START domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8H4_LEIIN

TriTrypDb:

LINF_320042600

Length:

300

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8H4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8H4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.700
CLV_C14_Caspase3-7	184	188	PF00656	0.528
CLV_C14_Caspase3-7	224	228	PF00656	0.660
CLV_NRD_NRD_1	206	208	PF00675	0.607
CLV_NRD_NRD_1	55	57	PF00675	0.459
CLV_PCSK_KEX2_1	126	128	PF00082	0.607
CLV_PCSK_KEX2_1	298	300	PF00082	0.755
CLV_PCSK_KEX2_1	57	59	PF00082	0.391
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.607
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.788
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.449
CLV_PCSK_SKI1_1	39	43	PF00082	0.532
CLV_PCSK_SKI1_1	46	50	PF00082	0.523
CLV_PCSK_SKI1_1	58	62	PF00082	0.365
DOC_ANK_TNKS_1	27	34	PF00023	0.558
DOC_CKS1_1	160	165	PF01111	0.611
DOC_MAPK_gen_1	126	134	PF00069	0.529
DOC_MAPK_gen_1	258	266	PF00069	0.632
DOC_PP4_FxxP_1	145	148	PF00568	0.573
DOC_PP4_FxxP_1	288	291	PF00568	0.648
DOC_USP7_MATH_1	107	111	PF00917	0.639
DOC_USP7_MATH_1	226	230	PF00917	0.659
DOC_USP7_UBL2_3	243	247	PF12436	0.654
DOC_USP7_UBL2_3	57	61	PF12436	0.583
DOC_WW_Pin1_4	159	164	PF00397	0.606
LIG_14-3-3_CanoR_1	149	155	PF00244	0.564
LIG_14-3-3_CanoR_1	39	49	PF00244	0.415
LIG_14-3-3_CanoR_1	80	86	PF00244	0.493
LIG_eIF4E_1	113	119	PF01652	0.611
LIG_FHA_1	184	190	PF00498	0.530
LIG_FHA_1	231	237	PF00498	0.568
LIG_FHA_1	80	86	PF00498	0.462
LIG_FHA_1	88	94	PF00498	0.419
LIG_FHA_2	18	24	PF00498	0.539
LIG_LIR_Apic_2	136	142	PF02991	0.428
LIG_LIR_Apic_2	285	291	PF02991	0.607
LIG_LIR_Gen_1	153	161	PF02991	0.572
LIG_LIR_Gen_1	217	226	PF02991	0.536
LIG_LIR_Gen_1	34	45	PF02991	0.601
LIG_LIR_Gen_1	59	70	PF02991	0.597
LIG_LIR_Nem_3	153	157	PF02991	0.568
LIG_LIR_Nem_3	217	221	PF02991	0.525
LIG_LIR_Nem_3	34	40	PF02991	0.511
LIG_LIR_Nem_3	59	65	PF02991	0.568
LIG_NRBOX	156	162	PF00104	0.581
LIG_SH2_CRK	115	119	PF00017	0.604
LIG_SH2_CRK	139	143	PF00017	0.455
LIG_SH2_CRK	218	222	PF00017	0.603
LIG_SH2_GRB2like	280	283	PF00017	0.610
LIG_SH2_PTP2	154	157	PF00017	0.516
LIG_SH2_SRC	62	65	PF00017	0.537
LIG_SH2_STAP1	216	220	PF00017	0.533
LIG_SH2_STAP1	62	66	PF00017	0.587
LIG_SH2_STAT5	102	105	PF00017	0.587
LIG_SH2_STAT5	154	157	PF00017	0.570
LIG_SH2_STAT5	199	202	PF00017	0.656
LIG_TRAF2_1	15	18	PF00917	0.735
LIG_TYR_ITIM	152	157	PF00017	0.566
MOD_CK1_1	153	159	PF00069	0.545
MOD_CK1_1	71	77	PF00069	0.609
MOD_CK2_1	249	255	PF00069	0.611
MOD_CK2_1	289	295	PF00069	0.721
MOD_GlcNHglycan	49	52	PF01048	0.630
MOD_GSK3_1	130	137	PF00069	0.518
MOD_GSK3_1	17	24	PF00069	0.448
MOD_GSK3_1	226	233	PF00069	0.644
MOD_GSK3_1	47	54	PF00069	0.610
MOD_N-GLC_1	107	112	PF02516	0.551
MOD_N-GLC_1	130	135	PF02516	0.576
MOD_NEK2_1	190	195	PF00069	0.408
MOD_NEK2_1	230	235	PF00069	0.556
MOD_NEK2_1	47	52	PF00069	0.612
MOD_NEK2_1	79	84	PF00069	0.591
MOD_NEK2_2	51	56	PF00069	0.544
MOD_PIKK_1	190	196	PF00454	0.525
MOD_PKA_1	207	213	PF00069	0.650
MOD_PKA_2	171	177	PF00069	0.755
MOD_PKA_2	79	85	PF00069	0.475
MOD_Plk_1	107	113	PF00069	0.548
MOD_Plk_1	130	136	PF00069	0.573
MOD_Plk_2-3	17	23	PF00069	0.698
MOD_Plk_2-3	250	256	PF00069	0.629
MOD_Plk_4	107	113	PF00069	0.575
MOD_Plk_4	216	222	PF00069	0.609
MOD_Plk_4	275	281	PF00069	0.523
MOD_ProDKin_1	159	165	PF00069	0.606
MOD_SUMO_rev_2	63	71	PF00179	0.588
TRG_ENDOCYTIC_2	115	118	PF00928	0.608
TRG_ENDOCYTIC_2	154	157	PF00928	0.570
TRG_ENDOCYTIC_2	218	221	PF00928	0.606
TRG_ENDOCYTIC_2	62	65	PF00928	0.618
TRG_ER_diArg_1	55	58	PF00400	0.393
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IH56	Leishmania donovani	99%	100%
A4HKZ3	Leishmania braziliensis	76%	100%
E9AEG9	Leishmania major	94%	66%
E9B3D4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%