Zinc-finger of a C2HC-type family protein

Quick info Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of a C2HC-type - putative

Species:

Leishmania infantum

UniProt:

A4I8G9_LEIIN

TriTrypDb:

LINF_320042000

Length:

558

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I8G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I8G9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.631
CLV_NRD_NRD_1	16	18	PF00675	0.509
CLV_NRD_NRD_1	192	194	PF00675	0.662
CLV_NRD_NRD_1	472	474	PF00675	0.346
CLV_NRD_NRD_1	496	498	PF00675	0.522
CLV_NRD_NRD_1	514	516	PF00675	0.616
CLV_PCSK_KEX2_1	16	18	PF00082	0.513
CLV_PCSK_KEX2_1	192	194	PF00082	0.662
CLV_PCSK_KEX2_1	50	52	PF00082	0.505
CLV_PCSK_KEX2_1	514	516	PF00082	0.680
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.499
CLV_PCSK_SKI1_1	140	144	PF00082	0.309
CLV_PCSK_SKI1_1	158	162	PF00082	0.540
CLV_PCSK_SKI1_1	328	332	PF00082	0.644
CLV_PCSK_SKI1_1	473	477	PF00082	0.338
CLV_PCSK_SKI1_1	514	518	PF00082	0.575
CLV_PCSK_SKI1_1	75	79	PF00082	0.560
DEG_Nend_Nbox_1	1	3	PF02207	0.467
DEG_SPOP_SBC_1	179	183	PF00917	0.584
DEG_SPOP_SBC_1	339	343	PF00917	0.552
DOC_CKS1_1	174	179	PF01111	0.668
DOC_CKS1_1	381	386	PF01111	0.479
DOC_MAPK_gen_1	497	504	PF00069	0.539
DOC_MAPK_MEF2A_6	281	290	PF00069	0.619
DOC_MAPK_NFAT4_5	281	289	PF00069	0.509
DOC_PP1_RVXF_1	305	311	PF00149	0.657
DOC_PP1_RVXF_1	49	56	PF00149	0.387
DOC_PP2B_LxvP_1	502	505	PF13499	0.570
DOC_USP7_MATH_1	175	179	PF00917	0.606
DOC_USP7_MATH_1	180	184	PF00917	0.615
DOC_USP7_MATH_1	219	223	PF00917	0.593
DOC_USP7_MATH_1	246	250	PF00917	0.626
DOC_USP7_MATH_1	351	355	PF00917	0.672
DOC_USP7_MATH_1	373	377	PF00917	0.689
DOC_USP7_MATH_1	390	394	PF00917	0.540
DOC_USP7_MATH_1	401	405	PF00917	0.530
DOC_USP7_MATH_1	524	528	PF00917	0.556
DOC_USP7_UBL2_3	71	75	PF12436	0.486
DOC_USP7_UBL2_3	9	13	PF12436	0.659
DOC_WW_Pin1_4	130	135	PF00397	0.346
DOC_WW_Pin1_4	173	178	PF00397	0.707
DOC_WW_Pin1_4	182	187	PF00397	0.504
DOC_WW_Pin1_4	215	220	PF00397	0.561
DOC_WW_Pin1_4	340	345	PF00397	0.624
DOC_WW_Pin1_4	380	385	PF00397	0.637
DOC_WW_Pin1_4	509	514	PF00397	0.739
DOC_WW_Pin1_4	516	521	PF00397	0.589
DOC_WW_Pin1_4	66	71	PF00397	0.450
LIG_14-3-3_CanoR_1	155	164	PF00244	0.567
LIG_14-3-3_CanoR_1	16	20	PF00244	0.476
LIG_14-3-3_CanoR_1	195	203	PF00244	0.561
LIG_14-3-3_CanoR_1	307	311	PF00244	0.594
LIG_14-3-3_CanoR_1	458	467	PF00244	0.495
LIG_BIR_III_4	391	395	PF00653	0.652
LIG_Clathr_ClatBox_1	287	291	PF01394	0.443
LIG_CtBP_PxDLS_1	297	301	PF00389	0.470
LIG_EVH1_1	502	506	PF00568	0.506
LIG_FHA_1	259	265	PF00498	0.656
LIG_FHA_1	35	41	PF00498	0.353
LIG_FHA_1	499	505	PF00498	0.573
LIG_FHA_2	312	318	PF00498	0.630
LIG_FHA_2	366	372	PF00498	0.661
LIG_FHA_2	413	419	PF00498	0.652
LIG_FHA_2	459	465	PF00498	0.502
LIG_Integrin_RGD_1	57	59	PF01839	0.424
LIG_LIR_Apic_2	198	203	PF02991	0.581
LIG_LIR_Apic_2	227	232	PF02991	0.563
LIG_LIR_Gen_1	117	127	PF02991	0.403
LIG_LIR_Gen_1	309	318	PF02991	0.637
LIG_LIR_Nem_3	117	122	PF02991	0.414
LIG_LIR_Nem_3	445	450	PF02991	0.507
LIG_PTAP_UEV_1	176	181	PF05743	0.530
LIG_SH2_CRK	119	123	PF00017	0.401
LIG_SH2_CRK	200	204	PF00017	0.650
LIG_SH2_CRK	229	233	PF00017	0.565
LIG_SH2_NCK_1	229	233	PF00017	0.565
LIG_SH2_NCK_1	411	415	PF00017	0.590
