Putative DEAD/DEAH box helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DEAD/DEAH box helicase - putative

Species:

Leishmania infantum

UniProt:

A4I8H3_LEIIN

TriTrypDb:

LINF_320042500

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I8H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8H3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004386	helicase activity	2	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	487	491	PF00656	0.414
CLV_C14_Caspase3-7	517	521	PF00656	0.583
CLV_C14_Caspase3-7	679	683	PF00656	0.563
CLV_NRD_NRD_1	2	4	PF00675	0.608
CLV_NRD_NRD_1	220	222	PF00675	0.313
CLV_NRD_NRD_1	233	235	PF00675	0.269
CLV_NRD_NRD_1	261	263	PF00675	0.356
CLV_NRD_NRD_1	270	272	PF00675	0.288
CLV_NRD_NRD_1	273	275	PF00675	0.225
CLV_NRD_NRD_1	344	346	PF00675	0.482
CLV_NRD_NRD_1	501	503	PF00675	0.528
CLV_NRD_NRD_1	505	507	PF00675	0.534
CLV_NRD_NRD_1	513	515	PF00675	0.489
CLV_NRD_NRD_1	537	539	PF00675	0.661
CLV_NRD_NRD_1	588	590	PF00675	0.479
CLV_NRD_NRD_1	648	650	PF00675	0.441
CLV_PCSK_KEX2_1	14	16	PF00082	0.562
CLV_PCSK_KEX2_1	220	222	PF00082	0.313
CLV_PCSK_KEX2_1	259	261	PF00082	0.345
CLV_PCSK_KEX2_1	267	269	PF00082	0.280
CLV_PCSK_KEX2_1	344	346	PF00082	0.482
CLV_PCSK_KEX2_1	43	45	PF00082	0.556
CLV_PCSK_KEX2_1	500	502	PF00082	0.513
CLV_PCSK_KEX2_1	537	539	PF00082	0.661
CLV_PCSK_KEX2_1	588	590	PF00082	0.517
CLV_PCSK_KEX2_1	648	650	PF00082	0.481
CLV_PCSK_KEX2_1	665	667	PF00082	0.520
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.568
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.351
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.317
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.648
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.578
CLV_PCSK_PC7_1	256	262	PF00082	0.395
CLV_PCSK_PC7_1	644	650	PF00082	0.503
CLV_PCSK_SKI1_1	204	208	PF00082	0.282
CLV_PCSK_SKI1_1	220	224	PF00082	0.282
CLV_PCSK_SKI1_1	314	318	PF00082	0.308
CLV_PCSK_SKI1_1	345	349	PF00082	0.497
CLV_PCSK_SKI1_1	36	40	PF00082	0.655
CLV_PCSK_SKI1_1	387	391	PF00082	0.490
CLV_PCSK_SKI1_1	49	53	PF00082	0.550
CLV_PCSK_SKI1_1	644	648	PF00082	0.555
CLV_Separin_Metazoa	225	229	PF03568	0.534
DEG_APCC_DBOX_1	399	407	PF00400	0.522
DEG_Nend_Nbox_1	1	3	PF02207	0.689
DEG_SIAH_1	75	83	PF03145	0.614
DEG_SPOP_SBC_1	112	116	PF00917	0.758
DEG_SPOP_SBC_1	117	121	PF00917	0.707
DOC_CYCLIN_RxL_1	311	320	PF00134	0.586
DOC_CYCLIN_RxL_1	344	356	PF00134	0.638
DOC_CYCLIN_RxL_1	9	22	PF00134	0.641
DOC_MAPK_gen_1	164	173	PF00069	0.482
DOC_MAPK_gen_1	318	328	PF00069	0.496
DOC_MAPK_gen_1	662	672	PF00069	0.537
