TPR_REGION domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I8H2_LEIIN

TriTrypDb:

LINF_320042300

Length:

636

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8H2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.737
CLV_NRD_NRD_1	390	392	PF00675	0.488
CLV_NRD_NRD_1	431	433	PF00675	0.485
CLV_NRD_NRD_1	6	8	PF00675	0.740
CLV_PCSK_KEX2_1	12	14	PF00082	0.635
CLV_PCSK_KEX2_1	389	391	PF00082	0.455
CLV_PCSK_KEX2_1	431	433	PF00082	0.426
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.668
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.455
CLV_PCSK_SKI1_1	13	17	PF00082	0.684
CLV_PCSK_SKI1_1	225	229	PF00082	0.430
CLV_PCSK_SKI1_1	343	347	PF00082	0.486
CLV_PCSK_SKI1_1	362	366	PF00082	0.551
CLV_PCSK_SKI1_1	80	84	PF00082	0.435
DEG_APCC_DBOX_1	12	20	PF00400	0.682
DEG_APCC_DBOX_1	257	265	PF00400	0.451
DEG_APCC_DBOX_1	442	450	PF00400	0.472
DOC_CKS1_1	24	29	PF01111	0.589
DOC_CYCLIN_RxL_1	77	86	PF00134	0.454
DOC_CYCLIN_yClb5_NLxxxL_5	469	478	PF00134	0.479
DOC_MAPK_MEF2A_6	243	251	PF00069	0.446
DOC_MAPK_MEF2A_6	258	265	PF00069	0.435
DOC_MAPK_MEF2A_6	270	277	PF00069	0.362
DOC_MAPK_NFAT4_5	270	278	PF00069	0.405
DOC_PP2B_LxvP_1	19	22	PF13499	0.666
DOC_PP2B_LxvP_1	561	564	PF13499	0.463
DOC_PP4_FxxP_1	15	18	PF00568	0.650
DOC_USP7_MATH_1	11	15	PF00917	0.615
DOC_USP7_MATH_1	168	172	PF00917	0.522
DOC_USP7_MATH_1	381	385	PF00917	0.587
DOC_USP7_MATH_1	482	486	PF00917	0.620
DOC_USP7_MATH_1	496	500	PF00917	0.662
DOC_USP7_MATH_1	528	532	PF00917	0.403
DOC_USP7_MATH_1	617	621	PF00917	0.516
DOC_USP7_UBL2_3	361	365	PF12436	0.555
DOC_USP7_UBL2_3	8	12	PF12436	0.748
DOC_WW_Pin1_4	23	28	PF00397	0.714
LIG_14-3-3_CanoR_1	184	194	PF00244	0.351
LIG_14-3-3_CanoR_1	198	206	PF00244	0.395
LIG_14-3-3_CanoR_1	343	348	PF00244	0.399
LIG_14-3-3_CanoR_1	431	435	PF00244	0.450
LIG_14-3-3_CanoR_1	443	447	PF00244	0.385
LIG_14-3-3_CanoR_1	506	512	PF00244	0.668
LIG_14-3-3_CanoR_1	90	98	PF00244	0.560
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_BRCT_BRCA1_1	522	526	PF00533	0.472
LIG_BRCT_BRCA1_1	608	612	PF00533	0.432
LIG_eIF4E_1	272	278	PF01652	0.441
LIG_FHA_1	142	148	PF00498	0.506
LIG_FHA_1	354	360	PF00498	0.369
LIG_FHA_1	418	424	PF00498	0.500
LIG_FHA_1	43	49	PF00498	0.450
LIG_FHA_1	496	502	PF00498	0.674
LIG_FHA_1	551	557	PF00498	0.441
LIG_FHA_2	200	206	PF00498	0.447
LIG_FHA_2	230	236	PF00498	0.587
LIG_FHA_2	344	350	PF00498	0.537
LIG_FHA_2	402	408	PF00498	0.435
LIG_FHA_2	97	103	PF00498	0.634
LIG_LIR_Apic_2	14	18	PF02991	0.650
LIG_LIR_Apic_2	181	186	PF02991	0.486
LIG_LIR_Gen_1	215	223	PF02991	0.356
LIG_LIR_Gen_1	433	442	PF02991	0.354
LIG_LIR_Gen_1	49	58	PF02991	0.510
LIG_LIR_Gen_1	508	517	PF02991	0.720
LIG_LIR_Gen_1	523	534	PF02991	0.316
LIG_LIR_Nem_3	215	220	PF02991	0.355
LIG_LIR_Nem_3	271	275	PF02991	0.443
LIG_LIR_Nem_3	433	437	PF02991	0.380
LIG_LIR_Nem_3	49	53	PF02991	0.518
LIG_LIR_Nem_3	508	512	PF02991	0.727
LIG_LIR_Nem_3	523	529	PF02991	0.330
LIG_LIR_Nem_3	608	613	PF02991	0.515
LIG_NRBOX	276	282	PF00104	0.308
LIG_Pex14_2	213	217	PF04695	0.366
LIG_SH2_CRK	183	187	PF00017	0.474
LIG_SH2_CRK	272	276	PF00017	0.440
LIG_SH2_NCK_1	288	292	PF00017	0.447
LIG_SH2_NCK_1	613	617	PF00017	0.496
LIG_SH2_SRC	288	291	PF00017	0.482
LIG_SH2_STAP1	613	617	PF00017	0.481
LIG_SH2_STAT3	633	636	PF00017	0.411
LIG_SH2_STAT5	151	154	PF00017	0.428
LIG_SH2_STAT5	240	243	PF00017	0.424
