL_1	56	66	PF00134	0.455
DOC_MAPK_MEF2A_6	165	173	PF00069	0.468
DOC_USP7_MATH_1	123	127	PF00917	0.481
DOC_USP7_MATH_1	155	159	PF00917	0.678
DOC_USP7_MATH_1	192	196	PF00917	0.647
DOC_USP7_MATH_1	231	235	PF00917	0.534
DOC_USP7_MATH_1	346	350	PF00917	0.614
DOC_USP7_MATH_1	371	375	PF00917	0.586
DOC_USP7_UBL2_3	403	407	PF12436	0.598
DOC_WW_Pin1_4	190	195	PF00397	0.601
DOC_WW_Pin1_4	266	271	PF00397	0.575
DOC_WW_Pin1_4	312	317	PF00397	0.569
DOC_WW_Pin1_4	339	344	PF00397	0.593
DOC_WW_Pin1_4	386	391	PF00397	0.584
LIG_14-3-3_CanoR_1	122	132	PF00244	0.509
LIG_14-3-3_CanoR_1	16	24	PF00244	0.511
LIG_14-3-3_CanoR_1	272	278	PF00244	0.609
LIG_14-3-3_CanoR_1	412	418	PF00244	0.588
LIG_14-3-3_CanoR_1	436	441	PF00244	0.587
LIG_14-3-3_CanoR_1	74	84	PF00244	0.665
LIG_Actin_WH2_2	156	174	PF00022	0.518
LIG_Actin_WH2_2	215	231	PF00022	0.466
LIG_CaM_NSCaTE_8	224	231	PF13499	0.429
LIG_Clathr_ClatBox_1	219	223	PF01394	0.469
LIG_DCNL_PONY_1	1	4	PF03556	0.494
LIG_FHA_1	155	161	PF00498	0.510
LIG_FHA_1	173	179	PF00498	0.380
LIG_FHA_2	88	94	PF00498	0.643
LIG_GBD_Chelix_1	206	214	PF00786	0.502
LIG_GBD_Chelix_1	53	61	PF00786	0.519
LIG_LIR_Apic_2	21	27	PF02991	0.637
LIG_LIR_Gen_1	223	232	PF02991	0.593
LIG_LIR_Nem_3	223	227	PF02991	0.573
LIG_PDZ_Class_1	436	441	PF00595	0.586
LIG_Pex14_1	213	217	PF04695	0.497
LIG_Pex14_2	217	221	PF04695	0.501
LIG_SH2_STAP1	297	301	PF00017	0.469
LIG_SH2_STAT3	296	299	PF00017	0.507
LIG_SH2_STAT5	216	219	PF00017	0.670
LIG_SH3_3	138	144	PF00018	0.537
LIG_SH3_3	198	204	PF00018	0.502
LIG_SH3_3	340	346	PF00018	0.593
LIG_SUMO_SIM_anti_2	198	203	PF11976	0.475
LIG_SUMO_SIM_par_1	195	200	PF11976	0.519
LIG_SUMO_SIM_par_1	427	433	PF11976	0.568
LIG_TRAF2_1	18	21	PF00917	0.628
MOD_CDK_SPK_2	312	317	PF00069	0.530
MOD_CDK_SPxK_1	266	272	PF00069	0.578
MOD_CDK_SPxK_1	312	318	PF00069	0.533
MOD_CK1_1	101	107	PF00069	0.556
MOD_CK1_1	195	201	PF00069	0.617
MOD_CK1_1	3	9	PF00069	0.534
MOD_CK1_1	310	316	PF00069	0.531
MOD_CK1_1	372	378	PF00069	0.647
MOD_CK1_1	66	72	PF00069	0.574
MOD_CK1_1	87	93	PF00069	0.679
MOD_CK2_1	15	21	PF00069	0.567
MOD_GlcNHglycan	101	104	PF01048	0.556
MOD_GlcNHglycan	126	129	PF01048	0.410
MOD_GlcNHglycan	156	160	PF01048	0.549
MOD_GlcNHglycan	229	232	PF01048	0.507
MOD_GlcNHglycan	233	236	PF01048	0.539
MOD_GlcNHglycan	309	312	PF01048	0.515
MOD_GlcNHglycan	348	351	PF01048	0.633
MOD_GlcNHglycan	379	383	PF01048	0.611
MOD_GlcNHglycan	64	68	PF01048	0.569
MOD_GlcNHglycan	86	89	PF01048	0.650
MOD_GSK3_1	143	150	PF00069	0.586
MOD_GSK3_1	227	234	PF00069	0.557
MOD_GSK3_1	251	258	PF00069	0.648
MOD_GSK3_1	307	314	PF00069	0.522
MOD_GSK3_1	369	376	PF00069	0.652
MOD_GSK3_1	63	70	PF00069	0.537
MOD_GSK3_1	87	94	PF00069	0.632
MOD_GSK3_1	97	104	PF00069	0.610
MOD_N-GLC_1	97	102	PF02516	0.561
MOD_NEK2_1	173	178	PF00069	0.541
MOD_NEK2_1	206	211	PF00069	0.440
MOD_NEK2_1	227	232	PF00069	0.559
MOD_NEK2_1	327	332	PF00069	0.579
MOD_NEK2_1	63	68	PF00069	0.524
MOD_PIKK_1	101	107	PF00454	0.684
MOD_PIKK_1	328	334	PF00454	0.577
MOD_PIKK_1	36	42	PF00454	0.470
MOD_PKA_1	255	261	PF00069	0.621
MOD_PKA_1	317	323	PF00069	0.592
MOD_PKA_1	73	79	PF00069	0.605
MOD_PKA_2	15	21	PF00069	0.498
MOD_PKA_2	251	257	PF00069	0.599
MOD_PKA_2	317	323	PF00069	0.592
MOD_PKA_2	67	73	PF00069	0.601
MOD_Plk_1	155	161	PF00069	0.694
MOD_Plk_4	192	198	PF00069	0.619
MOD_Plk_4	273	279	PF00069	0.634
MOD_Plk_4	3	9	PF00069	0.495
MOD_ProDKin_1	190	196	PF00069	0.604
MOD_ProDKin_1	266	272	PF00069	0.578
MOD_ProDKin_1	312	318	PF00069	0.572
MOD_ProDKin_1	339	345	PF00069	0.595
MOD_ProDKin_1	386	392	PF00069	0.582
TRG_DiLeu_BaEn_1	223	228	PF01217	0.416
TRG_ENDOCYTIC_2	216	219	PF00928	0.631
TRG_ER_diArg_1	119	122	PF00400	0.568
TRG_ER_diArg_1	364	367	PF00400	0.594
TRG_ER_diArg_1	400	402	PF00400	0.579
TRG_ER_diArg_1	435	438	PF00400	0.614
TRG_ER_diArg_1	57	59	PF00400	0.462
TRG_Pf-PMV_PEXEL_1	59	64	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7T2	Leishmania donovani	100%	100%
A4HKZ5	Leishmania braziliensis	57%	100%
E9B3D5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q4R7	Leishmania major	83%	100%