DOC_MAPK_gen_1	9	18	PF00069	0.680
DOC_MAPK_HePTP_8	8	20	PF00069	0.592
DOC_MAPK_MEF2A_6	11	20	PF00069	0.679
DOC_MAPK_MEF2A_6	153	161	PF00069	0.475
DOC_MAPK_MEF2A_6	321	330	PF00069	0.496
DOC_MAPK_MEF2A_6	441	448	PF00069	0.376
DOC_MAPK_NFAT4_5	441	449	PF00069	0.436
DOC_PP1_RVXF_1	202	208	PF00149	0.482
DOC_PP1_RVXF_1	34	41	PF00149	0.582
DOC_PP2B_LxvP_1	446	449	PF13499	0.473
DOC_PP2B_LxvP_1	584	587	PF13499	0.544
DOC_PP2B_LxvP_1	602	605	PF13499	0.482
DOC_PP4_FxxP_1	632	635	PF00568	0.566
DOC_USP7_MATH_1	112	116	PF00917	0.740
DOC_USP7_MATH_1	117	121	PF00917	0.689
DOC_USP7_MATH_1	208	212	PF00917	0.521
DOC_USP7_MATH_1	363	367	PF00917	0.655
DOC_USP7_MATH_1	371	375	PF00917	0.623
DOC_USP7_MATH_1	416	420	PF00917	0.689
DOC_USP7_MATH_1	530	534	PF00917	0.525
DOC_USP7_MATH_1	552	556	PF00917	0.793
DOC_USP7_MATH_1	573	577	PF00917	0.707
DOC_USP7_MATH_1	635	639	PF00917	0.531
DOC_WW_Pin1_4	247	252	PF00397	0.482
DOC_WW_Pin1_4	558	563	PF00397	0.790
DOC_WW_Pin1_4	565	570	PF00397	0.741
DOC_WW_Pin1_4	579	584	PF00397	0.657
LIG_14-3-3_CanoR_1	274	280	PF00244	0.480
LIG_14-3-3_CanoR_1	480	486	PF00244	0.526
LIG_14-3-3_CanoR_1	589	599	PF00244	0.531
LIG_14-3-3_CanoR_1	634	642	PF00244	0.563
LIG_Actin_WH2_2	16	33	PF00022	0.592
LIG_BRCT_BRCA1_1	119	123	PF00533	0.646
LIG_BRCT_BRCA1_1	532	536	PF00533	0.591
LIG_CaM_IQ_9	392	407	PF13499	0.564
LIG_Clathr_ClatBox_1	290	294	PF01394	0.482
LIG_deltaCOP1_diTrp_1	190	198	PF00928	0.541
LIG_deltaCOP1_diTrp_1	252	257	PF00928	0.496
LIG_eIF4E_1	346	352	PF01652	0.620
LIG_FHA_1	138	144	PF00498	0.539
LIG_FHA_1	152	158	PF00498	0.436
LIG_FHA_1	174	180	PF00498	0.534
LIG_FHA_1	208	214	PF00498	0.482
LIG_FHA_1	221	227	PF00498	0.482
LIG_FHA_1	231	237	PF00498	0.487
LIG_FHA_1	248	254	PF00498	0.397
LIG_FHA_1	285	291	PF00498	0.495
LIG_FHA_1	354	360	PF00498	0.565
LIG_FHA_1	480	486	PF00498	0.588
LIG_FHA_1	606	612	PF00498	0.435
LIG_FHA_1	615	621	PF00498	0.426
LIG_FHA_2	247	253	PF00498	0.586
LIG_FHA_2	393	399	PF00498	0.431
LIG_FHA_2	616	622	PF00498	0.551
LIG_HCF-1_HBM_1	216	219	PF13415	0.562
LIG_LIR_Apic_2	195	200	PF02991	0.562
LIG_LIR_Apic_2	320	325	PF02991	0.534
LIG_LIR_Gen_1	25	33	PF02991	0.522
LIG_LIR_Gen_1	278	285	PF02991	0.530
LIG_LIR_Gen_1	442	449	PF02991	0.526
LIG_LIR_Nem_3	120	126	PF02991	0.561
LIG_LIR_Nem_3	216	222	PF02991	0.534
LIG_LIR_Nem_3	25	30	PF02991	0.508
LIG_LIR_Nem_3	252	258	PF02991	0.485
LIG_LIR_Nem_3	442	446	PF02991	0.528
LIG_LIR_Nem_3	533	539	PF02991	0.629
LIG_MYND_1	412	416	PF01753	0.599
LIG_PCNA_yPIPBox_3	310	321	PF02747	0.507
LIG_PTB_Apo_2	239	246	PF02174	0.562