LIG_SH2_STAT5	593	596	PF00017	0.429
LIG_SH2_STAT5	613	616	PF00017	0.230
LIG_SH2_STAT5	630	633	PF00017	0.229
LIG_SH3_3	21	27	PF00018	0.725
LIG_SH3_3	38	44	PF00018	0.464
LIG_SH3_3	461	467	PF00018	0.564
LIG_SH3_3	618	624	PF00018	0.393
LIG_SUMO_SIM_anti_2	305	311	PF11976	0.338
LIG_SUMO_SIM_par_1	274	279	PF11976	0.359
LIG_SUMO_SIM_par_1	68	77	PF11976	0.420
LIG_TRAF2_1	136	139	PF00917	0.645
LIG_TRAF2_1	333	336	PF00917	0.512
LIG_TRAF2_2	627	632	PF00917	0.343
LIG_TRFH_1	509	513	PF08558	0.513
LIG_UBA3_1	261	270	PF00899	0.397
MOD_CK1_1	123	129	PF00069	0.685
MOD_CK1_1	34	40	PF00069	0.745
MOD_CK1_1	353	359	PF00069	0.537
MOD_CK1_1	92	98	PF00069	0.565
MOD_CK2_1	106	112	PF00069	0.741
MOD_CK2_1	11	17	PF00069	0.602
MOD_CK2_1	229	235	PF00069	0.594
MOD_CK2_1	381	387	PF00069	0.534
MOD_CK2_1	401	407	PF00069	0.495
MOD_CK2_1	43	49	PF00069	0.510
MOD_CK2_1	612	618	PF00069	0.413
MOD_CK2_1	96	102	PF00069	0.645
MOD_GlcNHglycan	1	4	PF01048	0.747
MOD_GlcNHglycan	108	111	PF01048	0.767
MOD_GlcNHglycan	121	125	PF01048	0.719
MOD_GlcNHglycan	170	173	PF01048	0.460
MOD_GlcNHglycan	34	37	PF01048	0.657
MOD_GlcNHglycan	352	355	PF01048	0.545
MOD_GlcNHglycan	384	387	PF01048	0.606
MOD_GlcNHglycan	45	48	PF01048	0.479
MOD_GlcNHglycan	498	501	PF01048	0.677
MOD_GlcNHglycan	514	517	PF01048	0.540
MOD_GlcNHglycan	60	63	PF01048	0.431
MOD_GlcNHglycan	614	617	PF01048	0.363
MOD_GlcNHglycan	91	94	PF01048	0.622
MOD_GSK3_1	397	404	PF00069	0.495
MOD_GSK3_1	92	99	PF00069	0.577
MOD_NEK2_1	276	281	PF00069	0.321
MOD_NEK2_1	406	411	PF00069	0.460
MOD_NEK2_1	437	442	PF00069	0.390
MOD_NEK2_1	550	555	PF00069	0.442
MOD_NEK2_1	556	561	PF00069	0.446
MOD_NEK2_1	58	63	PF00069	0.508
MOD_NEK2_1	612	617	PF00069	0.417
MOD_NEK2_2	507	512	PF00069	0.566
MOD_PIKK_1	437	443	PF00454	0.413
MOD_PIKK_1	556	562	PF00454	0.450
MOD_PKA_1	360	366	PF00069	0.551
MOD_PKA_2	229	235	PF00069	0.550
MOD_PKA_2	430	436	PF00069	0.445
MOD_PKA_2	442	448	PF00069	0.350
MOD_PKA_2	505	511	PF00069	0.556
MOD_PKA_2	89	95	PF00069	0.570
MOD_Plk_1	406	412	PF00069	0.330
MOD_Plk_1	556	562	PF00069	0.451
MOD_Plk_1	617	623	PF00069	0.469
MOD_Plk_2-3	229	235	PF00069	0.501
MOD_Plk_2-3	407	413	PF00069	0.406
MOD_Plk_4	129	135	PF00069	0.684
MOD_Plk_4	268	274	PF00069	0.445
MOD_Plk_4	276	282	PF00069	0.312
MOD_Plk_4	442	448	PF00069	0.455
MOD_Plk_4	529	535	PF00069	0.390
MOD_Plk_4	545	551	PF00069	0.310
MOD_ProDKin_1	23	29	PF00069	0.717
MOD_SUMO_rev_2	84	89	PF00179	0.518
TRG_DiLeu_BaEn_1	545	550	PF01217	0.380
TRG_DiLeu_BaEn_1	68	73	PF01217	0.501
TRG_DiLeu_BaEn_3	68	74	PF01217	0.551
TRG_DiLeu_BaEn_3	76	82	PF01217	0.481
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.491
TRG_DiLeu_BaLyEn_6	551	556	PF01217	0.476
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.494
TRG_ENDOCYTIC_2	272	275	PF00928	0.442
TRG_ER_diArg_1	390	392	PF00400	0.488
TRG_ER_diArg_1	430	432	PF00400	0.563
TRG_ER_diArg_1	447	450	PF00400	0.275
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK53	Leptomonas seymouri	60%	99%
A0A1X0NRY3	Trypanosomatidae	28%	100%
A0A3Q8IHE5	Leishmania donovani	99%	100%
A0A422P2Z2	Trypanosoma rangeli	27%	100%
A4HKZ1	Leishmania braziliensis	74%	100%
D0AAP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9B3D2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4S4	Leishmania major	94%	100%
V5BQY9	Trypanosoma cruzi	25%	100%