Putative RNA-binding, protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding - protein - putative

Species:

Leishmania infantum

UniProt:

A4I8H1_LEIIN

TriTrypDb:

LINF_320042200

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I8H1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8H1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.388
CLV_C14_Caspase3-7	430	434	PF00656	0.803
CLV_C14_Caspase3-7	440	444	PF00656	0.530
CLV_NRD_NRD_1	341	343	PF00675	0.459
CLV_NRD_NRD_1	377	379	PF00675	0.483
CLV_NRD_NRD_1	386	388	PF00675	0.475
CLV_NRD_NRD_1	389	391	PF00675	0.457
CLV_NRD_NRD_1	394	396	PF00675	0.476
CLV_NRD_NRD_1	58	60	PF00675	0.500
CLV_NRD_NRD_1	74	76	PF00675	0.432
CLV_PCSK_FUR_1	377	381	PF00082	0.481
CLV_PCSK_FUR_1	382	386	PF00082	0.486
CLV_PCSK_KEX2_1	341	343	PF00082	0.459
CLV_PCSK_KEX2_1	376	378	PF00082	0.482
CLV_PCSK_KEX2_1	379	381	PF00082	0.475
CLV_PCSK_KEX2_1	384	386	PF00082	0.491
CLV_PCSK_KEX2_1	393	395	PF00082	0.467
CLV_PCSK_KEX2_1	58	60	PF00082	0.515
CLV_PCSK_KEX2_1	74	76	PF00082	0.446
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.482
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.475
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.467
CLV_PCSK_PC7_1	380	386	PF00082	0.541
CLV_PCSK_PC7_1	390	396	PF00082	0.420
CLV_PCSK_SKI1_1	197	201	PF00082	0.608
CLV_PCSK_SKI1_1	342	346	PF00082	0.484
CLV_PCSK_SKI1_1	390	394	PF00082	0.484
CLV_PCSK_SKI1_1	395	399	PF00082	0.464
CLV_PCSK_SKI1_1	471	475	PF00082	0.269
CLV_PCSK_SKI1_1	82	86	PF00082	0.488
DEG_APCC_DBOX_1	81	89	PF00400	0.460
DEG_COP1_1	446	456	PF00400	0.477
DEG_Nend_UBRbox_2	1	3	PF02207	0.463
DEG_SPOP_SBC_1	424	428	PF00917	0.682
DOC_CDC14_PxL_1	17	25	PF14671	0.526
DOC_CKS1_1	115	120	PF01111	0.603
DOC_CKS1_1	155	160	PF01111	0.537
DOC_CYCLIN_RxL_1	194	205	PF00134	0.604
DOC_MAPK_gen_1	390	400	PF00069	0.557
DOC_MAPK_MEF2A_6	312	319	PF00069	0.365
DOC_MAPK_MEF2A_6	46	53	PF00069	0.396
DOC_PP1_RVXF_1	195	202	PF00149	0.602
DOC_PP4_FxxP_1	201	204	PF00568	0.622
DOC_USP7_MATH_1	126	130	PF00917	0.651
DOC_USP7_MATH_1	169	173	PF00917	0.641
DOC_USP7_MATH_1	355	359	PF00917	0.491
DOC_USP7_MATH_1	367	371	PF00917	0.453
DOC_USP7_MATH_1	420	424	PF00917	0.684
DOC_WW_Pin1_4	114	119	PF00397	0.590
DOC_WW_Pin1_4	130	135	PF00397	0.686
DOC_WW_Pin1_4	147	152	PF00397	0.598
DOC_WW_Pin1_4	154	159	PF00397	0.623
DOC_WW_Pin1_4	171	176	PF00397	0.644
DOC_WW_Pin1_4	249	254	PF00397	0.396
DOC_WW_Pin1_4	405	410	PF00397	0.551
DOC_WW_Pin1_4	434	439	PF00397	0.602
LIG_14-3-3_CanoR_1	484	488	PF00244	0.469
LIG_14-3-3_CanoR_1	501	506	PF00244	0.469
LIG_14-3-3_CanoR_1	521	526	PF00244	0.443