LIG_PTB_Phospho_1	239	245	PF10480	0.562
LIG_RPA_C_Fungi	256	268	PF08784	0.408
LIG_RPA_C_Fungi	99	111	PF08784	0.503
LIG_SH2_CRK	219	223	PF00017	0.335
LIG_SH2_CRK	322	326	PF00017	0.349
LIG_SH2_PTP2	443	446	PF00017	0.448
LIG_SH2_SRC	94	97	PF00017	0.560
LIG_SH2_STAP1	277	281	PF00017	0.447
LIG_SH2_STAT3	138	141	PF00017	0.355
LIG_SH2_STAT5	184	187	PF00017	0.447
LIG_SH2_STAT5	245	248	PF00017	0.335
LIG_SH2_STAT5	319	322	PF00017	0.480
LIG_SH2_STAT5	391	394	PF00017	0.399
LIG_SH2_STAT5	443	446	PF00017	0.525
LIG_SH2_STAT5	484	487	PF00017	0.562
LIG_SH2_STAT5	94	97	PF00017	0.423
LIG_SH3_2	583	588	PF14604	0.580
LIG_SH3_3	142	148	PF00018	0.447
LIG_SH3_3	458	464	PF00018	0.490
LIG_SH3_3	520	526	PF00018	0.660
LIG_SH3_3	580	586	PF00018	0.670
LIG_SUMO_SIM_anti_2	175	181	PF11976	0.447
LIG_SUMO_SIM_anti_2	286	292	PF11976	0.335
LIG_SUMO_SIM_anti_2	442	448	PF11976	0.404
LIG_SUMO_SIM_anti_2	608	614	PF11976	0.432
LIG_SUMO_SIM_par_1	175	181	PF11976	0.447
LIG_SUMO_SIM_par_1	289	295	PF11976	0.335
LIG_SUMO_SIM_par_1	444	450	PF11976	0.378
LIG_TRAF2_1	395	398	PF00917	0.438
LIG_TRFH_1	279	283	PF08558	0.355
LIG_UBA3_1	312	321	PF00899	0.335
LIG_UBA3_1	444	453	PF00899	0.466
LIG_WW_3	585	589	PF00397	0.561
MOD_CDC14_SPxK_1	582	585	PF00782	0.636
MOD_CDK_SPK_2	558	563	PF00069	0.585
MOD_CDK_SPxK_1	579	585	PF00069	0.650
MOD_CK1_1	105	111	PF00069	0.601
MOD_CK1_1	115	121	PF00069	0.581
MOD_CK1_1	211	217	PF00069	0.387
MOD_CK1_1	430	436	PF00069	0.693
MOD_CK2_1	392	398	PF00069	0.444
MOD_CK2_1	615	621	PF00069	0.457
MOD_GlcNHglycan	115	118	PF01048	0.627
MOD_GlcNHglycan	262	265	PF01048	0.266
MOD_GlcNHglycan	305	308	PF01048	0.468
MOD_GlcNHglycan	331	334	PF01048	0.330
MOD_GlcNHglycan	365	368	PF01048	0.724
MOD_GlcNHglycan	418	421	PF01048	0.691
MOD_GlcNHglycan	433	436	PF01048	0.450
MOD_GlcNHglycan	527	530	PF01048	0.680
MOD_GlcNHglycan	554	557	PF01048	0.722
MOD_GlcNHglycan	637	640	PF01048	0.417
MOD_GlcNHglycan	644	647	PF01048	0.440
MOD_GlcNHglycan	678	681	PF01048	0.601
MOD_GSK3_1	102	109	PF00069	0.550
MOD_GSK3_1	111	118	PF00069	0.623
MOD_GSK3_1	207	214	PF00069	0.432
MOD_GSK3_1	25	32	PF00069	0.520
MOD_GSK3_1	299	306	PF00069	0.468
MOD_GSK3_1	331	338	PF00069	0.335
MOD_GSK3_1	371	378	PF00069	0.609
MOD_GSK3_1	426	433	PF00069	0.686
MOD_GSK3_1	550	557	PF00069	0.732
MOD_GSK3_1	573	580	PF00069	0.675
MOD_GSK3_1	58	65	PF00069	0.570
MOD_N-GLC_1	102	107	PF02516	0.614
MOD_N-GLC_1	211	216	PF02516	0.447
MOD_N-GLC_1	230	235	PF02516	0.447
MOD_N-GLC_1	543	548	PF02516	0.605
MOD_NEK2_1	106	111	PF00069	0.691
MOD_NEK2_1	173	178	PF00069	0.408