LIG_SH2_NCK_1	96	100	PF00017	0.531
LIG_SH2_STAT5	229	232	PF00017	0.545
LIG_SH2_STAT5	29	32	PF00017	0.294
LIG_SH2_STAT5	470	473	PF00017	0.292
LIG_SH2_STAT5	48	51	PF00017	0.500
LIG_SH3_1	517	523	PF00018	0.557
LIG_SH3_2	276	281	PF14604	0.593
LIG_SH3_3	167	173	PF00018	0.607
LIG_SH3_3	174	180	PF00018	0.539
LIG_SH3_3	273	279	PF00018	0.752
LIG_SH3_3	323	329	PF00018	0.593
LIG_SH3_3	333	339	PF00018	0.603
LIG_SH3_3	500	506	PF00018	0.717
LIG_SH3_3	517	523	PF00018	0.455
LIG_SH3_3	64	70	PF00018	0.436
LIG_SUMO_SIM_anti_2	282	289	PF11976	0.622
LIG_SUMO_SIM_par_1	285	291	PF11976	0.557
LIG_TRAF2_1	232	235	PF00917	0.631
MOD_CDK_SPK_2	215	220	PF00069	0.532
MOD_CDK_SPK_2	509	514	PF00069	0.755
MOD_CDK_SPK_2	66	71	PF00069	0.504
MOD_CDK_SPxK_1	509	515	PF00069	0.675
MOD_CK1_1	178	184	PF00069	0.588
MOD_CK1_1	185	191	PF00069	0.545
MOD_CK1_1	222	228	PF00069	0.767
MOD_CK1_1	365	371	PF00069	0.759
MOD_CK1_1	393	399	PF00069	0.593
MOD_CK1_1	404	410	PF00069	0.476
MOD_CK1_1	527	533	PF00069	0.575
MOD_CK2_1	66	72	PF00069	0.429
MOD_Cter_Amidation	471	474	PF01082	0.346
MOD_GlcNHglycan	177	180	PF01048	0.642
MOD_GlcNHglycan	182	185	PF01048	0.673
MOD_GlcNHglycan	187	190	PF01048	0.580
MOD_GlcNHglycan	197	200	PF01048	0.543
MOD_GlcNHglycan	323	326	PF01048	0.673
MOD_GlcNHglycan	353	356	PF01048	0.587
MOD_GlcNHglycan	371	374	PF01048	0.682
MOD_GlcNHglycan	391	395	PF01048	0.561
MOD_GlcNHglycan	526	529	PF01048	0.636
MOD_GSK3_1	175	182	PF00069	0.583
MOD_GSK3_1	215	222	PF00069	0.700
MOD_GSK3_1	241	248	PF00069	0.684
MOD_GSK3_1	254	261	PF00069	0.512
MOD_GSK3_1	292	299	PF00069	0.729
MOD_GSK3_1	340	347	PF00069	0.614
MOD_GSK3_1	365	372	PF00069	0.640
MOD_GSK3_1	505	512	PF00069	0.680
MOD_N-GLC_1	127	132	PF02516	0.461
MOD_N-GLC_1	244	249	PF02516	0.647
MOD_N-GLC_1	351	356	PF02516	0.681
MOD_N-GLC_1	442	447	PF02516	0.513
MOD_NEK2_1	127	132	PF00069	0.461
MOD_NEK2_1	320	325	PF00069	0.598
MOD_NEK2_1	364	369	PF00069	0.629
MOD_PIKK_1	362	368	PF00454	0.651
MOD_PIKK_1	373	379	PF00454	0.449
MOD_PKA_2	15	21	PF00069	0.494
MOD_PKA_2	306	312	PF00069	0.594
MOD_PKA_2	369	375	PF00069	0.629
MOD_PKA_2	457	463	PF00069	0.517
MOD_PKB_1	193	201	PF00069	0.505
MOD_Plk_1	127	133	PF00069	0.410
MOD_Plk_1	222	228	PF00069	0.534
MOD_Plk_1	401	407	PF00069	0.565
MOD_Plk_1	442	448	PF00069	0.514
MOD_Plk_4	306	312	PF00069	0.728
MOD_ProDKin_1	130	136	PF00069	0.346
MOD_ProDKin_1	173	179	PF00069	0.705
MOD_ProDKin_1	182	188	PF00069	0.503
MOD_ProDKin_1	215	221	PF00069	0.561
MOD_ProDKin_1	340	346	PF00069	0.626
MOD_ProDKin_1	380	386	PF00069	0.637
MOD_ProDKin_1	509	515	PF00069	0.738
MOD_ProDKin_1	516	522	PF00069	0.589
MOD_ProDKin_1	66	72	PF00069	0.452
MOD_SUMO_rev_2	391	401	PF00179	0.697
MOD_SUMO_rev_2	544	550	PF00179	0.518
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.495
TRG_ENDOCYTIC_2	119	122	PF00928	0.408
TRG_ER_diArg_1	192	195	PF00400	0.612
TRG_ER_diArg_1	513	515	PF00400	0.618
TRG_NES_CRM1_1	282	294	PF08389	0.623
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.235

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJN9	Leptomonas seymouri	41%	82%
A0A3Q8ITN7	Leishmania donovani	99%	100%
A4HKY8	Leishmania braziliensis	61%	100%
E9B3C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q4S7	Leishmania major	89%	100%