LIG_14-3-3_CanoR_1	546	551	PF00244	0.531
LIG_14-3-3_CanoR_1	97	105	PF00244	0.538
LIG_BRCT_BRCA1_1	490	494	PF00533	0.469
LIG_DLG_GKlike_1	521	529	PF00625	0.565
LIG_eIF4E_1	520	526	PF01652	0.525
LIG_FHA_1	155	161	PF00498	0.585
LIG_FHA_1	219	225	PF00498	0.427
LIG_FHA_1	269	275	PF00498	0.399
LIG_FHA_1	284	290	PF00498	0.369
LIG_FHA_1	328	334	PF00498	0.464
LIG_FHA_1	493	499	PF00498	0.455
LIG_FHA_1	93	99	PF00498	0.533
LIG_FHA_2	148	154	PF00498	0.644
LIG_FHA_2	267	273	PF00498	0.561
LIG_FHA_2	463	469	PF00498	0.469
LIG_FHA_2	477	483	PF00498	0.469
LIG_FHA_2	557	563	PF00498	0.615
LIG_IBAR_NPY_1	240	242	PF08397	0.403
LIG_LIR_Nem_3	282	288	PF02991	0.348
LIG_LIR_Nem_3	518	523	PF02991	0.454
LIG_LIR_Nem_3	89	93	PF02991	0.489
LIG_NRBOX	469	475	PF00104	0.469
LIG_PCNA_PIPBox_1	81	90	PF02747	0.523
LIG_PDZ_Class_2	561	566	PF00595	0.544
LIG_PDZ_Wminus1_1	564	566	PF00595	0.553
LIG_PTB_Apo_2	237	244	PF02174	0.384
LIG_PTB_Apo_2	514	521	PF02174	0.516
LIG_PTB_Phospho_1	514	520	PF10480	0.516
LIG_Rb_pABgroove_1	18	26	PF01858	0.482
LIG_REV1ctd_RIR_1	198	203	PF16727	0.548
LIG_RPA_C_Fungi	373	385	PF08784	0.474
LIG_SH2_CRK	38	42	PF00017	0.531
LIG_SH2_CRK	477	481	PF00017	0.304
LIG_SH2_CRK	523	527	PF00017	0.368
LIG_SH2_NCK_1	523	527	PF00017	0.433
LIG_SH2_STAP1	24	28	PF00017	0.472
LIG_SH2_STAP1	285	289	PF00017	0.308
LIG_SH2_STAT5	225	228	PF00017	0.415
LIG_SH2_STAT5	242	245	PF00017	0.392
LIG_SH2_STAT5	262	265	PF00017	0.362
LIG_SH2_STAT5	285	288	PF00017	0.377
LIG_SH2_STAT5	310	313	PF00017	0.447
LIG_SH3_3	176	182	PF00018	0.669
LIG_SUMO_SIM_anti_2	532	538	PF11976	0.445
LIG_SUMO_SIM_par_1	291	298	PF11976	0.345
LIG_SUMO_SIM_par_1	50	55	PF11976	0.411
LIG_SUMO_SIM_par_1	535	541	PF11976	0.452
LIG_TRAF2_1	410	413	PF00917	0.660
LIG_TRAF2_1	504	507	PF00917	0.304
LIG_TRAF2_2	118	123	PF00917	0.538
MOD_CDK_SPK_2	154	159	PF00069	0.594
MOD_CDK_SPxK_1	135	141	PF00069	0.620
MOD_CDK_SPxxK_3	171	178	PF00069	0.666
MOD_CDK_SPxxK_3	249	256	PF00069	0.380
MOD_CK1_1	174	180	PF00069	0.670
MOD_CK1_1	280	286	PF00069	0.420
MOD_CK1_1	358	364	PF00069	0.510
MOD_CK1_1	407	413	PF00069	0.616
MOD_CK1_1	423	429	PF00069	0.534
MOD_CK1_1	431	437	PF00069	0.624
MOD_CK1_1	524	530	PF00069	0.427
MOD_CK1_1	99	105	PF00069	0.531
MOD_CK2_1	108	114	PF00069	0.562
MOD_CK2_1	147	153	PF00069	0.651
MOD_CK2_1	266	272	PF00069	0.420
MOD_CK2_1	407	413	PF00069	0.603
MOD_CK2_1	476	482	PF00069	0.304
MOD_CK2_1	501	507	PF00069	0.308
MOD_CK2_1	556	562	PF00069	0.548
MOD_CK2_1	86	92	PF00069	0.495
MOD_GlcNHglycan	126	129	PF01048	0.629
MOD_GlcNHglycan	165	168	PF01048	0.654
MOD_GlcNHglycan	169	172	PF01048	0.620