MOD_NEK2_1	207	212	PF00069	0.361
MOD_NEK2_1	317	322	PF00069	0.374
MOD_NEK2_1	335	340	PF00069	0.201
MOD_NEK2_1	407	412	PF00069	0.461
MOD_NEK2_1	489	494	PF00069	0.637
MOD_NEK2_1	577	582	PF00069	0.728
MOD_NEK2_1	58	63	PF00069	0.526
MOD_NEK2_1	642	647	PF00069	0.465
MOD_NEK2_1	653	658	PF00069	0.472
MOD_NEK2_1	99	104	PF00069	0.601
MOD_PIKK_1	137	143	PF00454	0.402
MOD_PIKK_1	300	306	PF00454	0.419
MOD_PIKK_1	392	398	PF00454	0.572
MOD_PIKK_1	472	478	PF00454	0.616
MOD_PIKK_1	554	560	PF00454	0.803
MOD_PKA_1	220	226	PF00069	0.378
MOD_PKA_1	260	266	PF00069	0.386
MOD_PKA_2	220	226	PF00069	0.335
MOD_PKA_2	260	266	PF00069	0.365
MOD_PKA_2	317	323	PF00069	0.438
MOD_PKA_2	479	485	PF00069	0.535
MOD_PKB_1	500	508	PF00069	0.598
MOD_Plk_1	102	108	PF00069	0.551
MOD_Plk_1	489	495	PF00069	0.594
MOD_Plk_1	49	55	PF00069	0.568
MOD_Plk_1	59	65	PF00069	0.510
MOD_Plk_4	173	179	PF00069	0.408
MOD_Plk_4	531	537	PF00069	0.582
MOD_Plk_4	637	643	PF00069	0.461
MOD_ProDKin_1	247	253	PF00069	0.335
MOD_ProDKin_1	558	564	PF00069	0.786
MOD_ProDKin_1	565	571	PF00069	0.741
MOD_ProDKin_1	579	585	PF00069	0.650
MOD_SUMO_for_1	452	455	PF00179	0.489
MOD_SUMO_rev_2	361	366	PF00179	0.614
MOD_SUMO_rev_2	419	424	PF00179	0.578
TRG_DiLeu_BaEn_2	503	509	PF01217	0.589
TRG_DiLeu_BaEn_4	25	31	PF01217	0.669
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.544
TRG_ENDOCYTIC_2	219	222	PF00928	0.335
TRG_ENDOCYTIC_2	443	446	PF00928	0.525
TRG_ER_diArg_1	219	221	PF00400	0.378
TRG_ER_diArg_1	260	262	PF00400	0.430
TRG_ER_diArg_1	343	345	PF00400	0.474
TRG_ER_diArg_1	500	502	PF00400	0.567
TRG_ER_diArg_1	536	538	PF00400	0.672
TRG_ER_diArg_1	587	589	PF00400	0.483
TRG_ER_diArg_1	648	650	PF00400	0.480
TRG_NES_CRM1_1	603	615	PF08389	0.484
TRG_NLS_Bipartite_1	259	275	PF00514	0.351
TRG_NLS_MonoCore_2	258	263	PF00514	0.383
TRG_NLS_MonoExtC_3	270	275	PF00514	0.305
TRG_NLS_MonoExtN_4	256	263	PF00514	0.383
TRG_NLS_MonoExtN_4	268	275	PF00514	0.243
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	220	225	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	471	476	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	537	542	PF00026	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I401	Leptomonas seymouri	68%	99%
A0A1X0NSB4	Trypanosomatidae	45%	100%
A0A3R7NUR2	Trypanosoma rangeli	51%	100%
A0A3S7X625	Leishmania donovani	100%	100%
A4HKZ2	Leishmania braziliensis	86%	100%
D0AAP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B3D3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q4S3	Leishmania major	95%	100%
V5BVL4	Trypanosoma cruzi	54%	100%