MOD_GlcNHglycan	282	285	PF01048	0.459
MOD_GlcNHglycan	359	363	PF01048	0.531
MOD_GlcNHglycan	370	373	PF01048	0.416
MOD_GlcNHglycan	422	425	PF01048	0.735
MOD_GlcNHglycan	443	446	PF01048	0.518
MOD_GlcNHglycan	488	493	PF01048	0.304
MOD_GlcNHglycan	526	529	PF01048	0.351
MOD_GlcNHglycan	62	65	PF01048	0.684
MOD_GSK3_1	126	133	PF00069	0.706
MOD_GSK3_1	145	152	PF00069	0.617
MOD_GSK3_1	163	170	PF00069	0.762
MOD_GSK3_1	189	196	PF00069	0.635
MOD_GSK3_1	403	410	PF00069	0.590
MOD_GSK3_1	420	427	PF00069	0.502
MOD_GSK3_1	428	435	PF00069	0.584
MOD_GSK3_1	437	444	PF00069	0.624
MOD_GSK3_1	488	495	PF00069	0.304
MOD_GSK3_1	60	67	PF00069	0.512
MOD_GSK3_1	92	99	PF00069	0.579
MOD_N-GLC_1	60	65	PF02516	0.486
MOD_NEK2_1	218	223	PF00069	0.436
MOD_NEK2_1	266	271	PF00069	0.463
MOD_NEK2_1	37	42	PF00069	0.466
MOD_NEK2_1	509	514	PF00069	0.334
MOD_NEK2_1	60	65	PF00069	0.530
MOD_PIKK_1	116	122	PF00454	0.597
MOD_PIKK_1	26	32	PF00454	0.538
MOD_PK_1	393	399	PF00069	0.543
MOD_PK_1	501	507	PF00069	0.347
MOD_PKA_1	393	399	PF00069	0.543
MOD_PKA_2	167	173	PF00069	0.682
MOD_PKA_2	202	208	PF00069	0.610
MOD_PKA_2	393	399	PF00069	0.543
MOD_PKA_2	483	489	PF00069	0.304
MOD_PKA_2	96	102	PF00069	0.545
MOD_Plk_1	235	241	PF00069	0.418
MOD_Plk_1	556	562	PF00069	0.524
MOD_Plk_4	283	289	PF00069	0.378
MOD_Plk_4	515	521	PF00069	0.297
MOD_ProDKin_1	114	120	PF00069	0.593
MOD_ProDKin_1	130	136	PF00069	0.686
MOD_ProDKin_1	147	153	PF00069	0.599
MOD_ProDKin_1	154	160	PF00069	0.621
MOD_ProDKin_1	171	177	PF00069	0.644
MOD_ProDKin_1	249	255	PF00069	0.397
MOD_ProDKin_1	405	411	PF00069	0.552
MOD_ProDKin_1	434	440	PF00069	0.601
TRG_DiLeu_BaEn_4	506	512	PF01217	0.369
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.518
TRG_ENDOCYTIC_2	225	228	PF00928	0.422
TRG_ENDOCYTIC_2	24	27	PF00928	0.473
TRG_ENDOCYTIC_2	246	249	PF00928	0.422
TRG_ENDOCYTIC_2	34	37	PF00928	0.490
TRG_ENDOCYTIC_2	38	41	PF00928	0.466
TRG_ENDOCYTIC_2	477	480	PF00928	0.304
TRG_ENDOCYTIC_2	523	526	PF00928	0.377
TRG_ER_diArg_1	340	342	PF00400	0.445
TRG_ER_diArg_1	377	380	PF00400	0.483
TRG_ER_diArg_1	382	385	PF00400	0.487
TRG_ER_diArg_1	58	60	PF00400	0.515
TRG_ER_diArg_1	74	76	PF00400	0.432
TRG_NLS_Bipartite_1	376	397	PF00514	0.474
TRG_NLS_MonoExtC_3	377	382	PF00514	0.491
TRG_NLS_MonoExtN_4	376	383	PF00514	0.479
TRG_NLS_MonoExtN_4	390	397	PF00514	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAT8	Leptomonas seymouri	53%	100%
A0A3Q8IDF9	Leishmania donovani	99%	100%
A4HKZ0	Leishmania braziliensis	79%	99%
E9B3D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q4S5	Leishmania major	92%	100%